Research Topics
| H El-SeragSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidenceHashem B El-Serag
Section of Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center at Baylor College of Medicine, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 4:369-80. 2006..We conducted a systematic review and a meta-analysis to estimate the magnitude and determinants of association between diabetes and hepatocellular carcinoma (HCC)...- Prevalence and determinants of histological abnormalities of the gastric cardia in volunteersHashem B El-Serag
Section of Gastroenterology, Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
Scand J Gastroenterol 42:1158-66. 2007..There have been no studies on non-patient populations. The aim of this study was to mitigate the potential effects of selection bias... - Prevalence and histological features of the gastric cardia-type mucosa in childrenHashem B El-Serag
Section of Gastroenterology, Houston Center for Quality of Care and Utilization Studies, The Michael E DeBakey Veterans Affairs Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
Dig Dis Sci 53:1792-6. 2008..We examined the presence and determinants of gastric cardia-type mucosa at a normally located z-line in children without underlying gastroesophageal reflux disease (GERD)-predisposing disorders... - Role of obesity in GORD-related disordersHashem El-Serag
Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Gut 57:281-4. 2008..Maintaining normal weight may reduce the likelihood of developing GORD and its potential complications... - Temporal trends in new and recurrent oesophageal strictures in a Medicare populationH B El-Serag
Section of Gastroenterology, The Houston Department of Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA
Aliment Pharmacol Ther 25:1223-9. 2007..The temporal trends of strictures have not been examined in population-based studies... - The extent and determinants of prescribing and adherence with acid-reducing medications: a national claims database studyHashem B El-Serag
Section of Gastroenterology and Hepatology, Houston Center for Quality of Care and Utilization Studies, The Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Am J Gastroenterol 104:2161-7. 2009..No community-based, large-scale studies have examined the extent of prescribing acid-reducing medications or adherence and persistence to these medication regimens... - Time trends of gastroesophageal reflux disease: a systematic reviewHashem B El-Serag
Gastroenterology and Health Services Research Sections, Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 5:17-26. 2007..If this trend continues, it could contribute to the rapidly increasing incidence of more serious complications associated with GERD, such as esophageal adenocarcinoma, as well as costs to healthcare systems and employers... - Obesity increases oesophageal acid exposureHashem B El-Serag
Section of Health Services Research, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
Gut 56:749-55. 2007..Obesity has been associated with gastro-oesophageal reflux disease (GERD); however, the mechanism by which obesity may cause GERD is unclear... - The prevalence of suspected Barrett's esophagus in children and adolescents: a multicenter endoscopic studyHashem B El-Serag
The Michael E DeBakey Veterans Affairs Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
Gastrointest Endosc 64:671-5. 2006..The prevalence of Barrett's esophagus (BE) in young individuals is unclear... - Anthropometric correlates of intragastric pressureHashem B El-Serag
Sections of Health Services Research and Gastroenterology, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Scand J Gastroenterol 41:887-91. 2006..However, the association between anthropometric measures of total body as well as abdominal obesity and intragastric pressure has not been examined... - Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: a population-based studyHashem B El-Serag
Section of Health Services Research, Houston Veterans Affairs Medical Center, Baylor College of Medicine, 2002 Holcombe Boulevard 152, Houston, TX 77030, USA
J Hepatol 44:158-66. 2006..Yet, neither the extent to which potentially curative or palliative therapy is used to treat HCC, nor the determinants of using such therapies are known. Further, it is unclear how effective different modalities are for treating HCC... - Obesity and disease of the esophagus and colonHashem B El-Serag
Section of Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center at Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Gastroenterol Clin North Am 34:63-82. 2005..This article discusses the evidence linking obesity to the different manifestations of gastroesophageal reflux disease and colorectal cancer... - Survival in hepatitis C and HIV co-infection: a cohort study of hospitalized veteransHashem B El-Serag
Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas, USA
Clin Gastroenterol Hepatol 3:175-83. 2005..However, the long-term effect of hepatitis C virus (HCV) co-infection on the mortality of HIV-infected patients remains unclear... - Management of the single liver nodule in a cirrhotic patient: a decision analysis modelHashem B El-Serag
