Research Topics
Genomes and GenesSpecies | Chung Che ChangSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphomaChung Che Chang
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
Am J Surg Pathol 28:464-70. 2004..Immunohistochemical analysis on paraffin-embedded tissues is more readily available than gene expression profiling by cDNA microarray and may provide similar prognostic information...- Expression of p53, c-Myc, or Bcl-6 suggests a poor prognosis in primary central nervous system diffuse large B-cell lymphoma among immunocompetent individualsChung Che Chang
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA
Arch Pathol Lab Med 127:208-12. 2003..Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) in immunocompetent individuals, although rare, has been rising in incidence. Currently, no reliable prognostic markers are available for these individuals... - CD5+ T-cell/histiocyte-rich large B-cell lymphomaChung Che Chang
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Mod Pathol 15:1051-7. 2002..This will lead to identifying more cases to understand the clinical and biologic characteristics of this variant... - Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibitionJianguo Wen
Department of Pathology, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
Leuk Res 34:85-92. 2010..The results suggest the opportunity for using p38 MAPK inhibition to enhance the efficacy of ATO+bortezomib in myeloma... - Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemiaChung Che Chang
Department of Pathology, Division of Hematology Oncology, and Division of Biostatistics, Medical College of Wisconsin, Milwaukee 53226, USA
Blood 100:4671-5. 2002..Our results suggest that B-CLL with expression of MUM1/IRF4, indicative of postgerminal center origin, has a more favorable clinical course and that MUM1/IRF4 is an important prognostic marker in B-CLL... - Combination of an aptamer probe to CD4 and antibodies for multicolored cell phenotypingPeng Zhang
Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Am J Clin Pathol 134:586-93. 2010..Multicolored flow cytometry analysis revealed that the CD4 aptamer could be combined with antibodies to phenotype cells from bone marrow, lymph nodes, and pleural fluid, suggesting that the aptamer probe has value for clinical use... - Using oligonucleotide aptamer probes for immunostaining of formalin-fixed and paraffin-embedded tissuesZihua Zeng
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
Mod Pathol 23:1553-8. 2010..Therefore, our findings indicate that the synthetic oligonucleotide CD30 aptamer can be used as a probe for immunostaining of fixed tissue sections for disease diagnosis... - The role of beta-catenin in chronic myeloproliferative disordersMonica P Jauregui
Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
Hum Pathol 39:1454-8. 2008..In addition, beta-catenin may be a useful marker for differentiating polycythemia vera and essential thrombocythemia from other types of chronic myeloproliferative disorders... - Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW melanoma cocktail'--a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinaseVinod B Shidham
Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA
BMC Cancer 3:15. 2003..If a cocktail of these antibodies could be used, only one section would be required instead of three generating significant cost savings... - Bone marrow stromal cells from myeloma patients support the growth of myeloma stem cellsYongdong Feng
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, Texas 77030, USA
Stem Cells Dev 19:1289-96. 2010..These findings indicate that the myeloma BMSCs create a microenvironment supportive of myeloma stem cells via, at least partially, the CXCR4 signaling pathway... - P38 MAPK inhibition enhancing ATO-induced cytotoxicity against multiple myeloma cellsJianguo Wen
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX, USA
Br J Haematol 140:169-80. 2008..These results suggest that ATO-induced p38 MAPK activation plays an important role in the resistance to ATO in myeloma cells and that p38 MAPK inhibition may overcome resistance to ATO treatment in myeloma patients... - Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesisSergej Konoplev
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 38:1760-3. 2007.... - Unique biomechanical interactions between myeloma cells and bone marrow stroma cellsYongdong Feng
