CHANGYI J CHEN

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Ginsenoside rb1 directly scavenges hydroxyl radical and hypochlorous Acid
    Jian ming Lu
    Michael E DeBakey Department of Surgery R413, Baylor College of Medicine, One Baylor Plaza, Mail Stop BCM391, Houston, Texas 77030, USA
    Curr Pharm Des 18:6339-47. 2012
  2. ncbi Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells
    Chanygi Chen
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Atherosclerosis 222:74-83. 2012
  3. ncbi Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma
    Sumalee Obchoei
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    Mol Cancer 10:102. 2011
  4. ncbi Roles of neuropilins in neuronal development, angiogenesis, and cancers
    Changyi Chen
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, 77030, USA
    World J Surg 29:271-5. 2005
  5. ncbi Roles of thymosins in cancers and other organ systems
    Changyi Chen
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    World J Surg 29:264-70. 2005
  6. ncbi C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells
    Changyi Chen
    The Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, United States
    Thromb Res 122:125-33. 2008
  7. ncbi Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells
    Changyi Chen
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex 77030, USA
    Arterioscler Thromb Vasc Biol 28:906-12. 2008
  8. ncbi Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells
    Changyi Chen
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    Blood 112:3205-16. 2008
  9. ncbi Chlamydia heat shock protein 60 decreases expression of endothelial nitric oxide synthase in human and porcine coronary artery endothelial cells
    Changyi Chen
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Molecular Surgeon Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cardiovasc Res 83:768-77. 2009
  10. ncbi HIV protease inhibitor ritonavir increases endothelial monolayer permeability
    Changyi Chen
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Biophys Res Commun 335:874-82. 2005

Research Grants

  1. HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Changyi Chen; Fiscal Year: 2004
  2. Effects of HIV Protease Inhibitors of Endothelial Barrie
    Changyi Chen; Fiscal Year: 2005
  3. Molecular Surgeon Symposium on Vascular Injury, Repair
    Changyi Chen; Fiscal Year: 2005
  4. Tissue engineering of small diameter vascular graft
    Changyi Chen; Fiscal Year: 2006
  5. Effects of HAART drugs on endothelial dysfunction of pu*
    Changyi Chen; Fiscal Year: 2007
  6. ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSION
    Changyi Chen; Fiscal Year: 2002
  7. HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIA
    Changyi Chen; Fiscal Year: 2002
  8. Effects of HAART drugs on endothelial dysfunction of pu*
    Changyi Chen; Fiscal Year: 2009

Collaborators

Detail Information

Publications79

  1. ncbi Ginsenoside rb1 directly scavenges hydroxyl radical and hypochlorous Acid
    Jian ming Lu
    Michael E DeBakey Department of Surgery R413, Baylor College of Medicine, One Baylor Plaza, Mail Stop BCM391, Houston, Texas 77030, USA
    Curr Pharm Des 18:6339-47. 2012
    ..ginseng and to the development of effective strategies for clinical applications of ginsenosides...
  2. ncbi Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells
    Chanygi Chen
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Atherosclerosis 222:74-83. 2012
    ..The objective of this study was to determine the effects of lysophosphatidic acid (LPA) on endothelial functions and molecular alternations in both porcine coronary arteries and human coronary artery endothelial cells (HCAECs)...
  3. ncbi Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma
    Sumalee Obchoei
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    Mol Cancer 10:102. 2011
    ..In this study, we investigated the expression of CypA in CCA tumor tissues and CCA cell lines as well as regulation mechanisms of CypA in tumor growth using CCA cell lines...
  4. ncbi Roles of neuropilins in neuronal development, angiogenesis, and cancers
    Changyi Chen
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, 77030, USA
    World J Surg 29:271-5. 2005
    ....
  5. ncbi Roles of thymosins in cancers and other organ systems
    Changyi Chen
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    World J Surg 29:264-70. 2005
    ..This review not only presents recent advances of basic science research of thymosins and their clinical applications but provides thoughtful views for future directions of investigation on thymosins...
