Morven S Edwards

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. doi request reprint Preventing the broad spectrum of perinatal morbidity and mortality through group B streptococcal vaccination
    Morven S Edwards
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Vaccine 31:D66-71. 2013
  2. pmc Persistence of functional antibodies to group B streptococcal capsular polysaccharides following immunization with glycoconjugate vaccines
    Morven S Edwards
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Vaccine 30:4123-6. 2012
  3. ncbi request reprint Group B streptococcal conjugate vaccine: a timely concept for which the time has come
    Morven S Edwards
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Hum Vaccin 4:444-8. 2008
  4. pmc Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease
    Pia S Pannaraj
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX 77030, USA
    Vaccine 26:502-8. 2008
  5. ncbi request reprint Group B Streptococcus bacteremia elicits beta C protein-specific IgMand IgG in humans
    Pia S Pannaraj
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX 77030, USA
    J Infect Dis 195:353-6. 2007
  6. ncbi request reprint Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults
    Carol J Baker
    Section of Infectious Diseases, Department of Pediatrics, Room 302A, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States
    Vaccine 25:55-63. 2007
  7. pmc Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation
    Pia S Pannaraj
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX, United States
    Vaccine 27:4452-6. 2009
  8. ncbi request reprint Group B streptococcal colonization and serotype-specific immunity in healthy elderly persons
    Morven S Edwards
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Infect Dis 40:352-7. 2005
  9. ncbi request reprint Immune response of healthy women to 2 different group B streptococcal type V capsular polysaccharide-protein conjugate vaccines
    Carol J Baker
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 189:1103-12. 2004
  10. ncbi request reprint Use of type V group B streptococcal conjugate vaccine in adults 65-85 years old
    Debra L Palazzi
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 190:558-64. 2004

