Lawrence Chan

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation
    Weiqin Chen
    Address correspondence to Lawrence Chan
    Mol Cell Biol 32:1099-111. 2012
  2. pmc Pathogenesis of diabetic neuropathy: bad to the bone
    Lawrence Chan
    Diabetes and Endocrinology Research Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1240:70-6. 2011
  3. pmc Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice
    Benny Hung Junn Chang
    Departmentsof Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Lipid Res 51:2132-42. 2010
  4. pmc Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis
    Antoni Paul
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circ Res 102:1492-501. 2008
  5. ncbi request reprint Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice
    Pradip K Saha
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol Chem 279:35150-8. 2004
  6. pmc Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
    Vijay Yechoor
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 16:358-73. 2009
  7. pmc Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice
    Vijay Yechoor
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, R614, Houston, Texas 77030, USA
    Endocrinology 150:4863-73. 2009
  8. pmc Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice
    Weiqin Chen
    Diabetes and Endocrinology Research Center, Section of Diabetes and Endocrinology, Departments of Medicine, Molecular and Cellular Biology and Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 304:E770-9. 2013
  9. pmc The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation
    Weiqin Chen
    Division of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Diabetes and Endocrinology Research Center, Houston, Texas 77030, USA
    Endocrinology 150:4552-61. 2009
  10. ncbi request reprint Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice
    Kerry W S Ko
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Lipid Res 46:2586-94. 2005

Collaborators

Detail Information

Publications71

  1. pmc Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation
    Weiqin Chen
    Address correspondence to Lawrence Chan
    Mol Cell Biol 32:1099-111. 2012
    ....
  2. pmc Pathogenesis of diabetic neuropathy: bad to the bone
    Lawrence Chan
    Diabetes and Endocrinology Research Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1240:70-6. 2011
    ..Poorly controlled diabetes is indeed bad to the bone...
  3. pmc Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice
    Benny Hung Junn Chang
    Departmentsof Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Lipid Res 51:2132-42. 2010
    ..The alteration of LD size in the liver of Lep(ob/ob)/Adfp(-/-) mice despite the relocation of other LDPs to the LD indicates a nonredundant role for ADFP in determining the size and distribution of hepatic LDs...
  4. pmc Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis
    Antoni Paul
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circ Res 102:1492-501. 2008
    ..In conclusion, Adfp inactivation in ApoE(-/-) background protects against atherosclerosis and appears to be a relatively pure model of impaired foam cell formation...
  5. ncbi request reprint Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice
    Pradip K Saha
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol Chem 279:35150-8. 2004
    ..These experiments uncover the metabolic adaptations associated with the constitutional lipolysis in plin(-/-) mice that allowed the mice to continue to exhibit normal glucose tolerance in the presence of peripheral insulin resistance...
  6. pmc Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
    Vijay Yechoor
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 16:358-73. 2009
    ..This paradigm of induced transdetermination of receptive progenitor cells in vivo may be generally applicable to therapeutic organogenesis for multiple diseases, including diabetes...
  7. pmc Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice
    Vijay Yechoor
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, R614, Houston, Texas 77030, USA
    Endocrinology 150:4863-73. 2009
    ....
  8. pmc Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice
    Weiqin Chen
    Diabetes and Endocrinology Research Center, Section of Diabetes and Endocrinology, Departments of Medicine, Molecular and Cellular Biology and Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 304:E770-9. 2013
    ..In conclusion, inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice...
  9. pmc The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation
    Weiqin Chen
    Division of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Diabetes and Endocrinology Research Center, Houston, Texas 77030, USA
    Endocrinology 150:4552-61. 2009
    ..Loss of Bscl2 function thus interferes with the normal transcriptional cascade of adipogenesis during fat cell differentiation, resulting in near total loss of fat or lipodystrophy...
  10. ncbi request reprint Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice
    Kerry W S Ko
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Lipid Res 46:2586-94. 2005
    ..Thus, although EL modulated lipoprotein profile in mice, there was no effect of EL inactivation on atherosclerosis development in two hyperlipidemic atherosclerosis-prone mouse models...
  11. pmc Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model
    Susan L Samson
    Division of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 16:1805-12. 2008
    ..These observations are important in considering the development of longer acting GLP-1R agonists for the treatment of type 2 diabetes...
