Li Liu

Summary

Affiliation: Bayer HealthCare
Country: USA

Publications

  1. ncbi request reprint Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    Li Liu
    Department of Cancer Biology, Bayer HealthCare Pharmaceuticals, West Haven, Connecticut 06516, USA
    Cancer Res 66:11851-8. 2006
  2. ncbi request reprint BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    Scott M Wilhelm
    Bayer Pharmaceuticals Corporation, West Haven, Connecticut 06516, USA
    Cancer Res 64:7099-109. 2004
  3. ncbi request reprint A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice
    Li Liu
    Tsinghua Institute of Genome Research, Department of Biological Sciences and Biotechnology and Institute of Biomedicine, Tsinghua University, China
    Cancer Res 64:3491-9. 2004
  4. ncbi request reprint The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism
    Paul C Chin
    Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 75083, USA
    J Neurochem 90:595-608. 2004
  5. ncbi request reprint [Radiosensitization by pentoxifylline in human hepatoma cell line HepG2 and its mechanism]
    De Hua Wu
    Department of Radiation Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:382-5. 2004
  6. ncbi request reprint [Cytotoxicity of pentoxifylline and its effect on human hepatoma cell line Hep3b radiosensitivity]
    De Hua Wu
    Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:305-7. 2006
  7. doi request reprint Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells
    Xiang Bo Wan
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou 510060, China
    Carcinogenesis 29:1930-7. 2008
  8. ncbi request reprint Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor
    Yu Rong
    Department of Biological Sciences and Biotechnology and Institute of Biomedicine, Tsinghua University, Beijing 10084, China
    Cancer Res 66:8049-57. 2006
  9. ncbi request reprint [Establishment of hepatic metastatic subline of nasopharyngeal carcinoma cell line]
    Chun Han
    Department of Pathology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:654-7. 2006
  10. ncbi request reprint Transcription factor EGR-1 inhibits growth of hepatocellular carcinoma and esophageal carcinoma cell lines
    Miao Wang Hao
    Department of Internal Medicine, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, Shaanxi Province, China
    World J Gastroenterol 8:203-7. 2002

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    Li Liu
    Department of Cancer Biology, Bayer HealthCare Pharmaceuticals, West Haven, Connecticut 06516, USA
    Cancer Res 66:11851-8. 2006
    ....
  2. ncbi request reprint BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    Scott M Wilhelm
    Bayer Pharmaceuticals Corporation, West Haven, Connecticut 06516, USA
    Cancer Res 64:7099-109. 2004
    ..These data demonstrate that BAY 43-9006 is a novel dual action RAF kinase and VEGFR inhibitor that targets tumor cell proliferation and tumor angiogenesis...
  3. ncbi request reprint A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice
    Li Liu
    Tsinghua Institute of Genome Research, Department of Biological Sciences and Biotechnology and Institute of Biomedicine, Tsinghua University, China
    Cancer Res 64:3491-9. 2004
    ..Thus, our results both in vitro and in vivo suggest that NOK is a novel oncogene with the capacity of promoting cell transformation, tumorigenesis, and metastasis...
  4. ncbi request reprint The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism
    Paul C Chin
    Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 75083, USA
    J Neurochem 90:595-608. 2004
    ....
  5. ncbi request reprint [Radiosensitization by pentoxifylline in human hepatoma cell line HepG2 and its mechanism]
    De Hua Wu
    Department of Radiation Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:382-5. 2004
    ..To investigate the radiosensitization by pentoxifylline (PTX) in human hepatoma cell line HepG2 and its possible mechanism...
  6. ncbi request reprint [Cytotoxicity of pentoxifylline and its effect on human hepatoma cell line Hep3b radiosensitivity]
    De Hua Wu
    Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:305-7. 2006
    ..To investigate the effects of pentoxifylline (PTX) on radiation induced-cell cycle redistribution and radiosensitivity of human hepatocellular carcinoma cell line Hep3b...
