Research Topics
Genomes and Genes | Ashok BalasubramanyamSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical TrialMelissa C Smart-Halajko
Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and UCL Medical School, London, UK
BMC Med Genet 12:89. 2011....
Developmental changes in expression of myotonic dystrophy protein kinase in the rat central nervous systemA Balasubramanyam
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Comp Neurol 394:309-25. 1998..The adult localizations suggest that DMPK may function in membrane trafficking and secretion within neurons associated with cognition, memory, and motor control...- Syndromes of ketosis-prone diabetes mellitusAshok Balasubramanyam
Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Room 700B, One Baylor Plaza, and Endocrine Service, Ben Taub General Hospital, Houston, Texas 77030, USA
Endocr Rev 29:292-302. 2008.... - Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in miceAshok Balasubramanyam
Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, BCM 700B, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Am J Physiol Endocrinol Metab 292:E40-8. 2007.... - New profiles of diabetic ketoacidosis: type 1 vs type 2 diabetes and the effect of ethnicityA Balasubramanyam
Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
Arch Intern Med 159:2317-22. 1999..We determined the "diabetic types," ethnic distributions, and phenotypes of patients with DKA in an urban hospital... - Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: a stable isotope studyRajagopal V Sekhar
Translational Metabolism Unit, Diabetes and Endocrinology Research Center, Baylor College of Medicine, Houston, TX 77030 2600, USA
Metabolism 60:754-60. 2011..Combining rosiglitazone with agents designed to blunt lipolysis could expand depleted peripheral adipose depots in patients with HIV lipodystrophy... - HLA class II alleles specify phenotypes of ketosis-prone diabetesRamaswami Nalini
Translational Metabolism Unit, Division of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA
Diabetes Care 31:1195-200. 2008..Genetic factors could contribute to their distinctive phenotypes. Our aim was to specify the role of HLA class II alleles associated with susceptibility or resistance to autoimmune type 1 diabetes in determining KPD phenotypes... - Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndromeJianjian Shi
Translational Metabolism Unit and the Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030-2600, USA
Am J Clin Nutr 84:204-11. 2006..3 mmol/L; P < 0.01). CONCLUSIONS: Physiologic GH replacement has salutary effects on abnormal lipid kinetics in HLS. The effects are mediated by diminished lipolysis and hepatic reesterification rather than by increased fat oxidation... - A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndromeWade C Haaland
Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA
Diabetes Care 32:873-7. 2009.... - Severely dysregulated disposal of postprandial triacylglycerols exacerbates hypertriacylglycerolemia in HIV lipodystrophy syndromeRajagopal V Sekhar
Translation Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030-2600, USA
Am J Clin Nutr 81:1405-10. 2005..05) 8 h after the meal. CONCLUSIONS: Patients with HLS have key defects that markedly impair postprandial disposal and storage of chylomicron-triacylglycerols. These defects contribute significantly to hypertriacylglycerolemia in HLS... - Association of amino-terminal-specific antiglutamate decarboxylase (GAD65) autoantibodies with beta-cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis-prone diabetes mellitusChristiane S Hampe
Robert H Williams Laboratory, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 92:462-7. 2007..The A+B- KPDM subgroup comprises patients with classic, autoimmune type 1 diabetes, whereas the A+B+ KPDM subgroup has only partial beta-cell loss and a distinct clinical phenotype... - Presence or absence of a known diabetic ketoacidosis precipitant defines distinct syndromes of "A-β+" ketosis-prone diabetes based on long-term β-cell function, human leukocyte antigen class II alleles, and sex predilectionRamaswami Nalini
Translational Metabolism Unit, Baylor College of Medicine, Houston, TX 77030, USA
Metabolism 59:1448-55. 2010..Unprovoked DKA predicts long-term β-cell functional reserve, insulin independence, and glycemic control in KPD... - Characteristics of ketosis-prone diabetes in a multiethnic indigent communityMario R Maldonado
