Damien Chaussabel

Summary

Affiliation: Baylor University Medical Center
Country: USA

Publications

  1. pmc Mining microarray expression data by literature profiling
    Damien Chaussabel
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Biol 3:RESEARCH0055. 2002
  2. pmc Gene expression patterns in blood leukocytes discriminate patients with acute infections
    Octavio Ramilo
    Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 109:2066-77. 2007
  3. ncbi request reprint Gene expression in peripheral blood mononuclear cells from children with diabetes
    Ellen C Kaizer
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 92:3705-11. 2007
  4. pmc A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    Damien Chaussabel
    Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:150-64. 2008
  5. pmc Translation of genomics research at the bedside: the promise and the challenge
    Damien Chaussabel
    Clin Immunol 129:179-81. 2008
  6. pmc A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
    Lisa H Butterfield
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA
    J Transl Med 6:81. 2008
  7. pmc Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
  8. pmc Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
    Rungnapa Pankla
    Department of Clinical Immunology, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, 123 Mittraparp Road, Khon Kaen, 40002, Thailand
    Genome Biol 10:R127. 2009
  9. ncbi request reprint Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytes
    Damien Chaussabel
    The Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
    Ann N Y Acad Sci 1062:146-54. 2005
  10. ncbi request reprint Biomedical literature mining: challenges and solutions in the 'omics' era
    Damien Chaussabel
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Am J Pharmacogenomics 4:383-93. 2004

