Ajay Goel

Summary

Affiliation: Baylor University Medical Center
Country: USA

Publications

  1. pmc A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer
    Marina Antelo
    Oncology and Pathology Sections, Hospital of Gastroenterology Dr C B Udaondo, Buenos Aires, Argentina
    PLoS ONE 7:e45357. 2012
  2. pmc Epigenetics of colorectal cancer
    Ajay Goel
    Gastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA
    Gastroenterology 143:1442-1460.e1. 2012
  3. doi request reprint Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hepatology 56:994-1003. 2012
  4. pmc Low frequency of Lynch syndrome among young patients with non-familial colorectal cancer
    Ajay Goel
    Department of Internal Medicine, Division of Gastroenterology, Charles A Sammons Cancer Center, and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
    Clin Gastroenterol Hepatol 8:966-71. 2010
  5. pmc Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency
    Ajay Goel
    Division of Gastroenterology, Department of Medicine, Baylor University, Medical Center, Dallas, Texas, USA
    Gastroenterology 138:1854-62. 2010
  6. pmc Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers
    Takeshi Nagasaka
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
    Cancer Res 70:3098-108. 2010
  7. pmc MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis
    Keun Hur
    Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA
    Gut 62:1315-26. 2013
  8. pmc Curcumin modulates DNA methylation in colorectal cancer cells
    Alexander Link
    Gastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e57709. 2013
  9. pmc Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family
    Masanobu Takahashi
    GI Cancer Research Laboratory, Baylor University Medical Center, 3500 Gaston Avenue, 250 Hoblitzelle, Dallas, TX 75246, USA
    Carcinogenesis 33:2441-9. 2012
  10. pmc De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one
    Ajay Goel
    Gastrointestinal Cancer Research Laboratory, Baylor University Medical Center, Dallas, TX, USA
    Int J Cancer 128:869-78. 2011

