Jin Zhong Zhang

Summary

Affiliation: Bausch and Lomb
Country: USA

Publications

  1. doi WY-14 643, a selective PPAR{alpha} agonist, induces proinflammatory and proangiogenic responses in human ocular cells
    Jin Zhong Zhang
    Pharmaceutical R and D, Bausch and Lomb, Inc, 1400 North Goodman Street, Rochester, NY 14603, USA
    Int J Toxicol 29:496-504. 2010
  2. ncbi Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy
    Jin Zhong Zhang
    Department of Ophthalmology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Curr Eye Res 32:883-9. 2007
  3. doi Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells
    Jin Zhong Zhang
    Global Preclinical Development, Bausch and Lomb, Rochester, New York 14603, USA
    Curr Eye Res 33:923-32. 2008
  4. pmc BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells
    Jin Zhong Zhang
    Pharmaceutical R and D, Bausch and Lomb Inc, Rochester, NY 14603, USA
    Mol Vis 15:2606-16. 2009
  5. pmc Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells
    Megan E Cavet
    Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, NY 14609, USA
    Mol Vis 16:1791-800. 2010
  6. ncbi Captopril inhibits glucose accumulation in retinal cells in diabetes
    Jin Zhong Zhang
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Invest Ophthalmol Vis Sci 44:4001-5. 2003
  7. pmc Anti-allergic effects of mapracorat, a novel selective glucocorticoid receptor agonist, in human conjunctival fibroblasts and epithelial cells
    Megan E Cavet
    Global Pharmaceutical R and D, Bausch and Lomb Inc, Rochester, NY 14609, USA
    Mol Vis 19:1515-25. 2013
  8. doi Correlation of tear inflammatory cytokines and matrix metalloproteinases with four dry eye diagnostic tests
    Karl R VanDerMeid
    Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, New York, USA
    Invest Ophthalmol Vis Sci 53:1512-8. 2012
  9. pmc Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells
    Megan E Cavet
    Global Pharmaceutical R and D, Bausch Lomb, Rochester, NY 14609, USA
    Mol Vis 17:533-42. 2011
  10. pmc Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1)
    Thomas R Vollmer
    Global Pharmaceutical R and D, Bausch Lomb, Inc, Rochester, New York 14609, USA
    J Biol Chem 287:35212-21. 2012

