Research Topics
| Jose M GarciaSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Hypogonadism in male patients with cancerJose M Garcia
Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
Cancer 106:2583-91. 2006..Patients with cancer often develop anorexia, fatigue, and decreased muscle mass. These signs and symptoms are nonspecific, and they frequently occur in other conditions, including hypogonadism...- Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteersJose M Garcia
Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
Oncologist 12:594-600. 2007..This randomized, double-blind, placebo-controlled, multiple-dose, dose-escalation phase I study in healthy volunteers evaluated RC-1291 once daily (qd) and twice daily (bid) for effect on body weight and safety... - Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteersJose M Garcia
Division of Diabetes, Endocrinology and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
Growth Horm IGF Res 19:267-73. 2009..Anamorelin is a novel, orally active, non-peptidic ghrelin mimetic and growth hormone secretagogue. Our objective was to evaluate its hormonal effects in healthy subjects... - Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexiaJose M Garcia
Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism and The Huffington Center on Aging, Baylor College of Medicine, and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
J Clin Endocrinol Metab 90:2920-6. 2005..Changes in the active to total ghrelin ratio suggest that a mechanism other than increased secretion must be responsible for the increase in active ghrelin levels. PYY is unlikely to play an important role in cancer-induced cachexia... - Adipokines in patients with cancer anorexia and cachexiaJoanna Smiechowska
The Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
J Investig Med 58:554-9. 2010..The objective of this study was to determine the levels of adipokines and their relation to appetite, weight loss, insulin resistance, and other hormones in cancer cachexia... - Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesityJose M Garcia
Division of Pulmonary, Critical Care and Sleep Medicine, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX 77025, USA
Respir Res 12:80. 2011..We postulated that CPAP will decrease IR, ghrelin and resistin and increase adiponectin levels in this setting... - Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexiaBasil O Burney
Division of Endocrinology, Diabetes, and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, Texas 77030, USA
J Clin Endocrinol Metab 97:E700-9. 2012..These symptoms are seen in men with hypogonadism and/or inflammatory conditions. However, the relative contribution of testosterone and inflammation to symptom burden in cancer has not been well-established... - Rise of plasma ghrelin with weight loss is not sustained during weight maintenanceJose M Garcia
Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
Obesity (Silver Spring) 14:1716-23. 2006..Baseline ghrelin concentrations are related to the degree of WL that can be achieved by active weight reduction... - Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexiaJose M Garcia
Division of Endocrinology, Diabetes and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
Endocrinology 149:455-60. 2008..Attenuation of mechanical hyperalgesia in the rat by the hormone ghrelin provides a unique model for elucidating the mechanisms involved, which are essential toward our understanding of these complications... - Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balanceYuxiang Sun
Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
Endocrinology 149:843-50. 2008..These results support our hypothesis that the primary metabolic function of ghrelin in adult mice is to modulate glucose sensing and insulin sensitivity, rather than directly regulate energy intake and energy expenditure... - Hypogonadism in male cancer patientsBasil O Burney
Division of Endocrinology, Diabetes and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, 2002 Holcombe Blvd, Bldg 109, Rm 210, Houston, TX, 77030, USA
J Cachexia Sarcopenia Muscle 3:149-55. 2012..Prospective and interventional trials are needed to test the efficacy and safety of testosterone treatment in improving quality of life of these patients... - Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumorsGemma Dominguez
Department of Medical Oncology, Hospital Universitario Puerta de Hierro, C/San Martin de Porres 4, E-28035, Madrid, Spain
Mutat Res 530:9-17. 2003.... - Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survivalJose M Silva
Department of Medical Oncology, Hospital Universitario Puerta de Hierro, E-28035 Madrid, Spain
Clin Cancer Res 8:3761-6. 2002..CONCLUSIONS: Tumor DNA in plasma at diagnosis in breast cancer patients can predict DFS, and its determination could be used as a prognostic factor in these patients...