Sections of Gastroenterology, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
J Clin Gastroenterol 39:152-9. 2005..The long waiting time prior to OLT limits its advantage over surgical resection in the treatment of patients with early HCC... - The use of acid-decreasing medication in veteran patients with gastro-oesophageal reflux disorder with and without Barrett's oesophagusH B El-Serag
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
Aliment Pharmacol Ther 27:1293-9. 2008..To examine use of acid-decreasing medications, especially proton pump inhibitors (PPIs), in patients with gastro-oesophageal reflux disorder (GERD) with and without Barrett's oesophagus (BO) in a large-scale study... - The utility of evaluating low serum albumin gradient ascites in patients with cirrhosisHashim E Khandwalla
Sections of Gastroenterology and Health Services Research, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Am J Gastroenterol 104:1401-5. 2009..However, the predictive value of a low SAAG in patients with existing cirrhosis in whom the pretest probability of portal hypertension is high is not clear... - Diagnosis and treatment of hepatocellular carcinomaHashem B El-Serag
Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 134:1752-63. 2008..In this article, we present a summary of the most recent information on screening, diagnosis, staging, and different treatment modalities of HCC, as well as our recommended management approach... - The association between obesity and GERD: a review of the epidemiological evidenceHashem El-Serag
The Sections of Gastroenterology and Health Services Research, The Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
Dig Dis Sci 53:2307-12. 2008..Overall, epidemiological data show that maintaining a normal BMI may reduce the likelihood of developing GERD and its potential complications... - Systematic review: the epidemiology of gastro-oesophageal reflux disease in primary care, using the UK General Practice Research DatabaseH El-Serag
Michael E DeBakey Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
Aliment Pharmacol Ther 29:470-80. 2009..Gastro-oesophageal reflux disease (GERD) is a common diagnosis in primary care; however, there has been no comprehensive review of the epidemiology of GERD in this setting... - Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veteransHashem B El-Serag
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Hepatology 49:116-23. 2009..Absence of an association with ECC was consistent in adjusted and unadjusted models. A significant association with pancreatic cancer was erased by alcohol use and other variables... - Epidemiology of hepatocellular carcinoma in Hispanics in the United StatesHashem B El-Serag
Section of Gastroenterology, The Houston Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Arch Intern Med 167:1983-9. 2007..In previous studies, the rates for Hispanics have not been reported separately from other racial or ethnic groups... - Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetesHashem B El-Serag
Section of Gastroenterology at the Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 136:1601-8. 2009..Given the increasing prevalence of statin use, and the increasing incidence of hepatocellular carcinoma (HCC), the potential association between statins and HCC is an important issue to examine... - Gene expression in Barrett's esophagus: laser capture versus whole tissueHashem B El-Serag
Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston, Texas, USA
Scand J Gastroenterol 44:787-95. 2009..The purpose of this study was to determine the degree of overlap of the two sample types and to define a set of genes that might serve as biochemical markers for BE... - Hepatocellular carcinoma: epidemiology and molecular carcinogenesisHashem B El-Serag
Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
Gastroenterology 132:2557-76. 2007..A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve our current concepts for screening and treatment of this disease... - Determinants of gastroesophageal reflux disease in adults with a history of childhood gastroesophageal reflux diseaseHashem B El-Serag
Section of Health Services Research, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 5:696-701. 2007..We conducted a nested case-control study to examine the prevalence and risk factors for current gastroesophageal reflux disease (GERD) symptoms in young adults with a history of childhood GERD... - Dietary intake and the risk of gastro-oesophageal reflux disease: a cross sectional study in volunteersH B El-Serag
Section of Gastroenterology and Health Services Research, The Houston Veterans Affairs Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
Gut 54:11-7. 2005..We examined associations of GORD symptoms with intakes of specific dietary components... - Systematic review: persistent reflux symptoms on proton pump inhibitor therapy in primary care and community studiesH El-Serag
Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Aliment Pharmacol Ther 32:720-37. 2010..Persistent gastro-oesophageal reflux disease (GERD) symptoms can occur despite proton pump inhibitor (PPI) therapy... - Hepatocellular carcinoma: recent trends in the United StatesHashem B El-Serag
The Houston Veterans Affairs Medical Center 152, 2002 Holcombe Boulevard, Houston, Texas 77030, USA
Gastroenterology 127:S27-34. 2004..The insulin resistance syndrome, manifesting as obesity and diabetes, is emerging as a risk factor for HCC in the United States; however, its impact on the current trend in HCC remains unclear... - Health-related quality of life in functional dyspepsiaH B El-Serag
Section of Gastroenterology, The Houston Veterans Affairs Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Aliment Pharmacol Ther 18:387-93. 2003..We performed a systematic review of the literature to compare the health-related quality of life (HRQOL) of patients with functional dyspepsia with either healthy controls or those with other diseases... - Extrahepatic manifestations of hepatitis C among United States male veteransHashem B El-Serag
Section of Gastroenterology and Section of Health Services Research at The Houston Veterans Affairs Medical Center, Houston, TX, USA
Hepatology 36:1439-45. 2002..In conclusion, we found a significant association between HCV infection and PCT, lichen planus, vitiligo, cryoglobulinemia, membranoproliferative GN, and NHL. Patients presenting with these disorders should be tested for HCV infection... - Hepatocellular carcinoma and hepatitis C in the United StatesHashem B El-Serag
Sections of Gastroenterology and Health Services Research at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, 77030, USA
Hepatology 36:S74-83. 2002..Future research should focus on improving understanding of the incidence and risk factors for HCC, causes of HCV-related carcinogenesis, means of early detection, and better treatment for HCC... - Prevention of complicated ulcer disease among chronic users of nonsteroidal anti-inflammatory drugs: the use of a nomogram in cost-effectiveness analysisHashem B El-Serag
Health Services Research Sections, Houston Center for Quality of Care and Utilization Studies, Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
Arch Intern Med 162:2105-10. 2002..Our objective in this study was to compare the cost-effectiveness of several strategies aimed at reducing the risk of clinical UGI events in NSAID users... - Risk factors for the severity of erosive esophagitis in Helicobacter pylori-negative patients with gastroesophageal reflux diseaseH B El-Serag
Gastroenterology and Health Services Research, Houston VA Medical Center, Baylor College of Medicine, Texas 77030, USA
Scand J Gastroenterol 37:899-904. 2002..The risk factors for the varying grades of erosive esophagitis (EE) severity could be better understood. For that reason. we evaluated the risk factors associated with EE in patients with gastroesophageal reflux disease... - The epidemic of esophageal adenocarcinomaHashem B El-Serag
Sections of Gastroenterology and Health Services Research, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA
Gastroenterol Clin North Am 31:421-40, viii. 2002.... - Diabetes increases the risk of acute hepatic failureHashem B El-Serag
Section of Gastroenterology, Houston Department of Veterans Affairs Medical Center, Texas 77030, USA
Gastroenterology 122:1822-8. 2002..It is unclear whether patients with diabetes are at an increased risk of developing acute liver failure (ALF). We performed a large cohort study to examine the occurrence of ALF by using the databases of the Department of Veterans Affairs... - Health-related quality of life among persons with irritable bowel syndrome: a systematic reviewH B El-Serag
Sections of Gastroenterology and Health Services Research, Houston Veterans Affairs Medical Center 152, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Aliment Pharmacol Ther 16:1171-85. 2002.... - Epidemiological differences between adenocarcinoma of the oesophagus and adenocarcinoma of the gastric cardia in the USAH B El-Serag
Section of Gastroenterology, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas77030, USA
Gut 50:368-72. 2002..We examined several epidemiological features of GCA and OA in the USA to elucidate differences/similarities between these malignancies... - Extraesophageal associations of gastroesophageal reflux disease in children without neurologic defectsH B El-Serag
Section of Gastroenterology, Houston Veterans Affairs Medical Center 152, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Gastroenterology 121:1294-9. 2001..We conducted a large case-control study to examine the association between GERD and several upper and lower respiratory disorders in these children... - Epidemiology of hepatocellular carcinomaH B El-Serag
Sections of Gastroenterology and Health Services Research, Houston VA Medical Center, and Baylor College of Medicine, Houston, Texas, USA
Clin Liver Dis 5:87-107, vi. 2001..The incidence and mortality of HCC has been rising in the US over the last two decades and is progressively affecting younger persons. The evidence indicates that HCV infection is responsible for the current trends... - Trends in survival of patients with hepatocellular carcinoma between 1977 and 1996 in the United StatesH B El-Serag
