JACQUES F BANCHEREAU

Summary

Affiliation: Baylor University Medical Center
Country: USA

Publications

  1. ncbi request reprint Dendritic cells as melanoma vaccines
    J Banchereau
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Dev Biol (Basel) 116:147-56; discussion 179-86. 2004
  2. ncbi request reprint Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    Jacques Banchereau
    Baylor Institute for Immmunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    Immunity 25:383-92. 2006
  3. pmc Immunological intervention in human diseases
    Hideki Ueno
    Baylor Institute for Immunology Research and Baylor Research Institute, 3434 Live Oak St, Dallas, TX 75204, USA
    J Transl Med 5:59. 2007
  4. pmc Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
    Rungnapa Pankla
    Department of Clinical Immunology, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, 123 Mittraparp Road, Khon Kaen, 40002, Thailand
    Genome Biol 10:R127. 2009
  5. pmc Cross-priming of cyclin B1, MUC-1 and survivin-specific CD8+ T cells by dendritic cells loaded with killed allogeneic breast cancer cells
    Hiroaki Saito
    Baylor Institute for Immunology Research, Live Oak, Dallas, Texas 75024, USA
    Breast Cancer Res 8:R65. 2006
  6. pmc Dendritic cells loaded with killed breast cancer cells induce differentiation of tumor-specific cytotoxic T lymphocytes
    Eve Marie Neidhardt-Bérard
    Centre Leon Berard, Laboratoire de thérapie cellulaire et greffes hématopoiètiques, Lyon, France
    Breast Cancer Res 6:R322-8. 2004
  7. pmc Assessing the human immune system through blood transcriptomics
    Damien Chaussabel
    Baylor Institute for Immunology Research and Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA
    BMC Biol 8:84. 2010
  8. ncbi request reprint Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, TX, USA
    J Immunother 28:505-16. 2005
  9. pmc Harnessing human dendritic cell subsets to design novel vaccines
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Ann N Y Acad Sci 1174:24-32. 2009
  10. ncbi request reprint Dendritic cells as therapeutic vaccines against cancer
    Jacques Banchereau
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    Nat Rev Immunol 5:296-306. 2005

Research Grants

  1. Altered CD8+ T cell Compartment in SLE Patients
    Jacques Banchereau; Fiscal Year: 2007
  2. Human Dendritic Cells and In Vivo Immunity to Biothreat
    Jacques Banchereau; Fiscal Year: 2007
  3. SUBPOPULATIONS OF HUMAN DENDRITIC CELLS
    Jacques Banchereau; Fiscal Year: 2007
  4. Dendritic Cell Vaccine in Metastatic Prostate Cancer
    Jacques Banchereau; Fiscal Year: 2002
  5. SUBPOPULATIONS OF HUMAN DENDRITIC CELLS
    Jacques Banchereau; Fiscal Year: 2003
  6. Dendritic Cells, Heat Shock Proteins and Tumor Immunity
    Jacques Banchereau; Fiscal Year: 2004
  7. Altered CD8+ T cell Compartment in SLE Patients
    JACQUES F BANCHEREAU; Fiscal Year: 2010

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Dendritic cells as melanoma vaccines
    J Banchereau
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Dev Biol (Basel) 116:147-56; discussion 179-86. 2004
  2. ncbi request reprint Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    Jacques Banchereau
    Baylor Institute for Immmunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    Immunity 25:383-92. 2006
    ..Genetic alterations in lineages other than B cells might explain other autoimmune syndromes where type I IFNs appear to be involved...
  3. pmc Immunological intervention in human diseases
    Hideki Ueno
    Baylor Institute for Immunology Research and Baylor Research Institute, 3434 Live Oak St, Dallas, TX 75204, USA
    J Transl Med 5:59. 2007
    ..Considerable progress in the development of model systems and methodologies to monitor human immune responses will help to develop and to evaluate new immune-based therapies at pre-clinical and clinical studies...
  4. pmc Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
    Rungnapa Pankla
    Department of Clinical Immunology, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, 123 Mittraparp Road, Khon Kaen, 40002, Thailand
    Genome Biol 10:R127. 2009
    ..Septicemia is the most common presentation of the disease with a 40% mortality rate even with appropriate treatments. Better diagnostic tests are therefore needed to improve therapeutic efficacy and survival rates...