Detail Information

Publications52

  1. pmc A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer
    Marina Antelo
    Oncology and Pathology Sections, Hospital of Gastroenterology Dr C B Udaondo, Buenos Aires, Argentina
    PLoS ONE 7:e45357. 2012
    ..The methylation status of LINE-1 elements in early-onset CRC has not been analyzed previously...
  2. pmc Epigenetics of colorectal cancer
    Ajay Goel
    Gastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA
    Gastroenterology 143:1442-1460.e1. 2012
    ..This review focuses on the epigenetics of colorectal cancer and illustrates the impact epigenetics has had on this field...
  3. doi request reprint Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hepatology 56:994-1003. 2012
    ..0001), and number of methylated genes was an independent risk factor for HCC (hazard ratio = 5.21, 95% confidence interval = 2.25-11.76, P = 0.0002)...
  4. pmc Low frequency of Lynch syndrome among young patients with non-familial colorectal cancer
    Ajay Goel
    Department of Internal Medicine, Division of Gastroenterology, Charles A Sammons Cancer Center, and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
    Clin Gastroenterol Hepatol 8:966-71. 2010
    ..We examined patterns of microsatellite instability (MSI) and MMR genes among patients <50 years old with non-familial CRC (patients with not more than 1 family member with CRC)...
  5. pmc Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency
    Ajay Goel
    Division of Gastroenterology, Department of Medicine, Baylor University, Medical Center, Dallas, Texas, USA
    Gastroenterology 138:1854-62. 2010
    ..The carcinogenic pathways and the best diagnostic approaches to detect microsatellite stable (MSS) HNPCC tumors are unclear. We investigated the contribution of epigenetic alterations to the development of MSS HNPCC tumors...
  6. pmc Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers
    Takeshi Nagasaka
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
    Cancer Res 70:3098-108. 2010
    ..High levels of aberrant methylation at CIMP-related markers in MSH2-methylated tumors raise the possibility that MSH2 is a target susceptible to aberrant methylation in Lynch syndrome...
  7. pmc MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis
    Keun Hur
    Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA
    Gut 62:1315-26. 2013
    ..Although the microRNA-200 (miR-200) family is a crucial inhibitor of epithelial-to-mesenchymal transition (EMT) in human cancer, the role of miR-200 members in the pathogenesis of metastatic CRC has not been investigated...
  8. pmc Curcumin modulates DNA methylation in colorectal cancer cells
    Alexander Link
    Gastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e57709. 2013
    ..Using systematic genome-wide approaches, we aimed to elucidate the effect of curcumin on DNA methylation alterations in colorectal cancer cells...
  9. pmc Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family
    Masanobu Takahashi
    GI Cancer Research Laboratory, Baylor University Medical Center, 3500 Gaston Avenue, 250 Hoblitzelle, Dallas, TX 75246, USA
    Carcinogenesis 33:2441-9. 2012
    ....
  10. pmc De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one
    Ajay Goel
    Gastrointestinal Cancer Research Laboratory, Baylor University Medical Center, Dallas, TX, USA
    Int J Cancer 128:869-78. 2011
    ..Individuals with mismatch repair-deficient cancers without the BRAF V600E mutation are candidates for germline screening for sequence or methylation changes in MLH1...
  11. pmc Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells
    Yan Shen
    GI Cancer Research Laboratory, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, USA
    Cancer Biol Ther 13:542-52. 2012
    ....
  12. pmc Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer
    Yuji Toiyama
    Gastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, USA
    J Natl Cancer Inst 105:849-59. 2013
    ..The oncogenic microRNAs (miRNAs) miR-21 and miR-31 negatively regulate tumor-suppressor genes. Their potential as serum biomarkers has not been determined in human colorectal cancer (CRC)...
  13. pmc Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis
    Francesc Balaguer
    Department of Internal Medicine, Division of Gastroenterology, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
    Cancer Res 70:6609-18. 2010
    ..Methylation silencing of miR-137 in colorectal adenomas suggests it to be an early event, which has prognostic and therapeutic implications...
  14. pmc Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    Naoshi Nishida
    Division of Gastroenterology, Department of Internal Medicine and Charles A Sammons Cancer Center, Dallas, TX, USA
    Hepatology 47:908-18. 2008
    ..However, the group 3 loci showed more dense and frequent methylation in HCV-positive cancers compared with both HBV-positive cancers and virus-negative cancers (P < 0.0001)...
  15. pmc JC virus mediates invasion and migration in colorectal metastasis
    Alexander Link
    Division of Gastroenterology, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e8146. 2009
    ..JCV large T-Ag (T-Ag) expressed in approximately half of all CRC's, however, its functional role in CRC is poorly understood. We hypothesized that JCV T-Ag may mediate metastasis in CRC cells through increased migration and invasion...
  16. pmc Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer
    Takeshi Nagasaka
    Division of Gastroenterology, Department of Internal Medicine, and Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
    Gastroenterology 134:1950-60, 1960.e1. 2008
    ..Because BRAF and KRAS belong to same signaling pathway, we hypothesized that not only mutations in BRAF but mutant KRAS may also associate with CIMP in CRC...
  17. ncbi request reprint Oncogenic T-antigen of JC virus is present frequently in human gastric cancers
    Sung Kwan Shin
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75206, USA
    Cancer 107:481-8. 2006
    ..However, to date, no studies have determined whether JCV sequences are present specifically in gastric cancers. The current study was designed to investigate whether JCV sequences and expression are found in human gastric cancers...
  18. pmc JC virus infection in colorectal neoplasia that develops after liver transplantation
    Michael Selgrad
    Department of Internal Medicine, Baylor University Medical Center, Dallas, TX 75246, USA
