Research Topics
Genomes and Genes | Joseph BryanSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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ABCC8 and ABCC9: ABC transporters that regulate K+ channelsJoseph Bryan
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Pflugers Arch 453:703-18. 2007..2 polymorphism has been suggested as a predisposing factor in type 2 diabetes mellitus. Studies on K(ATP) channel null mice are clarifying the roles of these metabolically sensitive channels in a variety of tissues...- Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K(+) channelsJ Bryan
Department of Cell Biology, Baylor College of Medicine, Houston, TX, USA
Biochim Biophys Acta 1461:285-303. 1999..K(ATP) channels are a unique example of the physiologic and medical importance of a transport ATPase and provide a paradigm for how other members of the family may interact with other ion channels... - Toward linking structure with function in ATP-sensitive K+ channelsJoseph Bryan
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Diabetes 53:S104-12. 2004.... - Insulin secretagogues, sulfonylurea receptors and K(ATP) channelsJ Bryan
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Curr Pharm Des 11:2699-716. 2005..The model has a central chamber which could serve as a multifaceted binding pocket... - Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvementAlvaro Munoz
Departments of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 146:5514-21. 2005..The results indicate that loss of alpha-cell K(ATP) channels uncouples glucagon release from inhibition by beta-cells and reveals a role for K(ATP) channels in the regulation of glucagon release by low glucose... - Activating mutations in the ABCC8 gene in neonatal diabetes mellitusAndrey P Babenko
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
N Engl J Med 355:456-66. 2006..We hypothesized that activating mutations in ABCC8, which encodes SUR1, cause neonatal diabetes... - Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretionL Aguilar-Bryan
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 268:423-6. 1995..The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release... - Adenosine diphosphate as an intracellular regulator of insulin secretionC G Nichols
Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Science 272:1785-7. 1996..Thus, by binding to SUR NBF2 and antagonizing ATP inhibition of KATP++ channels, intracellular MgADP may regulate insulin secretion... - Sur domains that associate with and gate KATP pores define a novel gatekeeperAndrey P Babenko
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza 112C, Houston, TX 77030, USA
J Biol Chem 278:41577-80. 2003..The results explain and predict pathologies associated with alteration of the 5' ends of clustered ABCC8 (9)/KCNJ11 (8) genes... - Defining a binding pocket for sulfonylureas in ATP-sensitive potassium channelsWanda H Vila-Carriles
Department of Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
FASEB J 21:18-25. 2007..These studies indicate that the B site involves L0 and the K(IR) amino terminus, elements that are critical for control of channel gating... - Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channelsAlvaro Munoz
Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
Stroke 34:164-70. 2003..To evaluate the role of neuronal/beta-cell-type K(ATP) channels, SUR1 null (Sur1KO) mice lacking (K(IR)6.x/SUR1)(4) K(ATP) channels were subjected to a preconditioning protocol with the use of double carotid occlusion... - SUR-dependent modulation of KATP channels by an N-terminal KIR6.2 peptide. Defining intersubunit gating interactionsAndrey P Babenko
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 277:43997-4004. 2002.... - cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null isletsMitsuhiro Nakazaki
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Diabetes 51:3440-9. 2002..We hypothesize that a reduced release of insulin in response to incretins may contribute to the unexpected normoglycemic phenotype of Sur1KO mice versus the pronounced hypoglycemia seen in neonates with loss of K(ATP) channel activity... - Toward understanding the assembly and structure of KATP channelsL Aguilar-Bryan
Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA
Physiol Rev 78:227-45. 1998..The availability of cloned KATP channel genes opens the way for characterization of this family of ion channels and identification of additional genetic defects... - Cloning and expression of a murine fascin homolog from mouse brainR A Edwards
