Research Topics
Species | Ernest A GonzalezSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosisErnest A Gonzalez
Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
J Trauma 59:1092-8. 2005..In contrast to I/R cell necrosis, apoptosis provides controlled cell death that minimizes inflammation. We therefore hypothesized that HS resuscitation after mesenteric I/R would induce apoptosis and decrease mucosal injury...- Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusionErnest A Gonzalez
Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
J Trauma 61:66-73; discussion 73-4. 2006..We hypothesized that a dose dependent effect exists related to increasing tonicity and that the optimal gut protective dose would provide better protection against remote organ injury than large volume isotonic crystalloids... - Performance of a computerized protocol for trauma shock resuscitationJoseph F Sucher
Department of Surgery, The Methodist Hospital, 6550 Fannin Street, Smith Tower 1661A, Houston, TX 77030, USA
World J Surg 34:216-22. 2010.... - Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2James W Suliburk
Department of Surgery, The University of Texas Medical School at Houston, 77030, USA
Surgery 138:134-40. 2005..Because ketamine anesthesia has anti-inflammatory effects in some tissues, we hypothesized that it would attenuate lipopolysaccharide (LPS)-induced liver injury... - Ketamine inhibits lipopolysacharide (LPS) induced gastric luminal fluid accumulationJames W Suliburk
Department of General Surgery, The University of Texas Medical School at Houston, Houston, Texas 77026, USA
J Surg Res 127:203-7. 2005..Moreover, while iNOS may play a role in LPS induced gastric luminal fluid accumulation, it does not appear to be a major mediator of the gastrointestinal ileus caused by LPS... - Early cytokine production risk stratifies trauma patients for multiple organ failureKenneth M Jastrow
Department of Surgery, University of Texas Medical School at Houston, Houston, TX
J Am Coll Surg 209:320-31. 2009..In animal models of hemorrhagic shock, early (< 24 hours) changes in cytokine production are an index of the systemic inflammatory response syndrome. However, their predictive value in trauma patients remains to be fully elucidated... - Fresh frozen plasma should be given earlier to patients requiring massive transfusionErnest A Gonzalez
Department of Surgery, University of Texas Houston Medical School, Houston, Texas, USA
J Trauma 62:112-9. 2007..The hypothesis for this study is that our pre-intensive care unit (ICU) massive transfusion (MT) protocol does not adequately correct coagulopathy, and that early uncorrected coagulopathy is predictive of mortality... - Gastric alkalinization after major traumaChristine S Cocanour
Department of Surgery, UC Davis Medical Center, Sacramento, California, USA
J Trauma 64:681-7. 2008..Therefore, we hypothesized that trauma patients have an alkaline gastric environment that may be because of bile reflux... - Poloxamer 188 prolongs survival of hypotensive resuscitation and decreases vital tissue injury after full resuscitationRongzhen Zhang
Department of Pathology, University of Texas Houston Medical School, Houston, Texas, USA
Shock 32:442-50. 2009..Because P188 prolongs survival, decreases fluid requirements, and reduces tissue damage, it deserves further consideration as an adjunct to hypotensive resuscitation... - Central venous pressure versus pulmonary artery catheter-directed shock resuscitationBruce A McKinley
Department of Surgery, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, Texas 77030, USA
Shock 32:463-70. 2009..Computerized decision support provides a technique to implement complex protocol care processes and analyze patient response... 
Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitationRicky J Haywood-Watson
Department of Surgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
PLoS ONE 6:e23530. 2011..These data suggest that plasma based resuscitation preserved endothelial syndecan-1 and maintained endothelial integrity, and may help to explain the protective effects of fresh frozen plasma after hemorrhagic shock...- Early predictors of prolonged mechanical ventilation in major torso trauma patients who require resuscitationSteven C Agle
Department of Surgery, Eastern Carolina University, Greenville, NC, USA
Am J Surg 192:822-7. 2006..CONCLUSIONS: The need for prolonged mechanical ventilation can be accurately predicted and these predictors may assist clinicians in resource allocation and patient management decisions... - Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patientsJohn B Holcomb
United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
Ann Surg 248:447-58. 2008.... - Effects of poloxamer 188 on human PMN cellsMatthew T Harting
Department of Pediatric Surgery, University of Texas Medical School, Houston, TX 77030, USA
Surgery 144:198-203. 2008..We studied human PMN oxidative burst and adhesion molecule expression when exposed to P188... - Defining the limits of resuscitative emergency department thoracotomy: a contemporary Western Trauma Association perspectiveErnest E Moore
Department of Surgery, Denver Health, Denver, Colorado 80204, USA
J Trauma 70:334-9. 2011..The purpose of this prospective multicenter study was to identify injury patterns and physiologic profiles at ED arrival that are compatible with survival... - Update on postinjury nutritionSamuel R Todd
Department of Surgery, The Methodist Hospital Weill Cornell Medical College, USA
Curr Opin Crit Care 14:690-5. 2008..The optimal utilization and benefit of pharmaconutrients, however, remains unclear, as does the need for full caloric provision in the early postinjury phase... - A multidisciplinary clinical pathway decreases rib fracture-associated infectious morbidity and mortality in high-risk trauma patientsS Rob Todd
Department of Surgery, The Methodist Hospital, 6550 Fannin Street, Smith Tower 1661, Houston, TX 77030, USA
Am J Surg 192:806-11. 2006..The purpose of the current study was to evaluate the effect of this pathway on infectious morbidity and mortality... - Differential effects of anesthetics on endotoxin-induced liver injuryJames W Suliburk
Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas, USA
J Trauma 58:711-6; discussion 716-7. 2005..Thus, ketamine may be the anesthetic agent of choice for septic patients requiring anesthesia... - Acute lower extremity compartment syndrome (ALECS) screening protocol in critically ill trauma patientsRoman Kosir
Department of Surgery, General and Teaching Hospital, Maribor, Slovenia
J Trauma 63:268-75. 2007..Acute lower extremity compartment syndrome (ALECS) is a devastating complication that often presents silently in critically injured patients; therefore, we developed a protocol to screen high-risk patients... - Damage control resuscitation: directly addressing the early coagulopathy of traumaJohn B Holcomb
USAISR, Fort Sam Houston, TX 78234-6315, USA
J Trauma 62:307-10. 2007