William E Fisher

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. doi request reprint Assessment of the learning curve for pancreaticoduodenectomy
    William E Fisher
    The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden, Suite 1500, Houston, TX 77030, USA
    Am J Surg 203:684-90. 2012
  2. pmc Pancreatic resection without routine intraperitoneal drainage
    William E Fisher
    The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77479, USA
    HPB (Oxford) 13:503-10. 2011
  3. doi request reprint Effect of BioGlue on the incidence of pancreatic fistula following pancreas resection
    William E Fisher
    The Elkins Pancreas Center, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA
    J Gastrointest Surg 12:882-90. 2008
  4. doi request reprint The promise of a personalized genomic approach to pancreatic cancer and why targeted therapies have missed the mark
    William E Fisher
    The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden, Suite 1500, Houston, TX 77030, USA
    World J Surg 35:1766-9. 2011
  5. pmc Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts
    Min Li
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 15:5993-6001. 2009
  6. ncbi request reprint IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells
    Louis W Feurino
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medidcine, Houston, Texas 77030, USA
    Cancer Biol Ther 6:1096-100. 2007
  7. pmc Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cancer Ther 7:286-96. 2008
  8. pmc Somatostatin receptor-1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer
    Min Li
    Michael E DeBakey Department of Surgery, Molecular Surgeon Research Center, Baylor College of Medicine, Houston, Texas, USA
    Cancer Sci 99:2218-23. 2008
  9. pmc Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation
    Min Li
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Invest 27:251-6. 2009
  10. doi request reprint Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas
    Sanjeet G Patel
    The Michael E DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden Street, Suite 1500, Houston, TX 77030, USA
    World J Surg 33:630-7. 2009

Research Grants

Collaborators

Detail Information

Publications51

  1. doi request reprint Assessment of the learning curve for pancreaticoduodenectomy
    William E Fisher
    The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden, Suite 1500, Houston, TX 77030, USA
    Am J Surg 203:684-90. 2012
    ..Experience with the Whipple procedure has been associated with improved outcomes, but the learning curve for this complex procedure is not well defined...
  2. pmc Pancreatic resection without routine intraperitoneal drainage
    William E Fisher
    The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77479, USA
    HPB (Oxford) 13:503-10. 2011
    ..Most surgeons routinely place intraperitoneal drains at the time of pancreatic resection but this practice has recently been challenged...
  3. doi request reprint Effect of BioGlue on the incidence of pancreatic fistula following pancreas resection
    William E Fisher
    The Elkins Pancreas Center, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA
    J Gastrointest Surg 12:882-90. 2008
    ..BioGlue is a new sealant that creates a flexible mechanical seal within minutes independent of the body's clotting mechanism...
  4. doi request reprint The promise of a personalized genomic approach to pancreatic cancer and why targeted therapies have missed the mark
    William E Fisher
    The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden, Suite 1500, Houston, TX 77030, USA
    World J Surg 35:1766-9. 2011
    ..It is to be hoped that this new approach will result in a significant improvement in the survival curve for patients with PC...
  5. pmc Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts
    Min Li
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 15:5993-6001. 2009
    ..We recently found that a zinc transporter, ZIP4, is overexpressed in pancreatic cancer. In this study, we further deciphered the role that ZIP4 plays in a pancreatic cancer mouse model by silencing ZIP4...
  6. ncbi request reprint IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells
    Louis W Feurino
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medidcine, Houston, Texas 77030, USA
    Cancer Biol Ther 6:1096-100. 2007
    ..In this study, we examined the expression of IL-6 in pancreatic cancer cells, and determined the effect of exogenous IL-6 on cytokine secretion, gene expression and signaling in human pancreatic cancer cells...
  7. pmc Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cancer Ther 7:286-96. 2008
    ..This study revealed novel functions of mesothelin and suggested a new therapeutic vaccine strategy whereby mesothelin is targeted to control pancreatic cancer progression...