  5. pmc Cross-priming of cyclin B1, MUC-1 and survivin-specific CD8+ T cells by dendritic cells loaded with killed allogeneic breast cancer cells
    Hiroaki Saito
    Baylor Institute for Immunology Research, Live Oak, Dallas, Texas 75024, USA
    Breast Cancer Res 8:R65. 2006
    ..The ability of dendritic cells (DCs) to take up whole tumor cells and process their antigens for presentation to T cells ('cross-priming') is an important mechanism for induction of tumor specific immunity...
  6. pmc Dendritic cells loaded with killed breast cancer cells induce differentiation of tumor-specific cytotoxic T lymphocytes
    Eve Marie Neidhardt-Bérard
    Centre Leon Berard, Laboratoire de thérapie cellulaire et greffes hématopoiètiques, Lyon, France
    Breast Cancer Res 6:R322-8. 2004
    ....
  7. pmc Assessing the human immune system through blood transcriptomics
    Damien Chaussabel
    Baylor Institute for Immunology Research and Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA
    BMC Biol 8:84. 2010
    ..Recent technological and methodological advances that will carry the blood transcriptome research field forward are also discussed...
  8. ncbi request reprint Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, TX, USA
    J Immunother 28:505-16. 2005
    ..Overall, these results suggest that IFN-alpha-activated CD34-DCs are safe but elicit only limited immune responses, underscoring the need to test different DC maturation factors...
  9. pmc Harnessing human dendritic cell subsets to design novel vaccines
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Ann N Y Acad Sci 1174:24-32. 2009
    ..Recent findings on human DC subsets and their functional specialization have provided insights for the design of novel human vaccines...
  10. ncbi request reprint Dendritic cells as therapeutic vaccines against cancer
    Jacques Banchereau
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    Nat Rev Immunol 5:296-306. 2005
    ..A better understanding of how dendritic cells regulate immune responses will allow us to better exploit these cells to induce effective antitumour immunity...
  11. ncbi request reprint IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL
    Peter Dubsky
    Baylor Institute for Immunology Research, Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    Eur J Immunol 37:1678-90. 2007
    ..Therefore, membrane-bound IL-15 might contribute to enhanced priming by IL15-DC. Thus, IL-15 induces myeloid DC that are efficient in priming and maturation of melanoma antigen-specific CTL...
  12. ncbi request reprint Measuring melanoma-specific cytotoxic T lymphocytes elicited by dendritic cell vaccines with a tumor inhibition assay in vitro
    Sophie Paczesny
    Baylor Institute for Immunology Research, Baylor University Medical Center, Dallas, Texas 75204, USA
    J Immunother 28:148-57. 2005
    ..Thus, TIA might prove valuable for measuring spontaneous and induced antigen-specific cytotoxic T cells...
  13. pmc Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR
    Eynav Klechevsky
    Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA
    Blood 116:1685-97. 2010
    ..Thus, antigen targeting via the human DCIR receptor allows activation of specific CD8(+) T-cell immunity...
  14. ncbi request reprint Boosting vaccinations with peptide-pulsed CD34+ progenitor-derived dendritic cells can expand long-lived melanoma peptide-specific CD8+ T cells in patients with metastatic melanoma
    A Karolina Palucka
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    J Immunother 28:158-68. 2005
    ..In two patients boosted over 15 months, induced melanoma peptide-specific recall memory CD8+ T cells lasted at least 6 months. Thus, boosting vaccination with peptide-loaded CD34-DCs can expand long-lived tumor peptide-specific immunity...
  15. ncbi request reprint The long arm of the immune system
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, USA
    Sci Am 287:52-9. 2002
  16. pmc Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells
    Eynav Klechevsky
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:497-510. 2008
    ..Thus, the human skin displays three DC subsets, two of which, i.e., CD14(+) DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively...
  17. ncbi request reprint Both Langerhans cells and interstitial DC cross-present melanoma antigens and efficiently activate antigen-specific CTL
    Tinghua Cao
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Eur J Immunol 37:2657-67. 2007
    ..Thus, this study provides the rationale to use CD34-DC loaded with necrotic/apoptotic allogeneic melanoma cells in a clinical trial...
