Chad J Creighton

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma
    Don L Gibbons
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 4:e5401. 2009
  2. pmc Widespread molecular patterns associated with drug sensitivity in breast cancer cell lines, with implications for human tumors
    Chad J Creighton
    Department of Medicine and Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e71158. 2013
  3. pmc The molecular profile of luminal B breast cancer
    Chad J Creighton
    Department of Medicine and Dan L Duncan Cancer Center Division of Biostatistics Baylor College of Medicine, Houston, TX, USA
    Biologics 6:289-97. 2012
  4. ncbi request reprint Molecular classification and drug response prediction in cancer
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Drug Targets 13:1488-94. 2012
  5. pmc Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma
    Chad J Creighton
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e34546. 2012
  6. pmc Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
    J Hematol Oncol 2:47. 2009
  7. pmc Multiple oncogenic pathway signatures show coordinate expression patterns in human prostate tumors
    Chad J Creighton
    Division of Biostatistics, Department of Medicine, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e1816. 2008
  8. pmc A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions
    Chad J Creighton
    The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    RNA 14:2290-6. 2008
  9. pmc Expression profiling of microRNAs by deep sequencing
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    Brief Bioinform 10:490-7. 2009
  10. pmc Molecular profiles of progesterone receptor loss in human breast tumors
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Cancer Res Treat 114:287-99. 2009

Collaborators

Detail Information

Publications89

  1. pmc Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma
    Don L Gibbons
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 4:e5401. 2009
    ..Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood...
  2. pmc Widespread molecular patterns associated with drug sensitivity in breast cancer cell lines, with implications for human tumors
    Chad J Creighton
    Department of Medicine and Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e71158. 2013
    ....
  3. pmc The molecular profile of luminal B breast cancer
    Chad J Creighton
    Department of Medicine and Dan L Duncan Cancer Center Division of Biostatistics Baylor College of Medicine, Houston, TX, USA
    Biologics 6:289-97. 2012
    ..Candidate pathways that might be targeted in luminal B include those involving growth factor receptors, including HER2 and EGFR, as well as PI3K/Akt/mTor...
  4. ncbi request reprint Molecular classification and drug response prediction in cancer
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Drug Targets 13:1488-94. 2012
    ....
  5. pmc Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma
    Chad J Creighton
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e34546. 2012
    ..Here, using TCGA ovarian data, we surveyed the miRNAs, in the context of their predicted gene targets...
  6. pmc Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
    J Hematol Oncol 2:47. 2009
    ..The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related) and PCM using array-based comparative genomic hybridization...
  7. pmc Multiple oncogenic pathway signatures show coordinate expression patterns in human prostate tumors
    Chad J Creighton
    Division of Biostatistics, Department of Medicine, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e1816. 2008
    ..It was not clear whether genes in these "oncogenic signatures" would show coordinate expression patterns in human prostate tumors, particularly as most of the signatures were derived from cell types other than prostate...
  8. pmc A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions
    Chad J Creighton
    The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    RNA 14:2290-6. 2008
    ..The software and Excel VBA source code are freely available at http://sigterms.sourceforge.net...
  9. pmc Expression profiling of microRNAs by deep sequencing
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    Brief Bioinform 10:490-7. 2009
    ..Here we discuss tools and methodologies for the analysis of microRNA expression data from deep sequencing...
  10. pmc Molecular profiles of progesterone receptor loss in human breast tumors
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Cancer Res Treat 114:287-99. 2009
    ..Patient prognosis and response to endocrine therapy in breast cancer correlate with protein expression of both estrogen receptor (ER) and progesterone receptor (PR), with poorer outcome in patients with ER+/PR- compared to ER+/PR+ tumors...
  11. ncbi request reprint Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    J Mammary Gland Biol Neoplasia 15:253-60. 2010
    ..Here, we review recent evidence of the involvement of EMT in breast cancer TICs, focusing on clinical studies...
  12. pmc Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
    Chad J Creighton
    Dan L Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 12:R40. 2010
    ..We thus examined whether deregulated PI3K signaling in luminal ER+ breast tumors is associated with ER level and activity and intrinsic molecular subtype...
