Richard De La Garza

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Modafinil administration improves working memory in methamphetamine-dependent individuals who demonstrate baseline impairment
    Ari D Kalechstein
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Addict 19:340-4. 2010
  2. pmc The cardiovascular and subjective effects of methamphetamine combined with gamma-vinyl-gamma-aminobutyric acid (GVG) in non-treatment seeking methamphetamine-dependent volunteers
    Richard De La Garza
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Pharmacol Biochem Behav 94:186-93. 2009
  3. pmc Evaluation of modafinil effects on cardiovascular, subjective, and reinforcing effects of methamphetamine in methamphetamine-dependent volunteers
    Richard De La Garza
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Drug Alcohol Depend 106:173-80. 2010
  4. pmc Acute modafinil exposure reduces daytime sleepiness in abstinent methamphetamine-dependent volunteers
    James J Mahoney
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Int J Neuropsychopharmacol 15:1241-9. 2012
  5. pmc Effects of D-cycloserine on cue-induced craving and cigarette smoking among concurrent cocaine- and nicotine-dependent volunteers
    Jin H Yoon
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, United States
    Addict Behav 38:1518-26. 2013
  6. pmc Effects of methamphetamine on the noradrenergic activity biomarker salivary alpha-amylase
    Colin N Haile
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Michael E DeBakey VA Medical Center, Houston, TX 77030, USA Electronic address
    Drug Alcohol Depend 133:759-62. 2013
  7. pmc The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial
    Colin N Haile
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
    PLoS ONE 7:e47702. 2012
  8. pmc Evaluation of subjective effects of aripiprazole and methamphetamine in methamphetamine-dependent volunteers
    Thomas F Newton
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Int J Neuropsychopharmacol 11:1037-45. 2008
  9. pmc Acute, low-dose methamphetamine administration improves attention/information processing speed and working memory in methamphetamine-dependent individuals displaying poorer cognitive performance at baseline
    James J Mahoney
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:459-65. 2011
  10. pmc The angiotensin-converting enzyme inhibitor perindopril treatment alters cardiovascular and subjective effects of methamphetamine in humans
    Thomas F Newton
    Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and the Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Psychiatry Res 179:96-100. 2010

Detail Information

Publications30

  1. pmc Modafinil administration improves working memory in methamphetamine-dependent individuals who demonstrate baseline impairment
    Ari D Kalechstein
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Addict 19:340-4. 2010
    ..The findings provide an initial indication that modafinil can reverse methamphetamine-associated impairments in working memory...
  2. pmc The cardiovascular and subjective effects of methamphetamine combined with gamma-vinyl-gamma-aminobutyric acid (GVG) in non-treatment seeking methamphetamine-dependent volunteers
    Richard De La Garza
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Pharmacol Biochem Behav 94:186-93. 2009
    ..Taken together, the data indicate that GVG treatment is generally well tolerated but not efficacious in attenuating the positive subjective effects of methamphetamine in the laboratory...
  3. pmc Evaluation of modafinil effects on cardiovascular, subjective, and reinforcing effects of methamphetamine in methamphetamine-dependent volunteers
    Richard De La Garza
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Drug Alcohol Depend 106:173-80. 2010
    ..Given these encouraging, though non-significant trends, the primary conclusion is that it appears safe to proceed with modafinil in further clinical evaluations of therapeutic efficacy...
  4. pmc Acute modafinil exposure reduces daytime sleepiness in abstinent methamphetamine-dependent volunteers
    James J Mahoney
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Int J Neuropsychopharmacol 15:1241-9. 2012
    ..The results of this study should be considered when investigating candidate medications for Meth-dependence, especially in those individuals who attribute their Meth use to overcoming deficits resulting from sleep abnormalities...
  5. pmc Effects of D-cycloserine on cue-induced craving and cigarette smoking among concurrent cocaine- and nicotine-dependent volunteers
    Jin H Yoon
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, United States
    Addict Behav 38:1518-26. 2013
    ..While no effects of D-cycloserine on craving or smoking were observed in the current study, the results do suggest that smoking treatment is well accepted and may be effective for cocaine-dependent individuals...
  6. pmc Effects of methamphetamine on the noradrenergic activity biomarker salivary alpha-amylase
    Colin N Haile
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Michael E DeBakey VA Medical Center, Houston, TX 77030, USA Electronic address
    Drug Alcohol Depend 133:759-62. 2013
    ..The purpose of this study was to determine the impact of METH on sAA activity and whether changes in sAA activity were correlated with subjective effects ratings...