  7. doi request reprint Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells
    Xiang Bo Wan
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou 510060, China
    Carcinogenesis 29:1930-7. 2008
    ..Small chemical inhibitor VX-680 may offer as a promising molecular targeting agent in human NPC...
  8. ncbi request reprint Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor
    Yu Rong
    Department of Biological Sciences and Biotechnology and Institute of Biomedicine, Tsinghua University, Beijing 10084, China
    Cancer Res 66:8049-57. 2006
    ..Strikingly, STAT3 translocates to the nucleus and interacts with WT1 in a variety of primary Wilms' tumor cells, raising the hypothesis that WT1 and activated STAT3 in Wilms' tumor accelerate tumorigenesis...
  9. ncbi request reprint [Establishment of hepatic metastatic subline of nasopharyngeal carcinoma cell line]
    Chun Han
    Department of Pathology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:654-7. 2006
    ..To establish a hepatic metastatic subline of nasopharyngeal carcinoma (NPC) cell line...
  10. ncbi request reprint Transcription factor EGR-1 inhibits growth of hepatocellular carcinoma and esophageal carcinoma cell lines
    Miao Wang Hao
    Department of Internal Medicine, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, Shaanxi Province, China
    World J Gastroenterol 8:203-7. 2002
    ..This experiment was designed to investigate the role of egr-1 in the cancerous process of hepatocellular carcinoma (HCC) and esophageal carcinoma (EC), and then to appraise the effects of EGR-1 on the growth of these tumor cells...
  11. ncbi request reprint Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells
    Hui Zhong Zhang
    Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Cancer Biol Ther 5:1457-61. 2006
    ..Our study indicates that survivin gene promoter-driven stathmin siRNA expression vector may have potential use in tumor gene therapy with targeted tumor gene silencing effect...
  12. ncbi request reprint 19F-NMR detection of lacZ gene expression via the enzymic hydrolysis of 2-fluoro-4-nitrophenyl beta-D-galactopyranoside in vivo in PC3 prostate tumor xenografts in the mouse
    Li Liu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390 9058, USA
    FASEB J 21:2014-9. 2007
    ..More importantly, we demonstrate for the first time the ability to differentiate wild-type and lacZ-expressing prostate tumor xenografts in mice using this approach...
  13. ncbi request reprint Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells
    Xiang Yue Zhang
    Department of Microbiology and Etiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
    Immunogenetics 57:934-43. 2006
    ....
  14. ncbi request reprint [On the role of liver-enriched transcription factors in regulating HBV transcription and replication]
    Song Wang
    Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:35-9. 2006
    ..To investigate the effects of various liver-enriched transcription factors in regulating HBV transcription and replication, and to explore their potential roles in HBV hepatotropism...
  15. ncbi request reprint [Tiam1 expression correlates with the biological behavior of human colorectal carcinoma cells]
    Li Liu
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Zhonghua Bing Li Xue Za Zhi 34:664-8. 2005
    ..To investigate whether the Tiam1 gene expression enhances the invasive and metastatic capabilities of colorectal carcinoma cells...
  16. pmc Lentivirus-mediated silencing of Tiam1 gene influences multiple functions of a human colorectal cancer cell line
    Li Liu
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
    Neoplasia 8:917-24. 2006
    ..Our results suggest that Tiam1 truly plays a causal role in the metastasis of colorectal cancer and that RNAi-mediated silencing of Tiam1 may provide an opportunity to develop a new treatment strategy for colorectal cancer...
  17. ncbi request reprint Dynamic expression of extracellular signal-regulated kinase in rat liver tissue during hepatic fibrogenesis
    Xiao Lan Zhang
    Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
    World J Gastroenterol 12:6376-81. 2006
    ..To investigate whether extracellular signal-regulated kinase 1 (ERK(1)) is activated and associated with hepatic stellate cell (HSC) proliferation in fibrotic rat liver tissue...
