CLEMENT BOLAND

Summary

Affiliation: Baylor University Medical Center
Country: USA

Publications

  1. ncbi request reprint Posthumous presentation of the Julius M. Friedenwald medal to Jon I. Isenberg, M.D
    C Richard Boland
    Division of Gastroenterology, Baylor University Medical Center H 250, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Gastroenterology 126:1884-9. 2004
  2. pmc The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer
    Masanobu Takahashi
    Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e46684. 2012
  3. pmc Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Biol Direct 8:14. 2013
  4. pmc Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    BMC Cancer 10:303. 2010
  5. pmc The molecular biology of gastrointestinal cancer: implications for diagnosis and therapy
    C Richard Boland
    Baylor Research Institute and Department of Internal Medicine, Baylor University Medical Center H 250, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Gastrointest Endosc Clin N Am 18:401-13, vii. 2008
  6. pmc Promoter methylation in the genesis of gastrointestinal cancer
    CLEMENT RICHARD BOLAND
    Division of Gastroenterology, Department of Internal Medicine, Sammons Cancer Center, Baylor Research Institute, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Yonsei Med J 50:309-21. 2009
  7. pmc The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside
    C Richard Boland
    Department of Internal Medicine and Sammons Cancer Center, Baylor University Medical Center 250 Hoblitzelle, Dallas, TX 75246, USA
    Fam Cancer 7:41-52. 2008
  8. pmc Microsatellite instability in colorectal cancer
    C Richard Boland
    GI Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA
    Gastroenterology 138:2073-2087.e3. 2010
  9. ncbi request reprint Evolution of the nomenclature for the hereditary colorectal cancer syndromes
    C Richard Boland
    Division of Gastroenterology, Medical Center, Baylor University, 4 Hoblitzelle, 3500 Gaston Ave, Dallas, TX, 75246, USA
    Fam Cancer 4:211-8. 2005
  10. ncbi request reprint Somatic evolution of cancer cells
    C Richard Boland
    GI Cancer Research Laboratory, Baylor University Medical Center, H 250, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Semin Cancer Biol 15:436-50. 2005

Research Grants

  1. Familial and Early Onset Colorectal Cancer
    CLEMENT RICHARD BOLAND; Fiscal Year: 2010
  2. JC Virus and Tumor Formation in the Human Colon
    CLEMENT BOLAND; Fiscal Year: 2006
  3. The Biology and Diagnosis of HNPCC
    CLEMENT BOLAND; Fiscal Year: 2006
  4. JC Virus and Tumor Formation in the Human Colon
    CLEMENT BOLAND; Fiscal Year: 2007
  5. The Biology and Diagnosis of Hereditary Non-Polyposis Colorectal Cancer (HNPCC)
    CLEMENT BOLAND; Fiscal Year: 2007
  6. Familial and Early Onset Colorectal Cancer
    CLEMENT BOLAND; Fiscal Year: 2009
  7. The Biology and Diagnosis of HNPCC
    CLEMENT BOLAND; Fiscal Year: 2005
  8. JC Virus and Tumor Formation in the Human Colon
    CLEMENT BOLAND; Fiscal Year: 2005
  9. BIOLOGY AND DIAGNOSIS OF HNPCC
    CLEMENT BOLAND; Fiscal Year: 2004
  10. BIOLOGY AND DIAGNOSIS OF HNPCC
    CLEMENT BOLAND; Fiscal Year: 1999