    Clin Cancer Res 14:6717-21. 2008
    ..JCV encodes for TAg and has been implicated in colorectal carcinogenesis. We hypothesized that the use of immunosuppression in LTRs facilitates activation of JCV and is responsible for the increased risk of neoplasia...
  19. pmc Colorectal cancers with microsatellite instability display unique miRNA profiles
    Francesc Balaguer
    Department of Internal Medicine, Division of Gastroenterology, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
    Clin Cancer Res 17:6239-49. 2011
    ..The aim of this study was to analyze global miRNA signatures in various groups of colorectal cancers (CRC) based on the presence of microsatellite instability (MSI)...
  20. pmc Fecal MicroRNAs as novel biomarkers for colon cancer screening
    Alexander Link
    Gastrointestinal Cancer Research Laboratory, Baylor University Medical Center, Dallas, TX 75246, USA
    Cancer Epidemiol Biomarkers Prev 19:1766-74. 2010
    ..MicroRNAs (miRNA) play an important role in a wide array of biological processes and are commonly dysregulated in neoplasia. We aimed to evaluate the feasibility of fecal miRNAs as biomarkers for colorectal neoplasia screening...
  21. pmc The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer
    Masanobu Takahashi
    Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e46684. 2012
    ..We aimed to determine whether expression status of certain miRNAs might have prognostic/predictive value in CRC patients treated with conventional cytotoxic chemotherapies...
  22. ncbi request reprint Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis
    Naoshi Nishida
    Department of Internal Medicine, Division of Gastroenterology, Sammons Cancer Center, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA
    Cancer Res 67:4586-94. 2007
    ..HCCs with extensive methylation harbor frequent beta-catenin mutations, whereas HCCs with high levels of CIN are associated with p53 mutations, suggesting the presence of two independent pathways for the pathogenesis of HCC...
  23. ncbi request reprint Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer
    Sung Kwan Shin
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA
    Gastroenterology 133:1849-57. 2007
    ..We hypothesized that UNC5C is silenced epigenetically in CRC, and that there are interactions between losses of UNC5C and DCC in colorectal tumorigenesis...
  24. pmc Microsatellite instability in colorectal cancer
    C Richard Boland
    GI Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA
    Gastroenterology 138:2073-2087.e3. 2010
    ..Discovery of MSI in colorectal tumors has increased awareness of the diversity of colorectal cancers and implications for specialized management of patients...
  25. pmc Epigenetic mechanisms in oral carcinogenesis
    Jacqueline A Gasche
    Division of Gastroenterology, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, 3500 Gaston Avenue, Suite 250 Hoblitzelle, Dallas, TX 75246, USA
    Future Oncol 8:1407-25. 2012
    ..We provide insights into recent studies on the prospect of biomarkers for early detection and indication of disease recurrence, and novel treatment modalities...
  26. pmc Cancer chemoprevention by dietary polyphenols: promising role for epigenetics
    Alexander Link
    Gastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA
    Biochem Pharmacol 80:1771-92. 2010
    ....
  27. ncbi request reprint Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
    Gastroenterology 130:1950-61. 2006
    ..This study tests the hypothesis that JCV T-Ag expression correlates with one or more forms of genomic or epigenetic instability in sporadic CRCs...
  28. pmc MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin, and a poly(ADP-ribose) polymerase inhibitor
    Masanobu Takahashi
    Gastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246 2017, USA
    J Biol Chem 286:12157-65. 2011
    ..These data lay the foundation for the development of effective prediction and treatments for cancers with MSH3 deficiency...
  29. pmc An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e9393. 2010
    ..We tested a panel of five quasi-monomorphic mononucleotide repeat markers amplified in a single multiplex PCR reaction (pentaplex PCR) to detect MSI...
  30. ncbi request reprint The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine and Baylor Charles A Sammons Cancer Center, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Gastroenterology 132:127-38. 2007
    ..The majority of MSS CRCs demonstrate chromosomal instability (CIN) with frequent loss of heterozygosity (LOH) at key tumor suppressor genes. We hypothesized that the majority of sporadic CRCs without CIN would be associated with CIMP...
  31. pmc Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning
    Yuriko Mori
    Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Endocr Relat Cancer 18:465-78. 2011
    ..These potential biomarkers significantly discriminate CRC patients from controls. Thus, they merit further evaluation in stool- and circulating DNA-based CRC detection studies...
  32. pmc Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability
    Melissa Garcia
    Gastrointestinal Cancer Research Laboratory, Baylor University Medical Center, Dallas, Texas 75246, USA
    Gastroenterology 143:48-50.e1. 2012
    ..MSI-L and/or EMAST were independent predictors of recurrent distant metastasis from primary stage II or III colorectal tumors (Cox proportional hazard analysis: hazard ratio, 1.83; 95% confidence interval, 1.06-3.15; P = .0301)...
  33. ncbi request reprint High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers
    Naoshi Nishida
    Department of Internal Medicine, Division of Gastroenterology, Charles A Sammons Caner Center, Baylor University Medical Center, Dallas, Texas 75246, USA
    Cancer Biol Ther 6:525-33. 2007
    ..Our data confirm involvement in the CDC4-cyclin E pathway of the development of the CIN phenotype in human CRC, and find that amplification of the Aurora-A is a common target for disruption of this pathway...
  34. pmc The role of viral and bacterial pathogens in gastrointestinal cancer
    Michael Selgrad
    Department of Internal Medicine, Gastroenterology, Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas 75246, USA
    J Cell Physiol 216:378-88. 2008
    ....
  35. pmc JC virus T-antigen expression in sporadic adenomatous polyps of the colon
