Research Topics
| S M FischerSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in miceSusan M Fischer
The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville 78957, USA
Carcinogenesis 24:945-52. 2003..It is concluded that the combination of celecoxib and DFMO are potent therapeutic agents for skin cancer, although the benefits are lost with the cessation of treatment...- Prostaglandins and cancerS M Fischer
The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
Front Biosci 2:d482-500. 1997..However, the apoptosis caused by these inhibitors as well as other drugs has raised some question concerning the relative importance of PGs. This is an issue that remains to be resolved... - Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless miceS M Fischer
The University of Texas MD Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville, TX 78957, USA
Carcinogenesis 22:83-8. 2001..The final tumor number at 30 weeks was 3.0 (96% incidence). Thus, DFMO has strong chemopreventive efficacy, as well as therapeutic activity, against UV-induced skin tumors. Histological and proliferative markers support this conclusion... - Phorbol ester induction of 8-lipoxygenase in inbred SENCAR (SSIN) but not C57BL/6J mice correlated with hyperplasia, edema, and oxidant generation but not ornithine decarboxylase inductionS M Fischer
University of Texas System Cancer Center, Science Park Research Division, Smithville 78957
Cancer Res 48:658-64. 1988..This suggests that oxidant generation or possibly 8-lipoxygenase activity may be the basis for the sensitivity or resistance to TPA as a hyperplasiogen and as a tumor promoter... - Role of intracellular interleukin-1 receptor antagonist in skin carcinogenesisE La
Department of Carcinogenesis, The University of Texas M. D. Anderson Cancer Center Science Park-Research Division, Smithville 78957, USA
Mol Carcinog 30:218-23. 2001..IcIL-1Ra appeared to significantly slow the growth of tumors in vivo. Collectively these observations suggest that IL-1Ra has antiproliferative effects in murine skin carcinoma cells... - IKK? represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skinB Liu
Department of Carcinogenesis, The University of Texas, MD Anderson Cancer Center, P O Box 389, Smithville, TX 78957, USA
Cell Death Differ 18:1854-64. 2011..Thus, IKK? maintains skin homeostasis through a broad range of signaling pathways... - Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic miceS D Hursting
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
J Natl Cancer Inst 91:215-25. 1999..In addition, the utility for mechanism-based cancer prevention research of new animal models that are based on the overexpression or inactivation of specific cancer-related genes is examined... - The role of the EP receptors for prostaglandin E(2) in skin and skin cancerJ E Rundhaug
The Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX, 78957, USA
Cancer Metastasis Rev 30:465-80. 2011..Understanding the role and mechanisms of action of the EP receptors potentially offers new targets for the prevention or therapy of NMSCs... - 8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytesS J Muga
University of Texas, M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
Cell Growth Differ 11:447-54. 2000..From these studies, it is concluded that 8S-HETE plays an important role in keratinocyte differentiation and that at least some of its effects are mediated by PPARalpha... - Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor developmentY M Sung
Science Park Research Division, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
Oncogene 25:5507-16. 2006..Together, our results suggest that the overexpression of the EP2 receptor plays a significant role in the protumorigenic action of PGE2 in mouse skin... - Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesisB Patamalai
University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957
Mol Carcinog 9:220-9. 1994..Overall, 28 +/- 6% of the tissue of the 12 analyzed carcinomas stained for the intracellular form and 18 +/- 5% for the extracellular form of TGF-beta 1... - Transcriptional regulation of intracellular IL-1 receptor antagonist gene by IL-1 alpha in primary mouse keratinocytesE La
Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, TX 78957, USA
J Immunol 166:6149-55. 2001..Finally, mutational analysis confirmed that these elements were both essential for maximal transcription induced by IL-1alpha... - Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppressionHui Xu
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center-Shreveport and the Feist-Weiller Cancer Center, Shreveport, Louisiana 17730, USA
Clin Cancer Res 12:969-79. 2006.... - Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytesGuobin He