Division of Endocrinology, Department of Medicine, Baylor College of Medicine Houston, Texas 77030, USA
Ethn Dis 14:243-9. 2004..To compare demographic and clinical characteristics among 3 ethnic groups of indigent patients exhibiting diabetic ketoacidosis (DKA), in Houston, Texas... - Re: A comparison of classification schemes for ketosis-prone diabetesRamaswami Nalini
Division of Diabetes, Endocrinology and Metabolism, N520 Alkek, One Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA
Nat Clin Pract Endocrinol Metab 3:E1. 2007 - Accuracy and predictive value of classification schemes for ketosis-prone diabetesAshok Balasubramanyam
Translational Metabolism Unit, Baylor College of Medicine, One Baylor Plaza, Room 520 N, Houston, TX 77030, USA
Diabetes Care 29:2575-9. 2006..972. CONCLUSIONS: The Abeta scheme has the highest accuracy and predictive value in classifying KPD patients with regard to clinical outcomes and pathophysiologic subtypes... - Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomesMario Maldonado
Division of Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Endocrinol Metab 88:5090-8. 2003..Novel, nonautoimmune causes of beta-cell dysfunction are likely to underlie the A-beta+ and A-beta- syndromes... - Combination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: results of "heart positive," a randomized, controlled trialAshok Balasubramanyam
Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Endocrinol Metab 96:2236-47. 2011..HIV patients on antiretroviral therapy (ART) have a unique dyslipidemia [elevated triglycerides and non-high-density lipoprotein-cholesterol (HDL-C), low HDL-C] with insulin resistance (characterized by hypoadiponectinemia)... - Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementationRajagopal V Sekhar
Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA
Am J Clin Nutr 94:847-53. 2011..Aging is associated with oxidative stress, but underlying mechanisms remain poorly understood... - Human monocytes accelerate proliferation and blunt differentiation of preadipocytes in association with suppression of C/EBPΑ mRNAJacob Couturier
Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, Texas, USA
Obesity (Silver Spring) 20:253-62. 2012..Additionally, the levels of both IL-6 and CXCL1 were highest when preadipocytes and monocytes were cultured together, compared to each cell in culture alone. Such cross-talk amplifies the production of mediators of tissue inflammation... - Presence of the metabolic syndrome distinguishes patients with ketosis-prone diabetes who have a Type 2 diabetic phenotypeMax E Otiniano
Division of Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
J Diabetes Complications 19:313-8. 2005.... - Dysregulation of glucose metabolism in HIV patients: epidemiology, mechanisms, and managementAbsalon D Gutierrez
Translational Metabolism Unit, Diabetes and Endocrinology Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, ABBR 607, One Baylor Plaza, Houston, TX 77030, USA
Endocrine 41:1-10. 2012..In this review, we have focused specifically on a comprehensive assessment of dysglycemia in the context of HIV infection and HAART... - Lipid lowering effects of statins and fibrates in the management of HIV dyslipidemias associated with antiretroviral therapy in HIV clinical practiceFehmida Visnegarwala
Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, TX 77009, USA
J Infect 49:283-90. 2004.... - Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programsDinakar Iyer
Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:4516-21. 2006..Hence, the phosphorylation status of serine-162 in the alphaI coil may constitute a novel switch that directs target gene expression into proliferation or differentiation programs... - Heart positive: design of a randomized controlled clinical trial of intensive lifestyle intervention, niacin and fenofibrate for HIV lipodystrophy/dyslipidemiaSusan L Samson
Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030, United States
Contemp Clin Trials 27:518-30. 2006.... - Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'Ashok Balasubramanyam
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Curr Opin Lipidol 15:59-67. 2004..Current evidence suggests that deranged energy storage in femoral-gluteal and other peripheral sites is important; the molecular details for the derangement are unknown but are under scrutiny by many investigators... - Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerabilityAbu R Vasudevan
Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA
Diabetes Technol Ther 6:850-63. 2004.... - HIV-associated lipodystrophy syndrome: an accelerated form of the metabolic syndrome of insulin resistance due to altered fat distributionAshok Balasubramanyam
Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, USA
Res Initiat Treat Action 12:5-11. 2006 - Regression of acanthosis nigricans correlates with disappearance of anti-insulin receptor autoantibodies and achievement of euglycemia in type B insulin resistance syndromeGilbert G Fareau
Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
Metabolism 56:670-5. 2007..We have documented, for the first time, regression of AN in temporal association with disappearance of circulating anti-insulin receptor autoantibodies and achievement of euglycemia in a patient with type B insulin resistance... - Short- and long-term effects of growth hormone (GH) replacement on protein metabolism in GH-deficient adultsJianjian Shi
Department of Medicine, Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Endocrinol Metab 88:5827-33. 2003..05). GH replacement in GHD acutely improves protein balance by stimulating synthesis and inhibiting catabolism. After 6 months, protein kinetics reached a new homeostasis to maintain the net gain in FFM... - Leptin replacement therapy does not improve the abnormal lipid kinetics of hypoleptinemic patients with HIV-associated lipodystrophy syndromeRajagopal V Sekhar
Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Diabetes and Endocrinology Research Center, USA
Metabolism 61:1395-403. 2012..Metreleptin does, however, improve glycemia and non-HDL-C in these patients. These results suggest a dissociation between leptin's effects on glucose metabolism compared to those on lipid kinetics in HADL... - Health outcomes beyond glucose controlAshok Balasubramanyam
Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, Texas, USA
Am J Manag Care 12:S382-91. 2006.... - Metabolic basis of HIV-lipodystrophy syndromeRajagopal V Sekhar
Section of Endocrinology and Department of Medicine, Children's Nutrition Research Center and US Department of Agriculture/Agricultural Research Service, Baylor College of Medicine, Houston 77030, USA
Am J Physiol Endocrinol Metab 283:E332-7. 2002..02). The lipoatrophy observed in HIV lipodystrophy is associated with accelerated lipolysis. Increased hepatic reesterification promotes the hypertriglyceridemia observed in this syndrome... - Treatment of dyslipidemia in HIV-infected patientsRajagopal V Sekhar
Translational Metabolism Unit, Diabetes and Endocrinology Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030 2600, USA
Expert Opin Pharmacother 11:1845-54. 2010..Patients infected with HIV are at high risk for dyslipidemia, insulin resistance and cardiovascular disease. Therapies to reverse these risks are complex, sometimes controversial, and not uniformly effective... - Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcriptionDinakar Iyer
Department of Medicine, Division of Endocrinology, Baylor College of Medicine, Houston, Texas 77030, USA
Biochemistry 42:7477-86. 2003..Phosphorylation of the MADS box may constitute a novel mechanism for regulation of SRF-dependent actin gene transcription... - Improved outcomes in indigent patients with ketosis-prone diabetes: effect of a dedicated diabetes treatment unitMario R Maldonado
Section of Endocrinology, Department of Medicine, Baylor College of Medicine, and Ben Taub General Hospital, Houston, Texas 77030-3498, USA
Endocr Pract 9:26-32. 2003.... - Cardiovascular implications of HIV-associated dyslipidemic lipodystrophyRajagopal V Sekhar
Division of Endocrinology, Baylor College of Medicine, 719E, One Baylor Plaza, Houston, TX 77030, USA
Curr Atheroscler Rep 6:173-9. 2004..In this article, we review HADL in terms of metabolic, molecular, and cytokine derangements leading to cardiovascular disease... - Rise of plasma ghrelin with weight loss is not sustained during weight maintenanceJose M Garcia
Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
Obesity (Silver Spring) 14:1716-23. 2006..Baseline ghrelin concentrations are related to the degree of WL that can be achieved by active weight reduction... - Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycineRajagopal V Sekhar
Translational Metabolism Unit, Baylor College of Medicine, Houston, Texas, USA
Diabetes Care 34:162-7. 2011.... - Novel syndromes of ketosis-prone diabetes: implications for management and medical economicsAshok Balasubramanyam