  6. ncbi C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells
    Changyi Chen
    The Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, United States
    Thromb Res 122:125-33. 2008
    ..CRP also increased its receptor CD32 expression which may further enhance its action. CRP-induced PAI-1 expression may be mediated by oxidative stress and p38 signal pathway as antioxidant effectively blocks the effect of CRP on HCAEC...
  7. ncbi Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells
    Changyi Chen
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex 77030, USA
    Arterioscler Thromb Vasc Biol 28:906-12. 2008
    ..However, the functional significance of STC1 is unknown. The objective of this study was to determine the effects of STC1 on TNF-alpha-induced monolayer permeability of human coronary artery endothelial cells (HCAECs)...
  8. ncbi Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells
    Changyi Chen
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    Blood 112:3205-16. 2008
    ....
  9. ncbi Chlamydia heat shock protein 60 decreases expression of endothelial nitric oxide synthase in human and porcine coronary artery endothelial cells
    Changyi Chen
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Molecular Surgeon Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cardiovasc Res 83:768-77. 2009
    ..The objective of this study was to determine whether cHSP60 could cause endothelial dysfunction in human coronary artery endothelial cells (HCAECs) and porcine coronary arteries...
  10. ncbi HIV protease inhibitor ritonavir increases endothelial monolayer permeability
    Changyi Chen
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Biophys Res Commun 335:874-82. 2005
    ..ERK1/2 activation is involved in the signal transduction pathway of ritonavir-induced endothelial permeability...
  11. ncbi MicroRNA-196: critical roles and clinical applications in development and cancer
    Changyi Chen
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Mol Med 15:14-23. 2011
    ..miR-196a may prove to be a novel therapeutic target for several cancers...
  12. ncbi Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells
    Changyi Chen
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Dept of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 299:H193-201. 2010
    ..Resistin-induced mitochondrial dysfunction and imbalance in cellular redox enzymes may be the underlying mechanisms of oxidative stress...
  13. ncbi Serum amyloid A induces endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells
    Xinwen Wang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Mail Stop BCM390, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 295:H2399-408. 2008
    ..These findings suggest that SAA may contribute to the progress of coronary artery disease...
  14. ncbi Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells
    Hong Mu
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 297:H400-8. 2009
    ..Thus, LacCer promotes cell migration and proliferation through oxidative stress and activation of ERK1/2 in AoSMCs. These findings demonstrate the functional role of LacCer in the vascular disease pathogenesis...
  15. ncbi Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors
    Min Li
    Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine/Methodist Hospital, Houston, Texas 77030, USA
    Cancer 101:2341-50. 2004
    ..These data suggested that NRP-1 may be involved in the pathogenesis of pancreatic carcinoma...
  16. ncbi Transfection of SSTR-1 and SSTR-2 inhibits Panc-1 cell proliferation and renders Panc-1 cells responsive to somatostatin analogue
    Min Li
    Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Am Coll Surg 201:571-8. 2005
    ..These studies may improve our understanding of the mechanism by which SSTR inhibits cell growth and lead to novel gene therapies for pancreatic cancer...
  17. ncbi IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells
    Louis W Feurino
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medidcine, Houston, Texas 77030, USA
    Cancer Biol Ther 6:1096-100. 2007
    ..In this study, we examined the expression of IL-6 in pancreatic cancer cells, and determined the effect of exogenous IL-6 on cytokine secretion, gene expression and signaling in human pancreatic cancer cells...
  18. ncbi Incorporation of CD40 ligand into SHIV virus-like particles (VLP) enhances SHIV-VLP-induced dendritic cell activation and boosts immune responses against HIV
    Rongxin Zhang
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, United States
    Vaccine 28:5114-27. 2010
    ..Therefore, incorporation of CD40L into VLP may represent a novel strategy to develop effective HIV vaccines...
  19. ncbi Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cancer Ther 7:286-96. 2008
    ..This study revealed novel functions of mesothelin and suggested a new therapeutic vaccine strategy whereby mesothelin is targeted to control pancreatic cancer progression...