  18. ncbi request reprint The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival
    Rakhee S Gupte
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 4:323-9. 2005
    ..Interestingly, downregulation of endogenous RIalpha by 8-chloro cAMP, in MCF7 breast cancer cells led to reduction in the amount of RFC40-RIalpha complex, together with decrease in cell survival...
  19. ncbi request reprint A new strategy to resume the apoptosis activity of p53 in leukemia cell lines retaining wild-type p53
    Ze Jun Liu
    Leuk Res 31:1156-8. 2007
  20. ncbi request reprint The carboxyl terminal tyrosine 417 residue of NOK has an autoinhibitory effect on NOK-mediated signaling transductions
    Ying hua Li
    Tsinghua Institute of Genome Research, Institute of Biomedicine and School of Medicine, Tsinghua University, Beijing 100084, China
    Biochem Biophys Res Commun 356:444-9. 2007
    ..Overall, our results demonstrate that the tyrosine Y417 residue at the carboxyl tail of NOK exhibits an autoinhibitory role in NOK-mediated signaling transductions...
  21. ncbi request reprint [Isolation and characterization of human colorectal cancer cell subline with unique metastatic potential in the liver]
    Yan Fei Zhang
    Department of Pathology, Southern Medical University, Key Lab for Molecular Tumor Pathology of Guangdong Province, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:126-30. 2007
    ..To isolate a subclone from human colorectal cancer cell line SW480 with unique metastatic potential in the liver...
  22. ncbi request reprint The influence of a newly developed quinolone: antofloxacin, on CYP activity in rats
    Xiao Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, People s Republic of China
    Eur J Drug Metab Pharmacokinet 33:1-7. 2008
    ....
  23. ncbi request reprint Exploring feasibility of multicolored CdTe quantum dots for in vitro and in vivo fluorescent imaging
    Junfeng Su
    College of Software, Nankai University, Tianjin 300071, PR China
    J Nanosci Nanotechnol 8:1174-7. 2008
    ..The studies indicate that CdTe QDs can provide alternative fluorescent probes for biological imaging...
  24. doi request reprint Treatment of cancer with a novel dual-targeted conditionally replicative adenovirus armed with mda-7/IL-24 gene
    Jingjing Luo
    Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
    Clin Cancer Res 14:2450-7. 2008
    ..However, better specificity and mode of transgene expression are required to improve the efficacy and safety if this vector is applied for clinical application...
  25. ncbi request reprint CD4+CD25high regulatory cells in peripheral blood of cancer patients
    Li Liu
    Cancer Center, Union Hospital, Hua Zhong University of Science and Technology, Wuhan 430022, China
    Neuro Endocrinol Lett 29:240-5. 2008
    ....
  26. pmc Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:680-90. 2008
    ..These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis...
  27. doi request reprint Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 28:2624-32. 2008
    ..Thus, cdk5 inhibitors may not be effective in targeting tau phosphorylation in the elderly...
  28. doi request reprint Protective effect of saponins from Panax notoginseng against doxorubicin-induced cardiotoxicity in mice
    Li Liu
    Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, P R China
    Planta Med 74:203-9. 2008
    ..These results imply the potentially clinical application of PNS to overcome the negative side effects of doxorubicin...
  29. ncbi request reprint Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats
    Rosemary J Santulli
    Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Rds, Spring House, PA 19477 0776, USA
    J Pharmacol Exp Ther 324:894-901. 2008
    ..Given this profile, JNJ-26076713 represents a potential therapeutic candidate for the treatment of age-related macular degeneration, macular edema, and proliferative diabetic retinopathy...
  30. ncbi request reprint Isolation and molecular characterization of the Triticum aestivum L. ethylene-responsive factor 1 (TaERF1) that increases multiple stress tolerance
    Zhao Shi Xu
    National Key Facility of Crop Gene Resources and Genetic Improvement, Key Laboratory of Crop Genetics and Breeding, Ministry of Agriculture, Institute of Crop Science, Chinese Academy of Agriculture Sciences, Beijing 100081, PR China
    Plant Mol Biol 65:719-32. 2007
    ..These results suggested that the TaERF1 gene encodes a GCC-box and CRT/DRE element binding factor that might be involved in multiple stress signal transduction pathways...