Collaborators

Detail Information

Publications26

  1. doi request reprint Preventing the broad spectrum of perinatal morbidity and mortality through group B streptococcal vaccination
    Morven S Edwards
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Vaccine 31:D66-71. 2013
    ..We offer a rationale to support our contention that implementation of GBS glycoconjugate immunization during pregnancy will reduce the global burden of GBS-related morbidity and mortality in pregnant women and their infants. ..
  2. pmc Persistence of functional antibodies to group B streptococcal capsular polysaccharides following immunization with glycoconjugate vaccines
    Morven S Edwards
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Vaccine 30:4123-6. 2012
    ....
  3. ncbi request reprint Group B streptococcal conjugate vaccine: a timely concept for which the time has come
    Morven S Edwards
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Hum Vaccin 4:444-8. 2008
    ....
  4. pmc Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease
    Pia S Pannaraj
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX 77030, USA
    Vaccine 26:502-8. 2008
    ..In vitro killing of alpha C-expressing GBS correlated with total alpha C-specific antibody concentration. Invasive disease but not colonization elicits alpha C-specific IgM and IgG in adults...
  5. ncbi request reprint Group B Streptococcus bacteremia elicits beta C protein-specific IgMand IgG in humans
    Pia S Pannaraj
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX 77030, USA
    J Infect Dis 195:353-6. 2007
    ..Serum from 3 women with beta C GBS bacteremia had significantly higher levels of IgM (6.0) and IgG (52.9) (P=.01 and 0.01, respectively). Invasive disease but not colonization elicits beta C-specific IgM and IgG...
  6. ncbi request reprint Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults
    Carol J Baker
    Section of Infectious Diseases, Department of Pediatrics, Room 302A, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States
    Vaccine 25:55-63. 2007
    ..V-TT vaccine-induced antibodies promoted opsonophagocytic killing of type V GBS and avidity maturation of V CPS-specific IgG...
  7. pmc Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation
    Pia S Pannaraj
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX, United States
    Vaccine 27:4452-6. 2009
    ..Thus, presence of O-acetyl groups on the GBS CPS is not essential for functional antibodies to be elicited by GBS glycoconjugate vaccines...
  8. ncbi request reprint Group B streptococcal colonization and serotype-specific immunity in healthy elderly persons
    Morven S Edwards
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Infect Dis 40:352-7. 2005
    ..Rates of colonization and prevalence of antibodies against capsular polysaccharides (CPS) that might confer protection against invasive GBS disease in such persons are not defined...
  9. ncbi request reprint Immune response of healthy women to 2 different group B streptococcal type V capsular polysaccharide-protein conjugate vaccines
    Carol J Baker
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 189:1103-12. 2004
    ..Infections caused by group B streptococcal (GBS) type V are increasingly common. Capsular polysaccharide (CPS)-protein conjugate GBS vaccines are immunogenic in healthy adults, but type V vaccines have not previously been tested...
  10. ncbi request reprint Use of type V group B streptococcal conjugate vaccine in adults 65-85 years old
    Debra L Palazzi
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 190:558-64. 2004
    ..These results suggest the potential for prevention of invasive type V GBS infections in healthy elderly adults through immunization...
  11. doi request reprint Long-term outcomes of group B streptococcal meningitis
    Romina Libster
    Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Pediatrics 130:e8-15. 2012
    ..We evaluated long-term outcomes among GBS meningitis survivors. We hypothesized that despite reduced mortality, GBS meningitis would remain a significant cause of morbidity among GBS survivors...
  12. ncbi request reprint Safety and immunogenicity of a bivalent group B streptococcal conjugate vaccine for serotypes II and III
    Carol J Baker
    Sections of Infectious Diseases, Department of Pediatrics, and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 188:66-73. 2003
    ..These results support the feasibility of a multivalent vaccine for the 5 prevalent invasive disease-causing GBS CPS serotypes...
  13. ncbi request reprint Antibodies to type III group B streptococcal polysaccharide in breast milk
    Morven S Edwards
    Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Pediatr Infect Dis J 23:961-3. 2004
    ....
  14. doi request reprint Early outcomes of group B streptococcal meningitis in the 21st century
    Fatma Levent
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX, USA
    Pediatr Infect Dis J 29:1009-12. 2010
    ..Group B streptococcal (GBS) meningitis is diagnosed less frequently than in the 1970s and 1980s. There are few contemporary data regarding outcomes from GBS meningitis and factors that might predict an adverse outcome...
  15. ncbi request reprint Healthy elderly people lack neutrophil-mediated functional activity to type V group B Streptococcus
    Rene A Amaya
    Departments of Pediatrics and Molecular Virology and Microbiology, Section of Infectious Disease, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Geriatr Soc 52:46-50. 2004
    ..To determine the function of capsular polysaccharide (CPS)-specific immunoglobulin-G (IgG) and neutrophils from older adults in increasing ingestion and killing of type V group B Streptococcus (GBS)...
  16. ncbi request reprint Group B streptococcal infections in elderly adults
    Morven S Edwards
    Section of Infectious Disease, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 41:839-47. 2005
    ..The safety and immunogenicity of GBS serotype V-tetanus toxoid conjugate vaccine in healthy elderly persons suggest the potential for vaccination as an approach to prevention of invasive GBS infections in elderly persons...
  17. doi request reprint Analysis of vancomycin therapeutic drug monitoring trends at pediatric hospitals
    Brady S Moffett
    Department of Pharmacy, Texas Children s Hospital, Houston, TX 77030, USA
    Pediatr Infect Dis J 32:32-5. 2013
    ..Vancomycin use in children has unique challenges, and consensus guidelines are lacking. We evaluated trends in vancomycin monitoring in children and estimated the impact of adult guidelines on patterns of vancomycin use...
  18. ncbi request reprint Safety and immunogenicity of tetanus diphtheria and acellular pertussis (tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial
    Flor M Munoz
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas2Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas
    JAMA 311:1760-9. 2014
    ..Further research is needed to provide definitive evidence of the safety and efficacy of Tdap immunization during pregnancy. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00707148. ..
  19. ncbi request reprint Features of invasive staphylococcal disease in neonates
    C Mary Healy
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Rm 302A, Houston, TX 77030, USA
    Pediatrics 114:953-61. 2004
    ..We aimed to describe the contemporary incidence, clinical features, and outcome of infants with ISD in a neonatal intensive care unit...
  20. doi request reprint Disseminated bartonellosis presenting as neuroretinitis in a young adult with human immunodeficiency virus infection
    Ankhi Dutta
    Department of Pediatrics, Texas Children s Hospital, Houston, TX, USA
    Pediatr Infect Dis J 29:675-7. 2010
    ..Tissue biopsy was required to establish the diagnosis and directed therapy was associated with restored vision...
  21. doi request reprint Escherichia coli--infected cephalohematoma in an infant
    Katherine J Weiss
    Section of Pediatric Residency Program, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Pediatr (Phila) 48:763-6. 2009
    ..This report serves as a reminder that, although occurring rarely, inflammation overlying a cephalohematoma in an infant with bacteremia can indicate focal infection that requires incision and drainage for resolution...
  22. doi request reprint Intraorbital and intracranial extension of sinusitis: comparative morbidity
    Veronica K Goytia
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    J Pediatr 158:486-91. 2011
    ..We hypothesized that intracranial extension of sinusitis carries greater morbidity than extension confined to the orbit and that presenting features can raise suspicion for intracranial extension...
  23. doi request reprint Vancomycin dosing in obese pediatric patients
    Brady S Moffett
    Texas Children s Hospital, Houston, TX, USA
    Clin Pediatr (Phila) 50:442-6. 2011
    ..Data are lacking to guide antimicrobial dosing for overweight children. The authors hypothesized that obese children would have increased vancomycin serum trough concentrations compared with nonobese children...
  24. ncbi request reprint Issues of antimicrobial resistance in group B streptococcus in the era of intrapartum antibiotic prophylaxis
    Morven S Edwards
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Pediatr Infect Dis 17:149-52. 2006
    ....
  25. ncbi request reprint Vagal nerve stimulator pocket infections
    Niraj C Patel
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatr Infect Dis J 23:681-3. 2004
    ..Infection was suppressed but recurred despite appropriate antimicrobial therapy when the device remained in situ. Device removal was required in all patients to achieve cure...
  26. pmc Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14
    Hilde Kari Guttormsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 70:1724-38. 2002
    ..When present, these vaccine-induced cross-reacting antibodies conferred in vitro antibody-mediated opsonophagocytosis and killing of both GBS III and Pn14, two pathogens that cause invasive disease in young infants...