Nabil Ahmed

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc T-cell-based therapies for malignancy and infection in childhood
    Nabil Ahmed
    Department of Pediatrics, Center for Cell and Gene Therapy, Baylor College of Medicine, 1102 Bates Street, Suite 1770, MC3 3320, Houston, TX 77030, USA
    Pediatr Clin North Am 57:83-96. 2010
  2. pmc Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment
    Vita S Salsman
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e20267. 2011
  3. ncbi request reprint Medulloblastoma-biology and microenvironment: a review
    Tiara Byrd
    Department of Pediatrics, Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, Texas 77030, USA
    Pediatr Hematol Oncol 29:495-506. 2012
  4. pmc HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 16:474-85. 2010
  5. ncbi request reprint Successful treatment of stem cell graft failure in pediatric patients using a submyeloablative regimen of campath-1H and fludarabine
    Nabil Ahmed
    Center for Cell and Gene Therapy, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Blood Marrow Transplant 14:1298-304. 2008
  6. ncbi request reprint Regression of experimental medulloblastoma following transfer of HER2-specific T cells
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, The Methodist Hospital, Houston, Texas 77030, USA
    Cancer Res 67:5957-64. 2007
  7. pmc Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma
    Meenakshi Hegde
    1 Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA 2 Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas, USA 3 Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Mol Ther 21:2087-101. 2013
  8. pmc Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    Mol Ther 17:1779-87. 2009
  9. pmc T cells redirected to EphA2 for the immunotherapy of glioblastoma
    Kevin K H Chow
    The Methodist Hospital, Baylor College of Medicine, Houston, TX, USA
    Mol Ther 21:629-37. 2013
  10. pmc The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS
    Stacey M Glasgow
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 33:13560-8. 2013