  12. pmc Microarray gene profiling of laser-captured cells: a new tool to study atherosclerosis in mice
    Antoni Paul
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Atherosclerosis 200:257-63. 2008
    ..We believe that this method represents a useful new tool for the unbiased analysis of global gene expression of specific sub-regions in atherosclerotic lesions in different rodent models...
  13. pmc Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion
    Kazuhiro Matsumura
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:6026-37. 2007
    ..In conclusion, we found that pancreatic beta cells express AQP7, which appears to be a key regulator of intraislet glycerol content as well as insulin production and secretion...
  14. pmc Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
    Weiqin Chen
    Diabetes and Endocrinology Research Center, Section of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Hepatology 52:1134-42. 2010
    ..CONCLUSION: Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin resistance in mice...
  15. pmc Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease
    Bingning Dong
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:18831-6. 2009
    ..We conclude that CAR activation improves type 2 diabetes, and that these actions of CAR suggest therapeutic approaches to the disease...
  16. pmc Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption
    Atul R Chopra
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 13:35-43. 2011
    ..Our results position the hepatic AMPK-SRC-2 axis as an energy rheostat, which upon cellular energy depletion resets whole-body energy by promoting absorption of dietary fuel...
  17. pmc The Kr├╝ppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription
    Yisheng Yang
    Diabetes and Endocrinology Research Center, Division of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Nucleic Acids Res 37:2529-38. 2009
    ..This study uncovers a role of Glis3 for regulation of insulin gene expression and expands our understanding of its role in the beta cell...
  18. pmc Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer's disease mouse model
    Motoyuki Kohjima
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 151:1532-40. 2010
    ....
  19. pmc Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein
    Benny Hung Junn Chang
    Division of Diabetes, Endocrinology, and Metabolism, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 26:1063-76. 2006
    ..In the absence of ADFP, impairment of LD formation is associated with the accumulation of microsomal TG but a reduction in TG in other subcellular compartments...
  20. ncbi request reprint Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice
    Paul P Lau
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 26:143-9. 2006
    ..We investigated the molecular mechanism of nicotine-accelerated atherosclerosis in a hyperlipidemic low-density lipoprotein receptor(-/-) mouse model...
  21. ncbi request reprint Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse models
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, and St Luke s Episcopal Hospital, Houston, Tex 77030, USA
    Arterioscler Thromb Vasc Biol 25:149-54. 2005
    ..Scavenger receptor-class B type I (SR-BI) is an HDL receptor that mediates the selective uptake of cholesteryl ester. This study investigates the role of EL and SR-BI in the regulation of HDL metabolism in gene knockout mouse models...
  22. ncbi request reprint Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Metab 3:379-86. 2006
    ..Hence, chronically, ghrelin controls glucose homeostasis by regulating pancreatic Ucp2 expression and insulin sensitivity...
  23. pmc Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease
    Atul R Chopra
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 322:1395-9. 2008
    ..In addition, SRC-2 ablation, in both a whole-body and liver-specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC-2 as a critical regulator of mammalian glucose production...
  24. pmc DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice
    Tomoya Terashima
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 119:2100-112. 2009
    ..The development of DRG neuron-targeted HDAd with proven efficacy in a preclinical model may have implications for the treatment of sensory neuronopathies of diverse etiologies...
  25. pmc Extrapancreatic insulin-producing cells in multiple organs in diabetes
    Hideto Kojima
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:2458-63. 2004
    ..These observations have implications for the regulation of insulin gene expression, modulation of self-tolerance by insulin gene expression, and strategies for the generation of insulin-producing cells for the treatment of diabetes...
  26. ncbi request reprint Regulation of Triglyceride Metabolism. III. Emerging role of lipid droplet protein ADFP in health and disease
    Benny Hung Junn Chang
    Division of Diabetes, Endocrinology, and Metabolism, Depts of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1465-8. 2007
    ..Space limitation has precluded a complete cataloging of all publications on the topic. We instead highlight some of the salient developments in the last few years...
  27. pmc Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice
    Aksam Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, R630, Houston, TX 77030, USA
    Cardiovasc Res 85:853-63. 2010
    ..Here, we investigated the effect of inactivation of beta2 integrins at different stages of atherosclerosis by timed bone marrow transplantation (BMT) of CD18(-/-) cells in low-density lipoprotein receptor knockout (LDLR(-/-)) mice...