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Posthumous presentation of the Julius M. Friedenwald medal to Jon I. Isenberg, M.D
    C Richard Boland
    Division of Gastroenterology, Baylor University Medical Center H 250, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Gastroenterology 126:1884-9. 2004
  2. pmc The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer
    Masanobu Takahashi
    Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e46684. 2012
    ..We aimed to determine whether expression status of certain miRNAs might have prognostic/predictive value in CRC patients treated with conventional cytotoxic chemotherapies...
  3. pmc Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Biol Direct 8:14. 2013
    ..Tumor cells with relatively high levels of CpG island methylation are considered CpG island methylator phenotypes (CIMP). The mechanisms that are responsible for regulating the activity of de novo methylation are not well understood...
  4. pmc Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability
    Masakazu Yashiro
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
    BMC Cancer 10:303. 2010
    ..In this study, early stage CRCs were examined for frameshift mutations in these target genes, and compared with late stage tumors and CRC cell lines...
  5. pmc The molecular biology of gastrointestinal cancer: implications for diagnosis and therapy
    C Richard Boland
    Baylor Research Institute and Department of Internal Medicine, Baylor University Medical Center H 250, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Gastrointest Endosc Clin N Am 18:401-13, vii. 2008
    ..This review summarizes the current understanding of the molecular pathogenesis of gastrointestinal neoplasia and provides explanations for some of the pathologic variability of lesions encountered by the endoscopist...
  6. pmc Promoter methylation in the genesis of gastrointestinal cancer
    CLEMENT RICHARD BOLAND
    Division of Gastroenterology, Department of Internal Medicine, Sammons Cancer Center, Baylor Research Institute, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Yonsei Med J 50:309-21. 2009
    ....
  7. pmc The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside
    C Richard Boland
    Department of Internal Medicine and Sammons Cancer Center, Baylor University Medical Center 250 Hoblitzelle, Dallas, TX 75246, USA
    Fam Cancer 7:41-52. 2008
    ....
  8. pmc Microsatellite instability in colorectal cancer
    C Richard Boland
    GI Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA
    Gastroenterology 138:2073-2087.e3. 2010
    ..Discovery of MSI in colorectal tumors has increased awareness of the diversity of colorectal cancers and implications for specialized management of patients...
  9. ncbi request reprint Evolution of the nomenclature for the hereditary colorectal cancer syndromes
    C Richard Boland
    Division of Gastroenterology, Medical Center, Baylor University, 4 Hoblitzelle, 3500 Gaston Ave, Dallas, TX, 75246, USA
    Fam Cancer 4:211-8. 2005
    ..The term 'Lynch syndrome' is proposed for the autosomal dominant disease caused by a germline mutation in a DNA MMR gene...
  10. ncbi request reprint Somatic evolution of cancer cells
    C Richard Boland
    GI Cancer Research Laboratory, Baylor University Medical Center, H 250, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Semin Cancer Biol 15:436-50. 2005
    ..Each of these processes is associated with a unique mutational or epigenetic "signature" identifiable in the tumor cells, and there are important conceptual and clinical implications of each...
  11. pmc Chronic inflammation, colorectal cancer and gene polymorphisms
    C Richard Boland
    Division of Gastroenterology, Baylor University Medical Center, GI Cancer Research Laboratory, Dallas, TX 75246, USA
    Dig Dis 28:590-5. 2010
    ..This represents an opportunity for informatics science to help personalize our approach to chronic inflammatory diseases of the gut and identify those at greatest risk for cancer...
  12. pmc Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency
    Ajay Goel
    Division of Gastroenterology, Department of Medicine, Baylor University, Medical Center, Dallas, Texas, USA
    Gastroenterology 138:1854-62. 2010
    ..The carcinogenic pathways and the best diagnostic approaches to detect microsatellite stable (MSS) HNPCC tumors are unclear. We investigated the contribution of epigenetic alterations to the development of MSS HNPCC tumors...
  13. pmc Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers
    Takeshi Nagasaka
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
    Cancer Res 70:3098-108. 2010
    ..High levels of aberrant methylation at CIMP-related markers in MSH2-methylated tumors raise the possibility that MSH2 is a target susceptible to aberrant methylation in Lynch syndrome...
  14. pmc Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer
    Takeshi Nagasaka
    Division of Gastroenterology, Department of Internal Medicine, and Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
    Gastroenterology 134:1950-60, 1960.e1. 2008
    ..Because BRAF and KRAS belong to same signaling pathway, we hypothesized that not only mutations in BRAF but mutant KRAS may also associate with CIMP in CRC...