    Woon Tae Jung
    Division of Gastroenterology, Department of Internal Medicine, The Charles A Sammons Cancer Center, and the Baylor Research Institute, Baylor University Medical Center, Dallas, TX 75246, USA
    Cancer 112:1028-36. 2008
    ..Furthermore, an association between JCV and microsatellite instability (MSI) was also sought in these lesions...
  36. pmc Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells
    Jacqueline A Gasche
    Division of Gastroenterology, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX 75246, USA
    Int J Cancer 129:1053-63. 2011
    ..These findings have clinical relevance, as both methylation and inflammation are suitable targets for developing novel preventive and therapeutic measures...
  37. pmc Promoter methylation in the genesis of gastrointestinal cancer
    CLEMENT RICHARD BOLAND
    Division of Gastroenterology, Department of Internal Medicine, Sammons Cancer Center, Baylor Research Institute, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Yonsei Med J 50:309-21. 2009
    ....
  38. pmc Recent insights into the pathogenesis of colorectal cancer
    Ajay Goel
    Department of Internal Medicine, Division of Gastroenterology, Baylor Sammons Cancer Center, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
    Curr Opin Gastroenterol 26:47-52. 2010
    ..The recent advent of new technologies has provided novel insights into the pathogenesis of CRC...
  39. doi request reprint Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
    Ajay Goel
    Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA
    Nutr Cancer 62:919-30. 2010
    ..These preclinical studies are expected to lead to clinical trials to prove the potential of this age-old golden spice for treating cancer patients...
  40. ncbi request reprint Role of zinc in mitigating the toxic effects of chlorpyrifos on hematological alterations and electron microscopic observations in rat blood
    Ajay Goel
    Department of Biophysics, Punjab University, Sector, 14, Chandigarh, 160 014, India
    Biometals 19:483-92. 2006
    ..Based upon these data, the present study is first of its kind and suggests that zinc treatment considerably attenuates chlorpyrifos induced toxicity induced in restoring the altered hematological indices and morphological changes...
  41. ncbi request reprint Detection of fecal DNA methylation for colorectal neoplasia: does it lead to an optimal screening test?
    Takeshi Nagasaka
    Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 60:249-56. 2006
    ....
  42. ncbi request reprint Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity
    Ajay Goel
    Department of Biophysics, Panjab University, Sector 14, Chandigarh 160014, India
    Chem Biol Interact 156:131-40. 2005
    ..Hence, the present study suggests the protective potential of zinc in alleviating the hepatic toxicity induced by chlorpyrifos...
  43. ncbi request reprint Zinc mediates normalization of hepatic drug metabolizing enzymes in chlorpyrifos-induced toxicity
    Ajay Goel
    Department of Biophysics, Panjab University, Sector 14, Chandigarh 160014, India
    Toxicol Lett 169:26-33. 2007
    ....
  44. ncbi request reprint Chlorpyrifos-induced alterations in the activities of carbohydrate metabolizing enzymes in rat liver: the role of zinc
    Ajay Goel
    Department of Biophysics, Panjab University, Sector 14, Chandigarh 160014, India
    Toxicol Lett 163:235-41. 2006
    ..Hence, the present study clearly suggests that zinc plays an important role in regulating the hepatic activities of the enzymes involved in carbohydrate metabolism under conditions of chlorpyrifos toxicity...
  45. pmc Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka Sayama, Japan Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e72312. 2013
    ..0011, well-differentiated; p=0.0089, moderately/poorly-differentiated HCCs). We conclude that DNA hypomethylation is an important cause of CIN in the earliest step of HCC, especially in a background of non-cirrhotic liver...
  46. ncbi request reprint Chemoprevention goes gourmet: different flavors of NO-aspirin
    Ajay Goel
    Division of Gastroenterology, Department of Medicine, Baylor University Medical Center, Dallas, Texas, USA
    Mol Interv 5:207-10. 2005
  47. doi request reprint Multi-targeted therapy by curcumin: how spicy is it?
    Ajay Goel
    Gastrointestinal Cancer Research Laboratory, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, USA
    Mol Nutr Food Res 52:1010-30. 2008
    ..The present article reviews the key molecular mechanisms of curcumin action and compares this to some of the single-targeted therapies currently available for human cancer...
  48. pmc Microsatellite instability among individuals of Hispanic origin with colorectal cancer
    Samir Gupta
    Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8887, USA
    Cancer 116:4965-72. 2010
    ....
  49. ncbi request reprint Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis
    Sang Heon Lee
    Division of Rheumatology, Allergy, and Immunology, Division of Gastroenterology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Immunol 170:2214-20. 2003
    ..We propose that oxidative stress not only creates DNA adducts that are potentially mutagenic, but also suppresses the mechanisms that limit the DNA damage...
  50. ncbi request reprint Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center and Baylor Research Institute, Dallas, Texas 75246, USA
    Cancer Biol Ther 5:529-35. 2006
    ..These results clearly suggest that selenomethionine exerts p53 dependent growth inhibitory effects in colon cancer cells by inducing G2/M cell cycle arrest as well as apoptosis...
  51. ncbi request reprint Somatic evolution of cancer cells
    C Richard Boland
    GI Cancer Research Laboratory, Baylor University Medical Center, H 250, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Semin Cancer Biol 15:436-50. 2005
    ..Each of these processes is associated with a unique mutational or epigenetic "signature" identifiable in the tumor cells, and there are important conceptual and clinical implications of each...
  52. pmc Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review
    Naoshi Nishida
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Curr Genomics 12:130-7. 2011
    ..In addition, we will specifically emphasize the clinical implication of some of these genetic and epigenetic alterations in the management of hepatocarcinogenesis...