Research Topics
Genomes and Genes | Yong Jian GengSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Publications
Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine heartsYue jin Yang
Department of Cardiology, Fu Wai Hospital and Cardiovascular Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, 167 BeiLiShi Rd, Beijing 100037, People s Republic of China
Eur Heart J 29:1578-90. 2008..To investigate whether Atorvastatin (Ator) treatment improves the cardiac micro-environment that facilitates survival and differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) implanted in the post-infarct myocardium...
Linking immunity to atherosclerosis: implications for vascular pharmacology--a tribute to Göran K. HanssonYong Jian Geng
Center of Cardiovascular Biology and Atherosclerosis Research, University of Texas Medical School at Houston, TX 77030, USA
Vascul Pharmacol 56:29-33. 2012..This review briefly summarizes the discoveries in basic and translational sciences in this area and recent advances in clinical medicine against atherosclerotic vascular diseases...- Biologic effect and molecular regulation of vascular apoptosis in atherosclerosisY J Geng
Department of Internal Medicine, University of Texas Houston Health Science Center Medical School, 6431 Fannin Street, MSB 6 045, Houston, TX 77030, USA
Curr Atheroscler Rep 3:234-42. 2001..Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes... - Molecular mechanisms for cardiovascular stem cell apoptosis and growth in the hearts with atherosclerotic coronary disease and ischemic heart failureYong Jian Geng
Center for Cardiovascular Biology and Atherosclerosis, Department of Internal Medicine, The University of Texas, Health Science Center at Houston, Medical School, Texas Heart Institute, Houston, Texas 77030, USA
Ann N Y Acad Sci 1010:687-97. 2003..Clarification of the molecular mechanisms may help us understand and design stem cell therapies... - Cholesterol crystallization and macrophage apoptosis: implication for atherosclerotic plaque instability and ruptureYong Jian Geng
Center for Cardiovascular Biology and Atherosclerosis, University of Texas Health Science Center at Houston School of Medicine, 6431 Fannin Street, MSB 6 001, Houston, TX 77030, USA
Biochem Pharmacol 66:1485-92. 2003..These results suggest that hyperthermia inhibits cholesterol crystallization and promotes apoptotic effects of oxysterols on macrophages... - Molecular signal transduction in vascular cell apoptosisY J Geng
Center for Cardiovascular Biology and Atherosclerosis Research, Department of Internal Medicine, University of Texas Houston Health Science Center Medical School, 77030, USA
Cell Res 11:253-64. 2001..Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes... - Myocardin a enhances telomerase activities in adipose tissue mesenchymal cells and embryonic stem cells undergoing cardiovascular myogenic differentiationRosalinda Madonna
The University of Texas Health Science Center at Houston and the Texas Heart Institute, Houston, Texas, USA
Stem Cells 26:202-11. 2008..The data from this study indicate a potentially novel function of myocardin A in maintaining the myogenic stemness in developing MSCs and EBs by enhancing telomerase activation and promoting myogenic gene expression... - Delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies against CD34 and intercellular adhesion molecule-1Stephanie M Herbst
Division of Cardiology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
Mol Pharm 7:3-11. 2010..Thus, under ultrasound enhancement, BF-ELIP bound CD34+ stem cells selectively bind to the ICAM-1 expressing endothelium of atherosclerotic lesions... - Clusterin induces CXCR4 expression and migration of cardiac progenitor cellsYangxin Li
Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX 77030, USA
Exp Cell Res 316:3435-42. 2010..Thus, CST expression may increase CPCs migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner... - Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regenerationRosalinda Madonna
Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX, USA
Eur Heart J 32:1190-6. 2011..Understanding the roles of telomerase and its associated proteins in the functional regulation of cardiovascular cells and their progenitors may lead to new strategies for cardiovascular tissue repair and regeneration... - Apolipoprotein-J prevention of fetal cardiac myoblast apoptosis induced by ethanolYangxin Li
Texas Heart Institute and The University of Texas Health Science Center, Houston, TX 77030, USA
Biochem Biophys Res Commun 357:157-61. 2007..Thus, ApoJ serves as a cytoprotective protein that protects cardiac stem cells against EtOH cytotoxicity... - MicroRNA-221 regulates high glucose-induced endothelial dysfunctionYangxin Li
Texas Heart Institute and The University of Texas Medical School, Heart Failure and Stem Cell, P O Box 20345, MC 2 255, 6770 Bertner Avenue, Houston, TX 77030, USA
Biochem Biophys Res Commun 381:81-3. 2009..These findings suggest that manipulation of the miR-221-c-kit pathway may offer a novel strategy for treatment of vascular dysfunction in diabetic patients... - Liposomal modular complexes for simultaneous targeted delivery of bioactive gases and therapeuticsMelvin E Klegerman
Division of Cardiology, Department of Internal Medicine, University of Texas Health Science Center, 6431 Fannin Street, MSB 1 246, Houston, Texas 77030, USA
J Control Release 142:326-31. 2010..It was concluded that this novel multi-functional conjugation methodology provides a platform technology for site-specific co-delivery of bioactive gases and other agents... - Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cellsMichael J Wassler
Center for Cardiovascular Biology and Atherosclerosis Research, Division of Cardiology, Department of Internal Medicine, The University of Texas Health Science Center at Houston, School of Medicine, Houston 77030, USA
Stem Cells 26:2006-18. 2008..Thus, GTAP functions as an evolutionarily conserved E2 enzyme, which may participate in intercellular adhesion and embryonic development. Disclosure of potential conflicts of interest is found at the end of this article... - Dysregulated response to mycobacterial cord factor trehalose-6,6'-dimycolate in CD1D-/- miceJ K Actor
Department of Pathology, University of Texas Houston Medical School, Houston, TX 77030, USA
J Interferon Cytokine Res 21:1089-96. 2001..CD1D(-/-) mice also demonstrated elevated mRNA for both inflammatory cytokines and chemokines by day 1 after administration, significantly earlier than responses seen in the heterozygous controls... - Erythropoietin protects myocardin-expressing cardiac stem cells against cytotoxicity of tumor necrosis factor-alphaRosalinda Madonna
The Center for Cardiovascular Biology and Atherosclerosis Research, The University of Texas Health Science Center, Houston, Texas, USA
Exp Cell Res 315:2921-8. 2009..Thus, Epo protects cardiac myocyte progenitors or myoblasts against the cytotoxic effects of TNF-alpha by inhibiting NF-kappaB-mediated iNOS expression and NO production and by preventing caspase-3 activation... - Angiotensin receptor agonistic autoantibody-mediated tumor necrosis factor-alpha induction contributes to increased soluble endoglin production in preeclampsiaCissy Chenyi Zhou
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
Circulation 121:436-44. 2010.... 