  15. ncbi request reprint Evaluation and management of Lynch syndrome
    C Richard Boland
    Baylor University Medical Center, Dallas, TX 75246, USA
    Clin Adv Hematol Oncol 5:851,873. 2007
  16. ncbi request reprint Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells
    Lucia Fini
    GI Cancer Research Laboratory, Department of Internal Medicine, Sammons Cancer Center, Dallas, TX 75246, USA
    J Nutr 137:2622-8. 2007
    ..In conclusion, APE have potent demethylating activity through the inhibition of DNMT proteins. The lack of toxicity in Annurca extracts makes them excellent candidates for the chemoprevention of CRC...
  17. ncbi request reprint Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
    Gastroenterology 130:1950-61. 2006
    ..This study tests the hypothesis that JCV T-Ag expression correlates with one or more forms of genomic or epigenetic instability in sporadic CRCs...
  18. pmc Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis
    Francesc Balaguer
    Department of Internal Medicine, Division of Gastroenterology, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
    Cancer Res 70:6609-18. 2010
    ..Methylation silencing of miR-137 in colorectal adenomas suggests it to be an early event, which has prognostic and therapeutic implications...
  19. pmc Low frequency of Lynch syndrome among young patients with non-familial colorectal cancer
    Ajay Goel
    Department of Internal Medicine, Division of Gastroenterology, Charles A Sammons Cancer Center, and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas 75246, USA
    Clin Gastroenterol Hepatol 8:966-71. 2010
    ..We examined patterns of microsatellite instability (MSI) and MMR genes among patients <50 years old with non-familial CRC (patients with not more than 1 family member with CRC)...
  20. ncbi request reprint Chemoprevention goes gourmet: different flavors of NO-aspirin
    Ajay Goel
    Division of Gastroenterology, Department of Medicine, Baylor University Medical Center, Dallas, Texas, USA
    Mol Interv 5:207-10. 2005
  21. pmc An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e9393. 2010
    ..We tested a panel of five quasi-monomorphic mononucleotide repeat markers amplified in a single multiplex PCR reaction (pentaplex PCR) to detect MSI...
  22. ncbi request reprint Structure and function of the components of the human DNA mismatch repair system
    Thomas Jascur
    Department of Internal Medicine, Baylor Research Institute, Baylor University Medical Center, Dallas, TX 75246, USA
    Int J Cancer 119:2030-5. 2006
    ..Germline mutations in some of the DNA MMR genes cause the hereditary cancer predisposition, Lynch syndrome. This review addresses advances in the biochemistry of DNA MMR and its relationship to carcinogenesis...
  23. ncbi request reprint The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine and Baylor Charles A Sammons Cancer Center, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Gastroenterology 132:127-38. 2007
    ..The majority of MSS CRCs demonstrate chromosomal instability (CIN) with frequent loss of heterozygosity (LOH) at key tumor suppressor genes. We hypothesized that the majority of sporadic CRCs without CIN would be associated with CIMP...
  24. ncbi request reprint Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis
    Sang Heon Lee
    Division of Rheumatology, Allergy, and Immunology, Division of Gastroenterology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Immunol 170:2214-20. 2003
    ..We propose that oxidative stress not only creates DNA adducts that are potentially mutagenic, but also suppresses the mechanisms that limit the DNA damage...
  25. ncbi request reprint Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis
    Naoshi Nishida
    Department of Internal Medicine, Division of Gastroenterology, Sammons Cancer Center, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA
    Cancer Res 67:4586-94. 2007
    ..HCCs with extensive methylation harbor frequent beta-catenin mutations, whereas HCCs with high levels of CIN are associated with p53 mutations, suggesting the presence of two independent pathways for the pathogenesis of HCC...
  26. pmc Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    Naoshi Nishida
    Division of Gastroenterology, Department of Internal Medicine and Charles A Sammons Cancer Center, Dallas, TX, USA
    Hepatology 47:908-18. 2008
    ..However, the group 3 loci showed more dense and frequent methylation in HCV-positive cancers compared with both HBV-positive cancers and virus-negative cancers (P < 0.0001)...
  27. pmc JC virus infection in colorectal neoplasia that develops after liver transplantation
    Michael Selgrad
    Department of Internal Medicine, Baylor University Medical Center, Dallas, TX 75246, USA
    Clin Cancer Res 14:6717-21. 2008
    ..JCV encodes for TAg and has been implicated in colorectal carcinogenesis. We hypothesized that the use of immunosuppression in LTRs facilitates activation of JCV and is responsible for the increased risk of neoplasia...
  28. pmc JC virus mediates invasion and migration in colorectal metastasis
    Alexander Link
