Research Topics
Species | Buckminster FarrowSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Characterization of tumor-derived pancreatic stellate cellsBuckminster Farrow
Michael E DeBakey Department of Surgery, Houston, Texas 77030, USA
J Surg Res 157:96-102. 2009..We sought to isolate and characterize tumor-derived pancreatic stellate (TDPS) cells to further understand how these stromal cells influence pancreatic cancer behavior...
Tumor-derived pancreatic stellate cells promote pancreatic cancer cell invasion through release of thrombospondin-2Buckminster Farrow
Michael E DeBakey Department of Surgery, Baylor College of Medicine, TX 77030, USA
J Surg Res 156:155-60. 2009..We sought to determine whether TDPS cells promote the local invasion of pancreatic cancer cells and mechanisms involved...
More than 150 consecutive open umbilical hernia repairs in a major Veterans Administration Medical CenterBuckminster Farrow
Department of Surgery, Michael E DeBakey VA Medical Center, Baylor College of Medicine Houston, Houston, TX, USA
Am J Surg 196:647-51. 2008..The purpose of this study was to determine the rate of surgical site infection for open elective umbilical hernia repairs and to identify the factors related to an increased risk of infection and/or recurrence...
The role of the tumor microenvironment in the progression of pancreatic cancerBuckminster Farrow
Department of Surgery, Baylor College of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
J Surg Res 149:319-28. 2008..Finally we suggest ideas for new avenues of research into the pancreatic tumor microenvironment which may permit the development of novel, more effective treatments for pancreatic cancer...
Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activatorBuckminster Farrow
Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77555, USA
Surgery 134:206-12. 2003..PPARgamma ligands inhibit pancreatic cancer cell invasion, suggesting that these agents may represent novel strategies to treat pancreatic cancer...
Analysis of differential gene expression patterns in colon cancer and cancer stroma using microdissected tissuesYuko Sugiyama
Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA
Gastroenterology 128:480-6. 2005....
Butyrate inhibits pancreatic cancer invasionBuckminster Farrow
Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555, USA
J Gastrointest Surg 7:864-70. 2003..NaBT may represent a novel strategy to inhibit pancreatic cancer invasion and improve the prognosis of this deadly disease...
Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase ABuckminster Farrow
Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
Surgery 134:197-205. 2003..Inhibition of PKA may represent a novel therapeutic strategy for the adjuvant treatment of pancreatic cancer...
Rectal cancer patients benefit from implementation of a dedicated colorectal cancer center in a Veterans Affairs Medical CenterJonathan A Wilks
Department of Surgery, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX, USA
Am J Surg 198:100-4. 2009..A dedicated colorectal cancer (CRC) center was created in a Veterans Affairs Medical Center with the intent of improving quality of patient care and multidisciplinary cooperation...
Outcomes of Veterans Affairs patients older than age 80 after surgical procedures for colon malignanciesLiz Lee
Department of Surgery, Michael E DeBakey VA Medical Center, 2002 Holcombe Blvd, OCL 5th Floor, Room 112, Houston, TX 77030, USA
Am J Surg 194:646-51. 2007..There is a lack of information concerning surgical outcomes in this patient population regarding colon cancer. Herein we report a 10-year experience of surgical outcomes...
Translation of recent advances and discoveries in molecular biology and immunology in the diagnosis and treatment of pancreatic cancerDaniel Albo
Michael E DeBakey Department of Surgery, Baylor College of Medicine, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, OCL 112A, Houston, TX 77030, USA
Surg Oncol Clin N Am 17:357-76, ix. 2008..Although a clear "magic bullet" has yet to emerge, this type of targeted approach offers hope in the management of this dreadful disease. This article offers an update on these promising diagnostic and treatment modalities...
Activation of conventional PKC isoforms increases expression of the pro-apoptotic protein Bad and TRAIL receptorsBuckminster Farrow
Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77555, USA
Int J Gastrointest Cancer 32:63-72. 2002..Agents that stimulate PKC may sensitize pancreatic cancer cells to apoptosis and provide a potential adjuvant therapy for the treatment of chemoresistant pancreatic cancers...
Inflammatory mechanisms contributing to pancreatic cancer developmentBuckminster Farrow
Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77555-0536, USA
Ann Surg 239:763-9; discussion 769-71. 2004..These findings may lead to novel strategies for pancreatic cancer prophylaxis based on inhibition of inflammatory mediators...
Stem cells: what is their future in surgery?Buckminster Farrow
Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
Adv Surg 37:51-69. 2003
Activation of PPARgamma increases PTEN expression in pancreatic cancer cellsBuckminster Farrow
Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
Biochem Biophys Res Commun 301:50-3. 2003..Taken together, our results suggest that activation of PPARgamma may represent a novel approach for the treatment of pancreatic cancer by increasing PTEN levels and inhibiting PI3K activity...
Inflammation and the development of pancreatic cancerBuckminster Farrow
Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston 77555, USA
Surg Oncol 10:153-69. 2002..CONCLUSION: Pancreatic inflammation, mediated by cytokines, reactive oxygen species, and upregulated pro-inflammatory pathways, may play a key role in the early development of pancreatic malignancy...