Collaborators

Detail Information

Publications15

  1. doi WY-14 643, a selective PPAR{alpha} agonist, induces proinflammatory and proangiogenic responses in human ocular cells
    Jin Zhong Zhang
    Pharmaceutical R and D, Bausch and Lomb, Inc, 1400 North Goodman Street, Rochester, NY 14603, USA
    Int J Toxicol 29:496-504. 2010
    ..These studies demonstrate for the first time that PPARα agonism may be proinflammatory and proangiogenic in a variety of ocular cells and suggest that therapeutic applications of such agents in ophthalmology may be limited...
  2. ncbi Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy
    Jin Zhong Zhang
    Department of Ophthalmology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Curr Eye Res 32:883-9. 2007
    ..This study was conducted to examine the effect of angiotensin-converting enzyme (ACE) inhibitors on the development of early stages of diabetic retinopathy...
  3. doi Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells
    Jin Zhong Zhang
    Global Preclinical Development, Bausch and Lomb, Rochester, New York 14603, USA
    Curr Eye Res 33:923-32. 2008
    ..The aim of this study was to determine the anti-inflammatory effects of besifloxacin, a novel fluoroquinolone under clinical evaluation for the treatment of ophthalmic infections, in human corneal epithelial cells (HCEpiC)...
  4. pmc BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells
    Jin Zhong Zhang
    Pharmaceutical R and D, Bausch and Lomb Inc, Rochester, NY 14603, USA
    Mol Vis 15:2606-16. 2009
    ..Data from in vitro and in vivo studies suggest an improved side-effect profile of this compound compared to classical glucocorticoids. The aim of this study was to determine the anti-inflammatory effect of BOL-303242-X in ocular cells...
  5. pmc Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells
    Megan E Cavet
    Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, NY 14609, USA
    Mol Vis 16:1791-800. 2010
    ..This study assessed the anti-inflammatory effects of mapracorat in an in vitro osmotic stress model which mimics some of the pathophysiological changes seen in dry eye...
  6. ncbi Captopril inhibits glucose accumulation in retinal cells in diabetes
    Jin Zhong Zhang
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Invest Ophthalmol Vis Sci 44:4001-5. 2003
    ....
  7. pmc Anti-allergic effects of mapracorat, a novel selective glucocorticoid receptor agonist, in human conjunctival fibroblasts and epithelial cells
    Megan E Cavet
    Global Pharmaceutical R and D, Bausch and Lomb Inc, Rochester, NY 14609, USA
    Mol Vis 19:1515-25. 2013
    ..To determine the ocular anti-allergic effects of mapracorat, a novel selective glucocorticoid receptor agonist (SEGRA) in primary human conjunctival fibroblasts and epithelial cells...
  8. doi Correlation of tear inflammatory cytokines and matrix metalloproteinases with four dry eye diagnostic tests
    Karl R VanDerMeid
    Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, New York, USA
    Invest Ophthalmol Vis Sci 53:1512-8. 2012
    ..This study examined the extracted levels of tear cytokines and MMPs from Schirmer strips and potential correlation with Schirmer's test, tear breakup time (TBUT), tear osmolarity, and ocular surface disease index (OSDI)...
  9. pmc Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells
    Megan E Cavet
    Global Pharmaceutical R and D, Bausch Lomb, Rochester, NY 14609, USA
    Mol Vis 17:533-42. 2011
    ..To determine the anti-inflammatory and anti-oxidant effects of epigallocatechin gallate (EGCG), the major polyphenol component of green tea, in human corneal epithelial cells (HCEpiC)...
  10. pmc Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1)
    Thomas R Vollmer
    Global Pharmaceutical R and D, Bausch Lomb, Inc, Rochester, New York 14609, USA
    J Biol Chem 287:35212-21. 2012
    ..Taken together, these results indicate that mapracorat exerts its anti-inflammatory effects, at least in part, by augmenting MKP-1 expression...
  11. ncbi Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes
    Jin Zhong Zhang
    Global Preclinical Development, Bausch and Lomb, 1400 North Goodman Street, Rochester, NY 14603, USA
    J Antimicrob Chemother 61:111-6. 2008
    ..This study was conducted to evaluate the anti-inflammatory effects of besifloxacin, a novel fluoroquinolone under clinical evaluation for treatment of ophthalmic infections...
  12. ncbi Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells
    Xia Xi
    Department of Ophthalmology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Biochem Biophys Res Commun 326:548-53. 2005
    ..Our data suggest that although acutely elevated glucose may be beneficial to the cell survival, chronically elevated glucose can cause apoptosis via downregulation of Akt survival signaling...
  13. doi Comparison of the effect of multipurpose contact lens solutions on the viability of cultured corneal epithelial cells
    Megan E Cavet
    Pharmaceutical R and D, Bausch and Lomb, 1400 North Goodman Street, Rochester, NY 14609, USA
    Cont Lens Anterior Eye 32:171-5. 2009
    ..To determine the effect of four marketed multipurpose contact lens solutions (MPSs) on corneal epithelial cell viability...
  14. pmc A method to extract cytokines and matrix metalloproteinases from Schirmer strips and analyze using Luminex
    Karl R VanDerMeid
    Pharmaceutical R and D, Bausch Lomb, Inc, Rochester, NY 14609, USA
    Mol Vis 17:1056-63. 2011
    ..This report describes a procedure which can be used to recover tears from the Schirmer strip for the measurement of multiple tear cytokines as well as matrix metalloproteinases (MMPs) by Luminex technology...
  15. doi Safety of repeated topical ocular administration of a polycarbophil-based formulation in several models of ocular surgery in rabbits
    Kathleen L Krenzer
    Bausch and Lomb, Rochester, New York 14609, USA
    J Cataract Refract Surg 38:696-704. 2012
    ..The rheological properties were evaluated to characterize the behavior of the formulation on the ocular surface...