Research Topics
| Nabil AhmedSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
T-cell-based therapies for malignancy and infection in childhoodNabil Ahmed
Department of Pediatrics, Center for Cell and Gene Therapy, Baylor College of Medicine, 1102 Bates Street, Suite 1770, MC3 3320, Houston, TX 77030, USA
Pediatr Clin North Am 57:83-96. 2010....
Medulloblastoma-biology and microenvironment: a reviewTiara Byrd
Department of Pediatrics, Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, Texas 77030, USA
Pediatr Hematol Oncol 29:495-506. 2012..This review seeks to highlight several key processes observed in cancer biology, particularly the involvement of the tumor microenvironment, with relevant examples from MB...- Successful treatment of stem cell graft failure in pediatric patients using a submyeloablative regimen of campath-1H and fludarabineNabil Ahmed
Center for Cell and Gene Therapy, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
Biol Blood Marrow Transplant 14:1298-304. 2008..Thus, the regimen that we describe can be used with minimal toxicity to effectively overcome graft failure after myeloablative HSCT in children... - HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumorsNabil Ahmed
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 16:474-85. 2010.... 
Regression of experimental medulloblastoma following transfer of HER2-specific T cellsNabil Ahmed
Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, The Methodist Hospital, Houston, Texas 77030, USA
Cancer Res 67:5957-64. 2007..In contrast, delivery of nontransduced T cells did not change the tumor growth pattern. Adoptive transfer of HER2-specific T cells may represent a promising immunotherapeutic approach for medulloblastoma...- Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expressionNabil Ahmed
Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
Mol Ther 17:1779-87. 2009..Genetic modification of T cells with CARs specific for target antigens, expressed at too low a level to be effectively recognized by monoclonal antibodies, may allow immunotherapy to be more broadly applicable for human cancer therapy... - PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptorYozo Nakazawa
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Ther 19:2133-43. 2011..Our results demonstrate that PB can be used to redirect virus-specific CTLs to tumor targets, which should prolong tumor-specific T cell survival in vivo producing more efficacious immunotherapy... - Generation of polyclonal CMV-specific T cells for the adoptive immunotherapy of glioblastomaAlexia Ghazi
Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
J Immunother 35:159-68. 2012..Infusion of such CMV-specific T-cell lines may extend the benefits of T-cell therapy to patients with CMV GBMs... - Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironmentVita S Salsman
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America
PLoS ONE 6:e20267. 2011..This in turn creates a chemotactic gradient for RANTES-receptor bearing T lymphocytes. Manipulation of this pathway could have important therapeutic implications... - T cells redirected to EphA2 for the immunotherapy of glioblastomaKevin K H Chow
The Methodist Hospital, Baylor College of Medicine, Houston, TX, USA
Mol Ther 21:629-37. 2013..Thus, EphA2-specific T-cell immunotherapy may be a promising approach for the treatment of EphA2-positive GBM... - Contact-activated monocytes: efficient antigen presenting cells for the stimulation of antigen-specific T cellsAnn Leen
Center for Cell and Gene Therapy, Texas Children s Cancer Center, Houston 77030, USA
J Immunother 30:96-107. 2007..The use of actMo as APCs simplifies the production/manufacture of antigen-specific T cells for clinical trials... - Viral lymphomagenesisNabil Ahmed
Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, Texas 77030, USA
Curr Opin Hematol 13:254-9. 2006..The presence of viral genomes in these lymphomas, however, offers targets for intervention and approaches under evaluation include adoptive immunotherapy, interferon, and small molecules targeting aspects of virus biology... - Nanoshell-mediated photothermal therapy improves survival in a murine glioma modelEmily S Day
Department of Bioengineering, Rice University, 6100 Main Street MS 142, Houston, TX 77005, USA
J Neurooncol 104:55-63. 2011..3 days. The results of these studies suggest that nanoshell-mediated photothermal therapy represents a promising novel treatment strategy for malignant glioma... - How to design effective vaccines: lessons from an old success storyNabil Ahmed
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Expert Rev Vaccines 8:543-6. 2009....