Robert B Couch

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Antibody correlates and predictors of immunity to naturally occurring influenza in humans and the importance of antibody to the neuraminidase
    Robert B Couch
    Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, One Baylor Plaza, MS BCM280, Houston, TX 77030, USA
    J Infect Dis 207:974-81. 2013
  2. pmc Evaluations for in vitro correlates of immunogenicity of inactivated influenza a H5, H7 and H9 vaccines in humans
    Robert B Couch
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e50830. 2012
  3. pmc A randomized clinical trial of an inactivated avian influenza A (H7N7) vaccine
    Robert B Couch
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e49704. 2012
  4. pmc Randomized comparative study of the serum antihemagglutinin and antineuraminidase antibody responses to six licensed trivalent influenza vaccines
    Robert B Couch
    Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Vaccine 31:190-5. 2012
  5. pmc Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans
    Robert B Couch
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM 280, Houston, TX, USA
    Vaccine 27:5344-8. 2009
  6. pmc A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects
    Thomas R Cate
    Baylor College of Medicine, One Baylor Plaza, MS BCM 280, Houston, TX 77030, United States
    Vaccine 28:2076-9. 2010
  7. pmc A dose-response evaluation of inactivated influenza vaccine given intranasally and intramuscularly to healthy young adults
    Robert L Atmar
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, United States
    Vaccine 25:5367-73. 2007
  8. pmc Evaluation of age-related differences in the immunogenicity of a G9 H9N2 influenza vaccine
    Robert L Atmar
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Vaccine 29:8066-72. 2011
  9. doi request reprint Increasing doses of an inactivated influenza A/H1N1 vaccine induce increasing levels of cross-reacting antibody to subsequent, antigenically different, variants
    Wendy A Keitel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 198:1016-8. 2008
  10. pmc Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects
    Robert B Couch
    Baylor College of Medicine, One Baylor Plaza, MS BCM280, Houston, TX 77030, United States
    Vaccine 25:7656-63. 2007