    Division of Gastroenterology, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e8146. 2009
    ..JCV large T-Ag (T-Ag) expressed in approximately half of all CRC's, however, its functional role in CRC is poorly understood. We hypothesized that JCV T-Ag may mediate metastasis in CRC cells through increased migration and invasion...
  29. ncbi request reprint High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers
    Naoshi Nishida
    Department of Internal Medicine, Division of Gastroenterology, Charles A Sammons Caner Center, Baylor University Medical Center, Dallas, Texas 75246, USA
    Cancer Biol Ther 6:525-33. 2007
    ..Our data confirm involvement in the CDC4-cyclin E pathway of the development of the CIN phenotype in human CRC, and find that amplification of the Aurora-A is a common target for disruption of this pathway...
  30. ncbi request reprint Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer
    Sung Kwan Shin
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA
    Gastroenterology 133:1849-57. 2007
    ..We hypothesized that UNC5C is silenced epigenetically in CRC, and that there are interactions between losses of UNC5C and DCC in colorectal tumorigenesis...
  31. ncbi request reprint Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines
    Lucia Fini
    Department of Internal Medicine, Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA
    Carcinogenesis 29:139-46. 2008
    ..The Mediterranean diet is rich in extra virgin olive oil (EVOO) and associated with a lower incidence of colorectal cancer. EVOO contains phenolic extracts with potential anticarcinogenic activity...
  32. ncbi request reprint Effects of low dose aspirin (81 mg) on proliferating cell nuclear antigen and Amaranthus caudatus labeling in normal-risk and high-risk human subjects for colorectal cancer
    Koyamangalath Krishnan
    Medical Service, James H Quillen Veterans Administration Medical Center and Division of Hematology Oncology, Department of Internal Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Cancer Detect Prev 28:107-13. 2004
    ..PCNA and ACA LIs are not useful as proliferation biomarkers for aspirin's chemopreventive activity in morphologically normal human colorectal mucosa...
  33. pmc Fecal MicroRNAs as novel biomarkers for colon cancer screening
    Alexander Link
    Gastrointestinal Cancer Research Laboratory, Baylor University Medical Center, Dallas, TX 75246, USA
    Cancer Epidemiol Biomarkers Prev 19:1766-74. 2010
    ..MicroRNAs (miRNA) play an important role in a wide array of biological processes and are commonly dysregulated in neoplasia. We aimed to evaluate the feasibility of fecal miRNAs as biomarkers for colorectal neoplasia screening...
  34. ncbi request reprint Lynch syndrome (hereditary non-polyposis colorectal cancer): current concepts and approaches to management
    Luigi Ricciardiello
    Gastrointestinal Cancer Research Laboratory, Department of Medicine, Division of Gastroenterology, Baylor University Medical Center, Dallas, TX 75246, USA
    Curr Gastroenterol Rep 7:412-20. 2005
    ..Specialists should be aware of the significance of inherited colon cancer and should become familiar with the molecular diagnostic tests now widely available...
  35. ncbi request reprint Oncogenic T-antigen of JC virus is present frequently in human gastric cancers
    Sung Kwan Shin
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75206, USA
    Cancer 107:481-8. 2006
    ..However, to date, no studies have determined whether JCV sequences are present specifically in gastric cancers. The current study was designed to investigate whether JCV sequences and expression are found in human gastric cancers...
  36. ncbi request reprint Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center and Baylor Research Institute, Dallas, Texas 75246, USA
    Cancer Biol Ther 5:529-35. 2006
    ..These results clearly suggest that selenomethionine exerts p53 dependent growth inhibitory effects in colon cancer cells by inducing G2/M cell cycle arrest as well as apoptosis...
  37. pmc Microsatellite instability among individuals of Hispanic origin with colorectal cancer
    Samir Gupta
    Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8887, USA
    Cancer 116:4965-72. 2010
    ....
  38. ncbi request reprint Surveillance of patients at high risk for colorectal cancer
    Sapna Syngal
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, MA, USA
    Med Clin North Am 89:61-84, vii-viii. 2005
    ..Available screening methods, recommended intervals, and screening for other associated cancers are reviewed for specific high-risk groups...
  39. pmc The role of viral and bacterial pathogens in gastrointestinal cancer
    Michael Selgrad
    Department of Internal Medicine, Gastroenterology, Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas 75246, USA
    J Cell Physiol 216:378-88. 2008
    ....
  40. pmc Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis
    Takeshi Nagasaka
    Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Int J Cancer 122:2429-36. 2008
    ..Our data suggest that MGMT methylation may evolve and spread throughout the promoter in a stepwise manner as the colonic epithelial cells progress through the classical-adenoma-cancer multistep cascade...