  8. pmc Somatostatin receptor-1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer
    Min Li
    Michael E DeBakey Department of Surgery, Molecular Surgeon Research Center, Baylor College of Medicine, Houston, Texas, USA
    Cancer Sci 99:2218-23. 2008
    ..This study suggests that gene therapy with SSTR-1 may be a potential adjuvant treatment for pancreatic cancer...
  9. pmc Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation
    Min Li
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Invest 27:251-6. 2009
    ..Exogenous T beta 10 caused the phosphorylation of JNK and increased the secretion of cytokines interleukin (IL)-7 and IL-8 in BxPC-3 cells. T beta 10 might be a promising marker and a novel therapeutic target for pancreatic cancer...
  10. doi request reprint Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas
    Sanjeet G Patel
    The Michael E DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden Street, Suite 1500, Houston, TX 77030, USA
    World J Surg 33:630-7. 2009
    ..We hypothesized that SSTR5 mediates the inhibitory effect of somatostatin (SST) on insulin secretion and islet proliferation by regulating a specific set of pancreatic genes...
  11. pmc Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation
    Yuqing Zhang
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Biol Ther 7:419-23. 2008
    ..In the current study, we examined the expression of T beta 4 in pancreatic cancer cells, and determined the effect of exogenous T beta 4 on cytokine secretion, and signal transduction in human pancreatic cancer cells...
  12. ncbi request reprint Transfection of SSTR-1 and SSTR-2 inhibits Panc-1 cell proliferation and renders Panc-1 cells responsive to somatostatin analogue
    Min Li
    Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Am Coll Surg 201:571-8. 2005
    ..We hypothesize that reintroduction of SSTR genes back into pancreatic cancer cells might be an effective gene therapy strategy for pancreatic cancer...
  13. ncbi request reprint Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Lett 248:58-67. 2007
    ..Furthermore, Thyalpha1 increased the secretion of multiple cytokines including IL-10, IL-13, and IL-17 in Panc-1 cells. Thus, Thyalpha1 may have a new role in pancreatic cancer pathogenesis...
  14. ncbi request reprint Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147
    Min Li
    Molecular Surgeon Research Center, Houston, Texas, USA
    Cancer 106:2284-94. 2006
    ..In this study the expression of CypA and its receptor CD147 on pancreatic cancer was determined as well as the effect of exogenous CypA on pancreatic cancer cell proliferation...
  15. pmc Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer
    Min Li
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Sci 99:733-7. 2008
    ..Targeting IL-8 along with other antiangiogenesis therapy could be an effective treatment for this malignancy...
  16. ncbi request reprint Effect of cyclophilin A on gene expression in human pancreatic cancer cells
    Min Li
    Molecular Surgeon Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Surg 190:739-45. 2005
    ..In this study, we further investigated the effect of CypA on gene expression of several key molecules that are involved in pancreatic cancer cell proliferation...
  17. doi request reprint The hypofunctional effect of P335L single nucleotide polymorphism on SSTR5 function
    Guisheng Zhou
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    World J Surg 35:1715-24. 2011
    ..In the present study we sought to determine the distribution of the SSTR5 P335L SNP in a cohort of pancreatic cancer patients and whether the P335L SNP affected cellular function of SSTR5 in human pancreatic cancer...
  18. ncbi request reprint Value of pancreatic resection for cancer metastatic to the pancreas
    Alex D Sweeney
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, The Elkins Pancreas Center, Houston, Texas, USA
    J Surg Res 160:268-76. 2010
    ..The value of pancreatic resection in this setting is unclear. The purpose of this study was to review cases of cancer metastatic to the pancreas...
  19. pmc Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis
    Yuqing Zhang
    Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Molecular Surgeon Research Center, Baylor College of Medicine and Michael E DeBakey VA Medical Center, One Baylor Plaza, Houston, TX 77030, USA
    World J Surg 33:698-709. 2009
    ..We hypothesized that pancreatic cancer may have a unique miRNA profile, which may play a critical role in pancreatic cancer development, progression, diagnosis, and prognosis...