Collaborators

Detail Information

Publications28

  1. pmc Mining microarray expression data by literature profiling
    Damien Chaussabel
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Biol 3:RESEARCH0055. 2002
    ..Nevertheless, the lack of efficient techniques for assessing the biological implications of gene-expression data remains an important obstacle in exploiting this information...
  2. pmc Gene expression patterns in blood leukocytes discriminate patients with acute infections
    Octavio Ramilo
    Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 109:2066-77. 2007
    ..Thus, microarray analyses of patient peripheral blood leukocytes might assist in the differential diagnosis of infectious diseases...
  3. ncbi request reprint Gene expression in peripheral blood mononuclear cells from children with diabetes
    Ellen C Kaizer
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 92:3705-11. 2007
    ....
  4. pmc A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    Damien Chaussabel
    Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:150-64. 2008
    ..Thus, this work describes the implementation and application of a methodology designed to support systems-scale analysis of the human immune system in translational research settings...
  5. pmc Translation of genomics research at the bedside: the promise and the challenge
    Damien Chaussabel
    Clin Immunol 129:179-81. 2008
  6. pmc A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
    Lisa H Butterfield
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA
    J Transl Med 6:81. 2008
    ..This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document...
  7. pmc Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
    ..The institution of an interactive consortium for high throughput molecular monitoring of clinical trials with voluntary participation might provide cost-effective solutions...
  8. pmc Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
    Rungnapa Pankla
    Department of Clinical Immunology, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, 123 Mittraparp Road, Khon Kaen, 40002, Thailand
    Genome Biol 10:R127. 2009
    ..Septicemia is the most common presentation of the disease with a 40% mortality rate even with appropriate treatments. Better diagnostic tests are therefore needed to improve therapeutic efficacy and survival rates...
  9. ncbi request reprint Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytes
    Damien Chaussabel
    The Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
    Ann N Y Acad Sci 1062:146-54. 2005
    ..Conversely, a "sentinel signature" that was common to all seven diseases was characterized. These findings bring new perspectives for the application of blood leukocyte expression signatures for diagnosis and early disease detection...
  10. ncbi request reprint Biomedical literature mining: challenges and solutions in the 'omics' era
    Damien Chaussabel
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Am J Pharmacogenomics 4:383-93. 2004
    ..Altogether, these examples illustrate how literature analysis can be employed to support knowledge discovery in biomedical research...
  11. pmc Assessing the human immune system through blood transcriptomics
    Damien Chaussabel
    Baylor Institute for Immunology Research and Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA
    BMC Biol 8:84. 2010
    ..Recent technological and methodological advances that will carry the blood transcriptome research field forward are also discussed...
  12. pmc Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade
    Florence Allantaz
    Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    J Exp Med 204:2131-44. 2007
    ..Availability of early diagnostic markers may allow prompt initiation of therapy and prevention of disabilities...
  13. pmc How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets
    Virginia Pascual
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunol Rev 223:39-59. 2008
    ..Finally, our pilot clinical trials using IL-1 blockers have shown remarkable clinical benefits in SoJIA patients refractory to other medications...
  14. pmc Microarray-based identification of novel biomarkers in IL-1-mediated diseases
    Florence Allantaz
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX, USA
    Curr Opin Immunol 19:623-32. 2007
    ..Blood gene expression profiling can be used to identify such biomarkers. This review will summarize recent studies in the field and will discuss some of the challenges raised by the use of this technology in biomarker discovery...
  15. pmc Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi
    Roshanak Tolouei Semnani
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20872, USA
    J Immunol 181:7081-9. 2008
    ..Our data suggest that mf induce DC apoptosis in a TRAIL- and TNF-alpha-dependent fashion...
  16. pmc ZnT8-Specific CD4+ T cells display distinct cytokine expression profiles between type 1 diabetes patients and healthy adults
    Daisuke Chujo
    Baylor Institute for Immunology Research, Dallas, Texas, USA
    PLoS ONE 8:e55595. 2013
    ..This strategy is applicable to determine the differences in the quality of antigen-specific T cells between health and disease...
  17. pmc Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion
    Alexis Boyd
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 81:1420-9. 2013
    ..Our data suggest that failure by LC to initiate an inflammatory response to the invasive stage of filarial parasites may be a strategy for immune evasion by the filarial parasite...
  18. pmc A genomic approach to human autoimmune diseases
    Virginia Pascual
    Baylor Institute for Immunology Research, INSERM U, Dallas, Texas 75204, USA
    Annu Rev Immunol 28:535-71. 2010
    ..We expect this to crystallize within the coming decade, as these methods become part of the personalized medicine armamentarium...
  19. pmc CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions
    Toshimichi Matsui
    Baylor National Institute of Allergy and Infectious Diseases, Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    J Immunol 182:6815-23. 2009
    ..Thus, human blood pDCs are composed of subsets with specific phenotype and functions...
  20. pmc The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1279-87. 2008
    ..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma...
  21. doi request reprint Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function
    Hirofumi Noguchi
    Baylor All Saints Medical Center Baylor Institute for Immunology Research, Baylor Research Institute, Dallas Fort Worth, TX 75204, USA
    Hum Gene Ther 20:73-85. 2009
    ..These findings suggest that the JNK pathway is the major mediator of islet deterioration during/immediately after isolation and that JNK inhibition before islet isolation could improve outcomes after pancreatic islet transplantation...
  22. pmc Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines
    Gerlinde Obermoser
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 38:831-44. 2013
    ..Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination...
  23. ncbi request reprint Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites
    Damien Chaussabel
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:672-81. 2003
    ..The association of characteristic functional clusters with each infectious agent is consistent with the concept that antigen-presenting cells have prewired signaling patterns for use in the response to different pathogens...
  24. ncbi request reprint Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Rm 6146, 50 South Drive, Bethesda, MD 20892, USA
    J Immunol 172:7229-34. 2004
    ..Therefore, TLR-pathogen interactions could play an indirect role in regulating HIV-associated disease. In this review, we summarize emerging evidence for the influence of TLR recognition on HIV gene activation and AIDS progression...
  25. pmc Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells
    Eynav Klechevsky
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:497-510. 2008
    ..Thus, the human skin displays three DC subsets, two of which, i.e., CD14(+) DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively...
  26. ncbi request reprint Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns
    Alexander D Edwards
    Immunobiology Laboratory and Computational Genome Analysis Laboratory, Cancer Research UK, London Research Institute, London, UK
    J Immunol 171:47-60. 2003
    ..Such associations offer clues to possible unique functions of the CD11c(high) DC subsets that to date have been difficult to define as rigid distinctions...
  27. pmc Pyogenic bacterial infections in humans with MyD88 deficiency
    Horst von Bernuth
    Human Genetics of Infectious Diseases, INSERM U550, Paris, France
    Science 321:691-6. 2008
    ..The MyD88-dependent TLRs and IL-1Rs are therefore essential for protective immunity to a small number of pyogenic bacteria, but redundant for host defense to most natural infections...
  28. ncbi request reprint SP100 inhibits ETS1 activity in primary endothelial cells
    John S Yordy
    Department of Pathology and Laboratory Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Oncogene 24:916-31. 2005
    ..Collectively, these data indicate that SP100 negatively modulates ETS1-dependent downstream biological processes...