Chetan Goudar

Summary

Affiliation: Bayer HealthCare
Country: USA

Publications

  1. ncbi Experimental and theoretical analysis of tubular membrane aeration for Mammalian cell bioreactors
    Hanshi N Qi
    Bayer Corporation, 800 Dwight Way, Berkeley, California 94710, USA
    Biotechnol Prog 19:1183-9. 2003
  2. ncbi Explicit oxygen concentration expression for estimating extant biodegradation kinetics from respirometric experiments
    C T Goudar
    School of Civil Engineering and Environmental Science, University of Oklahoma, Norman, OK 73019, USA
    Biotechnol Bioeng 75:74-81. 2001
  3. ncbi Towards industrial application of quasi real-time metabolic flux analysis for mammalian cell culture
    Chetan Goudar
    Research and Development, Process Sciences, Bayer HealthCare, Biological Products Division, 800 Dwight Way, Berkeley, CA 94710, USA
    Adv Biochem Eng Biotechnol 101:99-118. 2006
  4. doi Error propagation from prime variables into specific rates and metabolic fluxes for mammalian cells in perfusion culture
    Chetan T Goudar
    Cell Culture Development, Global Biologics Development, Bayer HealthCare, 800 Dwight Way, Berkeley, CA 94710, USA
    Biotechnol Prog 25:986-98. 2009
  5. ncbi Nonlinear estimation of microbial and enzyme kinetic parameters from progress curve data
    C T Goudar
    School of Civil Engineering and Environmental Science at the University of Oklahoma, Norman, USA
    Water Environ Res 73:260-5. 2001
  6. ncbi Progress curve analysis for enzyme and microbial kinetic reactions using explicit solutions based on the Lambert W function
    Chetan T Goudar
    Process and Technology Development, Bayer HealthCare, Biological Products Division, 800 Dwight Way, B56 A, Berkeley, CA 94710, USA
    J Microbiol Methods 59:317-26. 2004
  7. ncbi Logistic equations effectively model Mammalian cell batch and fed-batch kinetics by logically constraining the fit
    Chetan T Goudar
    Process and Technology Development, Bayer HealthCare, Biological Products Division, 800 Dwight Way, Berkeley, CA 94710, USA
    Biotechnol Prog 21:1109-18. 2005
  8. doi Robust parameter estimation during logistic modeling of batch and fed-batch culture kinetics
    Chetan T Goudar
    Cell Culture Development, Global Biologics Development, Bayer HealthCare, 800 Dwight Way, Berkeley, CA 94710, USA
    Biotechnol Prog 25:801-6. 2009
  9. ncbi Decreased pCO(2) accumulation by eliminating bicarbonate addition to high cell-density cultures
    Chetan T Goudar
    Research and Development, Process Sciences, Bayer HealthCare, Pharmaceutical Division, 800 Dwight Way, Berkeley, California 94710, USA
    Biotechnol Bioeng 96:1107-17. 2007
  10. doi Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy
    Chetan Goudar
    Cell Culture Development, Global Biological Development, Bayer HealthCare, 800 Dwight Way, Berkeley, CA 94710, USA
    Metab Eng 12:138-49. 2010