  31. ncbi request reprint A novel tissue array technique for high-throughput tissue microarray analysis -- microarray groups
    Hui Yong Jiang
    Department of General Surgery, Northern Hospital, No 83, Wenhua Road, Shenhe District, Shenyang, Liaoning Province, China
    In Vitro Cell Dev Biol Anim 43:109-12. 2007
    ....
  32. ncbi request reprint Differential proteomic analysis of human colorectal carcinoma cell lines metastasis-associated proteins
    Liang Zhao
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
    J Cancer Res Clin Oncol 133:771-82. 2007
    ....
  33. ncbi request reprint Proteomic analysis of Tiam1-mediated metastasis in colorectal cancer
    Li Liu
    Department of Pathology, Southern Medical University, Tonghe Street, Guangzhou 510515, Guangdong, China
    Cell Biol Int 31:805-14. 2007
    ..These results give some clues to elucidate the mechanism of Tiam1-mediated metastasis for colorectal cancer...
  34. ncbi request reprint Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice
    Yue Chen
    Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua Institute of Genome Research, Institute of Biomedicine, Tsinghua University, Beijing, China
    Cancer Res 65:10838-46. 2005
    ..Thus, our study shows that these potential tyrosine phosphorylation sites may play critical roles in NOK-mediated tumorigenesis both in vitro and in vivo...
  35. ncbi request reprint Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway
    Tie Shi Li
    Tsinghua Institute of Genome Research, Department of Biological Sciences and Biotechnology and Institute of Biomedicine, Tsinghua University, Beijing 100084, China
    Cell Signal 18:1287-98. 2006
    ..Overall, our results strongly indicate that mIL-17RE may belong to a novel growth-receptor like molecule that has the capability to support cellular mitogenesis through RAS/MAPK pathway...
  36. ncbi request reprint Therapeutic effects and prognostic factors in three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma
    De Hua Wu
    Department of Radiation Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Guangdong Province, China
    World J Gastroenterol 10:2184-9. 2004
    ..To evaluate the therapeutic efficacy of three-dimensional conformal radiotherapy (3D-CRT) combined with transcatheter arterial chemoembolization (TACE) on the patients with hepatocellular carcinoma (HCC)...
  37. ncbi request reprint Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells
    Xianwu Li
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:15309-16. 2002
    ..Our data indicate that inhibition of protein geranylgeranylation and RhoA pathways induce apoptosis in HUVEC and that induction of p53 or other proapoptotic proteins is required for this process...
  38. ncbi request reprint Injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or MPTP
    Li Liu
    Division of Applied and Interventional Research, Toronto Western Hospital Research Institute, University of Toronto, 399 Bathurst Street, Toronto ON, Canada, M5T 2S8
    Brain Res 994:243-52. 2003
    ..These data indicate that genetic factors and the type of lesion play an important role in determining death of dopaminergic neurons after injury...
  39. ncbi request reprint Three-dimensional power Doppler imaging in depicting vascularity in hepatocellular carcinoma
    Hui Xiong Xu
    Department of Medical Ultrasonics, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    J Ultrasound Med 22:1147-54. 2003
    ..To assess the ability of three-dimensional power Doppler imaging to depict vascularity in hepatocellular carcinoma...
  40. ncbi request reprint Pathomorphological study on location and distribution of Kupffer cells in hepatocellular carcinoma
    Kai Liu
    Division of Molecular Biology of Infectious Disease Key Laboratory of Biotherapy of Human Disease, Ministry of Education, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 9:1946-9. 2003
    ..To clarify the location and distribution of Kupffer cells in hepatocellular carcinoma (HCC), and to investigate their role in hepatocarcinogenesis...