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 270:10764-70. 1995..Electron cryomicroscopy images show that the reconstituted bundles are highly ordered. However, their fine structure differs from that of echinoid fascin-actin bundles. This structural difference can be attributed to fascin... - Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretionV Seghers
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 275:9270-7. 2000.... - Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2David Ortiz
Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 287:17985-95. 2012..NBD2, but not NBD1, has a higher affinity for ATP (and ADP) in mutant versus wild type (with or without Mg(2+)). Thus, the mutants spend more time in nucleotide-bound conformations, with reduced affinity for GBC, that activate the pore... - A conserved inhibitory and differential stimulatory action of nucleotides on K(IR)6.0/SUR complexes is essential for excitation-metabolism coupling by K(ATP) channelsA P Babenko
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 276:49083-92. 2001.... - Hetero-concatemeric KIR6.X4/SUR14 channels display distinct conductivities but uniform ATP inhibitionA P Babenko
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 275:31563-6. 2000..We propose that SUR-dependent, inhibitory ATP-enhanced interactions of the cytoplasmic domains of both K(IR)6.1 and K(IR)6.2 stabilize a closed form of the M2 bundle in the gating apparatus... - Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genesB E Tubb
Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
Genomics 65:146-56. 2000..The likely function of retinal fascin, in light of known fascin roles in other cell types, is to assemble actin microfilaments in support of photoreceptor disk morphogenesis... - Pharmaco-topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openersA P Babenko
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 275:717-20. 2000..These data are incorporated into a functional topology model for the regulatory SUR subunits of K(ATP) channels... - The tolbutamide site of SUR1 and a mechanism for its functional coupling to K(ATP) channel closureA P Babenko
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
FEBS Lett 459:367-76. 1999..These findings uncover a molecular basis for an inhibitory influence of SUR1, an ATP-binding cassette (ABC) protein, on K(IR)6.2, a ion channel subunit... - Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of KATP channel isoformsA P Babenko
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 274:11587-92. 1999..This is the first identification of parts of an ABC protein that interact with an ion channel subunit to modulate the spontaneous activity and ATP sensitivity of the heteromeric channel... - The N-terminus of KIR6.2 limits spontaneous bursting and modulates the ATP-inhibition of KATP channelsA P Babenko
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Biochem Biophys Res Commun 255:231-8. 1999..The results identify the N-terminus of KIR6.2 as a determinant of the interburst kinetics of KATP channels and suggest that the two cytoplasmic domains of KIR6.2 participate in ATP-inhibitory gating through distinct mechanisms... - Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cellsA P Babenko
Departments of Cell Biology and Medicine, Baylor College of Medicine, Houston, TX, USA
Circ Res 83:1132-43. 1998.... - Sulfonylurea receptors set the maximal open probability, ATP sensitivity and plasma membrane density of KATP channelsA P Babenko
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
FEBS Lett 445:131-6. 1999..2 modification. The results demonstrate allosteric interaction(s) are essential for normal intrinsic activity, ATP inhibition, and trafficking of KATP channels... - Of mice and men: K(ATP) channels and insulin secretionL Aguilar-Bryan
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Recent Prog Horm Res 56:47-68. 2001.... - Cloning of cDNAs encoding human caldesmonsM B Humphrey
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
Gene 112:197-204. 1992..Examination of the 'junctions' at either end of the deleted central domain gives a clear indication of the splice sites and suggests that the nonmuscle form is generated by exon skipping.(ABSTRACT TRUNCATED AT 250 WORDS).. - Fascin, an echinoid actin-bundling protein, is a homolog of the Drosophila singed gene productJ Bryan
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030 3498
Proc Natl Acad Sci U S A 90:9115-9. 1993..No extensive similarities were found with other known actin-binding/bundling proteins, indicating that this is a separate gene family... - Molecular biology of adenosine triphosphate-sensitive potassium channelsL Aguilar-Bryan
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Endocr Rev 20:101-35. 1999.... - Cloning and expression of a smooth muscle caldesmonJ Bryan