Research Grants21

  1. Familial and Early Onset Colorectal Cancer
    CLEMENT RICHARD BOLAND; Fiscal Year: 2010
    ..We also plan to test a strategy to correct epigenetic abnormalities that might be involved in the risk for early-onset cancer. ..
  2. JC Virus and Tumor Formation in the Human Colon
    CLEMENT BOLAND; Fiscal Year: 2006
    ..If this virus plays a mechanistic role in human carcinogenesis, this could lead to novel preventive and treatment strategies. ..
  3. The Biology and Diagnosis of HNPCC
    CLEMENT BOLAND; Fiscal Year: 2006
    ..abstract_text> ..
  4. JC Virus and Tumor Formation in the Human Colon
    CLEMENT BOLAND; Fiscal Year: 2007
    ..If this virus plays a mechanistic role in human carcinogenesis, this could lead to novel preventive and treatment strategies. ..
  5. The Biology and Diagnosis of Hereditary Non-Polyposis Colorectal Cancer (HNPCC)
    CLEMENT BOLAND; Fiscal Year: 2007
    ..abstract_text> ..
  6. Familial and Early Onset Colorectal Cancer
    CLEMENT BOLAND; Fiscal Year: 2009
    ..We also plan to test a strategy to correct epigenetic abnormalities that might be involved in the risk for early-onset cancer. ..
  7. The Biology and Diagnosis of HNPCC
    CLEMENT BOLAND; Fiscal Year: 2005
    ..abstract_text> ..
  8. JC Virus and Tumor Formation in the Human Colon
    CLEMENT BOLAND; Fiscal Year: 2005
    ..If this virus plays a mechanistic role in human carcinogenesis, this could lead to novel preventive and treatment strategies. ..
  9. BIOLOGY AND DIAGNOSIS OF HNPCC
    CLEMENT BOLAND; Fiscal Year: 2004
    ..abstract_text> ..
  10. BIOLOGY AND DIAGNOSIS OF HNPCC
    CLEMENT BOLAND; Fiscal Year: 1999
    ....
  11. BIOLOGY AND DIAGNOSIS OF HNPCC
    CLEMENT BOLAND; Fiscal Year: 2000
    ....
  12. BIOLOGY AND DIAGNOSIS OF HNPCC
    CLEMENT BOLAND; Fiscal Year: 2001
    ....
  13. BIOLOGY AND DIAGNOSIS OF HNPCC
    CLEMENT BOLAND; Fiscal Year: 2002
    ....
  14. BIOLOGY AND DIAGNOSIS OF HNPCC
    CLEMENT BOLAND; Fiscal Year: 2003
    ....
  15. JC Virus and Tumor Formation in the Human Colon
    CLEMENT BOLAND; Fiscal Year: 2004
    ..If this virus plays a mechanistic role in human carcinogenesis, this could lead to novel preventive and treatment strategies. ..
  16. JC Virus and Human Colorectal Neoplasia
    CLEMENT RICHARD BOLAND; Fiscal Year: 2010
    ..It is the long-term aim of this project to determine whether we should develop a vaccine that will prevent primary infection by JC virus, and prevent the occurrence of colorectal cancer. ..