Anthony R Flores

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Natural variant of collagen-like protein a in serotype M3 group a Streptococcus increases adherence and decreases invasive potential
    Anthony R Flores
    Section of Infectious Diseases, Department of Pediatrics, Texas Children s Hospital and Baylor College of Medicine, Houston, Texas, USA Department of Pathology and Genomic Medicine, Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA
    Infect Immun 83:1122-9. 2015
  2. pmc Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production
    Anthony R Flores
    Section of Infectious Diseases, Department of Pediatrics, Texas Children s Hospital and Baylor College of Medicine, Houston, Texas, USA Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Department of Pathology and Genomic Medicine, Houston Methodist, Houston, Texas, USA
    Infect Immun 82:3958-67. 2014
  3. doi request reprint Estimated burden of rotavirus-associated diarrhea in ambulatory settings in the United States
    Anthony R Flores
    Baylor College of Medicine, Department of Pediatrics, Section of Infectious Diseases, 1102 Bates Ave, Suite 1120, Houston, TX 77030, USA
    Pediatrics 125:e191-8. 2010
  4. pmc Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010
    Patrick R Shea
    The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Emerg Infect Dis 17:2010-7. 2011
  5. pmc Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus
    Randall J Olsen
    Department of Pathology and Laboratory Medicine, The Methodist Hospital Research Institute, Houston, TX, USA
    J Infect Dis 205:1719-29. 2012
  6. pmc Natural variation in the promoter of the gene encoding the Mga regulator alters host-pathogen interactions in group a Streptococcus carrier strains
    Anthony R Flores
    Section of Infectious Diseases, Department of Pediatrics, Texas Children s Hospital and Baylor College of MedicineHouston, Texas, USA
    Infect Immun 81:4128-38. 2013
  7. doi request reprint Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus
    Nahuel Fittipaldi
    Department of Pathology and Genomic Medicine, Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas 77030, USA
    Am J Pathol 180:1522-34. 2012
  8. doi request reprint Evolution of diversity in epidemics revealed by analysis of the human bacterial pathogen group A Streptococcus
    Ronan K Carroll
    Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, TX 77030, USA
    Epidemics 3:159-70. 2011
  9. pmc Molecular characterization of an invasive phenotype of group A Streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient
    Anthony R Flores
    Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital
    J Infect Dis 209:1520-3. 2014
  10. pmc Human disease isolates of serotype m4 and m22 group a streptococcus lack genes required for hyaluronic acid capsule biosynthesis
    Anthony R Flores
    Section of Infectious Diseases, Department of Pediatrics, Texas Children s Hospital and Baylor College of Medicine, Houston, Texas, USA
    MBio 3:e00413-12. 2012

Collaborators

  • James M Musser
  • Randall J Olsen
  • Samuel A Shelburne
  • Donald E Low
  • Gregory J Tyrrell
  • Carmen Ardanuy
  • Izabela Sitkiewicz
  • Olaf Schneewind
  • Adela G de la Campa
  • Paul Webb
  • Patrick R Shea
  • Stephen B Beres
  • Nahuel Fittipaldi
  • Misu Sanson
  • Ronan K Carroll
  • Muthiah Kumaraswami
  • Nishanth Makthal
  • Nicola Horstmann
  • Concepcion C Cantu
  • Pranoti Sahasrabhojane
  • Paul Sumby
  • Monica Serrano-Gonzalez
  • Javier H Gonzalez-Lugo
  • Juan C Martinez-Gutierrez
  • Amy L Ewbank
  • Alexandro J Martagon-Rosado
  • Hina A Rehman
  • Angela M Wright
  • Barbara M Willey
  • Miguel Saldaña
  • Hui Yao
  • Chang Gong Liu
  • Brian E O'Neill
  • Erika Thompson
  • Christof Karmonik
  • Jeff R Anderson
  • Nadim J Ajami
  • Priyanka Kachroo
  • Chandni Valson
  • Xiaoping Su
  • Leslie Jenkins
  • Vivek Kapur
  • M Ebru Watkins
  • Marguerite Lovgren
  • Daniel R Laucirica
  • Josefina Liñares
  • Ashley L Drews
  • S Wesley Long
  • Stephen D Ayers
  • Risë K Matsunami
  • So Young Oh
  • Bryce Suber
  • G Stefan Richter
  • Gabriella Garufi
  • Erin N Consamus
  • Hannah Maier
  • David A Engler
  • Leif Peterson
  • Roberto Barrios
  • Patricia Cernoch
  • Kathryn E Stockbauer

