Research Topics
Genomes and Genes
| Michael R BlackburnSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstructionM R Blackburn
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston Medical School, Houston, Texas 77030, USA
J Exp Med 192:159-70. 2000..These data suggest that disturbances in purinergic signaling mediate the lung inflammation and damage seen in ADA-deficient mice...- Too much of a good thing: adenosine overload in adenosine-deaminase-deficient miceMichael R Blackburn
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
Trends Pharmacol Sci 24:66-70. 2003.... - A role for neural pathways in adenosine-induced bronchoconstrictionMichael R Blackburn
Department of Biochemistry and Molecular Biology, University of Texas-Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
Am J Physiol Lung Cell Mol Physiol 293:L22-4. 2007 - The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalitiesM R Blackburn
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 275:32114-21. 2000..This model will be useful in examining the efficacy of ADA enzyme therapy and studying the mechanisms underlying the immunodeficiency and pulmonary phenotypes associated with ADA deficiency... - Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient miceAmir Mohsenin
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, University of Texas, Houston, Texas 77030, USA
Am J Physiol Lung Cell Mol Physiol 293:L753-61. 2007..There were no compensatory changes in the other adenosine receptors in the lungs of ADA/A(2A)R double knockout mice. These findings suggest that the A(2A)R plays a protective role in the ADA-deficient model of pulmonary inflammation... - Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signalingJiaming Wen
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, 6431 Fannin St, MSB 6 200, Houston, TX 77030, USA
FASEB J 24:740-9. 2010..Dai, Y., Zhang, Y., Tang, Y., Sun, H., Mi, T., Phatarpekar, P. V., Kellems, R. E., Blackburn, M. R., Xia, Y. Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A(2B) adenosine receptor signaling... - Enhanced airway inflammation and remodeling in adenosine deaminase-deficient mice lacking the A2B adenosine receptorYang Zhou
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
J Immunol 182:8037-46. 2009..These findings support an important protective role for A(2B)R signaling during acute stages of lung disease... - Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signalingTiejuan Mi
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
J Clin Invest 118:1491-501. 2008..These findings provide insight regarding the molecular basis of priapism and suggest that strategies to either reduce adenosine or block A2BR activation may prove beneficial in the treatment of this disorder... - Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevationsJanci L Chunn
Dept of Biochemistry and Molecular Biology, Univ of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
Am J Physiol Lung Cell Mol Physiol 290:L579-87. 2006.... - Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injuryChun Xiao Sun
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston 77030, USA
J Clin Invest 116:2173-2182. 2006..Thus in chronic lung diseases associated with increased adenosine, antagonism of A2BAR-mediated responses may prove to be a beneficial therapy... - A3 adenosine receptor signaling influences pulmonary inflammation and fibrosisEva Morschl
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Medical School, Houston, Texas77030, USA
Am J Respir Cell Mol Biol 39:697-705. 2008..Together, these results suggest that the A(3)R serves antiinflammatory functions in the bleomycin model, and is also involved in regulating the production of mediators that can impact fibrosis... - Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosisYang Zhou
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas, United States of America
PLoS ONE 5:e9224. 2010..Changes include an up-regulation of CD73, the major enzyme of adenosine production and down-regulation of adenosine deaminase (ADA), the major enzyme for adenosine metabolism. In addition, adenosine receptors are elevated... - Detrimental effects of adenosine signaling in sickle cell diseaseYujin Zhang
Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas, USA
Nat Med 17:79-86. 2011..Thus, excessive adenosine signaling through the A(2B)R has a pathological role in SCD. These findings may provide new therapeutic possibilities for this disease... - Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapismJiaming Wen
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
J Sex Med 7:3011-22. 2010..Recent studies have revealed a novel role of excess adenosine in priapism caused by heightened cavernosal relaxation, and therefore present an intriguing mechanism-based therapeutic possibility... - Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary diseaseDaniel J Schneider
Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School, 6431 Fannin Blvd, Houston, TX 77030, USA
FASEB J 24:70-80. 2010..These results suggest that OPN represents a novel biomarker and therapeutic target for patients with COPD... - A2B adenosine receptor contributes to penile erection via PI3K/AKT signaling cascade-mediated eNOS activationJiaming Wen