Collaborators

Detail Information

Publications21

  1. pmc T-cell-based therapies for malignancy and infection in childhood
    Nabil Ahmed
    Department of Pediatrics, Center for Cell and Gene Therapy, Baylor College of Medicine, 1102 Bates Street, Suite 1770, MC3 3320, Houston, TX 77030, USA
    Pediatr Clin North Am 57:83-96. 2010
    ....
  2. pmc Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment
    Vita S Salsman
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e20267. 2011
    ..This in turn creates a chemotactic gradient for RANTES-receptor bearing T lymphocytes. Manipulation of this pathway could have important therapeutic implications...
  3. ncbi request reprint Medulloblastoma-biology and microenvironment: a review
    Tiara Byrd
    Department of Pediatrics, Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, Texas 77030, USA
    Pediatr Hematol Oncol 29:495-506. 2012
    ..This review seeks to highlight several key processes observed in cancer biology, particularly the involvement of the tumor microenvironment, with relevant examples from MB...
  4. pmc HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 16:474-85. 2010
    ....
  5. ncbi request reprint Successful treatment of stem cell graft failure in pediatric patients using a submyeloablative regimen of campath-1H and fludarabine
    Nabil Ahmed
    Center for Cell and Gene Therapy, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Blood Marrow Transplant 14:1298-304. 2008
    ..Thus, the regimen that we describe can be used with minimal toxicity to effectively overcome graft failure after myeloablative HSCT in children...
  6. ncbi request reprint Regression of experimental medulloblastoma following transfer of HER2-specific T cells
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, The Methodist Hospital, Houston, Texas 77030, USA
    Cancer Res 67:5957-64. 2007
    ..In contrast, delivery of nontransduced T cells did not change the tumor growth pattern. Adoptive transfer of HER2-specific T cells may represent a promising immunotherapeutic approach for medulloblastoma...
  7. pmc Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma
    Meenakshi Hegde
    1 Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA 2 Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas, USA 3 Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Mol Ther 21:2087-101. 2013
    ..Further, T cells coexpressing HER2 and IL-13Rα2-CARs exhibited accentuated yet antigen-dependent downstream signaling and a particularly enhanced antitumor activity...
  8. pmc Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    Mol Ther 17:1779-87. 2009
    ..Genetic modification of T cells with CARs specific for target antigens, expressed at too low a level to be effectively recognized by monoclonal antibodies, may allow immunotherapy to be more broadly applicable for human cancer therapy...
  9. pmc T cells redirected to EphA2 for the immunotherapy of glioblastoma
    Kevin K H Chow
    The Methodist Hospital, Baylor College of Medicine, Houston, TX, USA
    Mol Ther 21:629-37. 2013
    ..Thus, EphA2-specific T-cell immunotherapy may be a promising approach for the treatment of EphA2-positive GBM...
  10. pmc The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS
    Stacey M Glasgow
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 33:13560-8. 2013
    ..These studies represent the first characterization of miR-223/NFIA axis function in glioma and demonstrate that it is a conserved proliferative mechanism across CNS development and tumorigenesis. ..
  11. pmc PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor
    Yozo Nakazawa
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 19:2133-43. 2011
    ..Our results demonstrate that PB can be used to redirect virus-specific CTLs to tumor targets, which should prolong tumor-specific T cell survival in vivo producing more efficacious immunotherapy...
  12. pmc T cells redirected to interleukin-13Rα2 with interleukin-13 mutein-chimeric antigen receptors have anti-glioma activity but also recognize interleukin-13Rα1
    Simone Krebs
    Center for Cell and Gene Therapy, Texas Children s Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, Texas, USA Texas Children s Cancer Center, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas, USA
    Cytotherapy 16:1121-31. 2014
    ..Whereas the specificity of IL13 muteins in the context of immunotoxins is well characterized, limited information is available for CAR T cells...
  13. pmc Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells
    Daofeng Liu
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Immunol 149:55-64. 2013
    ..Importantly, the numbers and function of peripheral blood type-I NKTs were preserved in MB patients. Therefore, CD1d is expressed on tumor cells in a subset of MB patients and represents a novel target for immunotherapy. ..
  14. pmc Generation of polyclonal CMV-specific T cells for the adoptive immunotherapy of glioblastoma
    Alexia Ghazi
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
    J Immunother 35:159-68. 2012
    ..Infusion of such CMV-specific T-cell lines may extend the benefits of T-cell therapy to patients with CMV GBMs...
  15. pmc A simple and sensitive method for measuring tumor-specific T cell cytotoxicity
    Xinping Fu
    Department of Biology and Biochemistry, University of Houston, Houston, Texas, United States of America
    PLoS ONE 5:e11867. 2010
    ..Instead, we found that the remaining luciferase inside the cells could accurately reflect the overall cell viability...
  16. ncbi request reprint Contact-activated monocytes: efficient antigen presenting cells for the stimulation of antigen-specific T cells
    Ann Leen
    Center for Cell and Gene Therapy, Texas Children s Cancer Center, Houston 77030, USA
    J Immunother 30:96-107. 2007
    ..The use of actMo as APCs simplifies the production/manufacture of antigen-specific T cells for clinical trials...
  17. ncbi request reprint Viral lymphomagenesis
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, Texas 77030, USA
    Curr Opin Hematol 13:254-9. 2006
    ..The presence of the viral genome in all these malignancies offers the prospect for therapeutic interventions targeting virus-encoded proteins...
  18. ncbi request reprint Novel approaches and mechanisms of immunotherapy for glioblastoma
    Meenakshi Hegde
    Center for Cell and Gene Therapy Texas Children s Cancer Center Department of Pediatrics, Baylor College of Medicine Houston, TX 77030, USA
    Discov Med 17:145-54. 2014
    ..This brief review discusses 'why' and 'how' various types of immunotherapies are being employed to treat glioblastoma. ..
  19. pmc Nanoshell-mediated photothermal therapy improves survival in a murine glioma model
    Emily S Day
    Department of Bioengineering, Rice University, 6100 Main Street MS 142, Houston, TX 77005, USA
    J Neurooncol 104:55-63. 2011
    ..3 days. The results of these studies suggest that nanoshell-mediated photothermal therapy represents a promising novel treatment strategy for malignant glioma...
  20. pmc How to design effective vaccines: lessons from an old success story
    Nabil Ahmed
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Expert Rev Vaccines 8:543-6. 2009
    ....