Research Topics
Genomes and Genes
| Shervin AssassiSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in systemic sclerosisShervin Assassi
Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, TX 77030, USA
Am J Med 118:907-11. 2005
Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohortShervin Assassi
Division of Rheumatology and Clinical Immunogenetics, University of Texas Houston, 6431 Fannin, Houston, TX 77030, USA
Arthritis Res Ther 12:R166. 2010....
Clinical and genetic factors predictive of mortality in early systemic sclerosisShervin Assassi
University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Arthritis Rheum 61:1403-11. 2009..To investigate the clinical and genetic variables at initial presentation that predict survival in the Genetics versus Environment in Scleroderma Outcome Study (GENISOS) cohort...
Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5Shervin Assassi
Department of Medicine, Division of Rheumatology, University of Texas Health Science Center, Houston, TX 77030, USA
J Rheumatol 38:87-98. 2011..to identify differentially expressed genes in peripheral blood cells (PBC) of patients with ankylosing spondylitis (AS) relative to healthy controls and controls with systemic inflammation...
Primary biliary cirrhosis (PBC), PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patientsShervin Assassi
The University of Texas Health Science Center at Houston, 6431 Fannin, MSB 5 232, Houston, TX 77030, USA
J Rheumatol 36:2250-6. 2009..Further, to assess the association of SSc-related antibodies with hepatic parameter abnormalities...
Clinical, immunologic, and genetic features of familial systemic sclerosisShervin Assassi
University of Texas Health Science Center, Houston, TX 77030, USA
Arthritis Rheum 56:2031-7. 2007....
Predictors of fatigue severity in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohortShervin Assassi
Department of Medicine, Division of Rheumatology, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
PLoS ONE 6:e26061. 2011..We also examined baseline predictors of change in fatigue severity over time...
Genetics of scleroderma: update on single nucleotide polymorphism analysis and microarraysShervin Assassi
Division of Rheumatology, Department of Internal Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
Curr Opin Rheumatol 17:761-7. 2005..The purpose of this review is to summarize the results of genetic association and gene expression profiling studies from January 2004 to May 2005...
Systemic sclerosis and lupus: points in an interferon-mediated continuumShervin Assassi
University of Texas Health Science Center, Houston, TX, USA
Arthritis Rheum 62:589-98. 2010..To investigate peripheral blood (PB) cell transcript profiles of systemic sclerosis (SSc) and its subtypes in direct comparison with systemic lupus erythematosus (SLE)...
Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosisSandeep K Agarwal
Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, Texas 77030, USA
J Rheumatol 36:2715-23. 2009..We investigated the possible association of IL23R with systemic sclerosis (SSc), an autoimmune disease that leads to the development of cutaneous and visceral fibrosis...
Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populationsPravitt Gourh
Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston UTHSC H, Houston, TX 77030, USA
J Autoimmun 34:155-62. 2010..The current report sought to determine if polymorphisms in the C8orf13-BLK region (chromosome 8p23.1-B lymphoid tyrosine kinase), which is associated with SLE, are associated also with SSc...
Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokinesPravitt Gourh
University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Arthritis Rheum 60:3794-806. 2009....
Psychological correlates of self-reported disease activity in ankylosing spondylitisTamar F Brionez
Department of Medicine, Division of Rheumatology, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
J Rheumatol 37:829-34. 2010..To investigate the role of psychological variables in self-reported disease activity in patients with ankylosing spondylitis (AS), while controlling for demographic and medical variables...
Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosisPravitt Gourh
University of Texas Health Science Center at Houston, TX 77030, USA
Arthritis Rheum 54:3945-53. 2006....
Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosisPravitt Gourh
Division of Rheumatology and Clinical Immunogenetics, MSB 5 278, Houston, Texas 77030, USA
Ann Rheum Dis 69:550-5. 2010..Accordingly, the aim of the current study was to investigate the possible association of the TNFSF4 gene region with systemic sclerosis (SSc), an autoimmune disease that leads to the development of cutaneous and visceral fibrosis...
Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestationsPravitt Gourh
Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin M S B 5 278, Houston, TX 77030, USA
Arthritis Res Ther 11:R147. 2009..The current report sought to determine whether plasma cytokine profiles differ in SSc patients grouped according to these SSc-associated autoantibody subsets...
IRF5 polymorphism predicts prognosis in patients with systemic sclerosisRoozbeh Sharif
Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Ann Rheum Dis 71:1197-202. 2012..The goal of this study was to investigate the impact of these gene variants on survival and severity of interstitial lung disease (ILD) in SSc...
Determinants of work disability in patients with systemic sclerosis: a longitudinal study of the GENISOS cohortRoozbeh Sharif
Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Semin Arthritis Rheum 41:38-47. 2011..We hypothesized that WD in systemic sclerosis (SSc) is a function of demographic, clinical, and psychosocial factors...
Separate influences of birth order and gravidity/parity on the development of systemic sclerosisTonya Cockrill
University of Texas Health Science Center at Houston, TX 77030, USA
Arthritis Care Res (Hoboken) 62:418-24. 2010..In order to better evaluate these influences, we studied the association of birth order and gravidity/parity as risk factors for systemic sclerosis (SSc; scleroderma)...
Anti-fibrillarin antibody in African American patients with systemic sclerosis: immunogenetics, clinical features, and survival analysisRoozbeh Sharif
Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
J Rheumatol 38:1622-30. 2011..We examined the immunogenetic, clinical, and survival correlates of AFA in a large group of AA patients with SSc...
Autoimmune diseases and autoantibodies in the first degree relatives of patients with systemic sclerosisRajpreet K Arora-Singh
Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX, USA
J Autoimmun 35:52-7. 2010....
The contribution of disease activity on functional limitations over time through psychological mediators: a 12-month longitudinal study in patients with ankylosing spondylitisJennifer H Jang
Department of Medicine, Division of Rheumatology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Becker B 131, Los Angeles, CA 90048, USA
Rheumatology (Oxford) 50:2087-92. 2011..To explore whether helplessness, internality and depression would mediate the relationship between disease activity and functional limitations in patients with AS in a 12-month longitudinal study...
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategyOlga Gorlova
Department of Epidemiology, M D Anderson Cancer Center, Houston, Texas, USA
PLoS Genet 7:e1002178. 2011..Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. These data emphasize the differential genetic components of subphenotypes of SSc...
Osteopontin in systemic sclerosis and its role in dermal fibrosisMinghua Wu
Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
J Invest Dermatol 132:1605-14. 2012..Finally, TGF-β production by OPN-deficient macrophages was reduced compared with WT. These data demonstrate an important role for OPN in the development of dermal fibrosis and suggest that it may be a new therapeutic target in SSc...
Cigarette smoking is not a risk factor for systemic sclerosisPrateek Chaudhary
University of Texas Health Science Center at Houston, Houston, TX, USA
Arthritis Rheum 63:3098-102. 2011..To investigate the association of cigarette smoking with susceptibility to systemic sclerosis (SSc) in a large, well-defined patient population...
Psychological correlates of self-reported functional limitation in patients with ankylosing spondylitisTamar F Brionez
Department of Medicine, Division of Rheumatology, University of Texas Houston, 6431 Fannin, Houston, Texas 77030, USA
Arthritis Res Ther 11:R182. 2009..The purpose of this study was to investigate the role of psychological variables in self-reported functional limitation in patients with AS, while controlling for demographic and medical variables...
Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblastsXiaodong Zhou
Division of Rheumatology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Arthritis Res Ther 13:R128. 2011..The aims of this study were to examine the catalytic function and sumoylation of topo I in the nuclei of SSc fibroblasts, a major cell type involved in the fibrotic process...