Section of Gastroenterology, The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
Hepatology 33:62-5. 2001..Most of this apparent benefit is restricted to the first year following cancer diagnosis, raising the possibility of lead-time bias. There were no significant differences related to gender or ethnicity... - Risk factors for the rising rates of primary liver cancer in the United StatesH B El-Serag
Houston VA Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
Arch Intern Med 160:3227-30. 2000..A recent increase in the incidence of hepatocellular carcinoma was reported in the United States. The cause of this witnessed rise remains unknown... - The continuing increase in the incidence of hepatocellular carcinoma in the United States: an updateHashem B El-Serag
The Houston Center for Quality of Care and Utilization Studies, Sections of Gastroenterology and Health Services Research at The Houston Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, Texas 77030, USA
Ann Intern Med 139:817-23. 2003..The incidence of hepatocellular carcinoma was reported to be increasing in the United States. However, alternate explanations were diagnostic or reclassification bias and changes in the demographic features of the general population... - Diabetes increases the risk of chronic liver disease and hepatocellular carcinomaHashem B El-Serag
Section of Gastroenterology, Houston Departmentof Veterans Affais Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Gastroenterology 126:460-8. 2004..An association between diabetes and chronic liver disease has been reported. However, the temporal relationship between these conditions remains unknown... - The use of screening colonoscopy for patients cared for by the Department of Veterans AffairsHashem B El-Serag
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
Arch Intern Med 166:2202-8. 2006..Because of differences in the delivery of health care, this trend in use of colonoscopy in fee-for-service settings might not be paralleled in the Department of Veterans Affairs (VA)... - The length of newly diagnosed Barrett's oesophagus and prior use of acid suppressive therapyH B El-Serag
Section of Gastroenterology, The Houston, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
Aliment Pharmacol Ther 19:1255-60. 2004..However, it remains unknown whether prior acid suppressive therapy affects the length of newly diagnosed Barrett's oesophagus... - Gastroesophageal reflux among different racial groups in the United StatesHashem B El-Serag
Section of Gastroenterology, Houston Department of Veterans Affairs Medical Center 152, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Gastroenterology 126:1692-9. 2004..It remains unknown whether this racial discrepancy reflects a higher prevalence of gastroesophageal reflux disease (GERD) symptoms or a higher degree of esophageal damage... - Systemic review: Natural history of irritable bowel syndromeH B El-Serag
Division of Gastroenterology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Aliment Pharmacol Ther 19:861-70. 2004..Understanding the stability of an irritable bowel syndrome diagnosis may limit repeated diagnostic evaluation among these patients... - Is the length of newly diagnosed Barrett's esophagus decreasing? The experience of a VA Health Care SystemHashem B El-Serag
Section of Gastroenterology, Houston VA Medical Center, and Baylor College of Medicine, Texas 77030, USA
Clin Gastroenterol Hepatol 2:296-300. 2004..Secular trends in the length of newly diagnosed Barrett's esophagus (BE) are unknown. We have anecdotally noticed less frequent new diagnoses of long segments of BE... - Systemic review: the prevalence and clinical course of functional dyspepsiaH B El-Serag
Sections of Gastroenterology and Health Services Research, Houston Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, TX, USA
Aliment Pharmacol Ther 19:643-54. 2004..To examine the prevalence of functional dyspepsia in the general population, and to evaluate the natural history/clinical course of patients with functional dyspepsia... - Is fibrolamellar carcinoma different from hepatocellular carcinoma? A US population-based studyHashem B El-Serag
Section of Health Services Research, The Houston Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Boulevard 152, Houston, TX 77030, USA
Hepatology 39:798-803. 2004..In conclusion, in a population-based study, we observed remarkable differences in the epidemiology and prognosis of FLC compared to HCC... - Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a hospital-based case-control studyYasser H Shaib
The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 102:1016-21. 2007..We evaluated hepatitis C virus (HCV), hepatitis B virus (HBV), and liver cirrhosis as risk factors for intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC)... - The use of cytokeratin stain to distinguish Barrett's esophagus from contiguous tissues: a systematic reviewZhannat Nurgalieva