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, 6565 Fannin, MS205, Houston, TX 77030, USA
Prog Biophys Mol Biol 103:148-56. 2010..The increase of stiffness may in turn support the growth of myeloma cells and myeloma stem cells... - Conditional random pattern model for copy number aberration detectionFuhai Li
Center for Bioengineering and Informatics, Department of Radiology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA
BMC Bioinformatics 11:200. 2010..Thus, more sophisticated statistical models are needed to make the CNAs detection, using the low SNR signals, more robust and reliable... - Relative importance of CD38 expression over myeloid-associated markers expression in predicting the clinical course of B-CLL patientsChung Che Chang
Department of Pathology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Leuk Lymphoma 44:977-82. 2003..10/16 or 63%). Thus, our results suggest that CD38 is superior to myeloid-associated markers in predicting the prognosis of patients with B-CLL. Further studies with a larger sample size are indicated to confirm our observation... - Detection of the JAK2(V617F) mutation in myeloproliferative disorders by melting curve analysis using the LightCycler systemRandall J Olsen
Department of Pathology, Baylor College of Medicine, Houston, Texas, USA
Arch Pathol Lab Med 130:997-1003. 2006..A specific mutation, JAK2(V617F), was recently recognized as having diagnostic value for myeloproliferative disorders. No practical assay is currently available for routine use in a clinical laboratory... - Using an RNA aptamer probe for flow cytometry detection of CD30-expressing lymphoma cellsPeng Zhang
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
Lab Invest 89:1423-32. 2009..In conclusion, the developed CD30 aptamer probe could act as a replacement and/or a supplement for antibodies in the diagnosis of the CD30-expressing lymphomas... - p38 mitogen-activated protein kinase has different degrees of activation in myeloproliferative disorders and myelodysplastic syndromesMunir Shahjahan
Department of Pathology, Methodist Hospital and Methodist Research Institute, Houston, TX, USA
Am J Clin Pathol 130:635-41. 2008..007) cases. Increased p38 MAPK activation may have a role in inhibiting hematopoiesis leading to cytopenias in MDS, and relatively decreased p38 activation in MPD might promote hematopoiesis, resulting in cytosis... - Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphomaChung Che Chang
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
J Hematol Oncol 2:47. 2009..The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related) and PCM using array-based comparative genomic hybridization... - Luteinizing Hormone-Releasing Hormone (LHRH)-I antagonist cetrorelix inhibits myeloma cell growth in vitro and in vivoJianguo Wen
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, 6565 Fannin MS205, Houston, TX 77030, USA
Mol Cancer Ther 10:148-58. 2011..Our findings indicate that Cetrorelix induces cytotoxicity in myeloma cells through various mechanisms and provide a rationale for investigating Cetrorelix for the treatment of MM... - Immunostaining of cytology smears: a comparative study to identify the most suitable method of smear preparation and fixation with reference to commonly used immunomarkersVinod B Shidham
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Diagn Cytopathol 29:217-21. 2003..Most importantly, method C, which is the desired choice for cytomorphological staining, was not suitable for immunostaining... - The implication of identifying JAK2 ( V617F ) in myeloproliferative neoplasms and myelodysplastic syndromes with bone marrow fibrosisRandall J Olsen
Department of Pathology and Laboratory Medicine, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX, USA
J Hematop 1:111-7. 2008..Our results suggest that JAK2 ( V617F ) allele evaluation can be a useful ancillary test for discriminating MDS from MPN in specimens with bone marrow fibrosis... - Selective gene transfection of individual cells in vitro with plasmonic nanobubblesEkaterina Y Lukianova-Hleb
Joint American, Belarussian Laboratory for Fundamental and Biomedical Nanophotonics, Rice University, Houston, TX, USA
J Control Release 152:286-93. 2011..Thus, PNBs provided targeted gene delivery at the single cell level in a single pulse procedure that can be used for safe and effective gene therapy... - Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic SyndromesDominik Beck
