Teodoro Bottiglieri

Summary

Affiliation: Baylor University Medical Center
Country: USA

Publications

  1. ncbi request reprint S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule
    Teodoro Bottiglieri
    Baylor University Medical Center, Institute of Metabolic Disease, Dallas, TX 75226, USA
    Am J Clin Nutr 76:1151S-7S. 2002
  2. ncbi request reprint Homocysteine and folate metabolism in depression
    Teodoro Bottiglieri
    Baylor University Medical Center, Institute of Metabolic Disease, Dallas, TX 75226, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1103-12. 2005
  3. doi request reprint Folate, vitamin B₁₂, and S-adenosylmethionine
    Teodoro Bottiglieri
    Institute of Metabolic Disease, Baylor Research Institute, Baylor University, 3812 Elm Street, Dallas, TX 75226, USA
    Psychiatr Clin North Am 36:1-13. 2013
  4. pmc Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain
    Teodoro Bottiglieri
    Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas 75226, USA
    J Neurosci 32:9173-81. 2012
  5. pmc Homocysteine levels in preterm infants: is there an association with intraventricular hemorrhage? A prospective cohort study
    Wendy J Sturtz
    Department of Neonatology, Christiana Care Health System, Newark, Delaware, USA
    BMC Pediatr 7:38. 2007
  6. ncbi request reprint Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: association is significant in men but not in women
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, 41900, Kocaeli, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 29:1113-23. 2005
  7. ncbi request reprint Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:2751-9. 2007
  8. pmc Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation
    Jean Marie Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Neurosci 28:11477-87. 2008
  9. ncbi request reprint Clinical course in Parkinson's disease with elevated homocysteine
    Padraig E O'Suilleabhain
    Department of Neurology, Southwestern Medical Center at Dallas, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9036, USA
    Parkinsonism Relat Disord 12:103-7. 2006
  10. ncbi request reprint Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations
    Padraig E O'Suilleabhain
    Department of Neurology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Arch Neurol 61:865-8. 2004