  18. pmc Influenza virus and poly(I:C) inhibit MHC class I-restricted presentation of cell-associated antigens derived from infected dead cells captured by human dendritic cells
    Davor Frleta
    Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, Texas 75204, USA
    J Immunol 182:2766-76. 2009
    ..Thus, DCs have a mechanism that prevents MHC class I-restricted cross-presentation of cell-associated Ag when they have captured dead infected cells...
  19. ncbi request reprint How dendritic cells and microbes interact to elicit or subvert protective immune responses
    Karolina Palucka
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Curr Opin Immunol 14:420-31. 2002
    ..Our progress in the understanding of DC physiology will hopefully help us create the necessary vaccines to counteract the infectious agents that still plague mankind...
  20. pmc Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I
    Tiziana Di Pucchio
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, Texas 75204, USA
    Nat Immunol 9:551-7. 2008
    ..Our data demonstrate that pDCs use 'ready-made' stores of MHC class I to rapidly present exogenous antigen to CD8+ T cells...
  21. ncbi request reprint Dendritic cells control B cell growth and differentiation
    Gaetan Jego
    Baylor Institute for Immunology Research and Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    Curr Dir Autoimmun 8:124-39. 2005
    ..It may also provide an explanation for spreading of the autoimmune repertoire as autoimmunity develops...
  22. pmc Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 38:1948-60. 2008
    ..In summary, the predominant impact of systemic IFN-alpha in this murine model is an exacerbation of mechanisms mediating end organ damage...
  23. pmc Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma
    Luis Vence
    Baylor Institute for Immunology Research and Baylor Research Institute, Baylor University, Dallas, TX 75204, USA
    Proc Natl Acad Sci U S A 104:20884-9. 2007
    ..Such tumor antigen-specific T regs were not detected in healthy individuals. These tumor antigen-specific T regs might thus represent another target for immunotherapy of metastatic melanoma...
  24. pmc Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines
    Chun I Yu
    Baylor National Institute of Allergy and Infectious Diseases NIAID Cooperative Center for Translational Research on Human Immunology, Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 112:3671-8. 2008
    ..This, in turn, will allow a new approach to the rational design and preclinical testing of vaccines that cannot be tested in human volunteers...
  25. pmc How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets
    Virginia Pascual
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunol Rev 223:39-59. 2008
    ..Finally, our pilot clinical trials using IL-1 blockers have shown remarkable clinical benefits in SoJIA patients refractory to other medications...
  26. pmc Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade
    Florence Allantaz
    Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    J Exp Med 204:2131-44. 2007
    ..Availability of early diagnostic markers may allow prompt initiation of therapy and prevention of disabilities...
  27. ncbi request reprint Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    Gaetan Jego
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
    Immunity 19:225-34. 2003
    ..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses...
  28. ncbi request reprint Dendritic cell subsets in health and disease
    Hideki Ueno
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Immunol Rev 219:118-42. 2007
    ..Alterations of the DC system result in diseases such as autoimmunity, allergy, and cancer. Conversely, DCs can be exploited for vaccination, and novel vaccines that directly target DCs in vivo are being designed...
  29. pmc Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines
    Eynav Klechevsky
    Baylor Institute for Immunology Research, Dallas, Texas, USA
    Hum Immunol 70:281-8. 2009
    ..The biologic raison d'être for separate DC subsets has been the focus of many studies including our own and is being reviewed with an emphasis on human skin DCs...
  30. pmc Microarray-based identification of novel biomarkers in IL-1-mediated diseases
    Florence Allantaz
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX, USA
    Curr Opin Immunol 19:623-32. 2007
    ..Blood gene expression profiling can be used to identify such biomarkers. This review will summarize recent studies in the field and will discuss some of the challenges raised by the use of this technology in biomarker discovery...
  31. ncbi request reprint Hyperthermia enhances CTL cross-priming
    Hongzhen Shi
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Immunol 176:2134-41. 2006
    ..Thus, heat treatment of tumor cells permits enhanced cross-priming, possibly via up-regulation of both HSPs and tumor Ag expression...
