Affiliation: Baylor University Medical Center
Boland C, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010;138:2073-2087.e3 pubmed publisher
..Discovery of MSI in colorectal tumors has increased awareness of the diversity of colorectal cancers and implications for specialized management of patients. ..
Boland C, Komarova N, Goel A. Chromosomal instability and cancer: not just one CINgle mechanism. Gut. 2009;58:163-4 pubmed publisher
Boland C. The molecular biology of gastrointestinal cancer: implications for diagnosis and therapy. Gastrointest Endosc Clin N Am. 2008;18:401-13, vii pubmed publisher
..This review summarizes the current understanding of the molecular pathogenesis of gastrointestinal neoplasia and provides explanations for some of the pathologic variability of lesions encountered by the endoscopist. ..
Boland C, Shike M. Report from the Jerusalem workshop on Lynch syndrome-hereditary nonpolyposis colorectal cancer. Gastroenterology. 2010;138:2197.e1-7 pubmed publisher
Koi M, Garcia M, Choi C, Kim H, Koike J, Hemmi H, et al
. Microsatellite Alterations With Allelic Loss at 9p24.2 SignifyÂ Less-Aggressive Colorectal Cancer Metastasis. Gastroenterology. 2016;150:944-55 pubmed publisher
..06; 95% CI: 0.01-0.57; PÂ = .01). E/L with 9p24-LOH appears to be a biomarker for less aggressive metastasis from stage III primary colorectal tumors. ..
Yashiro M, Hirakawa K, Boland C. Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability. BMC Cancer. 2010;10:303 pubmed publisher
..The frameshift mutations in these target genes might mediate progression from early to late stage cancer, rather than mediating the adenoma to carcinoma transition. ..
Boland C, Koi M, Chang D, Carethers J. The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside. Fam Cancer. 2008;7:41-52 pubmed