IGF-1 prevents oxidative stress induced-apoptosis in induced pluripotent stem cells which is mediated by microRNA-1Yangxin Li
The Texas Heart Institute and Center for Cardiovascular and Atherosclerosis Research, Department of Internal Medicine, University of Texas Medical School at Houston, TX 77030, USA
Biochem Biophys Res Commun 426:615-9. 2012..In conclusion, IGF-1 inhibits H(2)O(2)-induced mitochondrial dysfunction, cytochrome-c release and apoptosis. IGF-1's effect is, at least partially, regulated by miR-1 in iPS cells...- Failure of CD1D-/- mice to elicit hypersensitive granulomas to mycobacterial cord factor trehalose 6,6'-dimycolateTera V Guidry
Department of Pathology, University of Texas Houston Medical School, Houston, TX 77030, USA
J Interferon Cytokine Res 24:362-71. 2004..These experiments provide evidence for a role for CD1d in mediation of pathology during hypersensitive responses to the mycobacterial glycolipid TDM... - Insulin-like growth factor-1 receptor activation prevents high glucose-induced mitochondrial dysfunction, cytochrome-c release and apoptosisYangxin Li
Texas Heart Institute and The University of Texas Medical School, Houston, TX 77030, USA
Biochem Biophys Res Commun 384:259-64. 2009..These results may have therapeutic implications in preventing/reducing diabetes associated endothelial dysfunction... - A potential role for insulin-like growth factor signaling in induction of pluripotent stem cell formationYangxin Li
Texas Heart Institute, Houston, TX 77030, USA
Growth Horm IGF Res 20:391-8. 2010.... - Nitric oxide bioactivity of traditional Chinese medicines used for cardiovascular indicationsYaoping Tang
Brown Foundation Institute of Molecular Medicine, Health Science Center, The University of Texas at Houston, Houston, TX 77030, USA
Free Radic Biol Med 47:835-40. 2009..Repletion of biological nitrite and nitrate by these extracts and providing a natural system for NO generation in both endothelium-dependent and -independent mechanisms may account for some of the therapeutic effects of TCMs... - Enhanced iNOS function in myocytes one day after brief ischemic episodeSong Jung Kim
Cardiovascular Research Institute and Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
Am J Physiol Heart Circ Physiol 282:H423-8. 2002.... - Near-infrared spectroscopic characterization of human advanced atherosclerotic plaquesJing Wang
Vascular Cell Biology Laboratory, Texas Heart Institute, Houston, Texas, USA
J Am Coll Cardiol 39:1305-13. 2002..44 (p < 0.00003). CONCLUSIONS: The good ex vivo discrimination of histologically vulnerable and stable plaques in this study suggests that NIR spectroscopy has the potential to identify vulnerable atherosclerotic plaques in vivo... - Progression of atheroma: a struggle between death and procreationYong-Jian Geng
Cardiology Division, Department of Internal Medicine, University of Texas Houston Medical School, USA
Arterioscler Thromb Vasc Biol 22:1370-80. 2002..A clarification of the molecular mechanisms responsible for vascular cell death may aid in the development of novel therapeutic strategies to treat atherosclerosis and its complications, including the acute coronary syndromes... - Adult stem cell therapy in perspectiveEmerson C Perin
Department of Cardiology, Texas Heart Institute, and the University of Texas Health Science Center, Houston, USA
Circulation 107:935-8. 2003 - Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia modelGuilherme V Silva
Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Tex 77030, USA
Circulation 111:150-6. 2005..CONCLUSIONS: In a canine chronic ischemia model, MSCs differentiated into smooth muscle cells and endothelial cells, resulting in increased vascularity and improved cardiac function... - Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodiesS Sohail Ahmed
Boston University School of Medicine, Arthritis Center E 5, 715 Albany Street, Boston, MA 02118, USA
Arthritis Rheum 54:2250-62. 2006....
Research Grants
- CD1-restricted T cell response in atherosclerosisYong Jian Geng; Fiscal Year: 2003..Fulfillment of the above objectives will provide novel mechanisms by which lipid antigens activate immune cells and cause inflammation in the arteries with atherosclerosis. ..
- APOPTOTIC CASCADE IN ATHEROSCLEROSISYong Jian Geng; Fiscal Year: 2002..Specific Aim 3 will examine the function of fragments of actin an gelsolin in mediating apoptosis. Arteries from mice deficient in expression of functional Fas (MRC/lpr/lpr) or gelsolin will be examined. ..
- CD1-restricted T cell response in atherosclerosisYong Jian Geng; Fiscal Year: 2004..Accomplishment of this project is anticipated to generate valuable information that help understand the immune mechanisms underlying vascular injury during atherogenesis. ..