  13. doi request reprint Inaugural Genomics Automation Congress and the coming deluge of sequencing data
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, One Baylor Plaza MS 305, Houston, TX 77030, USA
    Expert Rev Mol Diagn 10:849-51. 2010
    ....
  14. pmc ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression
    Young Ho Ahn
    Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Invest 122:3170-83. 2012
    ..These findings demonstrate that ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression and provide a compelling rationale to develop miR-34a as a therapeutic agent in lung cancer patients...
  15. pmc The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice
    Yanan Yang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 121:1373-85. 2011
    ..These findings reveal what we believe to be a novel Jagged2/miR-200-dependent pathway that mediates lung adenocarcinoma EMT and metastasis in mice and may have implications for the treatment of human epithelial tumors...
  16. pmc A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer
    Ankur K Nagaraja
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 24:447-63. 2010
    ....
  17. pmc Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression
    Young Ho Ahn
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell Biol 31:4270-85. 2011
    ..We conclude that Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing PPARγ2 levels...
  18. pmc Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
    Don L Gibbons
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 23:2140-51. 2009
    ..We conclude that tumor cell metastasis is regulated by miR-200 expression, which changes in response to contextual extracellular cues...
  19. pmc miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1
    Jonathon D Roybal
    University of Texas MD Anderson Cancer Center, Box 432, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cancer Res 9:25-35. 2011
    ..Flt1 knockdown decreased the growth and metastasis of tumor cells in syngeneic mice. We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1...
  20. pmc Distinct biological roles for the notch ligands Jagged-1 and Jagged-2
    Kuicheon Choi
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:17766-74. 2009
    ..Our findings suggest that JAG1 and JAG2 have distinct biological roles including a previously undiscovered role for JAG2 in regulating the expression of cytokines that can promote antitumor immunity...
  21. pmc Survivin is a viable target for the treatment of malignant peripheral nerve sheath tumors
    Markus P Ghadimi
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Clin Cancer Res 18:2545-57. 2012
    ..The effect of the small-molecule survivin inhibitor YM155 on local and metastatic MPNST growth was examined in vivo...
  22. pmc Gene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients
    Dhruva K Mishra
    Department of Surgery, The Methodist Hospital Research Institute, Houston, TX
    Int J Cancer 134:789-98. 2014
    ..As patients with larger tumors have a worse rate of survival, the ex vivo 4D model may be a good mimic of natural progression of tumor growth in lung cancer patients. ..
  23. pmc Uterine leiomyosarcoma management, outcome, and associated molecular biomarkers: a single institution's experience
    Kristelle Lusby
    Department of Surgical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 20:2364-72. 2013
    ..Uterine leiomyosarcoma (ULMS) is an aggressive, rapidly progressive tumor lacking clinical and molecular predictors of outcome...
  24. pmc COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis
    Jun Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 493:236-40. 2013
    ....
  25. pmc Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression
    Shu Feng
    Department of Pathology and Immunology and Michael E DeBakey Department of Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 73:2551-62. 2013
    ..Our findings support the concept that therapies targeting FGFR signaling may have efficacy in prostate cancer and highlight FGF19 as a relevant endocrine FGF in this setting...
  26. pmc Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies
    Albert C Chen
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA
    Breast Cancer Res Treat 134:583-93. 2012
    ..These mucin-rich tumors reactivate the HER2 pathway and shift their molecular phenotype to become more ER-negative/HER2-positive...
  27. pmc Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth
    Angelo J Casa
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Cancer Res Treat 132:61-73. 2012
    ..This may be important clinically, as tumors with active ERα and IGF-IR signaling may require co-targeting of both pathways...
  28. pmc FGFR-4 Arg³⁸⁸ enhances prostate cancer progression via extracellular signal-related kinase and serum response factor signaling
    Wendong Yu
    Department of Pathology, Baylor College of Medicine, Houston, Texas, USA
    Clin Cancer Res 17:4355-66. 2011
    ..However, the impact of sustained signaling on cellular signal transduction pathways is unknown...