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
J Biol Chem 264:13873-9. 1989..A tentative map of the major binding domains is proposed on the basis of available data... - Sequence of an avian non-muscle caldesmonJ Bryan
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
J Muscle Res Cell Motil 12:372-5. 1991..This central segment is thought to be helical, suggesting that non-muscle caldesmon is approximately 35 nm shorter, about 40 nm overall length, than smooth muscle caldesmon... - Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channelsAndras Szollosi
Unit of Endocrinology and Metabolism, University of Louvain Faculty of Medicine, UCL 55 30, Avenue Hippocrate 55, B 1200 Brussels, Belgium
J Biol Chem 282:1747-56. 2007..It is suggested that unidentified potassium channels are sensitive to glucose and subserve the acute and long-term metabolic control of [Ca(2+)](c) in beta-cells without functional K(ATP) channels... - The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cellsMartina Dufer
Institute of Pharmacy, Department of Pharmacology, University of Tubingen, Tubingen, Germany
Cell Physiol Biochem 20:65-74. 2007..The change in Ca(2+) sequestration in beta cells treated with insulinotropic antidiabetics may have implications for beta cell survival and the therapeutic use of these drugs... - Transactivation of the mouse sulfonylurea receptor I gene by BETA2/NeuroDJi Won Kim
Department of Anatomy, Ajou University, School of Medicine, Suwon, 442 749, Korea
Mol Endocrinol 16:1097-107. 2002..These results also suggest that E3 is specific for BETA2/NeuroD, and the stimulatory effect of ngn3 in HIT cells may require factors specifically expressed in HIT cells... - Epinephrine-induced hyperpolarization of islet cells without KATP channelsAndrea Sieg
Institut fur Neurophysiologie, Universitat zu Koln, Cologne, Germany
Am J Physiol Endocrinol Metab 286:E463-71. 2004..We conclude that epinephrine can hyperpolarize beta-cells in the absence of KATP channels via activation of low-conductance BaCl2-sensitive K+ channels that are regulated by pertussis toxin-sensitive G proteins... - Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinismKhalid Hussain
The London Centre for Pediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children National Health Service Trust, University College London, UK
Diabetes 54:2946-51. 2005..Other possible mechanisms such as the suppressive effect of prolonged hyperinsulinemia on alpha-cell secretion should be considered... - Hypothalamic sensing of circulating fatty acids is required for glucose homeostasisTony K T Lam
Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 701, Bronx, New York 10461, USA
Nat Med 11:320-7. 2005..These findings indicate that a physiological elevation in circulating lipids can be sensed within the hypothalamus and that a defect in hypothalamic lipid sensing disrupts glucose homeostasis... - Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cellsMyriam Nenquin
Unité d Endocrinologie et Métabolisme, University of Louvain Faculty of Medicine UCL 55 30, Ave Hippocrate 55, B 1200 Brussels, Belgium
J Biol Chem 279:32316-24. 2004.... - Hypothalamic K(ATP) channels control hepatic glucose productionAlessandro Pocai
Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Nature 434:1026-31. 2005..These findings suggest that activation of hypothalamic K(ATP) channels normally restrains hepatic gluconeogenesis, and that any alteration within this central nervous system/liver circuit can contribute to diabetic hyperglycaemia... - Docking and fusion of insulin secretory granules in SUR1 knock out mouse beta-cells observed by total internal reflection fluorescence microscopyToshiteru Kikuta
Department of Biochemistry, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
FEBS Lett 579:1602-6. 2005..fusion with the plasma membrane. Thus, the impaired docking and fusion results in decreased insulin exocytosis from Sur1KO beta-cells... - Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivoHuarong Zhou
Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
Diabetes 56:1107-12. 2007..We conclude that zinc atoms, not the insulin molecule itself, provide the switch-off signal from the beta-cell to the alpha-cell to initiate glucagon secretion during hypoglycemia...
Research Grants
- Studies of Sulfonylurea Receptors and KATP ChannelsJoseph Bryan; Fiscal Year: 2007..x interacts with the L0 linker of SURs to control bursting. (3) To define further the sulfonylurea/glibenclamide binding pocket of SUR1, specifically to identify amino acids in proximity to the meglitinide head group. ..