  28. pmc Farnesoid X receptor is essential for normal glucose homeostasis
    Ke Ma
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 116:1102-9. 2006
    ..Taken together, our results identify a link between lipid and glucose metabolism mediated by the FXR-SHP cascade...
  29. ncbi request reprint Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis
    Aksam J Merched
    Department of Molecular, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circulation 110:3830-41. 2004
    ..p21 is also involved in the maturation and differentiation of monocytes into macrophages...
  30. pmc Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3
    Ming V Li
    Department of Medicine, Baylor College of Medicine N510, Houston, TX 77030, USA
    Mol Endocrinol 22:1658-72. 2008
    ..We conclude that individual subdomains in the GSM (MCR I through V) play diverse but crucial roles in cooperation with essential trans-acting cofactors such as 14-3-3 proteins to mediate the glucose response of ChREBP...
  31. pmc Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults
    Yisheng Yang
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Diabetes and Endocrinology Research Center, Baylor College of Medicine, Houston, TX, USA
    EMBO Mol Med 5:92-104. 2013
    ..We conclude that normal Glis3 expression is required for pancreatic beta cell function and mass maintenance during adulthood, which impairment leads to diabetes in adults...
  32. pmc Interleukin-7 induces recruitment of monocytes/macrophages to endothelium
    Rongying Li
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Eur Heart J 33:3114-23. 2012
    ..Increased IL-7 levels are associated with inflammatory diseases. The aims of this study were to determine whether IL-7 is a biomarker for inflammatory conditions or an active participant in atherogenesis...
  33. pmc GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility
    Xinfu Guan
    Department of Pediatrics, US Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, TX 77030, USA
    Am J Physiol Endocrinol Metab 303:E853-64. 2012
    ..This study indicates that CNS GLP-2R plays a physiological role in the control of feeding behavior and gastric emptying and that this is mediated probably through the melanocortin system...
  34. pmc Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues
    Ligen Lin
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 10:996-1010. 2011
    ..Growth hormone secretagogue receptor antagonists may be a new means of combating obesity by shifting the energy balance from obesogenesis to thermogenesis...
  35. pmc Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion
    Tomoya Terashima
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    FASEB J 26:295-308. 2012
    ..These complementary in vivo and in vitro experiments indicate that BMDC-PARP expression promotes diabetic neuropathy via BMDC-neuron fusion...
  36. ncbi request reprint T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
    Huaizhu Wu
    Section of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
    Circulation 115:1029-38. 2007
    ..T cells also play important roles in chronic inflammatory diseases such as atherosclerosis but have not been well studied in obesity...
  37. pmc A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins
    Keiko Sakai
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Brain Res 1276:11-21. 2009
    ..These results suggest that a VLDLR variant lacking the third complement-type repeat is generated by neuron-specific alternative splicing. Such differential splicing may result in different lipid uptake in neurons and astrocytes...
  38. ncbi request reprint Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance
    Dan Liao
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Circ Res 99:598-606. 2006
    ..These findings indicate that HHcy inhibits reverse cholesterol transport by reducing circulating HDL via inhibiting apoA-I protein synthesis and enhancing HDL-C clearance...
  39. pmc Regulatable atrial natriuretic peptide gene therapy for hypertension
    Kurt J Schillinger
    Department of Molecular and Cellular Biology, Section of Cardiovascular Sciences and Cardiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:13789-94. 2005
    ..Given these capabilities, this vector represents a paradigm for the gene therapy of HTN...
  40. pmc The PAT family of lipid droplet proteins in heart and vascular cells
    Antoni Paul
    Brown Foundation Institute of Molecular Medicine, Houston, TX 77030, USA
    Curr Hypertens Rep 10:461-6. 2008
    ....
  41. pmc Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP)
    Ming V Li
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Biophys Res Commun 395:395-400. 2010
    ..In addition, over-expression of phosphofructokinase (PFK) 1 and 2, synergistically diminishes the glucose response of GAL4-ChREBP. These multiple lines of evidence support the conclusion that G-6-P mediates the activation of ChREBP...
  42. pmc The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism
    Luoping Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Metab 9:77-87. 2009
    ..Thus, COUP-TFII regulates adipogenesis by regulating the key molecules in adipocyte development and can serve as a target for regulating energy metabolism...
