Research Topics
| Cesar A AriasSummaryAffiliation: Baylor College of Medicine Country: USA Publications
| Collaborators
|
Detail Information
Publications
The rise of the Enterococcus: beyond vancomycin resistanceCesar A Arias
Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Re Emerging Pathogens, Houston, Texas 77030, USA
Nat Rev Microbiol 10:266-78. 2012..Finally, we review the most important mechanisms of resistance to the antibiotics that are used to treat vancomycin-resistant enterococci...
Genetic basis for in vivo daptomycin resistance in enterococciCesar A Arias
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
N Engl J Med 365:892-900. 2011..However, the emergence of resistance to daptomycin during therapy threatens its usefulness...- Emergence and management of drug-resistant enterococcal infectionsCesar A Arias
Center for the Study of Emerging and Re Emerging Pathogens, Division of Infectious Diseases, and Department of Internal Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA
Expert Rev Anti Infect Ther 6:637-55. 2008.... 
Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene clusterCesar A Arias
Center for the Study of Emerging and Reemerging Pathogens, Division of Infectious Diseases, The University of Texas Medical School, Houston, TX 77030, USA
Clin Infect Dis 45:1343-6. 2007..The infecting organism exhibited in vivo emergence of a vancomycin-susceptible subpopulation lacking vanA. Treatment with a combination of high-dose daptomycin, gentamicin, and high-dose ampicillin cleared the infection...- Analysis of clonality and antibiotic resistance among early clinical isolates of Enterococcus faecium in the United StatesJessica R Galloway-Peña
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
J Infect Dis 200:1566-73. 2009..The Enterococcus faecium genogroup, referred to as clonal complex 17 (CC17), seems to possess multiple determinants that increase its ability to survive and cause disease in nosocomial environments... - The hylEfm gene in pHylEfm of Enterococcus faecium is not required in pathogenesis of murine peritonitisDiana Panesso
Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Reemerging Pathogens, Houston, TX, USA
BMC Microbiol 11:20. 2011..faecium, although its direct contribution to virulence has not been investigated. Here, we constructed mutants of the hylEfm-region and we evaluated their effect on virulence using a murine peritonitis model... - Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faeciumCesar A Arias
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
Antimicrob Agents Chemother 53:4240-6. 2009..Our findings indicate that the acquisition of the hyl(Efm) plasmids may explain, at least in part, the recent successful emergence of some E. faecium strains as nosocomial pathogens... - Evaluation of ceftobiprole medocaril against Enterococcus faecalis in a mouse peritonitis modelCesar A Arias
Center for the Study of Emerging and Reemerging Pathogens, Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 2 112, Houston, TX 77030, USA
J Antimicrob Chemother 60:594-8. 2007..The objective of this study was to assess the in vivo activity of ceftobiprole against four strains of E. faecalis, including beta-lactamase- producing (Bla+) and vancomycin-resistant strains... - Time-kill and synergism studies of ceftobiprole against Enterococcus faecalis, including beta-lactamase-producing and vancomycin-resistant isolatesCesar A Arias
University of Texas Medical School, Houston, TX 77030, USA
Antimicrob Agents Chemother 51:2043-7. 2007..In conclusion, ceftobiprole exhibited good in vitro activity against E. faecalis, including Bla(+) and vancomycin-resistant strains, and exhibited synergism with aminoglycosides against selected isolates... - Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: collateral damage from daptomycin therapy?Truc T Tran
University of Houston College of Pharmacy, Department of Internal Medicine, Division of Infectious Diseases, Houston, Texas, USA
Antimicrob Agents Chemother 56:3461-4. 2012..The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin... - Correlation between mutations in liaFSR of Enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpointsJosé M Munita
Laboratory for Antimicrobial Research, University of Texas Medical School at Houston, Houston, Texas, USA
Antimicrob Agents Chemother 56:4354-9. 2012..Concomitant susceptibility testing on BHIA may be useful for identifying these E. faecium first-step mutants. Our results also suggest that the current DAP breakpoint for E. faecium may need to be reevaluated... - A trilocus sequence typing scheme for hospital epidemiology and subspecies differentiation of an important nosocomial pathogen, Enterococcus faecalisShahreen A Chowdhury
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
J Clin Microbiol 47:2713-9. 2009..In conclusion, the TLST scheme described here was shown to be successful for investigating short-term epidemiology in a hospital setting and may provide an alternative to MLST for discriminating isolates... - Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalisLorena Diaz
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School at Houston, Houston, Texas, USA
Antimicrob Agents Chemother 56:3917-22. 2012..The cfr gene was flanked by IS256-like sequences both upstream and downstream. This is the first characterization of the potential horizontal transferability of the cfr gene from a human linezolid-resistant isolate of E. faecalis... - Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RFAgathe Bourgogne
Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
Genome Biol 9:R110. 2008..Enterococcus faecalis has emerged as a major hospital pathogen. To explore its diversity, we sequenced E. faecalis strain OG1RF, which is commonly used for molecular manipulation and virulence studies... - Whole-Genome Analysis of a Daptomycin-Susceptible Enterococcus faecium Strain and Its Daptomycin-Resistant Variant Arising during TherapyTruc T Tran
Department of Internal Medicine, Division of Infectious Diseases
Antimicrob Agents Chemother 57:261-8. 2013..Our results suggest that, apart from the LiaFSR system, the essential YycFG system is likely to be an important mediator of DAP resistance in some E. faecium strains... - Unmet needs and prospects for oritavancin in the management of vancomycin-resistant enterococcal infectionsCesar A Arias
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School, 6431 Fannin St, Houston, TX 77030, USA
Clin Infect Dis 54:S233-8. 2012.... - Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococciMilya Davlieva
Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, USA
Antimicrob Agents Chemother 57:289-96. 2013..As mutations to Cls are part of a larger genomic adaptation process, increased Cls activity is likely to be highly epistatic with other changes to facilitate DAP resistance... - Enterococcal endocarditis: can we win the war?José M Munita
Laboratory for Antimicrobial Research, University of Texas Medical School at Houston, Houston, TX, USA
Curr Infect Dis Rep 14:339-49. 2012..Although it appears that we are winning the war against E. faecalis, the battle rages on against isolates of multidrug-resistant E. faecium... - Rapid identification of Enterococcus hirae and Enterococcus durans by PCR and detection of a homologue of the E. hirae mur-2 Gene in E. duransCesar A Arias
Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston, TX 77030, USA
J Clin Microbiol 44:1567-70. 2006..A combination of murG and mur-2(ed) primers in a multiplex PCR assay differentiated E. hirae from E. durans in all cases. PCR using these primers appears to be a rapid alternative for identification of E. hirae and E. durans isolates...