Bioengineering and Bioinformatics Program, Department of Pathology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX, 77030, USA
BMC Med Genomics 4:19. 2011..Little is known about small regulatory RNAs and how they contribute to pathogenesis, progression and transcriptome changes in MDS... - Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patientsVinod B Shidham
Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA
BMC Gastroenterol 3:5. 2003..However, studies methodically evaluating different histomorphological features of A-GVHD are rare... - Transfecting the hard-to-transfect lymphoma/leukemia cells using a simple cationic polymer nanocomplexNianxi Zhao
Department of Pathology and Genomic Medicine, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
J Control Release 159:104-10. 2012..These findings demonstrated a simple, efficient method for in vitro gene delivery into hard-to-transfect cells. The nanocomplexes are biodegradable and have minimal cytotoxicity, suggesting the potential use for in vivo gene delivery... - NSMAP: a method for spliced isoforms identification and quantification from RNA-SeqZheng Xia
Department of Radiology, The Methodist Hospital Research Institute, Houston, TX 77030, USA
BMC Bioinformatics 12:162. 2011..Novel study on isoform inference and estimation purely from RNA-Seq without annotation information is desirable... - Molecular genetics of pediatric soft tissue tumors: clinical applicationChung Che Chang
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
J Mol Diagn 5:143-54. 2003..Furthermore, the potential development of targeted therapy based on the understanding of the molecular pathology of a specific soft tissue tumor may complement existing treatments and improve disease outcome... - Acute leukemia immunohistochemistry: a systematic diagnostic approachRandall J Olsen
Department of Pathology, The Methodist Hospital, 6565 Fannin St, M227, Houston, TX 77030, USA
Arch Pathol Lab Med 132:462-75. 2008..Although no one marker is pathognomonic for one malignancy, a well-chosen panel of antibodies can efficiently aid the diagnosis and classification of acute leukemias... - A systematic modeling study on the pathogenic role of p38 MAPK activation in myelodysplastic syndromesHuiming Peng
Department of Radiology, The Methodist Hospital, The Methodist Hospital Research Institute, and Weill Cornell Medical College, Houston, TX, USA
Mol Biosyst 8:1366-74. 2012..Our study suggests that the combination of molecular biological studies and systematic modeling is a powerful tool for comprehensive investigation of the complex cellular mechanisms involved in MDS pathogenesis... - Lymphocyte sub-populations and non-Langerhans' cell monocytoid cells in pulmonary Langerhans' cell histiocytosisR Nagarjun Rao
Department of Pathology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
Pathol Res Pract 204:315-22. 2008..A small sub-population of NLMC was also present. Further studies are required to better define and to evaluate the role of cytotoxic T cells and NLMC in the pathogenesis of PLCH... - Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literatureMing Cao
Department of Pathology, The Methodist Hospital, Weill Medical College of Cornell University, Houston, TX 77030, USA
Arch Pathol Lab Med 131:301-5. 2007..A thorough discussion of the differential diagnosis of histiocytic sarcoma and a review of primary central nervous system histiocytic sarcoma are also presented... - Array comparative genomic hybridization detects chromosomal abnormalities in hematological cancers that are not detected by conventional cytogeneticsLina Shao
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77021 2039, USA
J Mol Diagn 12:670-9. 2010..This pilot study clearly demonstrates high sensitivity of oligonucleotide aCGH for potential use in diagnosis and follow-up in patients with hematological neoplasms... - Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transferCatherine M Bollard
Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
Blood 110:2838-45. 2007..This study is registered at http://www.cancer.gov/clinicaltrials (protocol IDs: BCM-H-9936, NCT00062868, NCT00070226)... - A unique collision tumor in breast: invasive ductal carcinoma and mucosa-associated lymphoid tissue lymphomaBarbara Susnik
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA
Arch Pathol Lab Med 128:99-101. 2004..The morphology and results of immunohistochemistry, flow cytometry, and cytogenetic analysis were consistent with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue... - Mantle cell lymphoma in lymph nodes with metastatic small cell carcinoma of lung: a diagnostic and treatment dilemmaBal Kampalath
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Leuk Lymphoma 45:409-14. 2004..In such cases an optimum treatment strategy should be adopted to cover both malignancies with minimal toxic effect... - Conditional random pattern algorithm for LOH inference and segmentationLing Yun Wu
Center for Biotechnology and Informatics, Department of Radiology, The Methodist Hospital Research Institute, Weill Medical College, Cornell University, Houston, TX 77030, USA
Bioinformatics 25:61-7. 2009..But genotyping errors are always unavoidable, and there are about 70% non-informative SNPs whose LOH status can only be inferred from the neighboring informative SNPs... - The role of Janus Kinase 2 V617F mutation in extramedullary hematopoiesis of the spleen in neoplastic myeloid disordersPin Pen Hsieh
Department of Pathology and Laboratory Medicine, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
Mod Pathol 20:929-35. 2007..Also, dysregulation of downstream pathways such as Bcl-xL may be important to CMPD disease pathogenesis in the spleen... - Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis studyArsalan Ahmed
The Department of Pathology and Laboratory Medicine, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
Pathol Res Pract 205:634-8. 2009..Further studies are warranted to confirm our observation and to study the mechanisms by which mast cells contribute to fibrosis in the MPN setting... - Changes of red blood cell surface markers in a blood doping model of neocytolysisChung Che Chang
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Weill Medical College of Cornell University, NY, USA
J Investig Med 57:650-4. 2009..Progress in understanding the process is hampered by the lack of established markers to distinguish young from older RBC... - Phenotyping studies of clonotypic B lymphocytes from patients with multiple myeloma by flow cytometryE Joseph Conway
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, Texas 77030, USA
Arch Pathol Lab Med 133:1594-9. 2009..These cells have been postulated to act as a therapy-resistant tumor reservoir that drives recurrence... - MCW melanoma cocktail for the evaluation of micrometastases in sentinel lymph nodes of cutaneous melanomaVinod B Shidham
Medical College of Wisconsin, Department of Pathology, Milwaukee, WI 53226 USA
Expert Rev Mol Diagn 5:281-90. 2005.... - Correspondence re: Aguilera NS, Tomaszewski MM, Moad JC, Bauer FA, Taubenberger JK, Abbondanzo SL. Cutaneous follicle center lymphoma: a clinicopathologic study of 19 cases. Mod pathol. 2001;14:828-35. and Franco R, Fernandez-Vazquez A, Mollejo M, Cruz MAChung-Che Chang
Mod Pathol 15:584-5; author reply 585-6. 2002 - Conversion of CD38 and/or myeloid-associated marker expression status during the course of B-CLL: association with a change to an aggressive clinical courseChung-Che Chang
Blood 100:1106. 2002 - Follicular hyperplasia, follicular lysis, and progressive transformation of germinal centers. A sequential spectrum of morphologic evolution in lymphoid hyperplasiaChung-Che Chang
Department of Pathology, Medical College of Wisconsin, Milwaukee, USA
Am J Clin Pathol 120:322-6. 2003..The maintenance of bcl-2 expression in mantle B cells in PTGC may cause differential diagnostic pitfalls in florid PTGC vs follicular lymphoma, particularly the so-called floral variant... - CD10 expression and survivalChung-Che Chang
Am J Clin Pathol 117:660-1; author reply 661-2. 2002 - Restricted kappa/lambda light chain ratio by flow cytometry in germinal center B cells in Hashimoto thyroiditisHenry I Chen
Department of Pathology, Baylor College of Medicine, Houston, TX, USA
Am J Clin Pathol 125:42-8. 2006..This finding frequently is present in HT. Pathologists should be familiar with this phenomenon to prevent misdiagnosis of follicular lymphoma in patients with HT... - Expression of human 8-oxoguanine DNA glycosylase (hOGG1) in follicular lymphomaAndrea M Sheehan
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
Mod Pathol 18:1512-8. 2005..Additionally, finding absent/minimal hOGG1 expression in a subset of Bcl-2-negative follicular lymphomas suggests that hOGG1 may have utility in diagnosing Bcl-2-negative follicular lymphomas...