  29. pmc Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers
    Chad J Creighton
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:1906-15. 2010
    ....
  30. pmc Dual targeting of mTOR and aurora-A kinase for the treatment of uterine Leiomyosarcoma
    Kari J Brewer Savannah
    Department of Cancer Biology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1104, Houston TX 77030, USA
    Clin Cancer Res 18:4633-45. 2012
    ....
  31. pmc FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma
    Julienne L Carstens
    Authors Affiliations Departments of Pathology and Immunology and Molecular and Cellular Biology and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston M E DeBakey, Department of Veterans Affairs Medical Center, Houston, Texas
    Cancer Res 74:609-20. 2014
    ..Our findings establish the importance of the FGFR1-WNT-TGF-β signaling axes as driving forces behind reactive stroma in aggressive prostate adenocarcinomas, deepening their relevance as therapeutic targets...
  32. pmc Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity
    Joseph M Valdez
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Stem Cell 11:676-88. 2012
    ..These findings reveal crucial roles of the self-enforced positive reciprocal regulatory loop between TGFβ and Notch in maintaining prostate basal stem cell dormancy...
  33. pmc TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
    Xiaohua Su
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nature 467:986-90. 2010
    ....
  34. pmc CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland
    Heather L LaMarca
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Stem Cells 28:535-44. 2010
    ..These findings have critical implications for understanding both stem cell biology and the etiology of different breast cancer subtypes...
  35. pmc SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells
    Stephanie Hammerich-Hille
    Department of Medicine and Molecular and Cellular Biology, Lester and Sue Smith Breast Center, Texas Children s Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:3608-16. 2010
    ..Thus, this study confirms the primary role of SAFB1/SAFB2 as corepressors and also uncovers a previously unknown role for SAFB1 in the regulation of immune genes and in estrogen-mediated repression of genes...
  36. pmc Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer
    Adam C Pond
    Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:4868-79. 2010
    ..Further, they reveal protein translation initiation factors as potential therapeutic targets for human breast cancers with alterations in FGF signaling...
  37. pmc High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy
    Beate C Litzenburger
    Lester and Sue Smith Breast Center and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA
    Clin Cancer Res 17:2314-27. 2011
    ..We tested whether the IGF signature was affected by anti-IGF-I receptor (IGF-IR) inhibitors and whether the IGF signature correlated with response to a dual anti-IGF-IR/insulin receptor (InsR) inhibitor, BMS-754807...
  38. ncbi request reprint Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations
    Aviad Hoffman
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cancer 119:1868-77. 2013
    ..The authors of this report evaluated the natural history and outcome of patients with MLPS and commonly deregulated protein biomarkers...
  39. pmc Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer
    Shannon M Hawkins
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 26:1552-66. 2012
    ..These data implicate Dicer and appropriate miRNA expression as essential players in the regulation of multiple uterine signaling pathways required for uterine development and appropriate function...
  40. pmc MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes
    Lawrence A Donehower
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Pathol 229:99-110. 2013
    ..Examination of MLH1 expression status and frequencies of APC, KRAS, and BRAF mutation in CRC may provide a useful diagnostic tool that could supplement the standard microsatellite instability assays and influence therapeutic decisions...
  41. doi request reprint A gene transcription signature of obesity in breast cancer
    Chad J Creighton
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Cancer Res Treat 132:993-1000. 2012
    ..These results warrant further investigation of obesity-associated modifiers of breast cancer risk and disease outcome...
  42. pmc High-grade serous ovarian cancer arises from fallopian tube in a mouse model
    Jaeyeon Kim
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 109:3921-6. 2012
    ..Thus, this mouse model demonstrates a paradigm for the origin and initiation of high-grade serous ovarian carcinomas, the most common and deadliest ovarian cancer...
  43. doi request reprint Effects of TP53 mutational status on gene expression patterns across 10 human cancer types
    Neha Parikh
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
    J Pathol 232:522-33. 2014
    ..The data indicate that tumours with wild-type TP53 retain some aspects of p53-mediated growth inhibitory signalling through activation of p53 target genes and suppression of cell cycle regulatory genes...