  20. pmc A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer
    Christian Marin-Muller
    Authors Affiliations Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Department of Molecular Virology and Microbiology, Duncan Cancer Center, Baylor College of Medicine and Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan Center for Translational Research on Inflammatory Diseases, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas
    Clin Cancer Res 19:5901-13. 2013
    ..However, the MSLN regulatory network is still unclear. Here, we investigated the regulation of a panel of tumorigenic factors and explored the potential of MSLN-regulated miR-198 treatment in vivo...
  21. pmc Routine nasogastric suction may be unnecessary after a pancreatic resection
    William E Fisher
    The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    HPB (Oxford) 13:792-6. 2011
    ..Most surgeons routinely place a nasogastric tube at the time of a pancreatic resection. The goal of the present study was to evaluate the outcome when a pancreatic resection is performed without routine post-operative nasogastric suction...
  22. ncbi request reprint Roles of neuropilins in neuronal development, angiogenesis, and cancers
    Changyi Chen
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, 77030, USA
    World J Surg 29:271-5. 2005
    ....
  23. doi request reprint Preoperative prediction of complete resection in pancreatic cancer
    Dhruvil Shah
    The Elkins Pancreas Center, Dan L Duncan Cancer Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    J Surg Res 147:216-20. 2008
    ..With improvements in computed tomography (CT) scanning, the value of routine laparoscopy for preoperative staging of pancreatic cancer has been questioned because it changes the preoperative plan in less than 20% of unselected cases...
  24. pmc Drain data to predict clinically relevant pancreatic fistula
    Daniel J Moskovic
    Michael E DeBakey Department of Surgery and Dan L Duncan Cancer Center, The Elkins Pancreas Center, Baylor College of Medicine, Houston, TX 77030, USA
    HPB (Oxford) 12:472-81. 2010
    ..Post-operative pancreatic fistula (POPF) is a common and potentially devastating complication of pancreas resection. Management of this complication is important to the pancreas surgeon...
  25. ncbi request reprint Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine Methodist Hospital, Houston, Texas 77030, USA
    Cancer 101:2341-50. 2004
    ..In the current study, the authors assessed the expression of NRPs, VEGF, and vascular endothelial growth factor receptors (VEGFRs), as well as VEGF-induced cell proliferation, in pancreatic carcinoma cell lines and tissue specimens...
  26. ncbi request reprint Somatostatin, somatostatin receptors, and pancreatic cancer
    Min Li
    Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine and The Methodist Hospital, 6550 Fannin Street, Houston, Texas 77030, USA
    World J Surg 29:293-6. 2005
    ..In most pancreatic cancers, functional SSTRs are absent. Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models...
  27. pmc A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth
    Yuqing Zhang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    EMBO Mol Med 5:1322-34. 2013
    ....
  28. ncbi request reprint Signal transduction in human pancreatic cancer: roles of transforming growth factor beta, somatostatin receptors, and other signal intermediates
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77021, USA
    Arch Immunol Ther Exp (Warsz) 53:381-7. 2005
    ....
  29. ncbi request reprint Current update of cytokines in pancreatic cancer: pathogenic mechanisms, clinical indication, and therapeutic values
    Louis W Feurino
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Invest 24:696-703. 2006
    ....
  30. doi request reprint Value of pancreatic resection for cancer metastatic to the pancreas
    Alex D Sweeney
    The Elkins Pancreas Center, Dan L Duncan Cancer Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Surg Res 156:189-98. 2009
    ..The value of pancreatic resection in this setting is unclear. The purpose of this study was to review cases of cancer metastatic to the pancreas...