Sections of Gastroenterology and Health Services Research, Houston Veterans Affairs Medical Center, and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Dig Dis Sci 52:1345-54. 2007..CK immunostaining distinguished well between BE and IM in noncardiac segments of the stomach; however, these comparisons are not clinically relevant... - Prevalence of endoscopic findings of erosive esophagitis in children: a population-based studyMark A Gilger
Department of Pediatrics, Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Veterans Administration Hospital, Houston, TX, USA
J Pediatr Gastroenterol Nutr 47:141-6. 2008..The prevalence of such GERD complications in children is unknown. The purpose of this study was to determine the prevalence of endoscopic findings of erosive esophagitis in children... - Secular trends in the use, quality, and outcomes of gastrectomy for noncardia gastric cancer in the United StatesAnne Le
Department of Surgery, Baylor College of Medicine and Michael E DeBakey VA Medical Center, Houston, Texas, USA
Ann Surg Oncol 14:2519-27. 2007..We examined the trends, extent, and determinants of surgical treatment and the influence of gastrectomy and adequacy of lymphadenectomy (defined as collection of 15 or more lymph nodes) on non-cardia gastric cancer survival... - Medications (NSAIDs, statins, proton pump inhibitors) and the risk of esophageal adenocarcinoma in patients with Barrett's esophagusDang M Nguyen
Section of Gastroenterology and Section of Health Services Research, Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
Gastroenterology 138:2260-6. 2010..However, the possible effect these medications may have on the risk of esophageal adenocarcinoma (EAC) in patients with existing Barrett's esophagus (BE) is unclear... - Hepatocellular carcinoma: an epidemiologic viewHashem B El-Serag
Section of Gastroenterology and Health Services Research at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Gastroenterol 35:S72-8. 2002..The future incidence trends of HCC will be determined to a large extent by the clinical course of HCV-infected people... - The impact of immigration on the increasing incidence of hepatocellular carcinoma in the United StatesK Kulkarni
Department of Medicine, Divisions of Gastroenterology, Houston, TX 77030, USA
Aliment Pharmacol Ther 20:445-50. 2004..Hepatitis C and alcoholic cirrhosis are associated with a majority of cases, particularly in the latter half of the decade... - Statin therapy and serum transaminases among a cohort of HCV-infected veteransLouise M Henderson
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Dig Dis Sci 55:190-5. 2010..We sought to determine the effect of statin therapy on serum AST and ALT levels in a cohort of HCV-infected veterans with well-characterized liver disease... - Reducing referral delays in colorectal cancer diagnosis: is it about how you ask?Hardeep Singh
VA Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
Qual Saf Health Care 19:e27. 2010..The authors tested whether certain details of information transmitted through computerised provider order entry (CPOE)-based referrals affected timeliness of diagnostic colonoscopy for patients with newly diagnosed CRC... - Use of surveillance for hepatocellular carcinoma among patients with cirrhosis in the United StatesJessica A Davila
Section of Health Services Research, Houston Center for Quality of Care and Utilization Studies, Houston VA Medical Center and Baylor College of Medicine, Houston, TX, USA
Hepatology 52:132-41. 2010..CONCLUSION: Less than 20% of patients with cirrhosis who developed HCC received regular surveillance. Gastroenterologists/hepatologists or physicians with an academic affiliation are more likely to perform surveillance... - Gastroesophageal reflux and asthma in children: a systematic reviewKalpesh Thakkar
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, 6621 Fannin St, CCC 1010, Houston, TX 77030, USA
Pediatrics 125:e925-30. 2010..The relationship between gastroesophageal reflux disease (GERD) and asthma in children has been investigated; however, the nature of the association (if any) between these 2 conditions is unclear... - Utilization of surveillance for hepatocellular carcinoma among hepatitis C virus-infected veterans in the United StatesJessica A Davila
the Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas, USA
Ann Intern Med 154:85-93. 2011..Surveillance for hepatocellular carcinoma (HCC) is recommended for patients with hepatitis C virus (HCV) infection and cirrhosis. However, whether surveillance is being done as recommended is unknown... - Surveillance for hepatocellular carcinoma: development and validation of an algorithm to classify tests in administrative and laboratory dataPeter Richardson
Section of Health Services Research, Houston Center for Quality of Care and Utilization Studies, The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
Dig Dis Sci 55:3241-51. 2010..The purpose of alpha-fetoprotein (AFP) and abdominal ultrasound (US) cannot be discerned in administrative data... - Missed opportunities to initiate endoscopic evaluation for colorectal cancer diagnosisHardeep Singh