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, 6431 Fannin St, MSB 6 200, Houston, TX 77030, USA
FASEB J 25:2823-30. 2011..These studies suggest that this signaling pathway may be a novel therapeutic target for erectile disorders... - Distinct roles for the A2B adenosine receptor in acute and chronic stages of bleomycin-induced lung injuryYang Zhou
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, TX 77030, USA
J Immunol 186:1097-106. 2011..p. bleomycin. These studies highlight the distinct roles of A(2B)R signaling during acute and chronic stages of lung injury... - A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challengeHays W J Young
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Medical School, 6431 Fannin, Houston, TX 77030, USA
Am J Respir Cell Mol Biol 35:549-58. 2006..Thus, the A(3)AR contributes to mucin secretion in allergen-induced metaplasia. Signaling through this receptor may contribute to mucus airway obstruction seen in pulmonary disorders in which adenosine levels are elevated... - Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injuryMesias Pedroza
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, Texas, United States of America
PLoS ONE 6:e22667. 2011..Based on these observations, we hypothesized that IL-6 signaling contributes to tissue destruction and remodeling in a model of chronic lung disease where adenosine levels are elevated... - A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injuryChun Xiao Sun
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston Medical School, Houston, Texas 77030, USA
J Clin Invest 115:35-43. 2005.... - Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient miceJanci L Chunn
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Medical School, Houston, TX 77030, USA
J Immunol 175:1937-46. 2005..These findings demonstrate that chronic adenosine elevations are associated with pulmonary fibrosis in ADA-deficient mice and suggest that the adenosine functions as a profibrotic signal in the lung... - Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiencyM R Blackburn
Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 273:5093-100. 1998..ADA-deficient mice also exhibited severe pulmonary insufficiency, bone abnormalities, and kidney pathogenesis. These mice have provided in vivo information into the metabolic basis for the immune phenotype associated with ADA deficiency... - A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient miceHays W J Young
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
J Immunol 173:1380-9. 2004..These findings identify an important role for the A(3)R in regulating lung eosinophilia and mucus production in an environment of elevated adenosine... - Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damageWeiru Zhang
Department of Biochemistry, University of Texas Houston Medical School, Houston, TX, USA
Hypertension 59:136-44. 2012..These findings immediately suggest that the IL-6 signaling is a novel therapeutic target to manage this devastating disorder affecting millions worldwide... - Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathwayMichael R Blackburn
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Texas, USA
J Clin Invest 112:332-44. 2003..They also demonstrate that IL-13 and adenosine stimulate one another in an amplification pathway that may contribute to the nature, severity, progression, and/or chronicity of IL-13 and/or Th2-mediated disorders... - Enhanced CXCL1 production and angiogenesis in adenosine-mediated lung diseaseAmir Mohsenin
Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School, Houston, TX 77030, USA
FASEB J 21:1026-36. 2007..Our findings suggest that adenosine plays an important role, via CXCL1, in the induction of pulmonary angiogenesis... - Osteopontin in systemic sclerosis and its role in dermal fibrosisMinghua Wu
Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston UTHSC H, Houston, Texas, USA
J Invest Dermatol 132:1605-14. 2012..Finally, TGF-β production by OPN-deficient macrophages was reduced compared with WT. These data demonstrate an important role for OPN in the development of dermal fibrosis and suggest that it may be a new therapeutic target in SSc... - Impaired germinal center maturation in adenosine deaminase deficiencyMelissa B Aldrich
Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TX 77030, USA
J Immunol 171:5562-70. 2003..The altered splenic environment and signaling abnormalities may concurrently contribute to a block in B cell Ag-dependent maturation in ADA-deficient mouse spleens... - Adenosine signaling in asthma and chronic obstructive pulmonary diseaseAmir Mohsenin
Department of Biochemistry and Molecular Biology, University of Texas - Houston Medical School, Houston, Texas 77030, USA
Curr Opin Pulm Med 12:54-9. 2006..Adenosine has been implicated in promoting the inflammation and airway remodeling seen in chronic lung disease and thus makes an attractive therapeutic target... - Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elementsHays W J Young
Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Respir Cell Mol Biol 37:273-90. 2007..In conclusion, Muc5ac expression is the central event in antigen-induced mucous metaplasia, and phylogenetically conserved 5' noncoding domains control its regulation... - The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung diseaseHarry Karmouty-Quintana