Detail Information

Publications16

  1. pmc Natural variant of collagen-like protein a in serotype M3 group a Streptococcus increases adherence and decreases invasive potential
    Anthony R Flores
    Section of Infectious Diseases, Department of Pediatrics, Texas Children s Hospital and Baylor College of Medicine, Houston, Texas, USA Department of Pathology and Genomic Medicine, Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA
    Infect Immun 83:1122-9. 2015
    ..These data demonstrate that a mutation in GAS carrier strains increases adherence and decreases virulence and suggest selection against increased adherence in GAS invasive isolates. ..
  2. pmc Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production
    Anthony R Flores
    Section of Infectious Diseases, Department of Pediatrics, Texas Children s Hospital and Baylor College of Medicine, Houston, Texas, USA Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Department of Pathology and Genomic Medicine, Houston Methodist, Houston, Texas, USA
    Infect Immun 82:3958-67. 2014
    ..Our discoveries suggest a general model for bacterial pathogens in which mutations that downregulate or ablate virulence factor production contribute to carriage. ..
  3. doi request reprint Estimated burden of rotavirus-associated diarrhea in ambulatory settings in the United States
    Anthony R Flores
    Baylor College of Medicine, Department of Pediatrics, Section of Infectious Diseases, 1102 Bates Ave, Suite 1120, Houston, TX 77030, USA
    Pediatrics 125:e191-8. 2010
    ..Although previous studies of the burden of rotaviral disease have focused on hospitalizations, the assessment of baseline disease burden in ambulatory settings is useful for evaluating the overall impact of the vaccine...
  4. pmc Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010
    Patrick R Shea
    The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Emerg Infect Dis 17:2010-7. 2011
    ..We also discovered a striking increase in frequency of emm89 strains among isolates from patients with pharyngitis and invasive disease. These findings about the epidemiology of GAS are potentially useful for vaccine research...
  5. pmc Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus
    Randall J Olsen
    Department of Pathology and Laboratory Medicine, The Methodist Hospital Research Institute, Houston, TX, USA
    J Infect Dis 205:1719-29. 2012
    ..These studies provide a model strategy for applying whole-genome sequencing followed by deep single-gene sequencing to generate new insight to the rapid evolution and virulence regulation of human pathogens...
  6. pmc Natural variation in the promoter of the gene encoding the Mga regulator alters host-pathogen interactions in group a Streptococcus carrier strains
    Anthony R Flores
    Section of Infectious Diseases, Department of Pediatrics, Texas Children s Hospital and Baylor College of MedicineHouston, Texas, USA
    Infect Immun 81:4128-38. 2013
    ..Our findings provide new insight into the molecular basis of the carrier state of an important human pathogen. ..
  7. doi request reprint Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus
    Nahuel Fittipaldi
    Department of Pathology and Genomic Medicine, Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas 77030, USA
    Am J Pathol 180:1522-34. 2012
    ....
  8. doi request reprint Evolution of diversity in epidemics revealed by analysis of the human bacterial pathogen group A Streptococcus
    Ronan K Carroll
    Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, TX 77030, USA
    Epidemics 3:159-70. 2011
    ..These data provide enhanced understanding of genetic events resulting in strain variation in bacterial epidemics...
  9. pmc Molecular characterization of an invasive phenotype of group A Streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient
    Anthony R Flores
    Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital
    J Infect Dis 209:1520-3. 2014
    ..In contrast to previous theories, we found that elimination of production of the cysteine protease SpeB was not necessary for emergence of GAS with an invasive, "hypervirulent" phenotype. ..
  10. pmc Human disease isolates of serotype m4 and m22 group a streptococcus lack genes required for hyaluronic acid capsule biosynthesis
    Anthony R Flores
    Section of Infectious Diseases, Department of Pediatrics, Texas Children s Hospital and Baylor College of Medicine, Houston, Texas, USA
    MBio 3:e00413-12. 2012
    ..We speculate that serotype M4 and M22 GAS have alternative, compensatory mechanisms that promote virulence...
  11. pmc Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice
    Ronan K Carroll
    Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, and Department of Pathology and Laboratory Medicine, The Methodist Hospital, Houston, Texas, USA
    J Clin Invest 121:1956-68. 2011
    ..These data detail a paradigm in which unbiased, whole-genome sequence analysis of populations of clinical bacterial isolates creates new avenues of productive investigation into the pathogenesis of common human infections...
  12. pmc A naturally occurring single amino acid replacement in multiple gene regulator of group A Streptococcus significantly increases virulence
    Misu Sanson
    Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Center for Molecular and Translational Human Infectious Diseases Research, Houston, Texas School of Biotechnology, School of Medicine and Health Sciences, Tecnológico de Monterrey, Monterrey, Mexico
    Am J Pathol 185:462-71. 2015
    ..These findings show that the H201R replacement in Mga increases the virulence of M59 group A Streptococcus and provide new insight to how a naturally occurring SNP in bacteria contributes to human disease phenotypes. ..
  13. pmc Adhesin competence repressor (AdcR) from Streptococcus pyogenes controls adaptive responses to zinc limitation and contributes to virulence
    Misu Sanson
    Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Department of Pathology and Genomic Medicine, The Methodist Hospital System, Houston, TX, USA Escuela de Biotecnología y Alimentos, Escuela de Medicina y Ciencias de la Salud, Tecnológico de Monterrey, Monterrey, NL, Mexico
    Nucleic Acids Res 43:418-32. 2015
    ..Together, we demonstrate that AdcR regulates GAS adaptive responses to zinc limitation and identify molecular components required for GAS survival during zinc deficiency. ..
  14. pmc Characterization of the effect of the histidine kinase CovS on response regulator phosphorylation in group A Streptococcus
    Nicola Horstmann
    Department of Infectious Diseases, MD Anderson Cancer Center, Houston, Texas, USA
    Infect Immun 83:1068-77. 2015
    ....
  15. pmc Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations
    Patrick R Shea
    Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology, and Section of Genomic Medicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 108:5039-44. 2011
    ..The data provide previously undescribed information about the evolutionary history of pathogenic microbes that cause disease in different anatomical sites...
  16. doi request reprint Rapidly progressive, fatal, inhalation anthrax-like infection in a human: case report, pathogen genome sequencing, pathology, and coordinated response
    Angela M Wright
    Department of Pathology and Laboratory Medicine, The Methodist Hospital System, Houston, Texas, USA
    Arch Pathol Lab Med 135:1447-59. 2011
    ..Sporadic reports have described rare, fulminant, and sometimes fatal cases of pneumonia in humans and nonhuman primates caused by strains of Bacillus cereus , a species closely related to Bacillus anthracis...