  20. ncbi Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation
    Yuqing Zhang
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Biol Ther 7:419-23. 2008
    ..In the current study, we examined the expression of T beta 4 in pancreatic cancer cells, and determined the effect of exogenous T beta 4 on cytokine secretion, and signal transduction in human pancreatic cancer cells...
  21. ncbi Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation
    Min Li
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Invest 27:251-6. 2009
    ..Exogenous T beta 10 caused the phosphorylation of JNK and increased the secretion of cytokines interleukin (IL)-7 and IL-8 in BxPC-3 cells. T beta 10 might be a promising marker and a novel therapeutic target for pancreatic cancer...
  22. ncbi Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries
    Hong Chai
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Am Coll Surg 200:820-30. 2005
    ..Curcumin effectively blocks these detrimental effects of RTV...
  23. ncbi Roles and mechanisms of human immunodeficiency virus protease inhibitor ritonavir and other anti-human immunodeficiency virus drugs in endothelial dysfunction of porcine pulmonary arteries and human pulmonary artery endothelial cells
    Xinwen Wang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Mail Stop BCM390, Houston, TX 77030, USA
    Am J Pathol 174:771-81. 2009
    ..These findings suggest that HAART drugs may contribute to the high incidence of pulmonary artery hypertension in human immunodeficiency virus-infected patients...
  24. ncbi Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries
    Wei Zhou
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Vasc Surg 44:853-62. 2006
    ..This study underscores potential clinical benefits and applications of ginkgolide A in controlling homocysteine-associated vascular injury and cardiovascular disease...
  25. ncbi Effect of low shear stress on permeability and occludin expression in porcine artery endothelial cells
    Brian S Conklin
    Sections of Leukocyte Biology and Nutrition, Department of Pediatrics, Baylor College of Medicine, Children s Nutrition Research Center, 1100 Bates, Suite 6014, Houston, Texas 77030, USA
    World J Surg 31:733-43. 2007
    ..Therefore, the effects of shear stress on the permeability of arteries and the expression of the endothelial cell tight junction molecule occludin, an important regulator of vascular permeability, were investigated...
  26. ncbi Small-caliber heparin-coated ePTFE grafts reduce platelet deposition and neointimal hyperplasia in a baboon model
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Vasc Surg 39:1322-8. 2004
    ..The study found that heparin-coated ePTFE grafts resulted in less intimal hyperplasia and less platelet deposition after implantation, compared with noncoated control ePTFE grafts...
  27. ncbi Effects of lysophosphatidylcholine on monolayer cell permeability of human coronary artery endothelial cells
    Shaoyu Yan
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Surgery 138:464-73. 2005
    ..The antioxidant can effectively block LysoPC-induced endothelial permeability...
  28. ncbi Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells
    Nasim Hedayati
    Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Molecular Surgeon Research Center, Baylor College of Medicine, Houston, Texas 77030 3411, USA
    J Vasc Surg 49:199-207. 2009
    ..This study investigated the effect and potential mechanisms of ghrelin on Hcy-induced endothelial dysfunction...
  29. ncbi Eotaxin increases monolayer permeability of human coronary artery endothelial cells
    Md Saha Jamaluddin
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 29:2146-52. 2009
    ..The objective of this study was to determine the effects and molecular mechanisms of eotaxin, a newly discovered chemokine (CCL11), on endothelial permeability in the human coronary artery endothelial cells (HCAECs)...
  30. ncbi Secretoneurin increases monolayer permeability in human coronary artery endothelial cells
    Shaoyu Yan
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Surgery 140:243-51. 2006
    ..This study provides direct evidence that SN impairs endothelial barrier function...
  31. ncbi Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR
    Min Li
    Elkins Pancreas Center and Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Surg Res 119:130-7. 2004
    ..Down-regulation of SSTR transcription or SSTR mRNA instability may result in loss of a tumor suppressive effect of SSTRs in human pancreatic cancer...
  32. ncbi HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries
    Brian S Conklin
    Michael E. DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Molecular Surgeon Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cardiovasc Res 63:168-75. 2004
    ..Increased oxidative stress may be a possible mechanism of HIV protease inhibitor ritonavir-induced endothelial dysfunction...