Houston VA HSR and D Center of Excellence and The Center of Inquiry to Improve Outpatient Safety Through Effective Electronic Communication, Michael E DeBakey Veterans Affairs Medical Center and the Section of Health Services Research, Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 104:2543-54. 2009..Our objective was to describe missed opportunities to diagnose CRC before endoscopic referral, in terms of patient characteristics, nature of clinical clues, and types of diagnostic-process breakdowns involved... - Human immunodeficiency virus-associated squamous cell cancer of the anus: epidemiology and outcomes in the highly active antiretroviral therapy eraElizabeth Y Chiao
Department of Medicine, Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 26:474-9. 2008.... - Adapting the Rx-Risk-V for mortality prediction in outpatient populationsMichael L Johnson
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
Med Care 44:793-7. 2006..We sought to operationalize, test, and validate an outpatient pharmacy-based case-mix adjuster... - Is there a race-based disparity in the survival of veterans with HIV?Thomas P Giordano
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
J Gen Intern Med 21:613-7. 2006..Disparities in survival for black patients with HIV in the United States have been reported. The VA is an equal access health care system... - Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control studyYasser H Shaib
Section of Health Services Research, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 128:620-6. 2005..In this case-control study, we used the Surveillance, Epidemiology, and End Results-Medicare database to evaluate the prevalence of known risk factors for intrahepatic cholangiocarcinoma and explore other potential risk factors... - Utilization of screening for hepatocellular carcinoma in the United StatesJessica A Davila
Section of Health Services Research, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
J Clin Gastroenterol 41:777-82. 2007..Screening for hepatocellular carcinoma (HCC) has been recommended for patients at high-risk of developing HCC. Yet, the utilization and determinants of screening remain unclear... - Effect of human immunodeficiency virus and antiretrovirals on outcomes of hepatitis C: a systematic review from an epidemiologic perspectiveJennifer R Kramer
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
Clin Gastroenterol Hepatol 5:1321-1328.e7. 2007..We systematically reviewed the literature examining the association of human immunodeficiency virus (HIV) and antiretroviral therapy (ART) with liver disease in patients with hepatitis C virus (HCV) infection... - Racial disparities in utilization of liver transplantation for hepatocellular carcinoma in the United States, 1998-2002Abby B Siegel
Department of Medicine, Mailman School of Public Health, Columbia University, New York, New York, USA
Am J Gastroenterol 103:120-7. 2008..We assessed recent predictors of use of liver transplantation and its effect on survival for those with nonmetastatic HCC... - Hepatitis C coinfection increases the risk of fulminant hepatic failure in patients with HIV in the HAART eraJennifer R Kramer
Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, Michael E DeBakey Veterans Affairs Medical Center 152, Houston, TX 77030, USA
J Hepatol 42:309-14. 2005..It is uncertain if patients coinfected with hepatitis C and HIV are more likely to suffer fulminant hepatic failure (FHF) when compared to patients with HIV-only... - Cirrhosis and hepatocellular carcinoma in HIV-infected veterans with and without the hepatitis C virus: a cohort study, 1992-2001Thomas P Giordano
Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, Department of Veterans Affairs Medical Center, Houston, Tex 77030, USA
Arch Intern Med 164:2349-54. 2004.... - Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysisDonna L White
The Section of Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Am J Epidemiol 167:377-89. 2008..However, given the relatively limited total number of subjects examined and observed between-study heterogeneity, chance could not be excluded... - Endoscopic and surgical therapy for intrahepatic cholangiocarcinoma in the united states: a population-based studyYasser H Shaib
Sections of Health Services, Houston, TX, USA
J Clin Gastroenterol 41:911-7. 2007..Intrahepatic cholangiocarcinoma (ICC) is a highly fatal disease with limited therapeutic options. The determinants, trends, and outcomes of different therapies for ICC are largely unknown in the United States... - Psychiatric disorders among veterans with hepatitis C infectionHashem B El-Serag
Section of Gastroenterology, The Houston Center for Quality Care and Utilization Studies, The Houston Veterans Affairs Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 123:476-82. 2002..The presence of psychiatric, drug-, and alcohol-use disorders in hepatitis C virus (HCV)-infected patients may influence their management and prognosis. The frequency and the risk for these disorders among HCV-infected patients are unknown... - National adherence to evidence-based guidelines for the prescription of nonsteroidal anti-inflammatory drugsNeena S Abraham
