Research Topics
| Teodoro BottiglieriSummaryAffiliation: Baylor University Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic moleculeTeodoro Bottiglieri
Baylor University Medical Center, Institute of Metabolic Disease, Dallas, TX 75226, USA
Am J Clin Nutr 76:1151S-7S. 2002..This article provides an overview of the biochemical, molecular, and therapeutic effects of this pleiotrophic molecule...- Homocysteine and folate metabolism in depressionTeodoro Bottiglieri
Baylor University Medical Center, Institute of Metabolic Disease, Dallas, TX 75226, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:1103-12. 2005..This review describes the biochemical, neurochemical and clinical correlations of folate deficiency and hyperhomocysteinemia in relation to depression... 
Folate, vitamin B₁₂, and S-adenosylmethionineTeodoro Bottiglieri
Institute of Metabolic Disease, Baylor Research Institute, Baylor University, 3812 Elm Street, Dallas, TX 75226, USA
Psychiatr Clin North Am 36:1-13. 2013..This article reviews the metabolic and clinical importance of folate, vitamin B12, and SAMe, as well as clinical trials in relation to depression and dementia...
Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brainTeodoro Bottiglieri
Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas 75226, USA
J Neurosci 32:9173-81. 2012..These findings reveal a novel mechanism involving methylation-dependent pathways in L-dopa induces PP2A hypomethylation and increases Tau phosphorylation, which may be potentially detrimental to neuronal cells...- Homocysteine levels in preterm infants: is there an association with intraventricular hemorrhage? A prospective cohort studyWendy J Sturtz
Department of Neonatology, Christiana Care Health System, Newark, Delaware, USA
BMC Pediatr 7:38. 2007.... - Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: association is significant in men but not in womenAli Sazci
Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, 41900, Kocaeli, Turkey
Prog Neuropsychopharmacol Biol Psychiatry 29:1113-23. 2005..In conclusion, the MTHFR 677T allele and T677T, C1298C genotypes, and T677T/A1298A, C677C/C1298C compound genotypes are genetic risk factors for schizophrenia in men but not in women in a gender-specific manner... - Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulationEstelle Sontag
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 27:2751-9. 2007..The link between homocysteine, PPMT, PP2A methylation, and key CNS proteins involved in AD pathogenesis provides new mechanistic insights into this disorder... - Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylationJean Marie Sontag
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
J Neurosci 28:11477-87. 2008..Our results suggest that counteracting the neuronal loss of LCMT-1 and B(alpha) could be beneficial for all tauopathies and folate-dependent disorders of the CNS... - Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associationsPadraig E O'Suilleabhain
Department of Neurology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Arch Neurol 61:865-8. 2004..An Hcy elevation is prevalent in patients with Parkinson disease (PD) in part because levodopa metabolism produces Hcy. The clinical relevance of an elevated Hcy level in patients with PD is unknown... - Clinical course in Parkinson's disease with elevated homocysteinePadraig E O'Suilleabhain
Department of Neurology, Southwestern Medical Center at Dallas, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9036, USA
Parkinsonism Relat Disord 12:103-7. 2006..03). We conclude that hyperhomocysteinemia does not predict significantly worse progression over 2 years in early PD. The data raised the possibility of higher mortality, but the number of deaths was small... - Modest increase in plasma homocysteine follows levodopa initiation in Parkinson's diseasePadraig E O'Suilleabhain
Department of Neurology, University of Texas Southwestern Medical School, Dallas, Texas, USA
Mov Disord 19:1403-8. 2004..Levodopa elevates tHcy and lowers vitamin B12 concentration to modest degrees. The clinical implications, if any, have not yet been determined... - Adult Polyglucosan Body Disease (APBD): Anaplerotic diet therapy (Triheptanoin) and demonstration of defective methylation pathwaysCharles R Roe
Baylor Research Institute, Institute of Metabolic Disease, Baylor University Medical Center, Dallas, TX 75226, United States
Mol Genet Metab 101:246-52. 2010.... - Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophreniaJoshua L Roffman
Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 63:42-8. 2008..We examined whether the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C functional polymorphisms contribute to negative symptoms... - Hyperhomocysteinemia and cognitive function: more than just a casual link?Teodoro Bottiglieri
Am J Clin Nutr 82:493-4. 2005 - Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemiaSanjana Dayal
Dept of Internal Medicine, Univ of Iowa, C32 GH, Iowa City, IA 52242, USA