  41. ncbi request reprint hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling
    Shiqin Xiong
    Tsinghua Institute of Genome Research, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 278:50273-82. 2003
    ..These findings suggest that Sef may play an important role in the regulation of PC-12 cell differentiation...
  42. ncbi request reprint [Effect of tumor suppressor gene KAI1 on the biological behaviors of human colorectal carcinoma]
    Li Liu
    Department of Pathology, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 23:587-90, 594. 2003
    ..To determine whether the expression of tumor suppressor gene KAI1 can suppress the invasive or metastatic ability of colorectal carcinoma cells...
  43. ncbi request reprint Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential
    Henning Wege
    Transplant Research Institute, University of California, Davis Medical Center, Sacramento 95817, USA
    Gastroenterology 124:432-44. 2003
    ..Human somatic cells, including hepatocytes, exhibit no telomerase activity. Consequently, their telomeres progressively shorten with each cell cycle until critically short telomeres trigger replicative senescence...
  44. ncbi request reprint Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation
    Han Li
    Cell Pathways, Inc, 702 Electronic Drive, Horsham, PA 19044, USA
    Biochem Pharmacol 64:1325-36. 2002
    ....
  45. ncbi request reprint A phase I study of SPI-077 (Stealth liposomal cisplatin) concurrent with radiation therapy for locally advanced head and neck cancer
    David I Rosenthal
    Department of Radiation Oncology, Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Invest New Drugs 20:343-9. 2002
    ..We performed a Phase I study of Stealth liposomal cisplatin (SPI-077) concurrent with RT for head and neck squamous cell carcinoma (HNSCC)...
  46. ncbi request reprint Requirement for RhoA kinase activation in leukocyte de-adhesion
    Li Liu
    Department of Medicine, Division of Hematology, University of Washington, Seattle 98104, USA
    J Immunol 169:2330-6. 2002
    ..We conclude that activation of RhoA kinase promotes leukocyte de-adhesion by inhibiting cytoskeletal-dependent spreading, and that these effects of RhoA kinase constitute a new mechanism for regulation of integrin receptor avidity...
  47. ncbi request reprint [Localization and distribution of Kupffer cells in hepatocellular carcinoma]
    Xu He
    Key Laboratory of Infectious Diseases Molecular Biology, West China Hospital of Sichuan University, Chengdu 610041, China
    Zhonghua Gan Zang Bing Za Zhi 10:177. 2002
  48. ncbi request reprint KAI1 gene expression in colonic carcinoma and its clinical significances
    De Hua Wu
    Department of Radiation Oncology, First Military Medical University, Guangzhou 510515, Guangdong Province, China
    World J Gastroenterol 10:2245-9. 2004
    ..To investigate KAI1 gene expression in the progression of human colonic carcinoma and its clinical significances...
  49. ncbi request reprint Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins
    Bart L De Corte
    Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, PA 19477 0776, USA
    Bioorg Med Chem Lett 14:5227-32. 2004
    ....
  50. ncbi request reprint [TNF-alpha mRNA expression in lung cancer cell lines induced by ionizing radiation]
    Li Liu
    Union Tumor Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China
    Zhonghua Zhong Liu Za Zhi 27:347-9. 2005
    ..The aim of this study is to investigate the release of TNF-alpha mRNA in two lung cancer cell lines in vitro and the regulation of TNF-alpha mRNA expression by ionizing radiation...
  51. ncbi request reprint FEAR but not MEN genes are required for exit from meiosis I
    Rebecca J Kamieniecki
    Department of Microbiology and Molecular Biology, Sackler School of Biomedical Sciences, Tufts University, Boston, Massachusettes 02111, USA
    Cell Cycle 4:1093-8. 2005
    ..Our results demonstrate that the orderly transition from meiosis I to meiosis II is accomplished by eliminating MEN function and using the FEAR pathway to modulate cyclin dependent kinase activity, in part through the actions of SIC1...
