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| Robert L AtmarSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
A nosocomial outbreak of norovirus infection masquerading as clostridium difficile infectionHoonmo L Koo
Baylor College of Medicine, University of Texas Houston School of Public Health, Houston, Texas, USA
Clin Infect Dis 48:e75-7. 2009..We describe here the unique challenges of the identification of NoVs as the true etiologic pathogen in an outbreak occurring in a health care setting, where C. difficile infection is endemic, as well as the important lessons learned...
A dose-response evaluation of inactivated influenza vaccine given intranasally and intramuscularly to healthy young adultsRobert L Atmar
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, United States
Vaccine 25:5367-73. 2007..Nasal IgA antibody responses were more common when vaccine was administered IN; and, when the IN dosage was increased, the primary benefit from IN vaccine over IM vaccine appeared to be greater induction of nasal secretory antibody...- Norwalk virus shedding after experimental human infectionRobert L Atmar
Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Emerg Infect Dis 14:1553-7. 2008..Understanding of the relevance of prolonged fecal norovirus excretion must await the development of sensitive methods to measure virus infectivity... - Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humansMargarita K Lay
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Virology 406:1-11. 2010..These results demonstrate that NV does not replicate in human CD11c(+) DCs, monocyte-derived DCs and MPhi, but abortive infection may occur in a few DCs. These results suggest that NV tropism is distinct from that of murine noroviruses... - Picornavirus, the most common respiratory virus causing infection among patients of all ages hospitalized with acute respiratory illnessRobert L Atmar
Viral Respiratory Pathogens Research Unit and the Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
J Clin Microbiol 50:506-8. 2012..The molecular assays doubled the number of infections identified; picornaviruses were the most frequent in patients of all ages, followed by respiratory syncytial virus and influenza viruses... - Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humansRobert B Couch
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM 280, Houston, TX, USA
Vaccine 27:5344-8. 2009..Thus, despite exhibiting a significant adjuvant effect in mice, interferon did not exhibit an adjuvant effect for induction of antibody in respiratory secretions of humans to inactivated influenza virus vaccine given intranasally... - Evaluation of age-related differences in the immunogenicity of a G9 H9N2 influenza vaccineRobert L Atmar
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Vaccine 29:8066-72. 2011..Persons born before 1968 were not more likely to respond to a G9 H9N2 influenza vaccine than persons born in 1970 or later... - A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjectsThomas R Cate
Baylor College of Medicine, One Baylor Plaza, MS BCM 280, Houston, TX 77030, United States
Vaccine 28:2076-9. 2010..Ensuring an increased antibody response to the NA antigen in inactivated influenza virus vaccines should increase the protection against influenza. An increased quantity of the NA antigen in the vaccine will ensure an increased response... - Serological responses to experimental Norwalk virus infection measured using a quantitative duplex time-resolved fluorescence immunoassayOwen Kavanagh
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Clin Vaccine Immunol 18:1187-90. 2011..The duplex assay showed superior performance by detecting seroconversion following experimental NV infection at an earlier time point than a reference total immunoglobulin enzyme-linked immunosorbent assay (ELISA)... - Norwalk virus RNA is infectious in mammalian cellsSusana Guix
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza BCM 385, Houston, TX 77030, USA
J Virol 81:12238-48. 2007.... - Noroviruses as a cause of diarrhea in travelers to Guatemala, India, and MexicoHoonmo L Koo
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Clin Microbiol 48:1673-6. 2010..Significant variation in the prevalence of NoV diarrhea and in the predominant genogroup infecting travelers was demonstrated, dependent upon the specific geographic location and over time... - Outcomes of treatment for hematogenous Staphylococcus aureus vertebral osteomyelitis in the MRSA ERADaniel J Livorsi
Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA
J Infect 57:128-31. 2008..aureus (MRSA) has complicated the treatment of this infection. Our objective was to evaluate therapeutic outcomes for S. aureus vertebral osteomyelitis in a setting of high MRSA prevalence... - Safety of high doses of influenza vaccine and effect on antibody responses in elderly personsWendy A Keitel
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Tex 77030, USA
Arch Intern Med 166:1121-7. 2006..Immune responses after influenza immunization are reduced in elderly individuals, the group at greatest risk for complications and death after influenza. Improved vaccines are needed to address this problem... - Serological correlate of protection against norovirus-induced gastroenteritisAmanda Reeck
Departments of Molecular Virology, Baylor College of Medicine, Houston, Texas, USA