  33. ncbi Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line
    Hao Wang
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 25:1817-23. 2005
    ..Thus, this analysis may serve as a basis for further understanding the effect of shear on mesenchymal and vascular cell differentiation...
  34. ncbi Effects of HIV protease inhibitor ritonavir on vasomotor function and endothelial nitric oxide synthase expression
    Weiping Fu
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Acquir Immune Defic Syndr 39:152-8. 2005
    ..This study suggests that ritonavir may contribute to coronary artery disease formation in antiviral therapy for HIV-infected patients...
  35. ncbi Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries
    Wei Zhou
    Molecular Surgeon Research Center, Divison of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Vasc Surg 41:861-8. 2005
    ..This study suggests that ginseng compounds may have potential clinical applications in controlling Hcy-associated vascular diseases and other vascular lesions...
  36. ncbi Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells
    Sheng Zhang
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Immunol 46:1988-2001. 2009
    ..The current study details the interaction between VLPs and B cells which result in preferential IgG2a antibody production following VLP immunization...
  37. ncbi Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis
    Yuqing Zhang
    Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Molecular Surgeon Research Center, Baylor College of Medicine and Michael E DeBakey VA Medical Center, One Baylor Plaza, Houston, TX 77030, USA
    World J Surg 33:698-709. 2009
    ..We hypothesized that pancreatic cancer may have a unique miRNA profile, which may play a critical role in pancreatic cancer development, progression, diagnosis, and prognosis...
  38. ncbi Expression and regulation of neuropilins and VEGF receptors by TNF-alpha in human endothelial cells
    Hui Yang
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine and The Methodist Hospital, Houston, Texas 77030, USA
    J Surg Res 122:249-55. 2004
    ....
  39. ncbi TNF-alpha decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells
    Shaoyu Yan
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    J Surg Res 123:294-301. 2005
    ..Furthermore, treatment with exogenous SST significantly reduces cell proliferation, and this inhibitory effect is also decreased by TNF-alpha...
  40. ncbi Ginsenosides block HIV protease inhibitor ritonavir-induced vascular dysfunction of porcine coronary arteries
    Hong Chai
    Michael E. DeBakey Dept. of Surgery, One Baylor Plaza, NAB-2010, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 288:H2965-71. 2005
    ..This effect may be mediated by the downregulation of eNOS and overproduction of O(2)(-). These results suggest that ginsenosides can effectively block RTV-induced vascular dysfunction...
  41. ncbi The soybean isoflavonoid equol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells
    Charlie Cheng
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Nutr 140:12-7. 2010
    ..These novel data suggest that equol may have a clinical application in preventing HIV-associated cardiovascular complications...
  42. ncbi HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells
    Patrick Duffy
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Michael E DeBakey VA Medical Center, Houston, Texas 77030, USA
    J Surg Res 156:257-64. 2009
    ..The objective of this study was to test a novel hypothesis that HIV Nef, an accessory HIV protein, may directly affect endothelial functions and gene expression in pulmonary arteries...
  43. ncbi Lactosylceramide causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells
    Jean Bismuth
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Med Sci Monit 15:BR270-4. 2009
    ..The goal of this study was to determine the effects and molecular mechanisms of LacCer on endothelial functions in porcine coronary arteries and human coronary endothelial cells (HCAECs)...
  44. ncbi Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts
    Min Li
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 15:5993-6001. 2009
    ..We recently found that a zinc transporter, ZIP4, is overexpressed in pancreatic cancer. In this study, we further deciphered the role that ZIP4 plays in a pancreatic cancer mouse model by silencing ZIP4...
  45. ncbi Human immunodeficiency virus protease inhibitor ritonavir inhibits cholesterol efflux from human macrophage-derived foam cells
    Xinwen Wang
    Michael E DeBakey, Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Pathol 171:304-14. 2007
    ....
