Research Topics
Genomes and Genes | Pramod DashSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injuryGeorgene W Hergenroeder
The Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas, USA
J Neuroinflammation 7:19. 2010..While pressure catheters can be implanted to monitor ICP, there is no clinically proven method for determining a patient's risk for developing this pathology...- Inhibition of prefrontal protein synthesis following recall does not disrupt memory for trace fear conditioningSonja Blum
The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas, Houston, Texas 77225, USA
BMC Neurosci 7:67. 2006..In the present study, we examine whether protein synthesis inhibition in the mPFC following recall similarly results in the observation of reconsolidation of trace fear memory... - A molecular description of brain trauma pathophysiology using microarray technology: an overviewPramod K Dash
Department of Neurobiology and Anatomy, and The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
Neurochem Res 29:1275-86. 2004..Furthermore, we offer future directions for the continued evaluation of microarray results and discuss the usefulness of microarray techniques as a testing format for determining the efficacy of mechanism-based therapies... - Performance in long-term memory tasks is augmented by a phosphorylated growth factor receptor fragmentP K Dash
The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
J Neurosci Res 77:205-16. 2004..These findings suggest that stimulation of PI3-kinase activity by phosphorylated receptor fragments containing the YMDM motif augments long-term memory... - A role for hippocampal Rho-ROCK pathway in long-term spatial memoryPramod K Dash
Department of Neurobiology and Anatomy, The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, TX, USA
Biochem Biophys Res Commun 322:893-8. 2004..Our results demonstrate a role for the Rho-ROCK pathway in hippocampus-dependent spatial memory... - Post-trauma administration of caffeine plus ethanol reduces contusion volume and improves working memory in ratsPramod K Dash
Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
J Neurotrauma 21:1573-83. 2004..These results indicate that early administration of caffeinol may be beneficial in lessening some of the deficits and cortical tissue loss associated with brain trauma... - Sequestration of serum response factor in the hippocampus impairs long-term spatial memoryPramod K Dash
The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
J Neurochem 93:269-78. 2005..These findings suggest that SRF-mediated gene expression is required for long-term spatial memory... - Blockade of gamma-secretase activity within the hippocampus enhances long-term memoryPramod K Dash
The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
Biochem Biophys Res Commun 338:777-82. 2005..This suggests that a signaling molecule(s) generated by gamma-secretase activity may have a negative influence on long-term memory formation... - Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathwayPramod K Dash
The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
J Neurosci 26:8048-56. 2006..Together, these findings suggest that memory formation requires the mTOR cascade and that the memory-enhancing effect of glucose involves its ability to activate this pathway... - Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in ratsPramod K Dash
Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
PLoS ONE 5:e11383. 2010.... - Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcomePramod K Dash
Department of Neurobiology and Anatomy, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
PLoS ONE 6:e24648. 2011..Growth factors activate Akt, which in turn inhibits GSK-3 activity by direct phosphorylation, leading to a reduction in apoptosis... - Acutely increased cyclophilin a expression after brain injury: a role in blood-brain barrier function and tissue preservationJohn B Redell
Department of Neurobiology, University of Texas Medical School, Houston, Texass 77225, USA
J Neurosci Res 85:1980-8. 2007..These findings suggest that increased expression of cyclophilin A may play a protective role after TBI, whereas other cyclophilin isoforms may be detrimental... - Molecular activity underlying working memoryPramod K Dash
The Vivian L Smith Center for Neurologic Research, and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
Learn Mem 14:554-63. 2007..Finally, we will discuss considerations for the development of clinical treatments for working memory disorders... - Sulforaphane improves cognitive function administered following traumatic brain injuryPramod K Dash
Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, United States
Neurosci Lett 460:103-7. 2009..These studies support the use of sulforaphane in the treatment of TBI, and extend the previously observed protective effects to include enhanced cognition... - Serum ceruloplasmin and copper are early biomarkers for traumatic brain injury-associated elevated intracranial pressurePramod K Dash
Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, TX 77225, USA
J Neurosci Res 88:1719-26. 2010..These results suggest that initial serum ceruloplasmin/copper levels may have diagnostic value in predicting patients at risk for developing high intracranial pressure... - Biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy for traumatic brain injuryPramod K Dash
Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
Neurotherapeutics 7:100-14. 2010..This need is punctuated in mild injuries that cannot be readily detected using current techniques, as well as in defining patient risk for developing TBI-associated secondary injuries... - A unified theory for systems and cellular memory consolidationPramod K Dash