  7. pmc The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial
    Colin N Haile
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
    PLoS ONE 7:e47702. 2012
    ..5 and 125 mg/d) increased cocaine use. We conducted the present study to better understand how disulfiram alters the reinforcing effects of cocaine in cocaine users...
  8. pmc Evaluation of subjective effects of aripiprazole and methamphetamine in methamphetamine-dependent volunteers
    Thomas F Newton
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Int J Neuropsychopharmacol 11:1037-45. 2008
    ..Further research with lower doses of aripiprazole, possibly using study designs aimed at evaluating efficacy for relapse prevention, are needed before ruling out aripiprazole as a treatment for Meth dependence...
  9. pmc Acute, low-dose methamphetamine administration improves attention/information processing speed and working memory in methamphetamine-dependent individuals displaying poorer cognitive performance at baseline
    James J Mahoney
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:459-65. 2011
    ..As a result, stimulants may serve as a successful treatment for improving cognitive functioning in those Meth-dependent individuals experiencing neurocognitive impairment...
  10. pmc The angiotensin-converting enzyme inhibitor perindopril treatment alters cardiovascular and subjective effects of methamphetamine in humans
    Thomas F Newton
    Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and the Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Psychiatry Res 179:96-100. 2010
    ..There were significant perindoprilmethamphetamine interactions for diastolic blood pressure and for ratings of "Any Drug Effect", indicating inverted U dose-effect functions for these indices...
  11. pmc Quantitative EEG abnormalities are associated with memory impairment in recently abstinent methamphetamine-dependent individuals
    Ari D Kalechstein
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX 77030, USA
    J Neuropsychiatry Clin Neurosci 21:254-8. 2009
    ..e., memory deficits) when users are not intoxicated...
  12. pmc Influence of verbal recall of a recent stress experience on anxiety and desire for cocaine in non-treatment seeking, cocaine-addicted volunteers
    Richard De La Garza
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Addict 18:481-7. 2009
    ..These data suggest that simply recalling a stressful event may not be a sufficient enough stimulus to contribute to craving or relapse in cocaine-addicted individuals...
  13. pmc Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders
    Alex J Brewer
    aDepartment of Pharmacology bMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine cMichael E DeBakey Veterans Affairs Medical Center, Houston, Texas dLaboratory of Statistical Genetics, The Rockefeller University, New York, New York, USA
    Pharmacogenet Genomics 25:296-304. 2015
    ..The aim of this study was to identify gene variants of DAT1 (SLC6A3) that modulate subjective responses to acute cocaine exposure...
  14. pmc Treatment with modafinil and escitalopram, alone and in combination, on cocaine-induced effects: a randomized, double blind, placebo-controlled human laboratory study
    Christopher D Verrico
    Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine, One Baylor Plaza, MS BCM350, Houston, TX 77030, United States Department of Pharmacology, Michael E DeBakey VA Medical Center and Baylor College of Medicine, One Baylor Plaza, MS BCM350, Houston, TX 77030, United States Electronic address
    Drug Alcohol Depend 141:72-8. 2014
    ..We hypothesized that combining modafinil with escitalopram would attenuate the euphoric effects of cocaine to a greater degree than modafinil alone...
  15. doi request reprint Low dose, short-term rivastigmine administration does not affect neurocognition in methamphetamine dependent individuals
    Ari D Kalechstein
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX 77030, USA
    Pharmacol Biochem Behav 99:423-7. 2011
    ..The negative findings notwithstanding, the study serves as a springboard for future investigations that will examine whether other medications can alter neurocognition in methamphetamine dependent study participants...
  16. doi request reprint The relationship between impulsivity and craving in cocaine- and methamphetamine-dependent volunteers
    Desey Tziortzis
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
    Pharmacol Biochem Behav 98:196-202. 2011
    ..Taken together, this study shows a marginal relationship between impulsivity and craving, which may further the understanding of motivational factors contributing to ongoing drug use and addiction in psychostimulant users...