  46. ncbi ZIP4 upregulates the expression of neuropilin-1, vascular endothelial growth factor, and matrix metalloproteases in pancreatic cancer cell lines and xenografts
    Yuqing Zhang
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    Cancer Biol Ther 9:236-42. 2010
    ....
  47. ncbi HIV gp120 induces endothelial dysfunction in tumour necrosis factor-alpha-activated porcine and human endothelial cells
    Jun Jiang
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cardiovasc Res 87:366-74. 2010
    ..The aim of this study was to determine direct effects and potential molecular mechanisms of HIV gp120, a viral envelope glycoprotein, on endothelial function...
  48. ncbi ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB
    Yuqing Zhang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Molecular Surgeon Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 16:1423-30. 2010
    ..We have recently found that ZIP4 is overexpressed in pancreatic cancer. In this study, we investigated the signaling pathway through which ZIP4 regulates pancreatic cancer growth...
  49. ncbi Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries
    Weiping Fu
    Molecular Surgeon Research Center, Michael E. DeDakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    J Surg Res 115:82-91. 2003
    ..This study suggests that protecting coronary endothelial cells from homocysteine damage may be an important mechanism of red wine for preventing coronary artery disease...
  50. ncbi C-reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells
    Xinwen Wang
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 28:519-26. 2008
    ..The objective of this study was to determine the effects and potential mechanisms of C-reactive protein (CRP) on cholesterol efflux from human macrophage foam cells, which may play a critical role in atherogenesis...
  51. ncbi Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:18636-41. 2007
    ..These data reveal an important outcome of aberrant ZIP4 expression in contributing to pancreatic cancer pathogenesis and progression. It may suggest a therapeutic strategy whereby ZIP4 is targeted to control pancreatic cancer growth...
  52. ncbi Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries
    Hong Chai
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Acquir Immune Defic Syndr 40:12-9. 2005
    ..The antioxidant SeMet can block these adverse effects of RTV. The results suggest that antioxidant therapy may have applications for controlling PI-associated cardiovascular complications...
  53. ncbi Neutrophil antimicrobial peptide alpha-defensin causes endothelial dysfunction in porcine coronary arteries
    Panagiotis Kougias
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Vasc Surg 43:357-63. 2006
    ..Thus, targeting alpha-defensin and its associated molecular mechanisms may become a new strategy to prevent vascular diseases...
  54. ncbi Adipokine resistin promotes in vitro angiogenesis of human endothelial cells
    Hong Mu
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Mail stop: NAB-2010, Houston, Texas 77030, USA
    Cardiovasc Res 70:146-57. 2006
    ..Thus, resistin may play an important role in angiogenesis-associated vascular disorders...
  55. ncbi Adipocyte-derived cytokine resistin causes endothelial dysfunction of porcine coronary arteries
    Panagiotis Kougias
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, USA
    J Vasc Surg 41:691-8. 2005
    ..Thus, this study may suggest a new mechanism of obesity-associated vascular disease and that antioxidants may effectively prevent vascular disease in obese individuals...
  56. ncbi Rheolytic pharmacomechanical thrombectomy in experimental chronic deep vein thrombosis: effect of L-arginine on thrombogenicity and endothelial vasomotor function
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston VAMC 112, 2002 Holcomb Blvd, Houston, Texas 77030, USA
    World J Surg 31:664-75. 2007
    ....
  57. ncbi Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells
    Bicheng Nan
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Mail stop: NAB-2010, Houston, TX 77030, United States
    Thromb Res 115:417-26. 2005
    ..Curcumin can effectively block TNF-alpha-induced endothelial dysfunction. This study suggests a new molecular mechanism of inflammation-induced thrombosis and a new therapeutic strategy to prevent this clinical problem...
  58. ncbi Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147
    Min Li
    Molecular Surgeon Research Center, Houston, Texas, USA
    Cancer 106:2284-94. 2006
    ..In this study the expression of CypA and its receptor CD147 on pancreatic cancer was determined as well as the effect of exogenous CypA on pancreatic cancer cell proliferation...