Am J Physiol Heart Circ Physiol 295:H816-25. 2008..Our findings demonstrate that hyperhomocysteinemia causes tissue-specific decreases in DDAH expression without altering plasma ADMA levels in mice with endothelial dysfunction... - Elevated prenatal homocysteine levels as a risk factor for schizophreniaAlan S Brown
College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
Arch Gen Psychiatry 64:31-9. 2007.... - Folate, homocysteine, and negative symptoms in schizophreniaDonald C Goff
Schizophrenia Program and Neurology Service, Massachusetts General Hospital, Boston, USA
Am J Psychiatry 161:1705-8. 2004.... - Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductaseC Lee Elmore
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
Mol Genet Metab 91:85-97. 2007..The different metabolite profiles in the various genetic mouse models for hyperhomocyst(e)inemia may be useful in understanding biological effects of elevated homocyst(e)ine... - High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trialPaul S Aisen
Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
JAMA 300:1774-83. 2008..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline... - Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient miceKatina M Wilson
Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Arterioscler Thromb Vasc Biol 27:233-40. 2007..We tested the hypothesis that hyperhomocysteinemia and hypercholesterolemia promote arterial thrombosis in mice... - Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemiaSanjana Dayal
Department of Internal Medicine, C32 GH, University of Iowa, Iowa City, IA 52242, USA
Blood 108:2237-43. 2006.... - Hyperhomocyst(e)inemia: a risk factor for cerebrovascular diseaseLucilla Parnetti
Neuroscience Department, University of Perugia, Italy
Clin Exp Hypertens 24:501-9. 2002..Further studies are needed, in order to better characterize the association between Hcy concentrations and risk of stroke... - Anger attacks in major depressive disorder and serum levels of homocysteineRenerio Fraguas
Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 60:270-4. 2006..Increased levels of homocysteine have been associated with anger and depression separately. We investigated the association of anger attacks in major depressive disorder (MDD) with serum levels of homocysteine... - Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer diseaseJoseph J Locascio
Massachusetts Alzheimer s Disease Research Center, Wang Ambulatory Care Center, Suite 720, Room 731 G, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
Arch Neurol 65:776-85. 2008.... - Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemiaAngela M Devlin
Nutrition Research Program, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver V6H 3N1, Canada
J Biol Chem 282:37082-90. 2007..05), and lower Delta6-desaturase activity (p<0.001) in liver from mice with HHcy. These findings suggest that methylation silencing of liver Fads2 expression and changes in liver fatty acids may contribute to the pathology of HHcy... - Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiencyPaolo Moretti
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Autism Dev Disord 38:1170-7. 2008..These findings demonstrate that autistic features are salient in CFD and suggest that a subset of children with developmental regression, mental retardation, seizures, dyskinesia, and autism may have CNS folate abnormalities... - Cerebral vascular dysfunction in methionine synthase-deficient miceSanjana Dayal
Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
Circulation 112:737-44. 2005..We tested the hypothesis that deficiency of MS impairs endothelial function in mice heterozygous for disruption of the Mtr gene, which encodes MS... - The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in MthfrPamela Tran
Department of Human Genetics, McGill University Montreal Children s Hospital Research Institute, 4060 St Catherine St West, Room 200, QC, Canada
Mol Genet Metab 76:297-304. 2002.... - Role of S-adenosylmethionine in two experimental models of pancreatitisShelly C Lu
Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, Keck School of Medicine USC, Los Angeles, California 90033, USA
FASEB J 17:56-8. 2003..Third, in contrast to the situation in the liver, where absence of MAT1A and decreased hepatic SAM level can lead to spontaneous tissue injury, in the pancreas the roles of SAM and MAT1A appear more complex and remain to be defined... - Structure of cerebral arterioles in cystathionine beta-synthase-deficient miceGary L Baumbach
Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City, Iowa 52242, USA
Circ Res 91:931-7. 2002..These findings suggest that hyperhomocysteinemia promotes cerebral vascular hypertrophy and altered cerebral vascular mechanics, both of which may contribute to the increased incidence of stroke associated with hyperhomocysteinemia... - Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunctionSanjana Dayal
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
Arterioscler Thromb Vasc Biol 22:1996-2002. 2002..We tested the hypothesis that deficiency of cellular glutathione peroxidase (GPx-1) enhances susceptibility to endothelial dysfunction in mice with moderate hyperhomocysteinemia... - Potential for misdiagnosis due to lack of metabolic derangement in combined methylmalonic aciduria/hyperhomocysteinemia (cblC) in the neonateCary O Harding