Endocrine Service, Ben Taub General Hospital, Baylor College of Medicine, Houston, USA
Manag Care 13:7-10; discussion 19-21. 2004 - Dysregulated energy expenditure in HIV-infected patients: a mechanistic reviewEvelyn Chang
Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
Clin Infect Dis 44:1509-17. 2007..Identifying unifying mechanisms will be an important step to finding effective treatments for HIV-related alterations in energy expenditure and to reversing metabolic risks in patients with HIV infection... - In vivo arginine production and intravascular nitric oxide synthesis in hypotensive sepsisSalvador Villalpando
US Department of Agriculture, Agricultural Research Service, Children's Nutrition Research Center, Department of Pediatrics, and Medical Services, Ben Taub General Hospital, Houston, TX, USA
Am J Clin Nutr 84:197-203. 2006..CONCLUSIONS: Patients with septic shock have a shortage in the availability of arginine associated with a slower production. Impaired renal excretion of NOx is a contributor to the high plasma NOx in these patients... - Fenofibrate is effective in treating hypertriglyceridemia associated with HIV lipodystrophyArchana Rao
Division of Endocrinology, Baylor College of Medicine, and Endocrine Service, Ben Taub General Hospital, Houston, Texas, USA
Am J Med Sci 327:315-8. 2004..05). Fenofibrate was well tolerated, and no subjects dropped out of the study. CONCLUSION: Fenofibrate is an effective, well-tolerated treatment for hypertriglyceridemia associated with HLS... - Developmental expression of serum response factor in the rat central nervous systemJanet L Stringer
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Brain Res Dev Brain Res 138:81-6. 2002..These data suggest that SRF has a significant function in the early post-natal development of the CNS... - Cardiovascular event prevention in the person with type 2 diabetes: case examples for identifying and treating multiple risksAshok Balasubramanyam
Baylor College of Medicine, One Baylor Plaza, Room 719E, Houston, TX 77030, USA
Diabetes Educ 32:163S-173S; quiz 174S-177S. 2006 - Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetesMaria J Redondo
Department of Pediatrics, Section of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
Pediatr Diabetes 13:564-71. 2012..To examine the relationship between BMI and beta-cell function at diagnosis of autoimmune type 1 diabetes (T1D) in a large group of ethnically diverse children... - Economic impact of diabetic ketoacidosis in a multiethnic indigent population: analysis of costs based on the precipitating causeMario R Maldonado
Division of Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Diabetes Care 26:1265-9. 2003..Diabetic ketoacidosis (DKA) is a common complication of diabetes. We analyzed the inpatient costs of treating DKA in a multiethnic, indigent population in Houston, Texas... - Ethnic differences in beta-cell functional reserve and clinical features in patients with ketosis-prone diabetesMario R Maldonado
Diabetes Care 26:2469. 2003 - Long-term, randomized clinical trial of two diets in the metabolic syndrome and type 2 diabetesLynne W Scott
Diabetes Care 26:2481-2. 2003
Research Grants
- Viral mechanisms of adipocyte dysfuntion: Role of Vpr.Ashok Balasubramanyam; Fiscal Year: 2009..The goal of this project is to determine how a protein made by the HIV virus, termed Vpr, can cause chronic inflammation of fat cells and lead to these disorders. ..
- Viral mechanisms of adipocyte dysfuntion: Role of Vpr.Ashok Balasubramanyam; Fiscal Year: 2010..The goal of this project is to determine how a protein made by the HIV virus, termed Vpr, can cause chronic inflammation of fat cells and lead to these disorders. ..
- Diet/Exercise, Niacin, Fenofibrate for HIV LipodystrophyAshok Balasubramanyam; Fiscal Year: 2007..Thus, this study will determine the efficacy of diet and exercise, with and without niacin and fenofibrate, in reducing the cardiovascular risk of patients with HIV lipodystrophy / dyslipidemia. ..
- Diet/Exercise, Niacin, Fenofibrate for HIV LipodystrophyAshok Balasubramanyam; Fiscal Year: 2007..Thus, this study will determine the efficacy of diet and exercise, with and without niacin and fenofibrate, in reducing the cardiovascular risk of patients with HIV lipodystrophy / dyslipidemia. ..
- MOLECULAR BASIS OF HIV LIPODYSTROPHY: ROLE OF VPRAshok Balasubramanyam; Fiscal Year: 2003....