  32. ncbi request reprint Dendritic cells: controllers of the immune system and a new promise for immunotherapy
    Jacques Banchereau
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Novartis Found Symp 252:226-35; discussion 235-8, 257-67. 2003
    ..50% of SLE patients have high serum levels of IFNalpha, which could explain T/B lymphopenia. Yet, plasmacytoid DCs, a major IFNalpha source, are 80% decreased. pDCs and IFNalpha may play a role in SLE pathogenesis and therapy...
  33. pmc Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development
    Caroline Aspord
    Baylor Institute for Immunology Research and Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor University Medical Center, Dallas, TX 75204, USA
    J Exp Med 204:1037-47. 2007
    ..There, CD4(+) T cells promote early tumor development. This is dependent on DCs and can be partially prevented by administration of IL-13 antagonists. Thus, breast cancer targets DCs to facilitate its development...
  34. pmc Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors
    Bernard Piqueras
    Baylor NIAID National Institute of Allergy and Infectious Disease Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    Blood 107:2613-8. 2006
    ..Thus, human blood DC subsets carry a common program of CK production, which allows for a coordinated attraction of the different immune effectors in response to viral infection...
  35. pmc Expansion of melanoma-specific cytolytic CD8+ T cell precursors in patients with metastatic melanoma vaccinated with CD34+ progenitor-derived dendritic cells
    Sophie Paczesny
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 199:1503-11. 2004
    ..These results justify the design of larger follow-up studies to assess the immunological and clinical response to peptide-pulsed CD34-DC vaccines...
  36. ncbi request reprint Dendritic cells as vectors for immunotherapy of cancer
    Sophie Paczesny
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Semin Cancer Biol 13:439-47. 2003
    ....
  37. pmc Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12
    Nathalie Schmitt
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 31:158-69. 2009
    ..These data suggest that the developmental pathway of Tfh cells differs between mice and humans, which have considerable implications for vaccine development...
  38. pmc Gene expression patterns in blood leukocytes discriminate patients with acute infections
    Octavio Ramilo
    Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 109:2066-77. 2007
    ..Thus, microarray analyses of patient peripheral blood leukocytes might assist in the differential diagnosis of infectious diseases...
  39. pmc Building on dendritic cell subsets to improve cancer vaccines
    Karolina Palucka
    Baylor Institute for Immunology Research, Dallas, TX, USA
    Curr Opin Immunol 22:258-63. 2010
    ..The increased knowledge of the DC system, including the existence of distinct DC subsets is leading to new trials which aim at improved immune and clinical outcomes...
  40. pmc Designing vaccines based on biology of human dendritic cell subsets
    Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak Avenue, Dallas, TX 75204, USA
    Immunity 33:464-78. 2010
    ..In addition, we foresee that this increased knowledge will permit us to design vaccines that will reprogram the immune system to intervene therapeutically in cancer, allergy, and autoimmunity...
  41. pmc A genomic approach to human autoimmune diseases
    Virginia Pascual
    Baylor Institute for Immunology Research, INSERM U, Dallas, Texas 75204, USA
    Annu Rev Immunol 28:535-71. 2010
    ..We expect this to crystallize within the coming decade, as these methods become part of the personalized medicine armamentarium...
  42. pmc A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts
    Melissa Dullaers
    Baylor Institute for Immunology Research, Baylor Research Institute and INSERM 899, Dallas, TX 75204, USA
    Immunity 30:120-9. 2009
    ..This was supported by the presence of CCR10(+)IgA(+)PBs in tonsil GCs. These findings show that Tfh contribute to mucosal IgA. Thus, mucosal vaccines should aim to induce robust Tfh responses...
  43. doi request reprint Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function
    Hirofumi Noguchi
    Baylor All Saints Medical Center Baylor Institute for Immunology Research, Baylor Research Institute, Dallas Fort Worth, TX 75204, USA
    Hum Gene Ther 20:73-85. 2009
    ..These findings suggest that the JNK pathway is the major mediator of islet deterioration during/immediately after isolation and that JNK inhibition before islet isolation could improve outcomes after pancreatic islet transplantation...
