Research Topics
Genomes and Genes | Sandra L GrimmSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Keratin 6 is not essential for mammary gland developmentSandra L Grimm
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Breast Cancer Res 8:R29. 2006....
Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null miceSandra L Grimm
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 280:36301-9. 2005..Collectively, these changes prevent C/EBPbeta-null mammary epithelial cells from responding to hormone-induced proliferative signals...
The role of C/EBPbeta in mammary gland development and breast cancerSandra L Grimm
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Mammary Gland Biol Neoplasia 8:191-204. 2003..Thus, C/EBPbeta appears to play a role in the specification of progenitor cell fate not only in the mammary gland, but also in a number of other tissues...
Progesterone receptor directly inhibits β-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modificationsAdam C Buser
Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, Texas 77030, USA
Mol Endocrinol 25:955-68. 2011..These studies define a novel mechanism of steroid receptor-mediated transcriptional repression of a physiologically important gene in mammary gland development and differentiation...
Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferatingSandra L Grimm
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Breast Cancer Res 8:106. 2006....
Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar developmentSandra L Grimm
Department of Molecular and Cellular Biology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Mol Endocrinol 16:2675-91. 2002..Together, these data suggest that C/EBPbeta is a master regulator of mammary epithelial cell fate and that the correct spatial pattern of PR and PrlR expression is a critical determinant of hormone-regulated cell proliferation...
Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epitheliumJonathan M Shillingford
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Endocrinol 16:563-70. 2002..Taken together, our results demonstrate that Jak2 is a critical tyrosine kinase that conveys intracellular signals necessary for proliferation and differentiation of mammary epithelium during pregnancy...