Department of Carcinogenesis, Science Park-Research Division, University of Texas M.D. Anderson Cancer Center, 1808 Park Road 1C, P.O. Box 389, Smithville, TX 78957, USA
Prostaglandins Leukot Essent Fatty Acids 74:193-7. 2006..These data suggest that troglitazone is capable of inducing COX-2 expression through an ERK-dependent mechanism in mouse skin keratinocytes... - Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancerJason Gee
Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Oncol Rep 15:471-7. 2006..Induction of apoptosis in all three cell lines by celecoxib was associated with downregulation of Bcl-2. These changes occur independently of COX-2 expression levels suggesting the presence of a COX-2 independent pathway... - Lack of expression of the EP2 but not EP3 receptor for prostaglandin E2 results in suppression of skin tumor developmentYou Me Sung
The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
Cancer Res 65:9304-11. 2005..Our data suggest that the EP2 receptor plays a significant role in the protumorigenic action of PGE2 in skin tumor development... - The effect of PPARgamma ligands on UV- or chemically-induced carcinogenesis in mouse skinGuobin He
The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, USA
Mol Carcinog 43:198-206. 2005..Collectively, our data suggest that PPARgamma ligands may not be useful in the prevention of chemically or UV-induced skin tumors... - Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activityGuobin He
Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Science Park Research Division, 1808 Park Road 1C, Smithville, TX 78957, USA
Cancer Res 66:1873-8. 2006..Collectively, these data suggest that thiazolidinediones specifically inhibit IGF-I tumor-promoting activity in mouse skin through activation of AMPK and subsequent inhibition of p70S6K... - Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesisSusan M Fischer
The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Mol Carcinog 46:363-71. 2007..UV-induced apoptosis, however, was greater in COX-2 heterozygous mice. Collectively, these results clearly establish the requirement for COX-2 in the development of skin tumors... - A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesisJoyce E Rundhaug
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Mol Carcinog 46:692-8. 2007..Together these studies demonstrate that COX-2 expression/activity is critical to the development of UV-related nonmelanoma skin cancers... - Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in miceShelley B Riedel
Section of Molecular Genetics and Microbiology, The University of Texas, Austin, TX 78712, USA
Anticancer Drugs 19:175-81. 2008..In conclusion alpha-TEA is an effective late-stage chemopreventive agent for nonmelanoma skin cancer that exhibits lasting benefits... - Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesisJoyce E Rundhaug
The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX, USA
Photochem Photobiol 84:322-9. 2008..A combination of signaling from the PGE2 EP1, EP2 and/or EP4 receptors mediates the effects of COX-2 overexpression. These studies demonstrate the crucial role of COX-2 in the development of UV-related nonmelanoma skin cancers... - Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpressionJennifer Kl Colby
Science Park Research Division, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
Neoplasia 10:782-96. 2008..The progressive nature of the metaplastic/dysplastic changes observed in this model make it a valuable tool for examining the transition from chronic inflammation to neoplasia... - IKKalpha is required to maintain skin homeostasis and prevent skin cancerBigang Liu
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
Cancer Cell 14:212-25. 2008..Thus, IKKalpha serves as an innate surveillant... - Troglitazone inhibits cyclin D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytesGuobin He
The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas, USA
J Invest Dermatol 123:1110-9. 2004..Given the important role of keratinocyte proliferation in skin carcinogenesis, our data suggest that TZD may be useful tumor preventive agents in skin... - Is cyclooxygenase-2 important in skin carcinogenesis?Susan M Fischer
The University of Texas M D Anderson, Department of Carcinogenesis, Smithville 78957, USA
J Environ Pathol Toxicol Oncol 21:183-91. 2002..Collectively, these studies suggest that prostaglandins play a critical role in skin cancer development... - The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cellsImad Shureiqi