  44. pmc Harnessing human dendritic cell subsets for medicine
    Hideki Ueno
    Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA
    Immunol Rev 234:199-212. 2010
    ..In this article, we summarize our recent studies aimed at a better understanding of the DC system to unravel the pathophysiology of human diseases and design novel human vaccines...
  45. pmc Harnessing dendritic cells to generate cancer vaccines
    Karolina Palucka
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Ann N Y Acad Sci 1174:88-98. 2009
    ....
  46. pmc Dendritic cells and humoral immunity in humans
    Hideki Ueno
    Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA
    Immunol Cell Biol 88:376-80. 2010
    ..We will also discuss the mechanisms whereby DCs induce CD4(+) T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability...
  47. pmc Dendritic cells: are they clinically relevant?
    Karolina Palucka
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Cancer J 16:318-24. 2010
    ....
  48. pmc CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions
    Toshimichi Matsui
    Baylor National Institute of Allergy and Infectious Diseases, Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    J Immunol 182:6815-23. 2009
    ..Thus, human blood pDCs are composed of subsets with specific phenotype and functions...
  49. pmc Differential recruitment of dendritic cells and monocytes to respiratory mucosal sites in children with influenza virus or respiratory syncytial virus infection
    Michelle A Gill
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Infect Dis 198:1667-76. 2008
    ..Although there are important differences in the immunopathogenesis of these 2 viral pathogens, little is known about how they affect antigen-presenting cells in children with acute infections...
  50. pmc Dendritic cells: a critical player in cancer therapy?
    Anna Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunother 31:793-805. 2008
    ....
  51. pmc Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    Lynda Bennett
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 197:711-23. 2003
    ..Therefore, while the IFN signature confirms the central role of this cytokine in SLE, microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis...
  52. ncbi request reprint Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitors
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Blood 102:3302-10. 2003
    ..Injection of influenza virus into reconstituted mice triggers IFN-alpha release and maturation of mDCs. Thus, these mice may provide a model to study the pathophysiology of human DC subsets...
  53. ncbi request reprint The central role of dendritic cells and interferon-alpha in SLE
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Curr Opin Rheumatol 15:548-56. 2003
    ..This review summarizes the recently uncovered role of dendritic cell subsets and one of their products, interferon-alpha, in the pathophysiology of systemic lupus erythematosus...
  54. ncbi request reprint Dendritic cell subsets generated from CD34+ hematopoietic progenitors can be transfected with mRNA and induce antigen-specific cytotoxic T cell responses
    Hideki Ueno
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunol Methods 285:171-80. 2004
    ..Thus, RNA can be used to deliver antigens to two distinct myeloid DC subsets in CD34-DC cultures...
  55. pmc Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 201:1479-86. 2005
    ..We conclude that IL-1 is a major mediator of the inflammatory cascade that underlies SoJIA and that this cytokine represents a target for therapy in this disease...
  56. ncbi request reprint Immunotherapy via dendritic cells
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Adv Exp Med Biol 560:105-14. 2005
    ..Indeed, what we learn from studying autoimmunity will help us induce strong vaccine specific immunity, either protective, as in the case of microbes, or therapeutic, as in the case of tumors...
  57. ncbi request reprint Spontaneous proliferation and type 2 cytokine secretion by CD4+T cells in patients with metastatic melanoma vaccinated with antigen-pulsed dendritic cells
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    J Clin Immunol 25:288-95. 2005
    ..The index of spontaneous proliferation correlates with antigen-specific PBMC proliferation to the vaccine antigen KLH. Furthermore, both spontaneous- and antigen-specific proliferation in PBMC cultures are dependent on blood myeloid DCs...
  58. ncbi request reprint Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells
    Joseph W Fay
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Cancer Immunol Immunother 55:1209-18. 2006
    ..The present results therefore justify the design of larger follow-up studies to assess the immunological and clinical outcomes in patients with metastatic melanoma vaccinated with peptide-pulsed CD34-derived DCs...
  59. ncbi request reprint Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8+ T-cell immunity
    Anna K Palucka
    Baylor Institute for Immunology Research, Sammons Cancer Center, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunother 29:545-57. 2006
    ..Thus, the present results justify the design of larger follow-up studies to assess the clinical response to DC vaccines loaded with killed allogeneic tumor cells in patients with metastatic melanoma...