Collaborators

Detail Information

Publications21

  1. pmc Antibody correlates and predictors of immunity to naturally occurring influenza in humans and the importance of antibody to the neuraminidase
    Robert B Couch
    Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, One Baylor Plaza, MS BCM280, Houston, TX 77030, USA
    J Infect Dis 207:974-81. 2013
    ..Serum antibody to the hemagglutinin (HA) of influenza viruses is a correlate and predictor of immunity to influenza in humans; the relative values of other correlates are uncertain...
  2. pmc Evaluations for in vitro correlates of immunogenicity of inactivated influenza a H5, H7 and H9 vaccines in humans
    Robert B Couch
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e50830. 2012
    ....
  3. pmc A randomized clinical trial of an inactivated avian influenza A (H7N7) vaccine
    Robert B Couch
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e49704. 2012
    ..Concern for a pandemic caused by a newly emerged avian influenza A virus has led to clinical trials with candidate vaccines as preparation for such an event. Most trials have involved vaccines for influenza A (H5N1), A (H7N7) or A (H9N2)...
  4. pmc Randomized comparative study of the serum antihemagglutinin and antineuraminidase antibody responses to six licensed trivalent influenza vaccines
    Robert B Couch
    Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Vaccine 31:190-5. 2012
    ..Recently we have shown that NA inhibiting antibody can independently contribute to immunity to naturally-occurring influenza immunity in the presence of antibody to the HA...
  5. pmc Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans
    Robert B Couch
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM 280, Houston, TX, USA
    Vaccine 27:5344-8. 2009
    ..Thus, despite exhibiting a significant adjuvant effect in mice, interferon did not exhibit an adjuvant effect for induction of antibody in respiratory secretions of humans to inactivated influenza virus vaccine given intranasally...
  6. pmc A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects
    Thomas R Cate
    Baylor College of Medicine, One Baylor Plaza, MS BCM 280, Houston, TX 77030, United States
    Vaccine 28:2076-9. 2010
    ..Ensuring an increased antibody response to the NA antigen in inactivated influenza virus vaccines should increase the protection against influenza. An increased quantity of the NA antigen in the vaccine will ensure an increased response...
  7. pmc A dose-response evaluation of inactivated influenza vaccine given intranasally and intramuscularly to healthy young adults
    Robert L Atmar
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, United States
    Vaccine 25:5367-73. 2007
    ..Nasal IgA antibody responses were more common when vaccine was administered IN; and, when the IN dosage was increased, the primary benefit from IN vaccine over IM vaccine appeared to be greater induction of nasal secretory antibody...
  8. pmc Evaluation of age-related differences in the immunogenicity of a G9 H9N2 influenza vaccine
    Robert L Atmar
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Vaccine 29:8066-72. 2011
    ..Persons born before 1968 were not more likely to respond to a G9 H9N2 influenza vaccine than persons born in 1970 or later...
  9. doi request reprint Increasing doses of an inactivated influenza A/H1N1 vaccine induce increasing levels of cross-reacting antibody to subsequent, antigenically different, variants
    Wendy A Keitel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 198:1016-8. 2008
    ..Increasing the influenza vaccine dosage safely and predictably enhanced antibody responses to the vaccine virus and to subsequent, antigenically different, influenza A/H1N1 variants...
  10. pmc Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects
    Robert B Couch
    Baylor College of Medicine, One Baylor Plaza, MS BCM280, Houston, TX 77030, United States
    Vaccine 25:7656-63. 2007
    ..These increased immune responses should provide increased protection against influenza in the elderly...
  11. pmc Prior infections with seasonal influenza A/H1N1 virus reduced the illness severity and epidemic intensity of pandemic H1N1 influenza in healthy adults
    Robert B Couch
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 54:311-7. 2012
    ..A/H1N1 viruses had circulated in 1918-1957 and 1977-2009 and were in the annual vaccine during 1977-2009...
  12. pmc Early patterns of gene expression correlate with the humoral immune response to influenza vaccination in humans
    KRISTINE L BUCASAS
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030 2504, USA
    J Infect Dis 203:921-9. 2011
    ..However, great interindividual variability exists in vaccine responses, the cellular events that take place in vivo after vaccination are poorly understood, and appropriate biomarkers for vaccine responsiveness have not been developed...
  13. ncbi request reprint Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparations
    Robert L Atmar
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Clin Infect Dis 43:1135-42. 2006
    ..Influenza A/H9N2 viruses can infect humans and are considered to be a pandemic threat. Effective vaccines are needed for these and other avian influenza viruses...
  14. doi request reprint Global gene expression profiling in infants with acute respiratory syncytial virus broncholitis demonstrates systemic activation of interferon signaling networks
    KRISTINE L BUCASAS
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Infect Dis J 32:e68-76. 2013
    ..Variation in host response may influence the pathogenesis and disease severity. We evaluated global gene expression profiles to better understand the systemic host response to acute RSV bronchiolitis in infants and young children...
  15. pmc Picornavirus, the most common respiratory virus causing infection among patients of all ages hospitalized with acute respiratory illness
    Robert L Atmar
    Viral Respiratory Pathogens Research Unit and the Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Clin Microbiol 50:506-8. 2012
    ..The molecular assays doubled the number of infections identified; picornaviruses were the most frequent in patients of all ages, followed by respiratory syncytial virus and influenza viruses...
  16. ncbi request reprint Reducing the dose of smallpox vaccine reduces vaccine-associated morbidity without reducing vaccination success rates or immune responses
    Robert B Couch
    Baylor College of Medicine, Houston, TX, 77030, USA
    J Infect Dis 195:826-32. 2007
    ..later identified approximately 85 million additional doses in storage...
  17. pmc Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus
    CHIEN TE TSENG
    Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 7:e35421. 2012
    ..Evaluations of an inactivated whole virus vaccine in ferrets and nonhuman primates and a virus-like-particle vaccine in mice induced protection against infection but challenged animals exhibited an immunopathologic-type lung disease...
  18. pmc Seasonal inactivated influenza virus vaccines
    Robert B Couch
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM280, Houston, TX 77030, USA
    Vaccine 26:D5-9. 2008
    ....
  19. ncbi request reprint Safety of high doses of influenza vaccine and effect on antibody responses in elderly persons
    Wendy A Keitel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Tex 77030, USA
    Arch Intern Med 166:1121-7. 2006
    ..Immune responses after influenza immunization are reduced in elderly individuals, the group at greatest risk for complications and death after influenza. Improved vaccines are needed to address this problem...
  20. ncbi request reprint Dose-related safety and immunogenicity of baculovirus-expressed trivalent influenza vaccine: a double-blind, controlled trial in adult patients with non-Hodgkin B cell lymphoma
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Infect Dis 194:1394-7. 2006
    ..For each vaccine, the highest frequencies of increases in neutralizing antibody levels and the highest mean titers occurred in those given the 135- microg vaccine...
  21. pmc Control of mucosal virus infection by influenza nucleoprotein-specific CD8+ cytotoxic T lymphocytes
    Innocent N Mbawuike
    Viral Respiratory Pathogens Research Unit, Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Respir Res 8:44. 2007
    ..The role of CD8+ CTL directed toward the influenza nucleoprotein (NP) in defense against influenza virus infection at the respiratory mucosa was evaluated in two separate adoptive transfer experiments...