  43. ncbi request reprint NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    Hideto Kojima
    Section of Diabetes, Endocrinology and Metabolism, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Nat Med 9:596-603. 2003
    ..Our data suggest that Neurod-Btc gene therapy is a promising regimen to induce islet neogenesis for the treatment of insulin-dependent diabetes...
  44. ncbi request reprint Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile
    Fernando Castro-Chavez
    Section of Diabetes, Endocrinology and Metabolism, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Diabetes 52:2666-74. 2003
    ..The biochemical pathways involved in obesity resistance in plin(-/-) mice identified in this study may represent potential targets for the treatment of obesity...
  45. pmc Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators
    Aksam J Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine and St Luke s Episcopal Hospital, Houston, TX 77030, USA
    FASEB J 22:3595-606. 2008
    ..Taken together, these findings suggest that a failure of local endogenous resolution mechanisms may underlie the unremitting inflammation that fuels atherosclerosis...
  46. ncbi request reprint C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    Antoni Paul
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 109:647-55. 2004
    ..Plasma C-reactive protein (CRP) concentration is a strong predictor of atherosclerosis. However, to date, there is no in vivo evidence that CRP is proatherogenic...
  47. ncbi request reprint Helper-dependent adenoviral vector-mediated long-term expression of human apolipoprotein A-I reduces atherosclerosis in apo E-deficient mice
    Lucio Pastore
    Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA
    Gene 327:153-60. 2004
    ..In conclusion, liver-directed gene transfer of human APOA-I using a HD-Ad vector resulted in a reduction of the development of atherosclerosis with the absence of significant toxicity...
  48. pmc The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice
    Pradip K Saha
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:40581-92. 2010
    ..The in vivo anti-diabetogenic effects occur at a dose substantially lower than that used for anti-leukemia therapy. We suggest that CDDO-Me holds promise as a potential anti-diabetic agent...
  49. pmc Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis
    Jeongkyung Lee
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:19229-34. 2008
    ..These results suggest that ASCOM-MLL3 and ASCOM-MLL4 likely function as crucial but redundant H3K4MT complexes for PPARgamma-dependent adipogenesis...
  50. ncbi request reprint Response to comment on "a peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys"
    Kirstin F Barnhart
    David H Koch Center, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Sci Transl Med 4:131lr2. 2012
    ..Several lines of evidence indicate that the effects of adipotide on weight loss and food consumption in obese monkeys are not due to a toxic effect, but rather result from the targeting mechanism of adipotide...
  51. pmc Cloning of apoB intrabodies: specific knockdown of apoB in HepG2 cells
    Wei Liao
    Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, St Luke s Episcopal Hospital, Houston, TX, USA
    Biochem Biophys Res Commun 373:235-40. 2008
    ..This study demonstrates the utility of an intrabody to specifically block the secretion of a protein determinant of plasma LDL as a therapeutic strategy for the treatment of hyperlipidemia...
  52. ncbi request reprint Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module
    Ming V Li
    Program of Cardiovascular Sciences, Baylor College of Medicine N510, 1 Baylor Plaza, Houston, TX 77030, USA
    Diabetes 55:1179-89. 2006
    ..This evolutionally conserved mechanism may play an essential role in glucose-responsive gene regulation...
  53. ncbi request reprint Construction and characterization of helper-dependent adenoviral vectors for sustained in vivo gene therapy
    Kazuhiro Oka
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Med 108:329-50. 2005
    ..Vector characterization and troubleshooting are also provided at appropriate steps...
  54. ncbi request reprint Gene therapy for diabetes: reinventing the islet
    Susan L Samson
    Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Endocrinol Metab 17:92-100. 2006
    ..Further research is necessary, however, to better define the most effective pro-endocrine factors and the most amenable cell types to achieve transdifferentiation for beta cell replacement...
  55. pmc Extravascular inflammation does not increase atherosclerosis in apoE-deficient mice
    Kerry W S Ko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Biophys Res Commun 384:93-9. 2009
    ..We found that all three forms of chronic extravascular inflammation had no effect on the rate of atherosclerosis development...
  56. ncbi request reprint Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling
    Aksam J Merched
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 23:1608-14. 2003
    ..In this study, we investigated how macrophage-specific loss of p53 function might modulate atherosclerosis development in LDL receptor-deficient mice, a model for familial hypercholesterolemia...
  57. pmc Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
    ..We conclude that EL is a major determinant of HDL concentration, structure, and metabolism in mice, and a major determinant of HDL concentration in humans...