  31. pmc Developing a tissue resource to characterize the genome of pancreatic cancer
    Georgios Voidonikolas
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden, Suite 1500, Houston, TX 77030, USA
    World J Surg 33:723-31. 2009
    ..This article summarizes the basic principles that guide the creation of such a repository, including sample processing and preservation techniques, sample size and composition, and collection of clinical data elements...
  32. pmc Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:18636-41. 2007
    ..These data reveal an important outcome of aberrant ZIP4 expression in contributing to pancreatic cancer pathogenesis and progression. It may suggest a therapeutic strategy whereby ZIP4 is targeted to control pancreatic cancer growth...
  33. ncbi request reprint A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage
    George van Buren
    Baylor College of Medicine, The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, and The Dan L Duncan Cancer Center, Houston, TX Department of Surgery, The Ohio State University, Columbus, OH Department of Surgery, University of Florida, Gainesville, FL Department of Surgery, Jefferson Medical College, Philadelphia, PA Department of Surgery, Baptist Memorial Hospital The University of Tennessee Health Science Center, Memphis, TN Department of Surgery, Indiana University, Indianapolis, IN Department of Surgery, University of Pennsylvania, Philadelphia, PA Department of Surgery, University of South Florida, Tampa, FL and Department of Surgery, The University of Texas Medical Branch, Galveston, TX
    Ann Surg 259:605-12. 2014
    ..To test by randomized prospective multicenter trial the hypothesis that pancreaticoduodenectomy (PD) without the use of intraperitoneal drainage does not increase the frequency or severity of complications...
  34. ncbi request reprint Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts
    Scott A Celinski
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    J Surg Res 115:41-7. 2003
    ..SSTR2 expression may be an important tumor-suppressor pathway that is lost in human pancreatic cancer. We hypothesized that SSTR2 gene transfer would restore the growth-inhibitory response of human pancreatic cancer to somatostatin...
  35. pmc Treatment of bacteriobilia decreases wound infection rates after pancreaticoduodenectomy
    Somala Mohammed
    Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    HPB (Oxford) 16:592-8. 2014
    ..It was hypothesized that culture-directed treatment of bacteriobilia would decrease the incidence of infectious complications following pancreaticoduodenectomy...
  36. doi request reprint An assessment of the necessity of transfusion during pancreatoduodenectomy
    Amelia Ross
    The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77479, USA
    Surgery 154:504-11. 2013
    ..A retrospective analysis was performed to determine whether transfusions were indicated based on pre-determined criteria, and the impact of perioperative transfusions on postoperative outcomes was assessed...
  37. ncbi request reprint New roles of a neuropeptide cortistatin in the immune system and cancer
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine and The Methodist Hospital, 6550 Fannin Street, Houston, Texas 77030, USA
    World J Surg 29:354-6. 2005
    ..In this review, we discuss the new functions of CST in the immune system, cancer pathogenesis, and possible CST-specific receptors...
  38. pmc Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:2863-72. 2011
    ..Genetic variation in SSTR had been associated with risk of human cancers but had never been investigated in pancreatic cancer...
  39. ncbi request reprint Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications
    Joel A Rodriguez
    Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin Street, Houston, Texas 77030, USA
    World J Surg 29:297-305. 2005
    ..The S100 gene family, mesothelin, prostate stem cell antigen, and 14-3-3 sigma, may have important clinical implications in pancreatic cancer diagnosis and treatment...
  40. pmc Basic principles and technologies for deciphering the genetic map of cancer
    Georgios Voidonikolas
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    World J Surg 33:615-29. 2009
    ..We also describe the possible applications of the discovery of DNA changes to the approach of this disease and cite preliminary efforts where the knowledge has been translated into the clinical or preclinical setting...
  41. ncbi request reprint Somatostatin receptor subtype 2 gene therapy inhibits pancreatic cancer in vitro
    William E Fisher
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Surg Res 105:58-64. 2002
    ..SSR2 expression may be an important tumor suppressor pathway that is lost in human pancreatic cancer. We hypothesized that SSR2 gene transfer would restore the growth inhibitory response of human pancreatic cancer to somatostatin...