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, 6431 Fannin, Houston, TX 77030, USA
FASEB J 26:2546-57. 2012..These studies identify a novel mechanism of disease progression to pulmonary hypertension and support the development of A(2B)R antagonists for the treatment of pulmonary hypertension secondary to interstitial lung disease... - Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient miceWenbin Ma
Department of Immunology, Unit 902, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Houston, TX 77054, USA
Cell Res 21:1564-77. 2011.... - Adenosine signaling, priapism and novel therapiesYingbo Dai
University of Texas at Houston Medical School, Biochemistry and Molecular Biology, Houston, TX 77030, USA
J Sex Med 6:292-301. 2009..Adenosine is a signaling nucleoside that elicits many pathophysiological effects by engaging membrane receptors. Recent evidence shows that adenosine may play an important role in priapism via adenosine receptor... - A role of erythrocytes in adenosine monophosphate initiation of hypometabolism in mammalsIsadora Susan Daniels
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, TX 77030, USA
J Biol Chem 285:20716-23. 2010..In summary, our investigations reveal that 5'-AMP mediated hypometabolism is probably triggered by reduced oxygen transport by erythrocytes initiated by uptake of 5'-AMP... - Activation of murine lung mast cells by the adenosine A3 receptorHongyan Zhong
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
J Immunol 171:338-45. 2003..These results demonstrate that the A(3) adenosine receptor plays an important role in adenosine-mediated murine lung mast cell degranulation... - Abnormal alveolar development associated with elevated adenine nucleosidesSuman K Banerjee
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
Am J Respir Cell Mol Biol 30:38-50. 2004..These studies provide evidence that elevated lung adenosine can lead to abnormal alveogenesis by disrupting patterns of cell proliferation and apoptosis... - Coordinated changes in mRNA turnover, translation, and RNA processing bodies in bronchial epithelial cells following inflammatory stimulationYuxin Zhai
Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School, Houston, TX 77030, USA
Mol Cell Biol 28:7414-26. 2008..Our study reveals an orchestrated change among posttranscriptional mechanisms, which help sustain high levels of inflammatory mediator production in bronchial epithelium during the pathogenesis of inflammatory airway diseases... - Adenosine signaling and the regulation of chronic lung diseaseYang Zhou
Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School, 6431 Fannin St, Houston, Texas 77030, USA
Pharmacol Ther 123:105-16. 2009..This review discusses the current progress of research efforts and clinical trials aimed at understanding the complexities of these signaling pathway as they pertain to the development of treatment strategies for chronic lung diseases... - Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injuryJonathan B Volmer
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Medical School, Houston, 77030, USA
J Immunol 176:4449-58. 2006..Together, these findings suggest that CD73-dependent adenosine production contributes to anti-inflammatory pathways in bleomycin-induced lung injury... - Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthmaSergei I Ochkur
Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
J Immunol 178:7879-89. 2007..Genetic ablation of all eosinophils from this double transgenic model abolished the induced pulmonary pathologies, demonstrating that these pathologies are a consequence of one or more eosinophil effector functions... - Metabolic and immunologic consequences of limited adenosine deaminase expression in miceM R Blackburn
Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 271:15203-10. 1996..These mice represent the first genetic animal model for ADA deficiency and provide insight into the tissue-specific requirements of ADA... - Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient miceJ L Chunn
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston Medical School, Houston, TX 77030, USA
J Immunol 167:4676-85. 2001..Collectively, these findings suggest that elevations in adenosine can directly impact lung inflammation and physiology... - Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transitionDaniel J Schneider
1 Baylor College of Medicine, Department of Medicine, Section of Allergy, Immunology, and Rheumatology, Biology of Inflammation Center, One Baylor Plaza, Suite 672E, MS BCM285, Houston, TX 77030, USA
FASEB J 26:503-12. 2012..Schneider, D. J., Wu, M., Le, T. T., Cho, S.-H., Brenner, M. B., Blackburn, M. R., Agarwal, S. K. Cadherin-11 contributes to pulmonary fibrosis: potential role in TGFβ production and epithelial to mesenchymal transition... - A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6'-dimycolate induced granulomatous responseKerry J Welsh
Medical School, University of Texas Houston, Houston, TX 77030, USA
Microbiology 154:1813-24. 2008..These data suggest that TNF-alpha is critical for initiation of the granulomatous response, C5a is necessary for formation of cohesive granulomas, and IL-6 plays a key role in the granuloma maintenance response to mycobacterial TDM... - Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammationMichael R Blackburn