  17. pmc The relationship between sleep and drug use characteristics in participants with cocaine or methamphetamine use disorders
    James J Mahoney
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, United States 1
    Psychiatry Res 219:367-71. 2014
    ..e. in cocaine and METH users that do not meet criteria for a cocaine or METH use disorder) must be conducted in order to provide more conclusive evidence of the impact these usage variables may have on these sleep characteristics. ..
  18. pmc The influence of smoking cigarettes on the high and desire for cocaine among active cocaine users
    Alex J Brewer
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Pharmacol Biochem Behav 106:132-6. 2013
    ..Taken together, these data suggest that cigarette smoking may augment the craving and high produced by cocaine...
  19. pmc Pharmacotherapeutics for substance-use disorders: a focus on dopaminergic medications
    Christopher D Verrico
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3411, USA
    Expert Opin Investig Drugs 22:1549-68. 2013
    ..A complex disease, a substance-use disorder affects neural circuits involved in reinforcement, motivation, learning and memory, and inhibitory control...
  20. pmc Noradrenergic α₁ receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial
    Thomas F Newton
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
    PLoS ONE 7:e30854. 2012
    ..The objective of this study was to evaluate the impact of treatment with the noradrenergic α(1) receptor antagonist doxazosin on the positive subjective effects of cocaine...
  21. pmc Relationship between gender and psychotic symptoms in cocaine-dependent and methamphetamine-dependent participants
    James J Mahoney
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Gend Med 7:414-21. 2010
    ..However, the research and literature on gender differences and stimulant-induced psychosis have been mixed...
  22. doi request reprint A comparison of impulsivity, depressive symptoms, lifetime stress and sensation seeking in healthy controls versus participants with cocaine or methamphetamine use disorders
    James J Mahoney
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA Michael E DeBakey VA Medical Center, Houston, TX, USA
    J Psychopharmacol 29:50-6. 2015
    ....
  23. doi request reprint Short-term, low-dose varenicline administration enhances information processing speed in methamphetamine-dependent users
    Ari D Kalechstein
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA Electronic address
    Neuropharmacology 85:493-8. 2014
    ..05). Given the potential importance of this finding, it should be replicated in a larger sample over a longer treatment period with a higher dose of varenicline (2 mg)...
  24. doi request reprint The relationship between lifetime stress and addiction severity in cocaine-dependent participants
    James J Mahoney
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Eur Neuropsychopharmacol 23:351-7. 2013
    ..g. alcohol-dependence, mood disorders) were associated with higher LSC-R or ASI-Lite scores. We hypothesized that scores on the LSC-R would be positively correlated with ASI-Lite scores...
  25. pmc Preliminary findings of the effects of rivastigmine, an acetylcholinesterase inhibitor, on working memory in cocaine-dependent volunteers
    James J Mahoney
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX 77030, United States
    Prog Neuropsychopharmacol Biol Psychiatry 50:137-42. 2014
    ..This study provides additional data showing that cocaine-associated neurocognitive impairment, specifically working memory deficits, can be remediated, at least to some degree. ..
  26. pmc Safety and efficacy of varenicline to reduce positive subjective effects produced by methamphetamine in methamphetamine-dependent volunteers
    Christopher D Verrico
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Int J Neuropsychopharmacol 17:223-33. 2014
    ..The ability of varenicline to attenuate the positive subjective effects of methamphetamine in the laboratory suggests that varenicline should continue to be explored as a treatment for methamphetamine dependence. ..
  27. pmc Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate
    Colin N Haile
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    Pharmacol Ther 134:260-77. 2012
    ..This view is also consistent with treatment paradigms used in neuropsychiatry and general medicine...
  28. doi request reprint Remote physiological monitoring of acute cocaine exposure
    Jin H Yoon
    Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA
    J Med Eng Technol 38:244-50. 2014
    ..04). BioHarness is a promising remote physiological monitoring device that can accurately assess exposure to cocaine in the laboratory and may provide additional advantages when compared to standard hospital equipment...
  29. doi request reprint Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder
    Richard De La Garza
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 59:40-8. 2015
    ..Taken together, these data indicate that nepicastat is safe when co-administered with cocaine and may suppress its positive subjective effects, and may be viable as a pharmacotherapy for treatment of cocaine use disorder. ..
  30. pmc Theories of addiction: methamphetamine users' explanations for continuing drug use and relapse
    Thomas F Newton
    Menninger Department of Psychiatry and Behavioral Sciences and the Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Addict 18:294-300. 2009
    ....