J Infect Dis 202:1212-8. 2010..We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure... - Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virusRita Czakó
Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA
Clin Vaccine Immunol 19:284-7. 2012..02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease... - Sequential outbreaks of infections by distinct Acinetobacter baumannii strains in a public teaching hospital in Houston, TexasSamuel A Shelburne
Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Room 535E, 1 Baylor Plaza, Houston, TX 77030, USA
J Clin Microbiol 46:198-205. 2008..Taken together, we conclude that the outbreak of the A. calcoaceticus-A. baumannii complex in our institution was due to two distinct A. baumannii clones that were associated with significantly different patient outcomes... - Replication and packaging of Norwalk virus RNA in cultured mammalian cellsMiyuki Asanaka
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 102:10327-32. 2005..This work establishes a mammalian cell-based system for analysis of human norovirus replication and, thus, makes it feasible to investigate antiviral agents in mammalian cells... - Respiratory viral infections in patients with chronic, obstructive pulmonary diseaseJ David Beckham
Department of Medicine, Baylor College of Medicine and Ben Taub General Hospital, One Baylor Plaza, Houston, TX 77030, USA
J Infect 50:322-30. 2005..CONCLUSIONS: Respiratory viral infections are commonly associated with acute respiratory illness in COPD patients, and the use of RT-PCR assays significantly increases the ability to diagnose these infections... - A phase I evaluation of inactivated influenza A/H5N1 vaccine administered by the intradermal or the intramuscular routeShital M Patel
Baylor College of Medicine, Medicine Infectious Diseases, BCM MS 280, One Baylor Plaza, Houston, TX 77030, United States
Vaccine 28:3025-9. 2010..Higher dosages of H5 HA and/or inclusion of adjuvant will be required to enhance immunogenicity by the ID route... - Inactivated influenza vaccination for people with spinal cord injuryBarbara W Trautner
Department of Medicine Infectious Disease Section, Veterans Affairs Medical Center nd Baylor College of Medicine, Houston, TX 77030, USA
Arch Phys Med Rehabil 85:1886-9. 2004..To examine the antibody responses of people with spinal cord injury (SCI) to the commercially available trivalent influenza vaccine... - Increasing doses of an inactivated influenza A/H1N1 vaccine induce increasing levels of cross-reacting antibody to subsequent, antigenically different, variantsWendy A Keitel
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Infect Dis 198:1016-8. 2008..Increasing the influenza vaccine dosage safely and predictably enhanced antibody responses to the vaccine virus and to subsequent, antigenically different, influenza A/H1N1 variants... - Detection of human caliciviruses in fecal samples by rt-PCRRobert L Atmar
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Methods Mol Biol 665:39-50. 2011..This chapter describes methods for sample collection and processing of fecal specimens for molecular detection of enteric viruses, and it also describes both traditional and real-time RT-PCR assays for norovirus diagnosis... - Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to norovirusesTyler M Sharp
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA
Virol J 9:181. 2012..abstract:.. - Norovirus disease: changing epidemiology and host susceptibility factorsAnne M Hutson
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza BCM-385, Houston, TX 77030, USA
Trends Microbiol 12:279-87. 2004.... - Direct comparison of an inactivated subvirion influenza A virus subtype H5N1 vaccine administered by the intradermal and intramuscular routesShital M Patel
Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Infect Dis 206:1069-77. 2012..Direct comparisons of similar doses of a novel influenza virus antigen administered by the intradermal route and the intramuscular route have not been reported... - Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary diseaseManisha Singh
Department of Medicine, Division of Pulmonary and Critical Care, Baylor College of Medicine, Houston, Tex, USA
J Allergy Clin Immunol 125:1369-1378.e2. 2010..Acute exacerbation of COPD (AE-COPD) is commonly associated with upper and lower respiratory tract viral infections and can result in respiratory failure in those with advanced lung disease... - Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparationsRobert L Atmar
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Clin Infect Dis 43:1135-42. 2006..Influenza A/H9N2 viruses can infect humans and are considered to be a pandemic threat. Effective vaccines are needed for these and other avian influenza viruses... - Norwalk virus infection associates with secretor status genotyped from seraAnne M Hutson
Department of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
J Med Virol 77:116-20. 2005.... - Noroviruses everywhere: has something changed?Mary K Estes
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Curr Opin Infect Dis 19:467-74. 2006..This review summarizes new information about where and why these viruses are detected as well as new developments to prevent or treat these infections... - Influenza vaccine in patients with asthmaNicola A Hanania