  59. ncbi Effect of cyclophilin A on gene expression in human pancreatic cancer cells
    Min Li
    Molecular Surgeon Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Surg 190:739-45. 2005
    ..In this study, we further investigated the effect of CypA on gene expression of several key molecules that are involved in pancreatic cancer cell proliferation...
  60. ncbi CD40 ligand increases expression of its receptor CD40 in human coronary artery endothelial cells
    Hong Chai
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Surgery 140:236-42. 2006
    ..This study suggests a new mechanism by which CD40L could enhance its biologic functions in the vascular system and contribute to endothelial dysfunction and vascular disease...
  61. ncbi Evaluation of platelet deposition and neointimal hyperplasia of heparin-coated small-caliber ePTFE grafts in a canine femoral artery bypass model
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, and Methodist Hospital, Houston, Texas 77030, USA
    J Surg Res 118:45-52. 2004
    ..This may represent a promising treatment strategy for improving the clinical performance of small-caliber prosthetic vascular grafts...
  62. ncbi C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells
    Bicheng Nan
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Surgery 138:212-22. 2005
    ..The objective of the present study was to determine the effect of CRP on the expression of thrombomodulin (TM) and the endothelial protein C receptor (EPCR) in human endothelial cells...
  63. ncbi Differences in responses of platelets to fluid shear stress in patients with peripheral artery disease (PAD) and coronary artery disease (CAD)
    Vijay Nambi
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Platelets 20:199-205. 2009
    ..Although the mechanism for these observed differences are not clear, we hypothesize that in vivo platelet activation in PAD patients may contribute to the differences and will need to be further investigated...
  64. ncbi Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction
    Xinwen Wang
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Acquir Immune Defic Syndr 44:493-9. 2007
    ..These new discoveries provide a better understanding of the molecular mechanisms of the interaction between HIV PIs and vascular cells and may suggest potential approaches to control HIV PI-associated cardiovascular complications...
  65. ncbi Intraaortic stabilization of the AneuRx stent-graft system: a useful adjunct to minimize device migration
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    Cardiovasc Intervent Radiol 26:73-5. 2003
    ..We describe a simple, coaxial, stabilization technique utilizing the contralateral introducer sheath which minimizes potential caudal migration of the stent-graft in angulated aortic necks during runner withdrawal...
  66. ncbi Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications
    Joel A Rodriguez
    Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin Street, Houston, Texas 77030, USA
    World J Surg 29:297-305. 2005
    ..The S100 gene family, mesothelin, prostate stem cell antigen, and 14-3-3 sigma, may have important clinical implications in pancreatic cancer diagnosis and treatment...
  67. ncbi Transluminal stent graft repair with Wallgraft endoprosthesis in a porcine arteriovenous graft pseudoaneurysm model
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, The Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston VAMC 112, 2002 Holcomb Blvd, Houston, TX 77030, USA
    J Vasc Surg 37:175-81. 2003
    ..Histologic evaluation was performed to determine Wallgraft morphology. In vitro pulsatile flow chamber was used to determine maximal flow volume without peri-Wallgraft endoleak...
  68. ncbi A prospective evaluation of interrupted nitinol surgical clips in arteriovenous fistula for hemodialysis
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine and The Methodist Hospital, Houston VAMC 112, Houston, TX 77030, USA
    Am J Surg 186:625-30. 2003
    ..The purpose of this study was to compare the clinical outcome of arteriovenous fistulae (AVF) for hemodialysis as constructed using interrupted U-Clip devices and conventional continuous polypropylene sutures...
  69. ncbi A prospective evaluation of hypogastric artery embolization in endovascular aortoiliac aneurysm repair
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Vasc Surg 36:500-6. 2002
    ..This prospective study was performed to evaluate the clinical outcome of HAE in patients who underwent endovascular aortoiliac aneurysm repair...
  70. ncbi Signal transduction in human pancreatic cancer: roles of transforming growth factor beta, somatostatin receptors, and other signal intermediates
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77021, USA
    Arch Immunol Ther Exp (Warsz) 53:381-7. 2005
    ....