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center, Texas 77030, USA
Gastroenterology 129:1171-8. 2005..Our objective was to assess adherence to evidence-based guidelines by providers of the Department of Veterans Affairs nationwide... - Oral contraception and the risk of hepatocellular carcinomaShail Maheshwari
Sections of Gastroenterology and Health Services Research at the Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, USA
J Hepatol 47:506-13. 2007..We performed a meta-analysis of observational epidemiological studies to examine the association between oral contraceptives (OC) and hepatocellular carcinoma (HCC)... - The epidemiology of obesityDang M Nguyen
Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, USA
Gastroenterol Clin North Am 39:1-7. 2010..This article describes some of the epidemiologic features of obesity, including global prevalence, secular trends, risk factors, and burden of illness related to obesity with special emphasis on obesity trends in the United States... - Medication usage and the risk of neoplasia in patients with Barrett's esophagusDang M Nguyen
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
Clin Gastroenterol Hepatol 7:1299-304. 2009..However, only limited data are available on chemoprevention in patients with BE... - Epidemiology of non-erosive reflux diseaseHashem B El-Serag
Department of Medicine, Baylor College of Medicine and The Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, Department of Veterans Affairs Medical Center, Houston, Tex 77030, USA
Digestion 78:6-10. 2008..The temporal trends in NERD are unclear, and are probably increasing because GERD symptom prevalence has increased... - Hepatitis C infection and risk of diabetes: a systematic review and meta-analysisDonna L White
Section of Gastroenterology and Hepatology, Baylor College of Medicine, Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
J Hepatol 49:831-44. 2008..We performed meta-analyses to examine whether HCV infection does increase DM risk in comparison to the general population and in other sub-groups with increased liver disease rates including with hepatitis B (HBV)... - The impact of curative intent surgery on the survival of pancreatic cancer patients: a U.S. Population-based studyYasser Shaib
Division of Gastroenterology, Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Am J Gastroenterol 102:1377-82. 2007..Curative intent surgery (CIS) is presumed to be the only curative option in the treatment of pancreatic cancer. The determinants and the outcomes of surgical resection are not clear at the population level... - Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virusThomas P Giordano
Department of Medicine, Baylor College of Medicine, and The Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center, Houston, Tex 77030, USA
JAMA 297:2010-7. 2007..Previous studies have been too small to adequately assess these risks... - Racial disparities and socioeconomic status in association with survival in a large population-based cohort of elderly patients with colon cancerXianglin L Du
Division of Epidemiology, School of Public Health, The University of Texas Health Science Center, Houston, Texas, USA
Cancer 110:660-9. 2007..To the authors' knowledge, few studies have addressed racial disparities in the survival of patients with colon cancer by adequately incorporating treatment and socioeconomic factors in addition to patient and tumor characteristics... - Burden of liver disease in the United States: summary of a workshopW Ray Kim
Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Hepatology 36:227-42. 2002 - Hepatitis C infection: dying with or from the infection?Hashem El-Serag
J Hepatol 48:183-4. 2008
Research Grants
- Gene Expression in Barrett's EsophagusHashem El Serag; Fiscal Year: 2006..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
- Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransHashem El Serag; Fiscal Year: 2009..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
- Obesity, H pylori and Risk of Barrett's EsophagusHashem El Serag; Fiscal Year: 2009..Subsequently, in a case-control study, all newly diagnosed BE and randomly selected controls will be examined for the volume and activity of visceral obesity (CT scan and serum adipocytokines). ..
- Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransHashem El Serag; Fiscal Year: 2007..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
- Epidemiology and Outcomes of Digestive and Liver Diseases: A Mentoring ProgramHashem El Serag; Fiscal Year: 2007..pylori infection on BE tissue COX-2 expression. ..
- Obesity, H pylori and Risk of Barrett's EsophagusHashem El Serag; Fiscal Year: 2007..Subsequently, in a case-control study, all newly diagnosed BE and randomly selected controls will be examined for the volume and activity of visceral obesity (CT scan and serum adipocytokines). ..
- Obesity, H pylori and Risk of Barrett's EsophagusHashem B El Serag; Fiscal Year: 2010..Subsequently, in a case-control study, all newly diagnosed BE and randomly selected controls will be examined for the volume and activity of visceral obesity (CT scan and serum adipocytokines). ..