Research Grants

  1. Effect of S-adenosylmethionine on blood homocysteine
    Teodoro Bottiglieri; Fiscal Year: 2007

Detail Information

Publications46

  1. ncbi request reprint S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule
    Teodoro Bottiglieri
    Baylor University Medical Center, Institute of Metabolic Disease, Dallas, TX 75226, USA
    Am J Clin Nutr 76:1151S-7S. 2002
    ..This article provides an overview of the biochemical, molecular, and therapeutic effects of this pleiotrophic molecule...
  2. ncbi request reprint Homocysteine and folate metabolism in depression
    Teodoro Bottiglieri
    Baylor University Medical Center, Institute of Metabolic Disease, Dallas, TX 75226, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1103-12. 2005
    ..This review describes the biochemical, neurochemical and clinical correlations of folate deficiency and hyperhomocysteinemia in relation to depression...
  3. doi request reprint Folate, vitamin B₁₂, and S-adenosylmethionine
    Teodoro Bottiglieri
    Institute of Metabolic Disease, Baylor Research Institute, Baylor University, 3812 Elm Street, Dallas, TX 75226, USA
    Psychiatr Clin North Am 36:1-13. 2013
    ..This article reviews the metabolic and clinical importance of folate, vitamin B12, and SAMe, as well as clinical trials in relation to depression and dementia...
  4. pmc Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain
    Teodoro Bottiglieri
    Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas 75226, USA
    J Neurosci 32:9173-81. 2012
    ..These findings reveal a novel mechanism involving methylation-dependent pathways in L-dopa induces PP2A hypomethylation and increases Tau phosphorylation, which may be potentially detrimental to neuronal cells...
  5. pmc Homocysteine levels in preterm infants: is there an association with intraventricular hemorrhage? A prospective cohort study
    Wendy J Sturtz
    Department of Neonatology, Christiana Care Health System, Newark, Delaware, USA
    BMC Pediatr 7:38. 2007
    ....
  6. ncbi request reprint Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: association is significant in men but not in women
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, 41900, Kocaeli, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 29:1113-23. 2005
    ..In conclusion, the MTHFR 677T allele and T677T, C1298C genotypes, and T677T/A1298A, C677C/C1298C compound genotypes are genetic risk factors for schizophrenia in men but not in women in a gender-specific manner...
  7. ncbi request reprint Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:2751-9. 2007
    ..The link between homocysteine, PPMT, PP2A methylation, and key CNS proteins involved in AD pathogenesis provides new mechanistic insights into this disorder...
  8. pmc Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation
    Jean Marie Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Neurosci 28:11477-87. 2008
    ..Our results suggest that counteracting the neuronal loss of LCMT-1 and B(alpha) could be beneficial for all tauopathies and folate-dependent disorders of the CNS...
  9. ncbi request reprint Clinical course in Parkinson's disease with elevated homocysteine
    Padraig E O'Suilleabhain
    Department of Neurology, Southwestern Medical Center at Dallas, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9036, USA
    Parkinsonism Relat Disord 12:103-7. 2006
    ..03). We conclude that hyperhomocysteinemia does not predict significantly worse progression over 2 years in early PD. The data raised the possibility of higher mortality, but the number of deaths was small...
  10. ncbi request reprint Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations
    Padraig E O'Suilleabhain
    Department of Neurology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Arch Neurol 61:865-8. 2004
    ..An Hcy elevation is prevalent in patients with Parkinson disease (PD) in part because levodopa metabolism produces Hcy. The clinical relevance of an elevated Hcy level in patients with PD is unknown...
  11. ncbi request reprint Modest increase in plasma homocysteine follows levodopa initiation in Parkinson's disease
    Padraig E O'Suilleabhain
    Department of Neurology, University of Texas Southwestern Medical School, Dallas, Texas, USA
    Mov Disord 19:1403-8. 2004
    ..Levodopa elevates tHcy and lowers vitamin B12 concentration to modest degrees. The clinical implications, if any, have not yet been determined...
  12. doi request reprint Adult Polyglucosan Body Disease (APBD): Anaplerotic diet therapy (Triheptanoin) and demonstration of defective methylation pathways
    Charles R Roe
    Baylor Research Institute, Institute of Metabolic Disease, Baylor University Medical Center, Dallas, TX 75226, United States
    Mol Genet Metab 101:246-52. 2010
    ....
  13. pmc Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma
    Lesley M Butler
    Authors Affiliations Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute and Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California and Department of Epidemiology, Shanghai Cancer Institute, Shanghai, PR China
    Cancer Epidemiol Biomarkers Prev 22:1884-93. 2013
    ..Prospective studies in humans on circulating choline and other one-carbon metabolites and hepatocellular carcinoma risk have been lacking...
  14. ncbi request reprint Elevated prenatal homocysteine levels as a risk factor for schizophrenia
    Alan S Brown
    College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Arch Gen Psychiatry 64:31-9. 2007
    ....
  15. ncbi request reprint Folate, homocysteine, and negative symptoms in schizophrenia
