Brett H Graham

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. doi request reprint Diagnostic challenges of mitochondrial disorders: complexities of two genomes
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 837:35-46. 2012
  2. pmc Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:11143-53. 2010
  3. doi request reprint Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    J Bioenerg Biomembr 40:207-12. 2008
  4. pmc The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit
    Ke Zhang
    Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 200:807-20. 2013
  5. pmc Exome sequencing of a patient with suspected mitochondrial disease reveals a likely multigenic etiology
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    BMC Med Genet 14:83. 2013
  6. pmc Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans
    Vafa Bayat
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 10:e1001288. 2012
  7. doi request reprint An integrated approach for classifying mitochondrial DNA variants: one clinical diagnostic laboratory's experience
    Jing Wang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Genet Med 14:620-6. 2012
  8. doi request reprint Two mtDNA mutations 14487T>C (M63V, ND6) and 12297T>C (tRNA Leu) in a Leigh syndrome family
    Jing Wang
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, TX 77030, USA
    Mol Genet Metab 96:59-65. 2009
  9. pmc Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size
    Marwan Shinawi
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, Texas 77030, USA
    J Med Genet 47:332-41. 2010
  10. pmc Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance
    Penelope E Bonnen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 93:471-81. 2013

Collaborators

Detail Information

Publications25

  1. doi request reprint Diagnostic challenges of mitochondrial disorders: complexities of two genomes
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 837:35-46. 2012
    ..The growing list of known disease-causing genes and the promise of next generation sequencing technologies will undoubtedly improve diagnostic accuracy and genetic counseling for this challenging group of disorders...
  2. pmc Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:11143-53. 2010
    ....
  3. doi request reprint Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    J Bioenerg Biomembr 40:207-12. 2008
    ..Striking similarities to mouse VDAC mutants can be found that emphasize the conservation of function over a long evolutionary time frame...
  4. pmc The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit
    Ke Zhang
    Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 200:807-20. 2013
    ..Our data indicate that cytosolic chaperones are required for the subcellular transport of ND42...
  5. pmc Exome sequencing of a patient with suspected mitochondrial disease reveals a likely multigenic etiology
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    BMC Med Genet 14:83. 2013
    ....
  6. pmc Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans
    Vafa Bayat
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 10:e1001288. 2012
    ..Patient cells also exhibited reduced Complex I activity, increased ROS, and a slower cell proliferation rate, similar to Drosophila Aats-met mutants...
  7. doi request reprint An integrated approach for classifying mitochondrial DNA variants: one clinical diagnostic laboratory's experience
    Jing Wang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Genet Med 14:620-6. 2012
    ..Clinicians are increasingly interested in requesting mtDNA testing. However, interpretation of uncharacterized mtDNA variants is a great challenge. We suggest a stepwise interpretation procedure for clinical service...
  8. doi request reprint Two mtDNA mutations 14487T>C (M63V, ND6) and 12297T>C (tRNA Leu) in a Leigh syndrome family
    Jing Wang
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, TX 77030, USA
    Mol Genet Metab 96:59-65. 2009
    ..The 12297T>C mutation was not associated with dilated cardiomyopathy for the family members who were clinically evaluated and who were shown by testing to be nearly homoplasmic for that mutation...
  9. pmc Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size
    Marwan Shinawi
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, Texas 77030, USA
    J Med Genet 47:332-41. 2010
    ..Deletion and the reciprocal duplication in 16p11.2 were recently associated with autism and developmental delay...
  10. pmc Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance
    Penelope E Bonnen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 93:471-81. 2013
    ..Together our data demonstrate that mutations in FBXL4 are disease causing and establish FBXL4 as a mitochondrial protein with a possible role in maintaining mtDNA integrity and stability. ..
  11. doi request reprint Current molecular diagnostic algorithm for mitochondrial disorders
    Lee Jun C Wong
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Genet Metab 100:111-7. 2010
    ..The ever-expanding list of known disease-causing genes will undoubtedly improve diagnostic accuracy and genetic counseling...
  12. pmc Structures and molecular mechanisms for common 15q13.3 microduplications involving CHRNA7: benign or pathological?
    Przemyslaw Szafranski
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Hum Mutat 31:840-50. 2010
    ..Nevertheless, if they prove to have a pathological effects, their high frequency could make them a common risk factor for many neurobehavioral disorders...
  13. pmc Delineation of a deletion region critical for corpus callosal abnormalities in chromosome 1q43-q44
    Sandesh C Sreenath Nagamani
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Eur J Hum Genet 20:176-9. 2012
    ..Our results rule out the involvement of AKT3, and implicate CEP170 and/or ZNF238 as novel genes causative for CCA in patients with a terminal 1q deletion...
  14. doi request reprint Measurement of mitochondrial oxygen consumption using a Clark electrode
    Zhihong Li
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 837:63-72. 2012
    ..This chapter describes the traditional method of mitochondrial polarography using a Clark electrode for measuring coupled respiration in freshly isolated mitochondria from both mammalian tissues and Drosophila melanogaster...
  15. ncbi request reprint Noninvasive, in vivo approaches to evaluating behavior and exercise physiology in mouse models of mitochondrial disease
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Methods 26:364-70. 2002
    ..This review presents various behavioral and exercise physiology protocols that can be used for the evaluation of potential mouse models of human mitochondrial disorders...
  16. ncbi request reprint Genetic approaches to analyzing mitochondrial outer membrane permeability
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Top Dev Biol 59:87-118. 2004
  17. ncbi request reprint Mitochondrial voltage-dependent anion channel gene family in Drosophila melanogaster: complex patterns of evolution, genomic organization, and developmental expression
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Genet Metab 85:308-17. 2005
    ....
  18. doi request reprint The mitochondrial 13513G>A mutation is associated with Leigh disease phenotypes independent of complex I deficiency in muscle
    Ariel Brautbar
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, TX 77030, USA
    Mol Genet Metab 94:485-90. 2008
    ....
  19. doi request reprint Voltage-dependant anion channels: novel insights into isoform function through genetic models
    Adithya Raghavan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77025, USA
    Biochim Biophys Acta 1818:1477-85. 2012
    ..This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism...
  20. pmc Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis
    Peng Kang
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 74:79-94. 2012
    ....
  21. pmc A syndrome of short stature, microcephaly and speech delay is associated with duplications reciprocal to the common Sotos syndrome deletion
    Luis M Franco
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Hum Genet 18:258-61. 2010
    ..The phenotype is remarkably opposite to that of Sotos syndrome, suggesting a role for NSD1 in the regulation of somatic growth in humans...
  22. ncbi request reprint Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1
    Motoaki Sano
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 5:129-42. 2007
    ..PGC-1 bound to both MAT1 and Cdk7 in coprecipitation assays. Thus, we demonstrate a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism...
  23. pmc Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion
    Taraka R Donti
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dis Model Mech 7:271-80. 2014
    ..In addition, this report demonstrates the power of a genetic screen that combines gene trap mutagenesis and FACS analysis in mouse ES cells to identify mitochondrial phenotypes and to develop animal models of mitochondrial dysfunction. ..
  24. pmc Activin signaling: effects on body composition and mitochondrial energy metabolism
    Liunan Li
    Department of Pediatrics, MD Anderson Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 150:3521-9. 2009
    ....
  25. ncbi request reprint Intrauterine growth retardation and placental vacuolization as presenting features in a case of GM1 gangliosidosis
    Nicola Brunetti-Pierri
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Inherit Metab Dis 30:823. 2007
    ....