Departments of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 100:9968-73. 2003..Our findings indicate that the down-regulation of PPAR-delta by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs... - Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor developmentDavid K Bol
Bristol Myers Squibb Pharmaceutical Research Institute, Department of Oncology Drug Discovery, Princeton, New Jersey 08543, USA
Cancer Res 62:2516-21. 2002..These results clearly raise questions regarding the role of COX-2 and elevated prostaglandin levels in skin tumor development... - Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cellsPeiying Yang
Pharmaceutical Development Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77054, USA
J Lipid Res 45:1030-9. 2004..These data indicate that exposure of lung cancer cells to EPA results in a decrease in the COX-2-mediated formation of PGE(2), an increase in the level of PGE(3), and PGE(3)-mediated inhibition of tumor cell proliferation... - Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cellsShaohua Tang
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
J Biol Chem 277:16189-201. 2002..Taken together, these results suggest that 15-LOX2 could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression... - Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cellsRussell D Klein
The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
Carcinogenesis 23:217-21. 2002.... - Multiple signaling pathways are responsible for prostaglandin E2-induced murine keratinocyte proliferationKausar M Ansari
Science Park Research Division, The University of Texas M D Anderson Cancer Center, PO Box 389, Smithville, TX 78957, USA
Mol Cancer Res 6:1003-16. 2008..Our findings provide evidence for a link between cyclooxygenase-2 overexpression and EGFR-, ERK-, PI3K-, cAMP-mediated cell proliferation, and the tumor-promoting activity of PGE2 in mouse skin... - Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skinKausar M Ansari
The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
Carcinogenesis 28:2063-8. 2007..Taken together, EP2 activation of the PKA/CREB-signaling pathway is responsible for keratinocyte proliferation and our findings reveal a positive feedback loop between COX-2 and PGE2 that is mediated by the EP2 receptor... - Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitorsPhilippe Thuillier
Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smithville 78957, USA
Biochem J 366:901-10. 2002..Ligand-binding studies revealed that the LOX inhibitors bind directly to PPARs and demonstrate a novel mechanism for these inhibitors in altering PPAR-mediated gene expression... - The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependentJoyce E Rundhaug
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Mol Carcinog 46:981-92. 2007..COX2 mice treated only with DMBA developed approximately 3.5 times more tumors than wild-type mice, suggesting that PGs have intrinsic tumor promoting activity. We conclude that the role of PGs in skin tumorigenesis is context dependent... - Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomasEunmi Park
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
Cancer Res 67:9158-68. 2007..Our findings provide evidence that a reduction in IKKalpha expression promotes the development of papillomas and carcinomas and that the integrity of the Ikkalpha gene is required for suppressing skin carcinogenesis... - The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissueXingya Wang
Department of Human Nutrition and Molecular Carcinogenesis and Chemoprevention Program, The Ohio State University Comprehensive Cancer Center, The Ohio State University, 325 Campbell Hall, 1787 Neil Avenue, Columbus, OH 43210, USA
Carcinogenesis 29:120-8. 2008..Collectively, our results suggest that COX-2 may not play a tumorigenic role during prostate carcinogenesis in the TRAMP model... - Regulation of transcription of the intracellular interleukin-1 receptor antagonist gene by AP-1 in mouse carcinoma cellsEunhye La
The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Mol Carcinog 33:237-43. 2002..Moreover, electrophoretic mobility shift assay and cotransfection experiments showed that c-jun and c-fos proteins bound to the AP-1 site and functionally transactivated the icIL-1Ra promoter in mouse carcinoma CH72 cells... - GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cellsImad Shureiqi
Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Cancer Res 62:1178-83. 2002..Ectopic GATA-6 expression blocked NSAID induction of 15-LOX-1 and apoptosis. NSAIDs down-regulate GATA-6 to transcriptionally up-regulate 15-LOX-1 and induce apoptosis in colorectal cancer cells... - An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesisEunjung Kim
Science Park Research Division, University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, PO Box 389, Smithville, TX 78957, USA