    Donald C Goff
    Schizophrenia Program and Neurology Service, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 161:1705-8. 2004
    ....
  16. pmc Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase
    C Lee Elmore
    Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
    Mol Genet Metab 91:85-97. 2007
    ..The different metabolite profiles in the various genetic mouse models for hyperhomocyst(e)inemia may be useful in understanding biological effects of elevated homocyst(e)ine...
  17. ncbi request reprint Hyperhomocysteinemia and cognitive function: more than just a casual link?
    Teodoro Bottiglieri
    Am J Clin Nutr 82:493-4. 2005
  18. ncbi request reprint Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia
    Joshua L Roffman
    Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 63:42-8. 2008
    ..We examined whether the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C functional polymorphisms contribute to negative symptoms...
  19. pmc Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia
    Sanjana Dayal
    Dept of Internal Medicine, Univ of Iowa, C32 GH, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 295:H816-25. 2008
    ..Our findings demonstrate that hyperhomocysteinemia causes tissue-specific decreases in DDAH expression without altering plasma ADMA levels in mice with endothelial dysfunction...
  20. pmc High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
    Paul S Aisen
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
    JAMA 300:1774-83. 2008
    ..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline...
  21. ncbi request reprint Anger attacks in major depressive disorder and serum levels of homocysteine
    Renerio Fraguas
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 60:270-4. 2006
    ..Increased levels of homocysteine have been associated with anger and depression separately. We investigated the association of anger attacks in major depressive disorder (MDD) with serum levels of homocysteine...
  22. ncbi request reprint Effects of exercise on emerging and traditional cardiovascular risk factors
    Glen E Duncan
    Department of Epidemiology, Nutritional Sciences Program, University of Washington, Seattle, WA 98195, USA
    Prev Med 39:894-902. 2004
    ..insulin and aerobic fitness) are improved with exercise; however, few studies have addressed the potential for training to modify emerging cardiovascular disease risk factors such as homocysteine and high-sensitivity C-reactive protein...
  23. pmc Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia
    Sanjana Dayal
    Department of Internal Medicine, C32 GH, University of Iowa, Iowa City, IA 52242, USA
    Blood 108:2237-43. 2006
    ....
  24. ncbi request reprint Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice
    Katina M Wilson
    Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arterioscler Thromb Vasc Biol 27:233-40. 2007
    ..We tested the hypothesis that hyperhomocysteinemia and hypercholesterolemia promote arterial thrombosis in mice...
  25. pmc Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease
    Joseph J Locascio
    Massachusetts Alzheimer s Disease Research Center, Wang Ambulatory Care Center, Suite 720, Room 731 G, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Arch Neurol 65:776-85. 2008
    ....
  26. ncbi request reprint Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiency
    Paolo Moretti
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Autism Dev Disord 38:1170-7. 2008
    ..These findings demonstrate that autistic features are salient in CFD and suggest that a subset of children with developmental regression, mental retardation, seizures, dyskinesia, and autism may have CNS folate abnormalities...
  27. ncbi request reprint Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia
    Angela M Devlin
    Nutrition Research Program, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver V6H 3N1, Canada
    J Biol Chem 282:37082-90. 2007
    ..05), and lower Delta6-desaturase activity (p<0.001) in liver from mice with HHcy. These findings suggest that methylation silencing of liver Fads2 expression and changes in liver fatty acids may contribute to the pathology of HHcy...
  28. ncbi request reprint Cerebral vascular dysfunction in methionine synthase-deficient mice
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
    Circulation 112:737-44. 2005
    ..We tested the hypothesis that deficiency of MS impairs endothelial function in mice heterozygous for disruption of the Mtr gene, which encodes MS...
  29. ncbi request reprint The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr
    Pamela Tran
    Department of Human Genetics, McGill University Montreal Children s Hospital Research Institute, 4060 St Catherine St West, Room 200, QC, Canada
    Mol Genet Metab 76:297-304. 2002
    ....
  30. ncbi request reprint Role of S-adenosylmethionine in two experimental models of pancreatitis
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, Keck School of Medicine USC, Los Angeles, California 90033, USA
    FASEB J 17:56-8. 2003
    ..Third, in contrast to the situation in the liver, where absence of MAT1A and decreased hepatic SAM level can lead to spontaneous tissue injury, in the pancreas the roles of SAM and MAT1A appear more complex and remain to be defined...
  31. ncbi request reprint Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice
    Gary L Baumbach
    Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City, Iowa 52242, USA
    Circ Res 91:931-7. 2002