Collaborators

Detail Information

Publications11

  1. ncbi Experimental and theoretical analysis of tubular membrane aeration for Mammalian cell bioreactors
    Hanshi N Qi
    Bayer Corporation, 800 Dwight Way, Berkeley, California 94710, USA
    Biotechnol Prog 19:1183-9. 2003
    ..This information is vital for optimal design and scale-up of membrane-aerated bioreactors for mammalian cell culture...
  2. ncbi Explicit oxygen concentration expression for estimating extant biodegradation kinetics from respirometric experiments
    C T Goudar
    School of Civil Engineering and Environmental Science, University of Oklahoma, Norman, OK 73019, USA
    Biotechnol Bioeng 75:74-81. 2001
    ..The simplicity and accuracy associated with use of the W function to describe oxygen concentration data should make it an attractive approach for estimating extant Monod biodegradation kinetic parameters from respirometric experiments...
  3. ncbi Towards industrial application of quasi real-time metabolic flux analysis for mammalian cell culture
    Chetan Goudar
    Research and Development, Process Sciences, Bayer HealthCare, Biological Products Division, 800 Dwight Way, Berkeley, CA 94710, USA
    Adv Biochem Eng Biotechnol 101:99-118. 2006
    ..The framework presented in this study offers a convenient means for quasi real-time estimation of metabolic fluxes and represents a step towards realizing the potential of metabolic flux analysis for accelerated bioprocess optimization...
  4. doi Error propagation from prime variables into specific rates and metabolic fluxes for mammalian cells in perfusion culture
    Chetan T Goudar
    Cell Culture Development, Global Biologics Development, Bayer HealthCare, 800 Dwight Way, Berkeley, CA 94710, USA
    Biotechnol Prog 25:986-98. 2009
    ..Their ease of calculation, along with their ability to accurately describe the specific rate-metabolic flux error relationship, makes them a necessary component of metabolic flux analysis...
  5. ncbi Nonlinear estimation of microbial and enzyme kinetic parameters from progress curve data
    C T Goudar
    School of Civil Engineering and Environmental Science at the University of Oklahoma, Norman, USA
    Water Environ Res 73:260-5. 2001
    ..BIOKINFIT, available free of charge on request, offers a convenient and robust method of analyzing progress curve data in implicit kinetic expressions...
  6. ncbi Progress curve analysis for enzyme and microbial kinetic reactions using explicit solutions based on the Lambert W function
    Chetan T Goudar
    Process and Technology Development, Bayer HealthCare, Biological Products Division, 800 Dwight Way, B56 A, Berkeley, CA 94710, USA
    J Microbiol Methods 59:317-26. 2004
    ..531 microM/h and 2.136 microM, respectively. The algebraic nature of this solution, coupled with its relatively high accuracy, makes it an attractive candidate for kinetic parameter estimation from progress curve data...
  7. ncbi Logistic equations effectively model Mammalian cell batch and fed-batch kinetics by logically constraining the fit
    Chetan T Goudar
    Process and Technology Development, Bayer HealthCare, Biological Products Division, 800 Dwight Way, Berkeley, CA 94710, USA
    Biotechnol Prog 21:1109-18. 2005
    ..Overall, the advantages of the logistic modeling approach should make it an attractive option for effectively estimating specific rates from batch and fed-batch cultures...
  8. doi Robust parameter estimation during logistic modeling of batch and fed-batch culture kinetics
    Chetan T Goudar
    Cell Culture Development, Global Biologics Development, Bayer HealthCare, 800 Dwight Way, Berkeley, CA 94710, USA
    Biotechnol Prog 25:801-6. 2009
    ..The approach is relatively simple and can be implemented in a spreadsheet to robustly model mammalian cell culture batch or fed-batch data...
  9. ncbi Decreased pCO(2) accumulation by eliminating bicarbonate addition to high cell-density cultures
    Chetan T Goudar
    Research and Development, Process Sciences, Bayer HealthCare, Pharmaceutical Division, 800 Dwight Way, Berkeley, California 94710, USA
    Biotechnol Bioeng 96:1107-17. 2007
    ..This philosophy of pCO(2) reduction at the source through medium and base modification should be readily applicable to large-scale fed-batch cultivation of mammalian cells...
  10. doi Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy
    Chetan Goudar
    Cell Culture Development, Global Biological Development, Bayer HealthCare, 800 Dwight Way, Berkeley, CA 94710, USA
    Metab Eng 12:138-49. 2010
    ....
  11. ncbi The "push-to-low" approach for optimization of high-density perfusion cultures of animal cells
    Konstantin Konstantinov
    Bayer HealthCare, Biological Products Division, 800 Dwight Way, P O Box 1986, Berkeley, CA 94710, USA
    Adv Biochem Eng Biotechnol 101:75-98. 2006
    ....