Oncogene 24:1174-87. 2005..Collectively, these data suggest that 8S-LOX plays a role as a prodifferentiating, antitumorigenic, and tumor suppressing gene in mouse skin carcinogenesis... - Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cellsPeiying Yang
Department of Experimental Therapeutics, University of Texas, M. D. Anderson Cancer Center, Houston 77030, USA
Anal Biochem 308:168-77. 2002..Concomitantly, EPA increased formation of PGE(3) by 10-fold in A549 cells. This is the first report that unequivocally demonstrates that EPA can be converted to PGE(3) by cyclooxygenase in human cancer cells... - SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effectsJoyce E Rundhaug
Department of Carcinogenesis, The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, USA
Mol Carcinog 42:40-52. 2005.... - Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cellsShaohua Tang
Department of Carcinogenesis, Science Park Research Division, The University of Texas MD Anderson Cancer Center, 1808 Park Rd 1C, Smithville, TX 78957, USA
Oncogene 23:6942-53. 2004..The results indicate that androgen does not directly regulate 15-LOX2 gene expression. Together, these observations provide insight on how 15-LOX2 gene expression may be regulated in NHP cells... - Mutation frequencies in murine keratinocytes as a function of carcinogenic statusLaura A Christensen
Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas, USA
Mol Carcinog 40:122-33. 2004..These data suggested that a strong mutator phenotype was not required for progression to an advanced malignant phenotype in our model system... - The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesisImad Shureiqi
Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Cancer Res 65:11486-92. 2005..Therefore, 15-LOX-1 down-regulation rather than a shift in the balance of LOXs is likely the dominant alteration in LOX metabolism which contributes to colorectal tumorigenesis by repressing apoptosis... - Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factorsStefan Jüttner
Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
Cell Microbiol 5:821-34. 2003..pylori-dependent cox-2 gene expression in gastric epithelial cells, and may thus contribute to a better understanding of mechanisms underlying H. pylori pathogenicity... - Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinomaViola C Ruddat
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
Prostate 64:128-38. 2005..CONCLUSIONS: Proteomics of TRAMP mice provide an excellent method to observe changes in protein abundance, revealing changes in pathways during cancer progression... - Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyomaKevin D Houston
University of Texas M D Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, USA
Cancer Res 63:1221-7. 2003..These results suggest that in uterine leiomyomas PPARgamma activation is growth inhibitory and that this inhibition is mediated at least in part by negative cross-talk between ER and PPAR signaling pathways... - A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomasBigang Liu
Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA
Proc Natl Acad Sci U S A 103:17202-7. 2006..Thus, overexpression of IKKalpha in the epidermis antagonized chemical carcinogen-induced mitogenic and angiogenic activities, repressing tumor progression and metastases... - Modulation of UVB-induced and basal cyclooxygenase-2 (COX-2) expression by apigenin in mouse keratinocytes: role of USF transcription factorsRukiyah T van Dross
Department of Pharmacology and Toxicology, Leo Jenkins Cancer Center, East Carolina University, Greenville, North Carolina 27834, USA
Mol Carcinog 46:303-14. 2007..These results suggest that one pathway by which apigenin inhibits COX-2 expression is through modulation of USF transcriptional activity... - Protein expression profiles in the epidermis of cyclooxygenase-2 transgenic mice by 2-dimensional gel electrophoresis and mass spectrometryJianjun Shen
The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
J Proteome Res 6:273-86. 2007..The current data suggest that some of the differentially expressed proteins might increase apoptosis and cell cycle arrest, which, in turn, may provide insight into the role of COX-2 in skin tumorigenesis... - Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposureJacqueline K Akunda
Laboratory of Molecular Carcinogenesis, NIEHS NIH, Research Triangle Park, North Carolina 27709, USA
Mol Carcinog 46:354-62. 2007..The data indicate that COX-2 induction initially protects against the acute sunburn effects of UVB, but that continuous induction of COX-2 may contribute to skin cancer in chronic UVB exposure...