  44. pmc Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans
    Caterina Clementi
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America Departments of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 9:e1003863. 2013
    ....
  45. pmc Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells
    Yihui Fan
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX, USA Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    J Pathol 232:75-86. 2014
    ....
  46. pmc Development of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts
    Chad J Creighton
    The Dan L Duncan Cancer Center, Baylor College of Medicine, Room N1230 02, One Baylor Plaza BCM 600, Houston, TX 77030, USA
    Cancer Res 68:7493-501. 2008
    ..Over time, the molecular phenotype of breast cancer can change...
  47. pmc Functional microRNA involved in endometriosis
    Shannon M Hawkins
    Department of Obstetrics and Gynecology, Baylor College of Medicine, 1709 Dryden Drive, Suite 1100, Houston, Texas 77030, USA
    Mol Endocrinol 25:821-32. 2011
    ..Thus, miR-29c and other abnormally regulated microRNA appear to play important roles in the pathophysiology of uterine function and dysfunction...
  48. pmc Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis
    Chad J Creighton
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Clin Oncol 26:4078-85. 2008
    ..To more clearly elucidate the role of IGF in human breast cancer, we identified and then examined gene expression patterns of IGF-I-treated breast cancer cells...
  49. ncbi request reprint EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis
    Pingyu Zhang
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA Sarcoma Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Pathol 232:308-18. 2014
    ..Our findings identify a novel signalling pathway involved in MPNST tumourigenesis, and also suggest that EZH2-miR-30d-KPNB1 signalling represents multiple potential therapeutic targetable nodes for MPNST...
  50. pmc Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration
    Torey D Batts
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e27841. 2011
    ..However, at present the functional role for Sca-1 is poorly defined...
  51. pmc Genomic profiling of prostate cancers from African American men
    Patricia Castro
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Neoplasia 11:305-12. 2009
    ..Thus, the clinically localized cancers from AA men more closely resembled metastatic cancers from white men. This difference may in part explain the more aggressive clinical behavior of prostate cancer in AA men...
  52. pmc Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer
    Kentaro Iwanaga
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:1119-27. 2008
    ..Thus, Pten inactivation cooperated with oncogenic K-ras in promoting lung tumorigenesis...
  53. pmc Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations
    Kuicheon Choi
    Department of Thoracic Head and Neck Medical Oncology, M D Anderson Cancer Center, The University of Texas, Houston, Texas, United States of America
    PLoS ONE 2:e1226. 2007
    ....
  54. pmc Novel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas
    Claire M Mach
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Lett 335:314-22. 2013
    ..These results expand our insight into the repertoire of human miRNAs and identify novel pathways by which dysregulated miRNA expression promotes uterine cancer growth...
  55. ncbi request reprint A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma
    Weiwei Shan
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 18:3352-65. 2012
    ..Uterine leiomyosarcoma (ULMS) is a poorly understood cancer with few effective treatments. This study explores the molecular events involved in ULMS with the goal of developing novel therapeutic strategies...
  56. pmc Discovery of novel microRNAs in female reproductive tract using next generation sequencing
    Chad J Creighton
    The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e9637. 2010
    ..Our novel miRNAs were detectable in multiple samples, but expressed at low levels and not specific to any one tissue or cell type. To date, this study represents the largest set of samples analyzed together to identify novel miRNAs...
  57. pmc MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling
    Pingyu Zhang
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 72:1751-62. 2012
    ..In summary, our results point to important functions for miR-155 and β-catenin signaling in progression of liposarcoma, revealing mechanistic vulnerabilities that might be exploited for both prognostic and therapeutic purposes...
  58. doi request reprint Diagnosis, management, and outcome of patients with dedifferentiated liposarcoma systemic metastasis
    Markus P Ghadimi
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 18:3762-70. 2011
    ..Prevalence and pattern of DDLPS systemic metastases have not been extensively reported; information regarding diagnosis, treatment, and outcomes of metastatic DDLPS patients is limited. Our study seeks to address this knowledge gap...