  52. pmc The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication
    Hong Tang
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
    J Virol 79:5548-56. 2005
    ..These results suggest that HBx has an important role in stimulating HBV transcription and replication and that the transcriptional transactivation function of HBx may be critical for its augmentation effect on HBV replication...
  53. ncbi request reprint Differential display of proteins involved in the neural differentiation of mouse embryonic carcinoma P19 cells by comparative proteomic analysis
    Jie An
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Proteomics 5:1656-68. 2005
    ..As an initial step toward unveiling the regulations involved in the commitment of pluripotent cells to a neural fate, information from this study may be helpful to uncover the molecular mechanisms of neural differentiation...
  54. ncbi request reprint Tissue microarray for high-throughput analysis of gene expression profiles in hepatocellular carcinoma
    Kai Liu
    Division of Molecular Biology of Infectious Diseases, Key Laboratory of Biotherapy of Human Disease, Ministry of Education, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:1369-72. 2005
    ..To study the expression profiles of HBsAg, HBcAg, p21WAF1/CIP1 (p21), Rb genes in hepatocellular carcinoma (HCC) and to investigate their roles in the hepatocar-cinogenesis...
  55. ncbi request reprint [Reinfection of HBV and its possible mechanism in patients with liver-transplantation]
    Qing Fang
    Center of Infectious Diseases, Key Laboratory of Biotherapy of Human Diseases of the Ministry of Education, West China Hospital of Sichuan University, Chengdu 610041, China
    Zhonghua Gan Zang Bing Za Zhi 13:225-7. 2005
  56. ncbi request reprint Immortalization of human small airway epithelial cells by ectopic expression of telomerase
    Chang Q Piao
    Center for Radiological Research, College of Physicians and Surgens, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Carcinogenesis 26:725-31. 2005
    ....
  57. ncbi request reprint Tiam1 gene expression and its significance in colorectal carcinoma
    Li Liu
    Department of Pathology, First Military Medical University, Guangzhou 510515, Guangdong Province, China
    World J Gastroenterol 11:705-7. 2005
    ..To explore the expression of Tiam1 gene in colorectal carcinoma and its correlation with tumor metastasis...
  58. ncbi request reprint BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
    Suneil K Kalia
    Applied and Interventional Research, Toronto Western Hospital Research Institute, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Neuron 44:931-45. 2004
    ..This contrasts with the antideath functions ascribed to BAG family members and suggests a potential role for BAG5 in promoting neurodegeneration in sporadic PD through its functional interactions with parkin and Hsp70...
  59. ncbi request reprint Novel NMR platform for detecting gene transfection: synthesis and evaluation of fluorinated phenyl beta-D-galactosides with potential application for assessing LacZ gene expression
    Jianxin Yu
    Department Radiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9058, USA
    Bioconjug Chem 15:1334-41. 2004
    ..This class of molecules presents a new strategy for assaying gene expression with a highly versatile molecular structural platform...
  60. ncbi request reprint 1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability
    Shyamali Ghosh
    Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, L L C, Welsh and McKean Roads, Spring House, PA 19477 0776, USA
    Bioorg Med Chem Lett 14:5937-41. 2004
    ..Two isomers had significant alpha(V)beta(3) antagonist activity with improved oral bioavailability, relative to the corresponding quinoline derivative...
  61. ncbi request reprint The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity
    Bin Zhou
    Vascular Biology Center and Department of Medicine and Department of Molecular Science, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Cancer Res 64:7455-63. 2004
    ..Taken together, our results indicate that palmitoylation is crucial for the functional integrity of tetraspanin KAI1/CD82 during the suppression of cancer cell migration and invasion...
  62. ncbi request reprint Disrupting effects of polychlorinated biphenyls on gonadal development and reproductive functions in chickens
    Caiqiao Zhang
    College of Biological Sciences, China Agricultural University, Beijing
    J Environ Sci Health A Tox Hazard Subst Environ Eng 37:509-19. 2002
    ....