  71. ncbi New roles of a neuropeptide cortistatin in the immune system and cancer
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine and The Methodist Hospital, 6550 Fannin Street, Houston, Texas 77030, USA
    World J Surg 29:354-6. 2005
    ..In this review, we discuss the new functions of CST in the immune system, cancer pathogenesis, and possible CST-specific receptors...
  72. ncbi L-arginine improves endothelial vasoreactivity and reduces thrombogenicity after thrombolysis in experimental deep venous thrombosis
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, DeBakey Department of Surgery, Baylor College of Medicine, Houston VAMC 112, 2002 Holcomb Boulevard, Houston, TX 77030, USA
    J Vasc Surg 38:1396-403. 2003
    ....
  73. ncbi Abdominal aortic surgery in patients with human immunodeficiency virus infection
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, 2002 Holcomb Blvd 112, Houston, TX 77030, USA
    Am J Surg 188:690-7. 2004
    ..This report examined the clinical outcome of patients infected with HIV who underwent abdominal aortic reconstruction for aneurysm or occlusive disease...
  74. ncbi Roles of cyclophilins in cancers and other organ systems
    Qizhi Yao
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    World J Surg 29:276-80. 2005
    ..Understanding the roles of cyclophilins in cancers and other organ systems will be crucial in determining clinical applications for the treatment or diagnosis of human diseases...
  75. ncbi Anastomotic strategies to improve hemodialysis access patency--a review
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston VAMC 112, 2002 Holcomb Blvd, Houston, TX 77030, USA
    Vasc Endovascular Surg 39:135-42. 2005
    ....
  76. ncbi Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Lett 248:58-67. 2007
    ..Furthermore, Thyalpha1 increased the secretion of multiple cytokines including IL-10, IL-13, and IL-17 in Panc-1 cells. Thus, Thyalpha1 may have a new role in pancreatic cancer pathogenesis...
  77. ncbi Th cell-independent immune responses to chimeric hemagglutinin/simian human immunodeficiency virus-like particles vaccine
    Qizhi Yao
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 173:1951-8. 2004
    ..This study suggests a novel adjuvant role of influenza HA as well as a new strategy to develop more effective therapeutic vaccines for AIDS patients with low CD4(+) T cell counts...
  78. ncbi Peripheral arterial occlusive disease: magnetic resonance imaging and the role of aggressive medical management
    Alan B Lumsden
    Methodist DeBakey Heart Center, Baylor College of Medicine, 1709 Dryden Street, Suite 1500, Houston, Texas 77030, USA
    World J Surg 31:695-704. 2007
    ..These studies will advance our understanding of the molecular mechanisms of inflammation and thrombosis associated with aggressive lipid modification...
  79. ncbi Late complication of aortoiliac stent placement- atheroembolization of the lower extremities
    Peter H Lin
    Division of Vascular Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Surg Res 103:153-9. 2002
    ..Atheroembolization following aortoiliac stent placement is uncommon. The purpose of this study was to examine the management and risk factors of lower extremity atheroembolization following aortoiliac stent placement for occlusive disease...

Research Grants29

  1. HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Changyi Chen; Fiscal Year: 2004
    ..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
  2. Effects of HIV Protease Inhibitors of Endothelial Barrie
    Changyi Chen; Fiscal Year: 2005
    ..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
  3. Molecular Surgeon Symposium on Vascular Injury, Repair
    Changyi Chen; Fiscal Year: 2005
    ..A pre-approved letter for acceptance of submission of this application from NIH/NHLBI is included. ..
  4. Tissue engineering of small diameter vascular graft
    Changyi Chen; Fiscal Year: 2006
    ..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
  5. Effects of HAART drugs on endothelial dysfunction of pu*
    Changyi Chen; Fiscal Year: 2007
    ..abstract_text> ..
  6. ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSION
    Changyi Chen; Fiscal Year: 2002
    ....
  7. HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIA
    Changyi Chen; Fiscal Year: 2002
    ....
  8. Effects of HAART drugs on endothelial dysfunction of pu*
    Changyi Chen; Fiscal Year: 2009
    ..abstract_text> ..