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239-2998, USA
J Perinatol 23:384-6. 2003..In addition, this is the first documentation of cerebrospinal fluid hyperhomocysteinemia in cblC defect that was highly increased and is likely to be associated with neurotoxicity in cblC patients... - GABA, gamma-hydroxybutyric acid, and neurological diseaseC Guin Ting Wong
Institute of Medical Sciences, University of Toronto, Faculty of Medicine and Brain and Behavior Research Program, Hospital for Sick Children, Ontario, Canada
Ann Neurol 54:S3-12. 2003.... - Homocysteine and lipoprotein levels following resistance training in older adultsKevin R Vincent
Department of Physical Medicine and Rehabilitaion, The University of Virginia, Charlottesville, VA 22908 1004, USA
Prev Cardiol 6:197-203. 2003..These data indicate that significant reductions in serum levels of homocysteine in the elderly can be derived from resistance exercise training... - Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in miceAngela M Devlin
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City 52242, USA
Blood 103:2624-9. 2004..These findings demonstrate that the Mthfr(+/-) genotype sensitizes mice to diet-induced hyperhomocysteinemia and that hyperhomocysteinemia alters tissue methylation capacity and impairs endothelial function in cerebral microvessels... - Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluidCharles T Quinn
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Texas 75390 9063, USA
J Pediatr Hematol Oncol 26:386-8. 2004..No sulfur-containing excitatory amino acids were detected. This study demonstrates multiple profound effects of MTX on CNS metabolism and provides insight to the pathogenesis of MTX neurotoxicity... - Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic miceSanjana Dayal
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Stroke 35:1957-62. 2004..CONCLUSIONS: Superoxide is a key mediator of endothelial dysfunction in the cerebral circulation during diet-induced hyperhomocysteinemia... - Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depressionGeorge I Papakostas
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 65:1090-5. 2004.... - Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 2: predictors of relapse during the continuation phase of pharmacotherapyGeorge I Papakostas
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 65:1096-8. 2004.... - Effects of exercise on emerging and traditional cardiovascular risk factorsGlen E Duncan
Department of Epidemiology, Nutritional Sciences Program, University of Washington, Seattle, WA 98195, USA
Prev Med 39:894-902. 2004..insulin and aerobic fitness) are improved with exercise; however, few studies have addressed the potential for training to modify emerging cardiovascular disease risk factors such as homocysteine and high-sensitivity C-reactive protein... - S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxineJonathan E Alpert
Depression Clinical and Research Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 24:661-4. 2004..The purpose of this open trial was to evaluate the safety, tolerability, and efficacy of oral S-adenosyl-L-methionine as an antidepressant adjunct among partial and nonresponders to serotonin reuptake inhibitors or venlafaxine... - Creatine metabolism in combined methylmalonic aciduria and homocystinuriaOlaf A Bodamer
Unit of Biochemical Genetics, Department of Pediatrics, University of Vienna Children s Hospital, Vienna, Austria
Ann Neurol 57:557-60. 2005..The neurotoxic effects of guanidinoacetate may be partly responsible for the observed neurological phenotype... - The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetineGeorge I Papakostas
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Int J Neuropsychopharmacol 8:523-8. 2005..05). In conclusion, low serum folate levels were found to be associated with a delayed onset of clinical improvement during treatment with fluoxetine in MDD by, on average, 1.5 wk... - Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemiaAngela M Devlin
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
J Biol Chem 280:25506-11. 2005..05, r = 0.620). We conclude that hyperhomocysteinemia produces tissue-specific changes in H19 DMD methylation and increased vascular expression of H19 in adult mice... - Effect of hyperhomocysteinemia on protein C activation and activitySteven R Lentz
Department of Internal Medicine, Veterans Affairs Medical Center, C303 GH, University of Iowa, Iowa City, IA 52242, USA
Blood 100:2108-12. 2002..Our findings indicate that activation of protein C by thrombin and inactivation of plasma FVa by APC are not impaired during moderate hyperhomocysteinemia in vivo...
Research Grants
- Effect of S-adenosylmethionine on blood homocysteineTeodoro Bottiglieri; Fiscal Year: 2007..This study is important to better understand and assess the benefit to risk of SAMe supplementation. ..