  59. pmc Song exposure regulates known and novel microRNAs in the zebra finch auditory forebrain
    Preethi H Gunaratne
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA
    BMC Genomics 12:277. 2011
    ..To test this, we used massively parallel Illumina sequencing to analyse small RNAs from auditory forebrain of adult zebra finches exposed to tape-recorded birdsong or silence...
  60. pmc Low-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells
    Li Zhang
    Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Prostate 70:297-304. 2010
    ..miRNAs are a class of naturally occurring small RNAs that generally repress gene expression. They have been shown to actively control diverse biological processes including stem cell differentiation and lineage commitment...
  61. pmc Transcriptional response of the murine mammary gland to acute progesterone exposure
    Rodrigo Fernandez-Valdivia
    Department of Molecular and Cellular Biology, Room M732A, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA
    Endocrinology 149:6236-50. 2008
    ....
  62. pmc A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers
    Chad J Creighton
    Department of Medicine, Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Genomics 8:199. 2007
    ..The development of resistance to hormone therapy in both breast and prostate cancers is attributed to tens of thousands of patient deaths every year...
  63. ncbi request reprint Large-scale integration of MicroRNA and gene expression data for identification of enriched microRNA-mRNA associations in biological systems
    Preethi H Gunaratne
    Department of Biology and Biochemistry, University of Houston, Houston, TX, USA
    Methods Mol Biol 667:297-315. 2010
    ..These efforts are essential for determining false positive and negative rates of existing algorithms and refining our knowledge on the rules of miRNA-mRNA relationships...
  64. doi request reprint Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis
    Shu Feng
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Endocr Relat Cancer 17:1021-33. 2010
    ..Thus, the suppression of RLN/RXFP1 may have potential therapeutic benefits in prostate cancer...
  65. pmc A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells
    Ramakrishna Kommagani
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas
    Biol Reprod 90:75. 2014
    ....
  66. pmc Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways
    Benny Abraham Kaipparettu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 8:e61747. 2013
    ..These results suggest the critical oncogenic regulation by mitochondrial-nuclear cross talk and highlights rectifying mitochondrial functional properties as a promising target in cancer therapy...
  67. pmc SGK3 is associated with estrogen receptor expression in breast cancer
    Jun Xu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res Treat 134:531-41. 2012
    ..These findings implicate SGK3 as an additional component to a complex and heterogeneous disease, and point to the potential benefits of incorporating SGK3 into the process of breast cancer diagnosis and treatment...
  68. pmc A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
    Jessica D Kessler
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 335:348-53. 2012
    ..Thus, inhibition of SUMOylation may merit investigation as a possible therapy for Myc-driven human cancers...
  69. doi request reprint Increased midkine expression correlates with desmoid tumour recurrence: a potential biomarker and therapeutic target
    Chiara Colombo
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center MDACC, Houston, TX 77054, USA
    J Pathol 225:574-82. 2011
    ..Further studies to confirm the utility of midkine as a clinical DT molecular prognosticator and a potential therapeutic target are therefore warranted. Raw gene array data can be found at: http://smd.stanford.edu/..
  70. pmc Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse
    Heather L Franco
    Department of Molecular and Cellular Biology, Department of Molecular and Human Genetics, The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 82:991-9. 2010
    ..Thus, constitutive activation of Smo in the mouse uterus alters postnatal uterine differentiation which interferes with early pregnancy. These results provide new insight into the role of Hedgehog signaling during embryo implantation...
  71. pmc ID4 regulates mammary gland development by suppressing p38MAPK activity
    Jie Dong
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Development 138:5247-56. 2011
    ..This p38MAPK activation is required for the reduced proliferation and increased apoptosis in Id4-ablated mammary glands. Therefore, ID4 promotes mammary gland development by suppressing p38MAPK activity...
  72. pmc Prognostically relevant gene signatures of high-grade serous ovarian carcinoma
    Roel G W Verhaak
    Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 123:517-25. 2013
    ..Prospective validation of the CLOVAR model in the context of additional prognostic variables may provide a rationale for optimal combination of patient and treatment regimens...
  73. pmc Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation
    Amy N Shore
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 8:e1002840. 2012
    ..Additionally, a PRC2 complex that includes mPINC and RbAp46 may confer epigenetic modifications that maintain a population of mammary epithelial cells committed to the alveolar fate in the involuted gland...