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX 77030 USA
Adv Immunol 86:1-41. 2005..Thus, the examination of ADA deficiency has identified the importance of purinergic signaling during lymphoid development and in the regulation of aspects of chronic lung disease... - Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient miceH Zhong
Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School, Houston, Texas 77030, USA
J Pharmacol Exp Ther 298:433-40. 2001.... - Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation developmentM R Blackburn
Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA
Development 124:3089-97. 1997..These experiments provide genetic evidence that Ada expression at the maternal-fetal interface is essential for early postimplantation development in mice... - Gene expression profiling in inflammatory airway disease associated with elevated adenosineSuman K Banerjee
Department of Biochemistry and Molecular Biology, University of Texas-Houston Medical School, Houston, Texas 77030, USA
Am J Physiol Lung Cell Mol Physiol 282:L169-82. 2002..These mice will serve as a useful in vivo model for characterizing molecular mechanisms of adenosine-mediated lung damage... - Certain surfactants show promise in the therapy of pulmonary tuberculosisJames K Stoops
UT Houston Medical School, 6431 Fannin St, Houston, TX 77030, USA
In Vivo 24:687-94. 2010..This protective barrier was removed by exposing the bacteria to certain surfactants... - Expression of capacitative calcium TrpC proteins in rat myometrium during pregnancyLidiya G Babich
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
Biol Reprod 70:919-24. 2004..These data suggest that rTrpC4 may play a major role in regulated Ca2+ entry in myometrial cells and throughout pregnancy but do not rule out contributions from other Trp proteins... - Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in miceM Wakamiya
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 92:3673-7. 1995..The results presented here demonstrate that ADA is important for the homeostatic maintenance of purines in mice... - Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in miceM R Blackburn
Verna and Mars McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 270:23891-4. 1995..Our findings suggest that placental ADA is important for murine fetal development and illustrate a general strategy for the tissue specific correction of phenotypes associated with null mutations in mice... - Diverse genetic regulatory motifs required for murine adenosine deaminase gene expression in the placentaD Shi
Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 272:2334-41. 1997..These findings indicate that multiple protein binding motifs are necessary for Ada expression in the placenta... - Constant darkness is a circadian metabolic signal in mammalsJianfa Zhang
Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA
Nature 439:340-3. 2006..Induction of mClps expression by 5'-AMP in LD mice was reciprocally linked to blood glucose levels. Our findings uncover a circadian metabolic rhythm in mammals... - Mucin is produced by clara cells in the proximal airways of antigen-challenged miceChristopher M Evans
Pulmonary Medicine, M D Anderson Cancer Center, 2121 West Holcombe Blvd, Houston, TX 77030, USA
Am J Respir Cell Mol Biol 31:382-94. 2004..Thus, Clara cells show great plasticity in structure and secretory products, yet have molecular and functional continuity in their identity as specialized apical secretory cells... - Adenosine receptors in regulation of dendritic cell differentiation and functionSergey V Novitskiy
Division of Hematology Oncology, Vanderbilt University, Nashville, TN 37232, USA
Blood 112:1822-31. 2008..Adenosine signaling through A(2B) receptor is an important factor of aberrant DC differentiation and generation of tolerogenic, angiogenic, and proinflammatory cells... - Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulationC Justin Van De Wiele
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
J Clin Invest 110:395-402. 2002..Our data are consistent with dATP-induced mitochondrial cytochrome c release followed by apoptosis as the mechanism by which ADA deficiency leads to reduced thymic T cell production... - Mechanisms of apoptosis in developing thymocytes as revealed by adenosine deaminase-deficient fetal thymic organ culturesLinda F Thompson
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE, 13th Street, Oklahoma City, OK 73104, USA
Biochem Pharmacol 66:1595-9. 2003..These data suggest that thymocyte apoptosis as a consequence of failing developmental checkpoints involves one or more caspases that are not regulated by Bcl-2... - Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ cultureC Justin Van De Wiele
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
J Immunol 176:5925-33. 2006..These data suggest that ADA deficiency leads to the induction of mitochondria-dependent apoptosis as a consequence of the accumulation of dATP derived from thymocytes failing the positive/negative selection checkpoint... - In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: a novel form of enzyme replacement therapy for ADA deficiencyDenise A Carbonaro
