WILLIAM JAMES CRAIGEN

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Exome sequencing of a patient with suspected mitochondrial disease reveals a likely multigenic etiology
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    BMC Med Genet 14:83. 2013
  2. doi request reprint Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    J Bioenerg Biomembr 40:207-12. 2008
  3. doi request reprint Mitochondrial DNA mutations: an overview of clinical and molecular aspects
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 837:3-15. 2012
  4. ncbi request reprint Mitochondrial voltage-dependent anion channel gene family in Drosophila melanogaster: complex patterns of evolution, genomic organization, and developmental expression
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Genet Metab 85:308-17. 2005
  5. doi request reprint MPV17-associated hepatocerebral mitochondrial DNA depletion syndrome: new patients and novel mutations
    Ayman W El-Hattab
    Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Mol Genet Metab 99:300-8. 2010
  6. ncbi request reprint Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy
    Lee Jun C Wong
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hepatology 46:1218-27. 2007
  7. pmc Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:11143-53. 2010
  8. doi request reprint Current molecular diagnostic algorithm for mitochondrial disorders
    Lee Jun C Wong
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Genet Metab 100:111-7. 2010
  9. ncbi request reprint Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease
    Fernando Scaglia
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Pediatrics 114:925-31. 2004
  10. ncbi request reprint Noninvasive, in vivo approaches to evaluating behavior and exercise physiology in mouse models of mitochondrial disease
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Methods 26:364-70. 2002

Research Grants

  1. The Role of Mitochondrial VDACs in Apoptosis
    William Craigen; Fiscal Year: 2009
  2. The Role of Mitochondrial VDACs in Apoptosis
    William Craigen; Fiscal Year: 2004
  3. GENETIC APPROACHES TO MITOCHONDRIAL VDAC FUNCTION
    William Craigen; Fiscal Year: 2001
  4. The Role of Mitochondrial VDACs in Apoptosis
    WILLIAM JAMES CRAIGEN; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. pmc Exome sequencing of a patient with suspected mitochondrial disease reveals a likely multigenic etiology
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    BMC Med Genet 14:83. 2013
    ....
  2. doi request reprint Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    J Bioenerg Biomembr 40:207-12. 2008
    ..Striking similarities to mouse VDAC mutants can be found that emphasize the conservation of function over a long evolutionary time frame...
  3. doi request reprint Mitochondrial DNA mutations: an overview of clinical and molecular aspects
    William J Craigen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 837:3-15. 2012
    ..This chapter reviews the classification of mtDNA mutations and the clinical features that determine the diagnosis of a primary mtDNA disorder...
  4. ncbi request reprint Mitochondrial voltage-dependent anion channel gene family in Drosophila melanogaster: complex patterns of evolution, genomic organization, and developmental expression
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Genet Metab 85:308-17. 2005
    ....
  5. doi request reprint MPV17-associated hepatocerebral mitochondrial DNA depletion syndrome: new patients and novel mutations
    Ayman W El-Hattab
    Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Mol Genet Metab 99:300-8. 2010
    ..Localizing the mutations within the predicted MPV17 protein structure reveals clustering of mutations in the region of the putative protein kinase C phosphorylation site...
  6. ncbi request reprint Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy
    Lee Jun C Wong
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hepatology 46:1218-27. 2007
    ..We report 4 cases from 3 ethnically diverse families with MPV17 mutations. Importantly, 2 of these cases presented with isolated liver failure during infancy without notable neurologic dysfunction...
  7. pmc Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:11143-53. 2010
    ....
  8. doi request reprint Current molecular diagnostic algorithm for mitochondrial disorders
    Lee Jun C Wong
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Genet Metab 100:111-7. 2010
    ..The ever-expanding list of known disease-causing genes will undoubtedly improve diagnostic accuracy and genetic counseling...
  9. ncbi request reprint Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease
    Fernando Scaglia
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Pediatrics 114:925-31. 2004
    ..The aim of this study was to elucidate the frequency of major clinical manifestations in children with mitochondrial disease and establish their clinical course, prognosis, and rates of survival depending on their clinical features...
  10. ncbi request reprint Noninvasive, in vivo approaches to evaluating behavior and exercise physiology in mouse models of mitochondrial disease
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Methods 26:364-70. 2002
    ..This review presents various behavioral and exercise physiology protocols that can be used for the evaluation of potential mouse models of human mitochondrial disorders...
  11. ncbi request reprint The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity
    Edwin J Weeber
    Division of Neuroscience, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:18891-7. 2002
    ..These results demonstrate a dynamic functional role for mitochondrial porins and the permeability transition pore in learning and synaptic plasticity...
  12. ncbi request reprint Genetic approaches to analyzing mitochondrial outer membrane permeability
    Brett H Graham
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Top Dev Biol 59:87-118. 2004
  13. ncbi request reprint Mitochondrial regulation of synaptic plasticity in the hippocampus
    Michael Levy
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:17727-34. 2003
    ..The data suggest a role for the mitochondrial permeability transition pore and voltage-dependent anion channels in mitochondrial synaptic calcium buffering and in hippocampal synaptic plasticity...
  14. ncbi request reprint VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles
    Keltoum Anflous-Pharayra
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Biochim Biophys Acta 1767:136-42. 2007
    ..Therefore, we demonstrated a link between VDAC1 mediated mitochondria-bound hexokinase activity and the capacity for glucose clearance...
  15. pmc Spectrum of CHD7 mutations in 110 individuals with CHARGE syndrome and genotype-phenotype correlation
    Seema R Lalani
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 78:303-14. 2006
    ..We conclude that cardiovascular malformations, coloboma, and facial asymmetry are common findings in CHARGE syndrome caused by CHD7 mutation...
  16. pmc SNP genotyping to screen for a common deletion in CHARGE syndrome
    Seema R Lalani
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    BMC Med Genet 6:8. 2005
    ..Recently, microdeletion at 8q12 locus was reported in two patients with CHARGE, although point mutation in CHD7 on chromosome 8 was the underlying etiology in most of the affected patients...
  17. ncbi request reprint A mouse model of argininosuccinic aciduria: biochemical characterization
    V Reid Sutton
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Genet Metab 78:11-6. 2003
    ..Plasma nitrites, derived from NO, were not reduced in AL deficient mice and there was no significant difference is the level of cyclic GMP, the second messenger induced by NO...
  18. ncbi request reprint Increased MECP2 gene copy number as the result of genomic duplication in neurodevelopmentally delayed males
    Daniela del Gaudio
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Genet Med 8:784-92. 2006
    ..Recent clinical testing for MECP2 gene rearrangements revealed that entire MECP2 gene duplication occurs in some males manifesting a progressive neurodevelopmental syndrome...

Research Grants13

  1. The Role of Mitochondrial VDACs in Apoptosis
    William Craigen; Fiscal Year: 2009
    ..Using genetic and biochemical techniques, in combination with genetically engineered cultured cells and mice, the aim is to establish that these channels are potential targets for therapeutic interventions. ..
  2. The Role of Mitochondrial VDACs in Apoptosis
    William Craigen; Fiscal Year: 2004
    ..These studies may validate VDACs as targets for inhibiting or enhancing apoptosis. ..
  3. GENETIC APPROACHES TO MITOCHONDRIAL VDAC FUNCTION
    William Craigen; Fiscal Year: 2001
    ....
  4. The Role of Mitochondrial VDACs in Apoptosis
    WILLIAM JAMES CRAIGEN; Fiscal Year: 2010
    ..Using genetic and biochemical techniques, in combination with genetically engineered cultured cells and mice, the aim is to establish that these channels are potential targets for therapeutic interventions. ..