DON CHEREK

..Critical issues in the effectiveness of the evidence-based pharmacotherapy for CD are raised and future directions of the psychopharmacology of CD are examined...

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..The possible role of GABA in human aggression was evaluated by administering gabapentin to subjects with and without a history of conduct disorder and comparing the effects on laboratory measures of aggression and escape...

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..Increasing the monetary value of the reinforcer diminished the acute marijuana effects on PR responding, suggesting that marijuana exerted an effect primarily on reinforcers of a smaller magnitude...

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..The role of serotonin in human aggression was evaluated by administering D-fenfluramine and comparing the effects on laboratory measures of aggression, escape and impulsivity among subjects with and without a history of conduct disorder...

..ECF is neither a necessary nor a sufficient condition to explain aggression following alcohol drinking...

..A possible behavioral mechanism for the rate-decreasing effects on aggressive responding produced in the present study is that tiagabine may modify aggressive responding by suppressing reactions to aversive stimuli...

..D., Cherek, D.R., Pietras, C.J., and Steinberg, J.L. (2005). Performance of heavy marijuana-smoking adolescents on a laboratory measure of motivation. Addictive Behaviors, 30, 815-828]...

..The data are consistent with other studies on the effects of marijuana on time estimation...

..Additional laboratory research is needed to better clarify the behavioural mechanisms by which BZD receptor antagonists modify human aggressive responding...

..A significant correlation between cannabinoid levels and percent of earnings derived from the non-work option suggests that these effects could be associated with the presence of cannabinoids in the marijuana-smoking group...

..Recent data indicate that in the United States alprazolam is the benzodiazepine most frequently misused for recreational purposes...

..Altered sensitivity to consequences may be a mechanism in drug-induced changes in risk taking. Possible neurobiological sites of action related to THC are discussed...

..The outcome is consistent with current nonhuman studies examining the role of the cannabinoid system on delayed matching procedures, and the data help illuminate one behavioral mechanism through which marijuana alters memory performance...

..Despite a well-established relationship between alcohol and risky behavior in the natural environment, laboratory investigations have not reliably shown acute alcohol effects on human risk-taking...

..Little is known, however, about the effects of the stimulant methylphenidate on choice for delayed reinforcers in humans...

..The data are discussed with regard to marijuana effects on dopamine/cannabinoid systems and adaptive behavior change...

..Previous reports suggest that the misuse of the benzodiazepine flunitrazepam is associated with several forms of harmful risky behavior, including theft, violence, and intoxication-related auto accidents...

..These hypotheses were supported. These results suggest that proactive aggression may be identified in a laboratory-based task, and differences between proactive and reactive-only aggressors can be detected...

..Pharmacological effects of these therapeutics drugs on such behavior in a high risk population may provide information relating to alternative strategies in dealing with drug dependence. ..

..Demonstrating such fundamental differences may lead to different approaches in attempts to modify antisocial behavior among high risk populations with such behavioral tendencies. ..

..Understanding the different biological factors involved in human aggression may lead to intervention/prevention strategies that will reduce the risk for substance dependence among high-risk populations. ..

..e., retaliation-attack or escape-flight. The project will provide information on how commonly used drugs interact with environmental factors to alter the responses of normal human volunteers to aggression-provoking situations...

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..The results of such studies may guide and supplement future clinical studies aimed at the suppression of human aggression, which may in turn impact other impulse problem behaviors. ..