Juan BotasSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseasesJoana Branco
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Hum Mol Genet 17:376-90. 2008..Our results point to potential common therapeutic targets in novel pathways, and to genes and pathways responsible for differences between Ataxin-1 and Huntingtin-induced neurodegeneration...- Drosophila researchers focus on human diseaseJuan Botas
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
Nat Genet 39:589-91. 2007 - MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1Maria de Haro
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 15:2138-45. 2006..Perhaps more importantly, they also provide proof of the principle that CUG-induced muscle toxicity can be suppressed... 
Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasmEliana Romero
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 57:27-40. 2008..Thus, our data indicate that increased neurotransmission is at the root of neuronal degeneration caused by expanded full-length htt during early stages of pathogenesis...- RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTASOyinkan A Sofola
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Neuron 55:565-71. 2007..Furthermore, we show that hnRNP A2/B1 directly interacts with riboCGG repeats and that the CUGBP1 protein interacts with the riboCGG repeats via hnRNP A2/B1... - Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeatOyinkan A Sofola
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 16:2326-32. 2007..These data support the concept that RNA toxicity is the mechanism of neuronal toxicity and suggests potential reversal of RNA-mediated phenotypes with complementary RNA molecules... - Mouse and fly models of neurodegenerationHuda Y Zoghbi
Depts of Pediatrics, Neurology, and Molecular and Human Genetics, and Howard Hughes Medical Institute, Baylor College of Medicine, 77030, Houston, TX, USA
Trends Genet 18:463-71. 2002..In each case, we will stress what has been learned about the role of protein clearance and the questions that remain about how misfolded proteins acquire their toxicity... - CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradationIsmael Al-Ramahi
Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 281:26714-24. 2006..These data underscore the importance of the protein framework for modulating the effects of polyglutamine-induced neurodegeneration... - The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteinsHiroshi Tsuda
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 122:633-44. 2005..Interestingly, loss of Gfi-1 mimics SCA1 phenotypes in Purkinje cells. These results indicate that the Atx-1/Gfi-1 interaction contributes to the selective Purkinje cell degeneration in SCA1... - Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1Hung Kai Chen
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Cell 113:457-68. 2003..Our finding that phosphatidylinositol 3-kinase/Akt signaling and 14-3-3 cooperate to modulate the neurotoxicity of ataxin-1 provides insight into SCA1 pathogenesis and identifies potential targets for therapeutic intervention... - The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behaviorOyinkan Sofola
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 28:10200-5. 2008..Furthermore, we show genetic interactions between the corresponding genes indicating that dFMRP and LARK function together to regulate eye development and circadian behavior... 
Huntingtin interacting proteins are genetic modifiers of neurodegenerationLinda S Kaltenbach
Prolexys Pharmaceuticals, Salt Lake City, Utah, United States of America
PLoS Genet 3:e82. 2007..These studies demonstrate that high-throughput screening for protein interactions combined with genetic validation in a model organism is a powerful approach for identifying novel candidate modifiers of polyglutamine toxicity...- Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genomeCasey M Bergman
Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
Genome Biol 3:RESEARCH0086. 2002..Furthermore, this work shows how decoding the spatial organization of conserved sequences, such as the clustering of CNCSs, can complement efforts to annotate eukaryotic genomes on the basis of sequence conservation alone...
Research Grants
- Probing Neurodegeneration with DrosophilaJuan Botas; Fiscal Year: 2010..These basic studies are a prerequisite to developing therapies for these neurodegenerative disorders for which there are no effective treatments. ..
- A genetic analysis of Drosophila limb patterningJuan Botas; Fiscal Year: 2005..Many of these genes are implicated in human developmental malformations and in an increasing number of human diseases. These include different types of cancer, stroke and dementia. ..
- Neurodegeneration with DrosophilaJuan Botas; Fiscal Year: 2005..They will provide valuable targets for future pharmacological research aimed at developing drugs for therapy. ..
- Probing Neurodegeneration with DrosophilaJuan Botas; Fiscal Year: 2009..These basic studies are a prerequisite to developing therapies for these neurodegenerative disorders for which there are no effective treatments. ..
- STRUCTURE/FUNCTION STUDIES ON DROSOPHILA APTEROUSJuan Botas; Fiscal Year: 2000..no abstract available ..
- STRUCTURE/FUNCTION STUDIES ON DROSOPHILA APTEROUSJuan Botas; Fiscal Year: 2001..no abstract available ..