Division of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Expert Rev Vaccines 5:111-8. 2006..In this review, the risk-versus-benefit of influenza vaccination in children and adults with asthma is evaluated, based on the current evidence... - Prior infections with seasonal influenza A/H1N1 virus reduced the illness severity and epidemic intensity of pandemic H1N1 influenza in healthy adultsRobert B Couch
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Infect Dis 54:311-7. 2012..A/H1N1 viruses had circulated in 1918-1957 and 1977-2009 and were in the annual vaccine during 1977-2009... - Adjuvants for pandemic influenza vaccinesRobert L Atmar
Department of Medicine, Baylor College of Medicine 280, One Baylor Plaza, Houston, TX 77030, USA
Curr Top Microbiol Immunol 333:323-44. 2009..A number of other adjuvants are under investigation to evaluate their ability to improve the immunogenicity of inactivated vaccines targeting influenza A/H5N1... - Increased fluoroquinolone resistance with time in Escherichia coli from >17,000 patients at a large county hospital as a function of culture site, age, sex, and locationLauren Becnel Boyd
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
BMC Infect Dis 8:4. 2008..In this study, we analyzed the effects of time, culture site, and patient age, sex, and location on fluoroquinolone resistance in E. coli clinical isolates... - Noroviruses: The leading cause of gastroenteritis worldwideHoonmo L Koo
Baylor College of Medicine, Houston, Texas, USA
Discov Med 10:61-70. 2010..However, vaccines based on norovirus capsid protein virus-like particles are promising and may one day become widely available through transgenic expression in plants... - Intanza(®): a new intradermal vaccine for seasonal influenzaRobert L Atmar
Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, MS BCM280, Houston, TX 77030, USA
Expert Rev Vaccines 9:1399-409. 2010..Intanza has more frequent injection-site reactions than intramuscularly delivered vaccine, but it is safe and well tolerated. Intanza provides a new option for the prevention of influenza... - Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigensAnne M Hutson
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 77:405-15. 2003..Overall, our results indicate that carbohydrate antigens in the gut are a previously unrecognized factor in NV pathogenesis... - The epidemiologic and clinical importance of norovirus infectionRobert L Atmar
Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, MS BCM280, Houston, TX 77030, USA
Gastroenterol Clin North Am 35:275-90, viii. 2006..This article reviews the epidemiology, clinical manifestations and pathogenesis of norovirus infection, and it describes the diagnostic and therapeutic approaches to this disease... - Norwalk virus infection and disease is associated with ABO histo-blood group typeAnne M Hutson
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Infect Dis 185:1335-7. 2002..096; 95% CI, 0.16-0.56) and symptomatic disease (OR, 0; 95% CI, 0-0.999). This is the first report demonstrating an association between a genetic factor and the risk of NV infection and symptomatic disease... - Immunopathogenesis of respiratory syncytial virus bronchiolitisBerkeley L Bennett
Department of Pediatrics, Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Infect Dis 195:1532-40. 2007..The objective of this study was to elucidate the relation between respiratory syncytial virus (RSV) infection and cytokine/chemokine concentrations, as well as the impact that these factors have on the severity of bronchiolitis... - Immune response to influenza vaccination in children and adults with asthma: effect of corticosteroid therapyNicola A Hanania
Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
J Allergy Clin Immunol 113:717-24. 2004..However, the effect of maintenance corticosteroid therapy on the immune response to influenza vaccine has received limited evaluation... - Vaccines for pandemic influenza: summary of recent clinical trialsWendy A Keitel
Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, 280 One Baylor Plaza, Houston, TX 77030, USA
Curr Top Microbiol Immunol 333:431-51. 2009..The results of these and future trials will help to identify formulations and immunization regimens for various populations, and will better prepare us to address the threat of both pandemic and interpandemic influenza... - Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitisNaval G Daver
Infectious Disease Section, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
J Infect 54:539-44. 2007..We hypothesized that regimens with an early switch to oral antibiotics are as effective as prolonged parenteral regimens for staphylococcal osteomyelitis... - Structural analysis of histo-blood group antigen binding specificity in a norovirus GII.4 epidemic variant: implications for epochal evolutionSreejesh Shanker
Verna Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Virol 85:8635-45. 2011.... - Reducing the dose of smallpox vaccine reduces vaccine-associated morbidity without reducing vaccination success rates or immune responsesRobert B Couch
Baylor College of Medicine, Houston, TX, 77030, USA
J Infect Dis 195:826-32. 2007..later identified approximately 85 million additional doses in storage... - Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodiesPedro A Piedra
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Rm 248E, One Baylor Plaza, Houston, TX, USA