The Vivian L Smith Center for Neurologic Research and the Department of Neurobiology and Anatomy, The University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
Brain Res Brain Res Rev 45:30-7. 2004.... - The role of extracellular signal-regulated kinase in cognitive and motor deficits following experimental traumatic brain injuryP K Dash
Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, PO Box 20708, Houston, TX 77225, USA
Neuroscience 114:755-67. 2002..These findings suggest that the Erk cascade plays an essential role for the maintenance of neuronal function and plasticity following TBI... - Intrahippocampal wortmannin infusion enhances long-term spatial and contextual memoriesPramod K Dash
Department of Neurobiology and Anatomy, The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
Learn Mem 9:167-77. 2002..These results are consistent with the hypothesis that memory consolidation involves competing processes, and that blockade of an inhibitory constraint facilitates the consolidation process... - Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injuryP K Dash
Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, TX 77225, USA
Neuroscience 163:1-8. 2009.... - Enhanced neurogenesis in the rodent hippocampus following traumatic brain injuryP K Dash
The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
J Neurosci Res 63:313-9. 2001..These findings show that traumatic brain injury increases neurogenesis in the granule cell layer and suggests that these new cells may contribute to the function of the hippocampus... - Altered expression of novel genes in the cerebral cortex following experimental brain injuryNobuhide Kobori
The Vivian L. Smith Center for Neurological Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, PO Box 20708, Houston, TX 77255, USA
Brain Res Mol Brain Res 104:148-58. 2002..The functional significance of these genes in neurite outgrowth, neuronal regeneration, and plasticity following injury are discussed... - Comparative analysis of mRNA levels in the frontal cortex and the hippocampus in the basal state and in response to experimental brain injuryJ M Rall
The Vivian L Smith Center for Neurologic Research, Department of Neurobiology, The University of Texas Medical School, Houston, TX 77225, USA
Neuropathol Appl Neurobiol 29:118-31. 2003..In addition to genes previously reported in the literature, this study found several genes that have not been associated with TBI. The functional implications of changes in the expression of some of these genes are discussed... - Altered adrenergic receptor signaling following traumatic brain injury contributes to working memory dysfunctionN Kobori
The Vivian L Smith Department of Neurosurgery, The University of Texas Medical School at Houston, Houston, TX 77225, USA
Neuroscience 172:293-302. 2011.... - Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injuryP K Dash
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225, USA
J Neurotrauma 17:69-81. 2000.... - Persistent working memory dysfunction following traumatic brain injury: evidence for a time-dependent mechanismM M Hoskison
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, The University of Texas Medical School, Houston, TX 77225, USA
Neuroscience 159:483-91. 2009..Taken together, the present findings, along with previously published reports, suggest that temporal considerations must be taken into account when designing mechanism-based therapies to improve working memory function in TBI patients... - Characterization and phosphorylation of CREB-like proteins in Aplysia central nervous systemP K Dash
Department of Neurobiology and Anatomy, University of Texas Houston Health Science Center 77225, USA
Brain Res Mol Brain Res 39:43-51. 1996..This biochemical data further supports the involvement of CREB-like proteins in memory storage... - Sequestration of cAMP response element-binding proteins by transcription factor decoys causes collateral elaboration of regenerating Aplysia motor neuron axonsP K Dash
Department of Neurobiology and Anatomy, University of Texas Houston Health Science Center, Houston, TX 77225, USA
Proc Natl Acad Sci U S A 95:8339-44. 1998..These findings show that Ca2+/cAMP-mediated gene expression via CRE-binding transcription factors participates in the regeneration of motor neuron axons... - Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and miceS K Mani
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 287:1053-6. 2000..P also enhanced phosphorylation of DARPP-32 on threonine 34 in the hypothalamus of mice. DARPP-32 activation is thus an obligatory step in progestin receptor regulation of sexual receptivity in rats and mice... - Elevated albumin in retinas of monkeys with experimental glaucomaLouvenia Carter-Dawson
Richard S Ruiz Department of Ophthalmology and Visual Science, University of Texas Medical School at Houston, Houston, Texas 77030, USA
Invest Ophthalmol Vis Sci 51:952-9. 2010.... - Expression of cytochromes P450 4F4 and 4F5 in infection and injury models of inflammationX Cui
Department of Biochemistry and Molecular Biology, The University of Texas-Houston Medical School, P.O. Box 20708, 6431 Fannin Street, Houston, TX 77225, USA
Biochim Biophys Acta 1619:325-31. 2003..As time after injury increases those conditions reverse. Increased CYP 4F expression leads to diminished concentrations of leukotriene and prostaglandin mediators and then to recovery and repair... - Extracellular signal-regulated kinase activity in the entorhinal cortex is necessary for long-term spatial memoryApril E Hebert
Department of Neurobiology and Anatomy, The Vivian L. Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