  58. ncbi request reprint In vivo gene therapy for diabetes mellitus
    Lawrence Chan
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Texas Medical Center, Houston, TX 77030, USA
    Trends Mol Med 9:430-5. 2003
    ..Much work remains to be done, however, before this regimen can be taken from the bench to the bedside...
  59. doi request reprint Helper-dependent adenoviral vectors
    Kazuhiro Oka
    Baylor College of Medicine, Houston, Texas, USA
    Curr Protoc Hum Genet . 2005
    ..Included are protocols for Southern blot analysis to monitor vector amplification, slot blot assay to determine the infectious titer of the purified HDAd, and real-time PCR to detect helper virus contamination in the preparation...
  60. pmc Liver-directed gene therapy for dyslipidemia and diabetes
    Kazuhiro Oka
    Departments of Molecular and Cellular Biology and Medicine, Division of Endocrinology and Metabolism, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Atheroscler Rep 6:203-9. 2004
    ..A novel strategy for gene therapy for diabetes was published recently. Gene therapy for dyslipidemia and diabetes is still in its infancy. Nonetheless, recent progress in this area is encouraging and bodes well for the future...
  61. pmc Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis
    Aksam J Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Nutrigenet Nutrigenomics 4:12-24. 2011
    ..The present study was designed to determine whether augmenting dietary lipids modulates the body's endogenous anti-inflammatory pro-resolving mechanisms and promotes atherosclerosis...
  62. pmc Inhibition and regression of atherosclerotic lesions
    Kazuhiro Oka
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Acta Biochim Pol 52:311-9. 2005
    ..Recent results on the long-term effect of gene therapy suggest that hepatic expression of therapeutic genes suppresses inflammation and has profound effects on the nature of the atherogenic process...
  63. pmc Hyperglycemia induces oxidative stress and impairs axonal transport rates in mice
    Ruchi Sharma
    Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e13463. 2010
    ....
  64. doi request reprint Helper-dependent adenoviral vectors
    Kazuhiro Oka
    Baylor College of Medicine, Houston, Texas, USA
    Curr Protoc Mol Biol . 2005
    ..Included are protocols for Southern blot analysis to monitor vector amplification, slot blot assay to determine the infectious titer of the purified HDAd, and real-time PCR to detect helper virus contamination in the preparation...
  65. ncbi request reprint Reversal of obesity by targeted ablation of adipose tissue
    Mikhail G Kolonin
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Med 10:625-32. 2004
    ..Because prohibitin is also expressed in blood vessels of human white fat, this work may lead to the development of targeted drugs for treatment of obese patients...
  66. pmc Minireview: beta-cell replacement therapy for diabetes in the 21st century: manipulation of cell fate by directed differentiation
    Vijay Yechoor
    One Baylor Plaza, R614, Baylor College of Medicine, Houston, Texas, USA
    Mol Endocrinol 24:1501-11. 2010
    ..We will examine the pros and cons of each strategy as well as the hurdles that must be overcome before these approaches to generate new beta-cells will be ready for clinical application...
  67. pmc Stem cell approaches for the treatment of type 1 diabetes mellitus
    Ryan T Wagner
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Transl Res 156:169-79. 2010
    ..We discussed the pros and cons of the different strategies that are being used to re-invent the pancreatic b cell...
  68. ncbi request reprint A proatherogenic role for C-reactive protein in vivo
    Antoni Paul
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Lipidol 16:512-7. 2005
    ..We have selectively reviewed some of the latest papers on the mechanistic role of C-reactive protein in atherosclerotic cardiovascular disease...
  69. ncbi request reprint Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing
    Paul P Lau
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:52988-96. 2003
    ....
  70. pmc Glucagon-like peptide-2-stimulated protein synthesis through the PI 3-kinase-dependent Akt-mTOR signaling pathway
    Xuemei Shi
    USDA ARS Children s Nutrition Research Center, Dept of Pediatrics, Baylor College of Medicine, 1100 Bates St, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 300:E554-63. 2011
    ..GLP-2-stimulated protein synthesis may be physiologically relevant to maintaining neuronal long-term potentiation and providing secondary mediators (namely neuropeptides or growth factors)...
  71. doi request reprint A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis
    Ning Hui Cheng
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS J 278:2525-39. 2011
    ....