Division of Research Immunology/B.M.T, Childrens Hospital Los Angeles, California 90027, USA
Mol Ther 13:1110-20. 2006..These studies illustrate the potential for sustained in vivo production of enzymatically active ADA, as an alternative to therapy by frequent injection of exogenous ADA protein... - Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosineMelissa E Reichelt
Heart Foundation Research Centre, Griffith University, Southport, QLD 4217, Australia
Exp Physiol 92:175-85. 2007.... - Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse heartsLaura Willems
Heart Foundation Research Center, Griffith University, Southport, QLD 4217, Australia
Cardiovasc Res 71:79-87. 2006..Herein we assess effects of ADA (and A1AR) deficiency on AR-mediated responses and ischaemic tolerance... - Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issuesKevin J Ashton
Heart Foundation Research Centre, Griffith University Southport, QLD 4217, Australia
J Mol Cell Cardiol 42:693-705. 2007..However, some outcomes are both novel and controversial. This review outlines AR-modified murine models currently under study from the perspective of cardiovascular phenotype... - A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coliBalázs Csóka
Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Blood 110:2685-95. 2007..C/EBPbeta-deficient macrophages failed to produce IL-10 in response to adenosine and E coli. Our results suggest that the A(2A) receptor-C/EBPbeta axis is critical for IL-10 production after bacterial infection... - Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokinesSergey Ryzhov
Divisions of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Pharmacol Exp Ther 324:694-700. 2008.... - Neonatal bone marrow transplantation of ADA-deficient SCID mice results in immunologic reconstitution despite low levels of engraftment and an absence of selective donor T lymphoid expansionDenise A Carbonaro
Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital, Los Angeles, CA 90027, USA
Blood 111:5745-54. 2008..Thus, ADA-deficient SCID is unique in its responses to nonmyeloablative bone marrow transplantation, which has implications for clinical bone marrow transplantation or gene therapy... - CD73-generated adenosine restricts lymphocyte migration into draining lymph nodesMasahide Takedachi
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
J Immunol 180:6288-96. 2008..Adenosine receptor signaling to restrict lymphocyte migration across HEV may be an important mechanism to control the magnitude of an inflammatory response... - Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosinePatricia Fernandez
Department of Medicine, New York University School of Medicine, NewYork, New York 10016, USA
Am J Pathol 172:1675-82. 2008..These data confirm a fibrogenic role for adenosine in the skin and reveal A(2A) receptor antagonists as novel therapeutic agents for the modulation of dermal fibrotic disorders... - Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cellsSergey Ryzhov
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
J Immunol 180:7212-20. 2008..Thus, our study confirmed the proinflammatory role of adenosine signaling via A(2B) receptors and the anti-inflammatory actions of A(2B) antagonists in mouse BMMCs... - Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosisMichelle L Joachims
Department of Immunobiology and Cancer, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
Nucleosides Nucleotides Nucleic Acids 27:816-20. 2008..Thus, both deoxynucleoside kinases are involved in this model of ADA deficiency... - Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosisBing Ma
Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Clin Invest 116:1274-83. 2006..They also demonstrate that IL-4 has different effects on adenosine metabolism in Balb/c and C57BL/6 mice and that these differences contribute to the different responses that IL-4 induces in these inbred animals...
Research Grants
- Adenosine Signaling and Lung FibrosisMichael Blackburn; Fiscal Year: 2005..abstract_text> ..
- Molecular Models of Adenosine Signaling and AsthmaMichael Blackburn; Fiscal Year: 2007..These studies will lead to a better understanding of adenosine's impact on the severity of chronic lung diseases such as asthma and COPD, which will help guide the development of novel therapies for their treatment. ..
- Adenosine Signaling and Lung FibrosisMichael Blackburn; Fiscal Year: 2007..These experiments will help guide the development of novel therapeutic approaches to treat pulmonary disorders in which fibrosis is a component. ..
- ADENOSINE SIGNALING AND LUNG INFLAMMATIONMichael Blackburn; Fiscal Year: 2001..4. Evaluate acute and long-term changes of airway function in ADA deficient mice as well as ADA deficient mice exposed to environmental challenges. ..
- GENETIC MODEL FOR ASTHMA IN THE MOUSEMichael Blackburn; Fiscal Year: 2002..4. Identify and characterize the adenosine receptor subtypes involved in the inflammation and airway damage seen in ADA deficient mice. ..
- Adenosine Signaling and Lung FibrosisMichael R Blackburn; Fiscal Year: 2010..These experiments will help guide the development of novel therapeutic approaches to treat pulmonary disorders in which fibrosis is a component. ..