Learn Mem 9:156-66. 2002..The findings presented in this article are consistent with the idea that the EC is involved in spatial memory and indicate that Erk activity is necessary for memory consolidation in this structure... - GDNF abates serum deprivation-induced tyrosine hydroxylase Ser19 phosphorylation and activityNobuhide Kobori
Department of Neurobiology and Anatomy, The Vivian L. Smith Center for Neurological Research, The University of Texas Medical School, PO Box 20708, Houston, 77255, USA
Brain Res 1086:142-51. 2006..Taken together, these findings suggest that GDNF may reduce dopamine synthesis in pathological conditions... - Brain trauma leads to enhanced lung inflammation and injury: evidence for role of P4504Fs in resolutionAuinash Kalsotra
Department of Biochemistry and Molecular Biology, The Vivian L Smith Center for Neurologic Research, The University of Texas, Houston Medical School, Houston, Texas 77225, USA
J Cereb Blood Flow Metab 27:963-74. 2007.... - Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microgliaJohn B Redell
Departments of Neurobiology and Anatomy, Neurosurgery, and The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, TX 77030, United States
Neurosci Lett 413:36-41. 2007..Since dopamine transporter expression has been reported to be down-regulated after brain injury, COMT-mediated catecholamine metabolism may play a more prominent role in terminating catecholamine signaling in injured areas... - High-density microarray analysis of hippocampal gene expression following experimental brain injuryDavid A Matzilevich
The Vivian L. Smith Center for Neurologic Research, Departments of Neurobiology and Anatomy, Neurosurgery, The University of Texas Medical School, Houston, Texas 77225, USA
J Neurosci Res 67:646-63. 2002..The analysis revealed genes whose expression levels have been reported to be altered in response to injury as well as several genes not previously implicated in TBI pathophysiology... - Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injuryJing Zhao
The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
J Neurosci 27:10240-8. 2007..These findings indicate a potential therapeutic usefulness for Nrf2-activating molecules to improve the function of the neurovascular unit after injury... - Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injuryJing Zhao
The Vivian L. Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, 77225, USA
J Neurosci Res 82:499-506. 2005..These findings suggest that the reduction of brain edema in response to SUL administration could be due, in part, to water clearance by AQP4 from the injured brain... - A role for the prefrontal cortex in recall of recent and remote memoriesSonja Blum
The Vivian L. Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
Neuroreport 17:341-4. 2006.... - Rho/ROCK and Cdk5 effects on phosphorylation of a beta-thymosin repeat protein in HermissendaTerry Crow
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA
Biochem Biophys Res Commun 323:395-401. 2004..Using a pull-down assay we found that LPA treatments activated Rho and exposure to 5-HT decreased Rho activity. Our results indicate that the Rho/ROCK and Cdk5 signaling pathways contribute to the regulation of Csp24 phosphorylation... - Intra-medial prefrontal administration of SCH-23390 attenuates ERK phosphorylation and long-term memory for trace fear conditioning in ratsJason D Runyan
The Vivian L. Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225, USA
Neurobiol Learn Mem 82:65-70. 2004..These findings implicate mPFC dopamine D1 receptor activity in the storage of long-term memory for higher-cognitive associative tasks... - Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in ratsJason M Rall
Department of Neurobiology and Anatomy, Neurosurgery, Vivian L. Smith Center for Neurologic Research, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225, USA
Brain Res 968:273-6. 2003..These findings, along with previously published reports, implicate COX-2 activity in both memory acquisition and retention... - Inhibition of conditioned stimulus pathway phosphoprotein 24 expression blocks the development of intermediate-term memory in HermissendaTerry Crow
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
J Neurosci 23:3415-22. 2003..These results demonstrate that the synthesis of Csp24 is required for the development and maintenance of intermediate memory... - A cell-permeable phospholipase Cgamma1-binding peptide transduces neurons and impairs long-term spatial memorySonja Blum
Department of Neurobiology and Anatomy, The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
Learn Mem 11:239-43. 2004..These results, along with previous studies on extracellular signal-regulated kinase (ERK) and phosphoinositide-3 kinase (PI3K), implicate all three key growth factor receptor-activated intracellular signaling pathways in memory storage... - Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factorNobuhide Kobori
The Vivian L Smith Center for Neurological Research, University of Texas Medical School, Houston, TX 77225, USA
J Biol Chem 279:2182-91. 2004..Our results indicate that, in addition to its role as a survival factor for dopaminergic neurons, GDNF can directly increase dopamine synthesis... - A role for prefrontal cortex in memory storage for trace fear conditioningJason D Runyan
The Vivian L. Smith Center for Neurologic Research and the Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
J Neurosci 24:1288-95. 2004.... - Differential effects of traumatic brain injury on the cytochrome p450 system: a perspective into hepatic and renal drug metabolismAuinash Kalsotra
Department of Biochemistry, The Vivian L. Smith Center for Neurologic Research, The University of Texas-Houston Medical School, Houston, Texas, USA
