Research Topics | Richard B ClarkSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Probing the roles of protein kinases in g-protein-coupled receptor desensitizationRichard B Clark
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Mol Pharmacol 64:1015-7. 2003- Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocationDavid J Vaughan
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
J Biol Chem 281:7684-92. 2006.... - Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalizationRobert H Moore
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Am J Respir Cell Mol Biol 36:254-61. 2007..Defects in these components of salmeterol-induced receptor desensitization may be important determinants of its sustained bronchodilation with chronic use... - Measurement of receptor desensitization and internalization in intact cellsRichard B Clark
Department of Integrative Biology and Pharmacology, University of Texas Medical School, Houston, Texas 77025, USA
Methods Enzymol 343:506-29. 2002 - Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356Varsha Iyer
Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Science and Research Bldg 2, Houston, TX 77204, USA
Br J Pharmacol 147:249-59. 2006.... - Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodiesTuan M Tran
The University of Texas, Houston, Medical School, Houston, TX 77225, USA
Mol Pharmacol 65:196-206. 2004.... - Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switchingJacqueline Friedman
Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston Medical School, Houston, Texas 77225, USA
Mol Pharmacol 62:1094-102. 2002.... - Endosome sorting of beta 2-adrenoceptors is GRK5 independentEllen E Millman
Department of Pediatrics and Molecular Physiology and Biophysics, Baylor College of Medicine, 6621 Fannin, CCC1040, Houston, TX 77030, U S A
Br J Pharmacol 141:277-84. 2004..4. These data indicate that GRK5 does not regulate the sorting of beta(2)-adrenoceptors in the endocytic pathway... - Phosphorylation of the proline-rich domain of Xp95 modulates Xp95 interaction with partner proteinsRobert E Dejournett
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 019, Houston, TX 77030, USA
Biochem J 401:521-31. 2007..These findings establish that Xp95/Alix is phosphorylated within the PRD during M-phase induction, and indicate that the phosphorylation may both positively and negatively modulate their interaction with partner proteins... - Characterization of beta2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitizationTuan M Tran
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center Houston, Medical School, 6431 Fannin, Houston, TX, USA
Mol Pharmacol 71:47-60. 2007..43 +/- 0.009/min; t(1/2) = 1.6 min), than PKA and GRK site dephosphorylation, respectively, clearly dissociating the rapid phase of resensitization (0-5 min) from dephosphorylation... - Phosphorylation of the beta2-adrenergic receptor in plasma membranes by intrinsic GRK5Tuan M Tran
The University of Texas Health Science Center Houston, P O Box 20708, Houston, Texas 77225, USA
Biochemistry 46:14438-49. 2007..On the basis of the level of GRK5-mediated phosphorylation we observe in isolated membrane fractions and co-localization of the beta2AR and GRK5, we conclude that GRK5 plays a distinctive role in the phosphorylation of the beta2AR... - Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylationFaiza Baameur
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Medical School, 6431 Fannin St, Houston, TX 77030, USA
Mol Pharmacol 77:405-15. 2010.... - Quantitative modeling of GRK-mediated beta2AR regulationSharat J Vayttaden
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, United States of America
PLoS Comput Biol 6:e1000647. 2010..It also provides insight into how the signaling machinery can retain memory of prior stimulation long after near complete resensitization has been achieved...
Research Grants
- BETA-ADRENERGIC RECEPTOR STRUCTURE AND DESENSITIZATIONRichard Clark; Fiscal Year: 2004..abstract_text> ..
- Beta Adrenergic Receptor Structure and DesensitizationRichard Clark; Fiscal Year: 2007....
- Beta Andrenergic Receptor Structure and DesensitizationRichard Clark; Fiscal Year: 2009..abstract_text> ..
- B-ADRENERGIC RECEPTOR STUCTURE & DESENSITIZATIONRichard Clark; Fiscal Year: 1992....
- BETA-ADRENERGIC RECEPTOR STRUCTURE AND DESENSITIZATIONRichard Clark; Fiscal Year: 1999....
- BETA-ADRENERGIC RECEPTOR STRUCTURE AND DESENSITIZATIONRichard Clark; Fiscal Year: 1993..The third aim is to identify phosphatases involved in the desensitization/sensitization in intact cells through the use of phosphatase inhibitors...
- Beta Andrenergic Receptor Structure and DesensitizationRichard B Clark; Fiscal Year: 2010..abstract_text> ..