    ..These findings suggest that hyperhomocysteinemia promotes cerebral vascular hypertrophy and altered cerebral vascular mechanics, both of which may contribute to the increased incidence of stroke associated with hyperhomocysteinemia...
  32. ncbi request reprint Hyperhomocyst(e)inemia: a risk factor for cerebrovascular disease
    Lucilla Parnetti
    Neuroscience Department, University of Perugia, Italy
    Clin Exp Hypertens 24:501-9. 2002
    ..Further studies are needed, in order to better characterize the association between Hcy concentrations and risk of stroke...
  33. ncbi request reprint Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Arterioscler Thromb Vasc Biol 22:1996-2002. 2002
    ..We tested the hypothesis that deficiency of cellular glutathione peroxidase (GPx-1) enhances susceptibility to endothelial dysfunction in mice with moderate hyperhomocysteinemia...
  34. ncbi request reprint Potential for misdiagnosis due to lack of metabolic derangement in combined methylmalonic aciduria/hyperhomocysteinemia (cblC) in the neonate
    Cary O Harding
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 2998, USA
    J Perinatol 23:384-6. 2003
    ..In addition, this is the first documentation of cerebrospinal fluid hyperhomocysteinemia in cblC defect that was highly increased and is likely to be associated with neurotoxicity in cblC patients...
  35. ncbi request reprint GABA, gamma-hydroxybutyric acid, and neurological disease
    C Guin Ting Wong
    Institute of Medical Sciences, University of Toronto, Faculty of Medicine and Brain and Behavior Research Program, Hospital for Sick Children, Ontario, Canada
    Ann Neurol 54:S3-12. 2003
    ....
  36. ncbi request reprint Homocysteine and lipoprotein levels following resistance training in older adults
    Kevin R Vincent
    Department of Physical Medicine and Rehabilitaion, The University of Virginia, Charlottesville, VA 22908 1004, USA
    Prev Cardiol 6:197-203. 2003
    ..These data indicate that significant reductions in serum levels of homocysteine in the elderly can be derived from resistance exercise training...
  37. ncbi request reprint Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Blood 103:2624-9. 2004
    ..These findings demonstrate that the Mthfr(+/-) genotype sensitizes mice to diet-induced hyperhomocysteinemia and that hyperhomocysteinemia alters tissue methylation capacity and impairs endothelial function in cerebral microvessels...
  38. ncbi request reprint Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid
    Charles T Quinn
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Texas 75390 9063, USA
    J Pediatr Hematol Oncol 26:386-8. 2004
    ..No sulfur-containing excitatory amino acids were detected. This study demonstrates multiple profound effects of MTX on CNS metabolism and provides insight to the pathogenesis of MTX neurotoxicity...
  39. ncbi request reprint Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Stroke 35:1957-62. 2004
    ..We tested the hypothesis that chronic hyperhomocysteinemia in mice causes endothelial dysfunction in cerebral arterioles through a mechanism that involves superoxide...
  40. ncbi request reprint Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 65:1090-5. 2004
    ....
  41. ncbi request reprint Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 2: predictors of relapse during the continuation phase of pharmacotherapy
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 65:1096-8. 2004
    ....
  42. ncbi request reprint S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine
    Jonathan E Alpert
    Depression Clinical and Research Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:661-4. 2004
    ..The purpose of this open trial was to evaluate the safety, tolerability, and efficacy of oral S-adenosyl-L-methionine as an antidepressant adjunct among partial and nonresponders to serotonin reuptake inhibitors or venlafaxine...
  43. ncbi request reprint Creatine metabolism in combined methylmalonic aciduria and homocystinuria
    Olaf A Bodamer
    Unit of Biochemical Genetics, Department of Pediatrics, University of Vienna Children s Hospital, Vienna, Austria
    Ann Neurol 57:557-60. 2005
    ..The neurotoxic effects of guanidinoacetate may be partly responsible for the observed neurological phenotype...
  44. ncbi request reprint The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine
    George I Papakostas
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 8:523-8. 2005
    ..05). In conclusion, low serum folate levels were found to be associated with a delayed onset of clinical improvement during treatment with fluoxetine in MDD by, on average, 1.5 wk...
  45. ncbi request reprint Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 280:25506-11. 2005
    ..05, r = 0.620). We conclude that hyperhomocysteinemia produces tissue-specific changes in H19 DMD methylation and increased vascular expression of H19 in adult mice...
  46. ncbi request reprint Effect of hyperhomocysteinemia on protein C activation and activity
    Steven R Lentz
    Department of Internal Medicine, Veterans Affairs Medical Center, C303 GH, University of Iowa, Iowa City, IA 52242, USA
    Blood 100:2108-12. 2002
    ..Our findings indicate that activation of protein C by thrombin and inactivation of plasma FVa by APC are not impaired during moderate hyperhomocysteinemia in vivo...

Research Grants1

  1. Effect of S-adenosylmethionine on blood homocysteine
    Teodoro Bottiglieri; Fiscal Year: 2007
    ..This study is important to better understand and assess the benefit to risk of SAMe supplementation. ..