  74. pmc Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor
    Taghi Manshouri
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 71:3831-40. 2011
    ..Therefore, our results indicate that humoral factors secreted by stromal cells protect MPN clones from JAK2 inhibitor therapy, thus underscoring the importance of targeting the marrow niche in MPN for therapeutic purposes...
  75. pmc Global gene expression analysis of reactive stroma in prostate cancer
    Olga Dakhova
    Departments of Patholog, Baylor College of Medicine, and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:3979-89. 2009
    ..To understand the biological processes and signaling mechanisms underlying the formation of such reactive stroma, we carried out microarray gene expression analysis of laser-captured reactive stroma and matched normal stroma...
  76. pmc Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment
    Li Zhong
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Cancer Res 68:7237-45. 2008
    ..Strategies to inhibit tumor/stromal cell interactions may be useful as therapeutic approaches in NSCLC patients...
  77. pmc Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    Chad J Creighton
    Department of Molecular and Cellular Biology, Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:13820-5. 2009
    ..Targeting proteins involved in EMT may provide a therapeutic strategy for eliminating surviving cells to prevent recurrence and improve long-term survival in breast cancer patients...
  78. pmc Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment
    Alfonso Quintas-Cardama
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77005, USA
    Cancer 118:5283-92. 2012
    ..The biologic basis for progression from chronic phase to blastic phase and for regulating the homeostasis of tyrosine kinase inhibitor-resistant CML stem cells is not entirely understood...
  79. doi request reprint Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
    Tingting Sun
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell 144:703-18. 2011
    ....
  80. pmc Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer
    Mark J Schliekelman
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 71:7670-82. 2011
    ..Lastly, we identified ECM proteins and peptidases that were directly regulated by miR-200. Taken together, our results reveal how expression of miR-200 alters the tumor microenvironment to inhibit the processes of EMT and metastasis...
  81. ncbi request reprint Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation
    Chad J Creighton
    Bioinformatics Program, Department of Pathology, University of Michigan, 4237 Med Sci I, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Mol Cancer Res 3:119-29. 2005
    ..Thus, analysis of tumor xenografts by gene expression profiling has the potential for identifying genes involved in tumor development that may not be expressed in cancer cells grown in vitro...
  82. ncbi request reprint A functional annotation of subproteomes in human plasma
    Peipei Ping
    Department of Physiology and Medicine, Division of Cardiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA
    Proteomics 5:3506-19. 2005
    ..The HPPP-organized, multi-laboratory effort, as described herein, resulted in much synergy and was essential to the success of this project...
  83. pmc Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors
    Chad J Creighton
    Bioinformatics Program, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Genome Biol 7:R28. 2006
    ....
  84. ncbi request reprint Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins
    Christian S Haas
    University of Michigan Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 54:2047-60. 2006
    ..To identify disease-specific gene expression profiles in patients with rheumatoid arthritis (RA), using complementary DNA (cDNA) microarray analyses on lymphoblastoid B cell lines (LCLs) derived from RA-discordant monozygotic (MZ) twins...
  85. pmc When will tumor gene expression profiling be incorporated into clinical breast cancer decision making?
    Chad J Creighton
    Bioinformatics Program, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Breast Cancer Res 8:302. 2006
    ..Recent gene expression profiling studies using cell line models to identify downstream transcriptional targets of oncogenic signaling pathways may help achieve this goal...
  86. ncbi request reprint Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer
    Jindan Yu
    Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 12:419-31. 2007
    ..Taken together, we demonstrate the power of integrating multiple diverse genomic data to decipher targets of disease-related genes...
  87. doi request reprint Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
    Suleiman Massarweh
    Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA
    Cancer Res 68:826-33. 2008
    ..This study provides a rationale to combine HER inhibitors with tamoxifen in clinical studies, even in tumors that do not initially overexpress EGFR/HER2...
  88. ncbi request reprint Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty
    Saravana Mohan Dhanasekaran
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0602, USA
    FASEB J 19:243-5. 2005
    ....