J Neurotrauma 20:1339-50. 2003..CYP4F subfamily showed induction in kidney only. Collectively, the data reveal the differential effects of TBI on hepatic and renal drug metabolism... - Nonredundant roles for hippocampal and entorhinal cortical plasticity in spatial memory storageApril E Hebert
The Vivian L. Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225, USA
Pharmacol Biochem Behav 79:143-53. 2004.... - Inhibition of hippocampal protein synthesis following recall disrupts expression of episodic-like memory in trace conditioningJason D Runyan
The Vivian L. Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, University of Texas, Houston, Texas 77225, USA
Hippocampus 15:333-9. 2005..This and other studies are consistent with the role of the hippocampus in coordinating episodic memory retrieval... - Plasticity in the entorhinal cortex suppresses memory for contextual fearApril E Hebert
The Vivian L. Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
J Neurosci 24:10111-6. 2004.... - Genetic networks controlling retinal injuryFelix R Vazquez-Chona
Department of Ophthalmology, The Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Mol Vis 11:958-70. 2005..The present study defines genomic loci underlying coordinate changes in gene expression following retinal injury... - Distinct prefrontal molecular mechanisms for information storage lasting seconds versus minutesJason D Runyan
The Vivian L. Smith Center for Neurological Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
Learn Mem 12:232-8. 2005.... - Expression of the prodynorphin gene after experimental brain injury and its role in behavioral dysfunctionJohn B Redell
The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
Exp Biol Med (Maywood) 228:261-9. 2003..These results suggest that dynorphin action may serve a beneficial role after TBI... - A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memoryJason D Runyan
The Vivian L. Smith Center for Neurological Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
Learn Mem 12:103-10. 2005..Our findings suggest that the active maintenance of information required for working memory involves transient changes in the balance of these enzymes' activities... - Reversal of brain injury-induced prefrontal glutamic acid decarboxylase expression and working memory deficits by D1 receptor antagonismNobuhide Kobori
The Vivian L. Smith Center for Neurological Research, The University of Texas Medical School, Houston, Texas 77225, USA
J Neurosci 26:4236-46. 2006..These findings indicate that inhibition of prefrontal neuronal activity contributes to WM deficits and that strategies to reduce GAD67 expression can offer prolonged WM improvement in brain-injured patients... - Acute ethanol intake attenuates inflammatory cytokines after brain injury in rats: a possible role for corticosteroneZehava Gottesfeld
Vivian L. Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, University of Texas, Medical School, Houston 77225, USA
J Neurotrauma 19:317-26. 2002..Our findings suggest that ethanol-induced decrease in pro-inflammatory cytokine production may be linked to increased circulating corticosterone, both of which may contribute to the outcome of brain injury... - Sulforaphane reduces infarct volume following focal cerebral ischemia in rodentsJing Zhao
Vivian L. Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, P.O. Box 20708, Houston, TX 77225, USA
Neurosci Lett 393:108-12. 2006..Delayed administration (15 min) of a single dose of SUL significantly decreased cerebral infarct volume following focal ischemia, suggesting a potential therapeutic value for this compound... - Enhanced catecholamine synthesis in the prefrontal cortex after traumatic brain injury: implications for prefrontal dysfunctionNobuhide Kobori
Vivian L. Smith Center for Neurological Research, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, 77225, USA
J Neurotrauma 23:1094-102. 2006.... - Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressureGeorgene Hergenroeder
Vivian L Smith Center for Neurologic Research, University of Texas Medical School, Houston, TX, USA
J Neurotrauma 25:79-93. 2008..Our results support the use of serum as a source for discovery of TBI biomarkers, and indicate that serum biomarkers may have utility for predicting secondary pathologies (e.g., elevated ICP) associated with TBI...
Research Grants
- Tuberous sclerosis complex in memory formationPramod Dash; Fiscal Year: 2007..The results from these studies will provide a crucial step towards development of pharmacological and/or molecular strategies to treat memory disorders. ..
- MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURYPramod Dash; Fiscal Year: 2006..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
- Prefrontal cortex and memory storagePramod Dash; Fiscal Year: 2007....
- Prefrontal cortex and memory storagePramod K Dash; Fiscal Year: 2010....
- Working memory deficits following brain traumaPramod Dash; Fiscal Year: 2009..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
- LONG TERM HIPPOCAMPAL MEMORYPramod Dash; Fiscal Year: 2001..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
- MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURYPramod Dash; Fiscal Year: 2001..The results obtained from these studies may lead to development of new molecular therapies for memory deficits associated with TBI and other neurological conditions. ..
- Tuberous sclerosis complex in memory formationPramod K Dash; Fiscal Year: 2010..The results from these studies will provide a crucial step towards development of pharmacological and/or molecular strategies to treat memory disorders. ..