  42. pmc Engineered T cells for pancreatic cancer treatment
    Usha L Katari
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030, USA
    HPB (Oxford) 13:643-50. 2011
    ..The aim of this study is to develop an adoptive T cell transfer approach to target tumours expressing prostate stem cell antigen (PSCA), a tumour-associated antigen that is frequently expressed by pancreatic cancer cells...
  43. ncbi request reprint Pancreatic polypeptide administration reduces insulin requirements of artificial pancreas in pancreatectomized dogs
    Tetsuya Kono
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Artif Organs 29:83-7. 2005
    ..7 +/- 126.5 mU/kg vs. 1007.7 +/- 144.9 mU/kg; P < 0.05, respectively). We conclude that infusion of PP reduces the insulin requirement for the initial 48 h in pancreatectomized dogs treated with an artificial endocrine pancreas...
  44. doi request reprint Quality metrics in pancreatic surgery
    Somala Mohammed
    Division of General Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Suite 404D, Houston, TX 77030, USA
    Surg Clin North Am 93:693-709. 2013
    ..It also highlights surgical outcomes from several high-volume institutions and recent developments in quality metrics within pancreatic surgery...
  45. ncbi request reprint Effective treatment of pancreatic cancer xenografts with a conditionally replicating virus derived from type 2 herpes simplex virus
    Xinping Fu
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 12:3152-7. 2006
    ..Because the replication potential of FusOn-H2 depends on the activation of the Ras signaling pathway, we evaluated its antitumor effect against pancreatic cancer, which often harbors K-ras gene mutations...
  46. ncbi request reprint Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter
    Xiao Ping Wang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Gastrointest Surg 8:98-108; discussion 106-8. 2004
    ..Significantly increased levels of PDX-1 have been found in human pancreatic cancer specimens. These results suggest that RIP could be used for cell-specific suicide gene therapy to target human pancreatic tumors...
  47. ncbi request reprint Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR
    Min Li
    Elkins Pancreas Center and Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Surg Res 119:130-7. 2004
    ..In the current study, we used a powerful real-time RT-PCR technique to examine the mRNA expression levels of all five SSTR subtypes in human pancreatic cancer...
  48. ncbi request reprint Value of laparoscopy in the staging of pancreatic cancer
    Diego Camacho
    The Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    JOP 6:552-61. 2005
    ....
  49. ncbi request reprint Angiogenesis and antiangiogenic strategies in pancreatic cancer
    William E Fisher
    Houston VAMC, Baylor College of Medicine, Michael E DeBakey Department of Surgery, Houston, TX 77030, USA
    Int J Gastrointest Cancer 33:79-88. 2003
    ..This article reviews the process of angiogenesis and antiangiogenic strategies with a special emphasis on pancreatic cancer...
  50. ncbi request reprint Current progress in suicide gene therapy for cancer
    Kazuyuki Yazawa
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin, Suite 1661, Houston, Texas 77030, USA
    World J Surg 26:783-9. 2002
    ..Advances in tissue- and cell-specific delivery of suicide genes using specific promoters will improve the clinical utility of suicide gene therapy...
  51. ncbi request reprint Activation of somatostatin receptor subtype 2 inhibits insulin secretion in the isolated perfused human pancreas
    F Charles Brunicardi
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Pancreas 27:e84-9. 2003
    ..Five distinct somatostatin receptors (SSTRs) have been cloned, characterized, and designated SSTRs 1-5. The role of these receptors in B-cell signaling has not been well characterized...

Research Grants1

  1. Role of Somatostatin Receptors in Pancreatic Cancer
    William Fisher; Fiscal Year: 2003
    ..Since somatostatin expression has been demonstrated in other tumor types, the findings may also be relevant to other cancers. ..