Vaccine 21:3479-82. 2003..To determine if respiratory syncytial virus (RSV) specific, serum antibody titers correlate with protection against RSV associated-hospitalization at all ages... - Preparing for a possible pandemic: influenza A/H5N1 vaccine developmentWendy A Keitel
Baylor College of Medicine, Room 221D, One Baylor Plaza, BCM 280, Houston, TX 77030, United States
Curr Opin Pharmacol 7:484-90. 2007..Whether or not a pandemic spread of the A/H5N1 virus occurs, lessons learned as a result of these activities will better prepare us for future pandemics, as well as for interpandemic influenza... - Stem cell-derived human intestinal organoids as an infection model for rotavirusesStacy R Finkbeiner
Department of Molecular Virology, Baylor College of Medicine, Houston, Texas, USA
MBio 3:e00159-12. 2012.... - Bacteraemia in the elderly: predictors of outcome in an urban teaching hospitalBenjamin M Greenberg
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
J Infect 50:288-95. 2005..Physiologic abnormalities on admission predict worse outcomes in the elderly bacteraemic patient. Hypoalbuminemia on admission is associated with higher mortality rates in the elderly... - Infections in Hispanic immigrantsA Clinton White Jr
Infectious Disease Section, Department of Medicine, Baylor College of Medicine and Ben Taub General Hospital, Houston, TX, 77030, USA
Clin Infect Dis 34:1627-32. 2002..When included in the differential diagnosis, most of these infections can be readily diagnosed and treated with currently available methods... - The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapySamuel A Shelburne
Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA
Clin Infect Dis 40:1049-52. 2005..Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis... - Infectious exacerbations of chronic obstructive pulmonary disease associated with respiratory viruses and non-typeable Haemophilus influenzaeVenkata Bandi
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA
FEMS Immunol Med Microbiol 37:69-75. 2003..The results show that exacerbations in adults with COPD were associated with infection caused by virus alone, non-typeable H. influenzae alone, or virus and non-typeable H. influenzae simultaneously... - Recovery of drug-resistant influenza virus from immunocompromised patients: a case seriesMichael G Ison
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
J Infect Dis 193:760-4. 2006..We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir... - Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapySamuel A Shelburne
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Medicine (Baltimore) 81:213-27. 2002 - Clinical responses to undiluted and diluted smallpox vaccineSharon E Frey
Department of Medicine, National Institute of Allergy and Infectious Diseases Vaccine and Treatment Evaluation Unit, Saint Louis University School of Medicine, St. Louis, USA
N Engl J Med 346:1265-74. 2002..0) pfu per milliliter (approximately 10,000 pfu per dose) and induce local viral replication and vesicle formation in more than 97 percent of persons... - Norwalk virus-specific binding to oyster digestive tissuesFrançoise Le Guyader
Laboratoire de Microbiologie, Institut Francais de Recherche pour l Exploitation de la Mer, Nantes, France
Emerg Infect Dis 12:931-6. 2006..These data show that the oyster can selectively concentrate a human pathogen and that conventional depuration will not eliminate noroviruses from oyster tissue... - Uncommon(ly considered) manifestations of infection with rhinovirus, agent of the common coldRobert L Atmar
Clin Infect Dis 41:266-7. 2005 - Widespread outbreak of norovirus gastroenteritis among evacuees of Hurricane Katrina residing in a large "megashelter" in Houston, Texas: lessons learned for preventionEileen L Yee
Centers for Disease Control and Prevention, Coordinating Center for Infectious Diseases, Div of Viral Diseases, Atlanta, GA 30333, USA
Clin Infect Dis 44:1032-9. 2007.... - Laboratory efforts to cultivate norovirusesErwin Duizer
National Institutes for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
J Gen Virol 85:79-87. 2004..Thus, attempts to develop a method for the cultivation of NoV were unsuccessful... - A semiquantitative approach to estimate Norwalk-like virus contamination of oysters implicated in an outbreakFrancoise S Le Guyader
Laboratoire de Microbiologie, IFREMER, BP 21105, 44311 Nantes Cedex 03, France
Int J Food Microbiol 87:107-12. 2003..This finding is useful in beginning to understand shellfish contamination and depuration for use in future hazard analyses... - Practical and sensitive screening strategy for detection of influenza virusDuane W Newton
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14607, USA
J Clin Microbiol 40:4353-6. 2002..This abbreviated protocol was a useful and effective tool and resulted in a substantial reduction in time, effort, and money spent, while not compromising sensitivity of influenza virus detection... - Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary diseaseYusheng Qiu
Lung Pathology, Department of Gene Therapy, Imperial College, Royal Brompton Hospital, London, United Kingdom
Am J Respir Crit Care Med 168:968-75. 2003..Thus, in COPD, in addition to CXCL8 and CXCR1, CXCL5 and CXCR2 appear to play important roles in the airway neutrophilia characteristic of severe exacerbations...