  60. ncbi request reprint Systemic lupus erythematosus: all roads lead to type I interferons
    Virginia Pascual
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
    Curr Opin Immunol 18:676-82. 2006
    ..This novel information is leading to the development of IFN antagonists as a potential therapeutic intervention in SLE, thus bringing hope to SLE patients...
  61. ncbi request reprint Gene expression in peripheral blood mononuclear cells from children with diabetes
    Ellen C Kaizer
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 92:3705-11. 2007
    ....
  62. ncbi request reprint Taming cancer by inducing immunity via dendritic cells
    A Karolina Palucka
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX, USA
    Immunol Rev 220:129-50. 2007
    ..Therapeutic vaccination protocols will combine improved ex vivo DC vaccines with therapies that offset the suppressive environment established by tumors...
  63. ncbi request reprint Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytes
    Damien Chaussabel
    The Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
    Ann N Y Acad Sci 1062:146-54. 2005
    ..These findings bring new perspectives for the application of blood leukocyte expression signatures for diagnosis and early disease detection...
  64. pmc A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    Damien Chaussabel
    Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:150-64. 2008
    ..Thus, this work describes the implementation and application of a methodology designed to support systems-scale analysis of the human immune system in translational research settings...
  65. ncbi request reprint The interplay of dendritic cell subsets in systemic lupus erythematosus
    A Karolina Palucka
    Baylor Institute for Immunology Research and University of Texas Southwestern Medical Center, Dallas 75204, USA
    Immunol Cell Biol 80:484-8. 2002
    ..Thus, interplay between DC subsets might represent a key component of SLE pathogenesis...
  66. ncbi request reprint Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    J Immunother 26:432-9. 2003
    ..Thus, a single injection of CD34 HPC-derived DCs can lead to rapid immune response to CD4 epitopes or to melanoma antigens...

Research Grants24

  1. Altered CD8+ T cell Compartment in SLE Patients
    Jacques Banchereau; Fiscal Year: 2007
    ..These studies will help us conclude whether killer CD8+T cells and/or suppressor CD8+ T cells i) can be used as markers and/or predictors of disease activity, ii) represent a valuable new option in lupus therapy. ..
  2. Human Dendritic Cells and In Vivo Immunity to Biothreat
    Jacques Banchereau; Fiscal Year: 2007
    ..Rockefeller U., NIAID, U. of New Mexico and UT Southwestern. By harnessing human DC subsets in vivo we surmise that we will able to propose novel potent vaccines to protect humans against category A-C pathogens. ..
  3. SUBPOPULATIONS OF HUMAN DENDRITIC CELLS
    Jacques Banchereau; Fiscal Year: 2007
    ..This research, which focuses on the biology of human DC subsets has two important medical applications:1) better understanding of autoimmune diseases such as SLE; 2) the generation of more potent DC-based cancer vaccines. ..
  4. Dendritic Cell Vaccine in Metastatic Prostate Cancer
    Jacques Banchereau; Fiscal Year: 2002
    ..This study will permit us to establish the safety and tolerability of DCs loaded with killed allogeneic tumor cells as a source of TAA. It will also permit us to gain insights into the level of prostate cancer immunity induced by DCs. ..
  5. SUBPOPULATIONS OF HUMAN DENDRITIC CELLS
    Jacques Banchereau; Fiscal Year: 2003
    ..Addressing these questions will provide a better understanding of the DC system in the initiation of immune responses. These studies should also permit more effective use of DC for the immunotherapy of cancer and infectious diseases. ..
  6. Dendritic Cells, Heat Shock Proteins and Tumor Immunity
    Jacques Banchereau; Fiscal Year: 2004
    ..These studies will permit us to produce an altered melanoma cell line, with enhanced immunogenicity, that will be used to generate tumor cell bodies to load onto DCs for vaccination protocols. ..
  7. Altered CD8+ T cell Compartment in SLE Patients
    JACQUES F BANCHEREAU; Fiscal Year: 2010
    ..These studies will help us conclude whether killer CD8+T cells and/or suppressor CD8+ T cells i) can be used as markers and/or predictors of disease activity, ii) represent a valuable new option in lupus therapy. ..