Jerry D Johnson

Summary

Affiliation: Battelle Memorial Institute
Country: USA

Publications

  1. doi request reprint Comparative Toxicology Studies in Sprague-Dawley Rats, Rhesus Monkeys, and New Zealand White Rabbits to Determine a No Observed Adverse Effect Level for 1,1'-Methylenebis[4-[(hydroxyimino)methyl]-pyridinium] Dimethanesulfonate
    Merrill R Osheroff
    505 King Avenue, Battelle Columbus, OH 43201, USA Email
    Int J Toxicol 32:59S-74S. 2013
  2. ncbi request reprint Toxicokinetics of 2-methylimidazole in male and female F344 rats
    Jerry D Johnson
    Battelle Memorial Institute, Columbus, Ohio 43201, USA
    J Toxicol Environ Health A 65:869-79. 2002
  3. doi request reprint Comparative Toxicokinetics of MMB4 DMS in Rats, Rabbits, Dogs, and Monkeys Following Single and Repeated Intramuscular Administration
    S Peter Hong
    Battelle, Columbus, OH 43201, USA Email
    Int J Toxicol 32:38S-48S. 2013
  4. doi request reprint Absorption, Distribution, Metabolism, and Excretion of 14C-MMB4 DMS Administered Intramuscularly to Sprague-Dawley Rats and New Zealand White Rabbits
    Bozena D Lusiak
    Battelle, 505 King Avenue, Columbus, OH 43201, USA Email
    Int J Toxicol 32:88S-98S. 2013
  5. doi request reprint In Vivo Acetylcholinesterase Reactivation in Male Guinea Pigs and Rhesus Macaques Following Cyclosarin Exposure and Treatment With 1,1'-Methylenebis{4-[(hydroxyimino)methyl] pyridinium} Dimethanesulfonate
    Jill A Harvilchuck
    Medical Chemical Defense, Battelle, 505 King Avenue, Columbus, OH 43201, USA Email
    Int J Toxicol 32:99S-107S. 2013
  6. doi request reprint Evaluations of In Vitro Metabolism, Drug-Drug Interactions Mediated by Reversible and Time-Dependent Inhibition of CYPs, and Plasma Protein Binding of MMB4 DMS
    S Peter Hong
    Battelle, 505 King Avenue, Columbus, OH 43201, USA Email
    Int J Toxicol 32:75S-87S. 2013
  7. doi request reprint Pharmacokinetics of MMB4 DMS in Rats, Rabbits, and Dogs Following a Single IV Administration
    S Peter Hong
    Battelle, 505 King Avenue, Columbus, OH 43201, USA Email
    Int J Toxicol 32:30S-7S. 2013
  8. ncbi request reprint Oral and dermal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces cutaneous papillomas and squamous cell carcinomas in female hemizygous Tg.AC transgenic mice
    Michael E Wyde
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 82:34-45. 2004
  9. ncbi request reprint Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice
    Michelle J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicology 204:123-40. 2004
  10. ncbi request reprint Toxicity and carcinogenicity of Elmiron in F344/N rats and B6C3F1 mice following 2 years of gavage administration
    Kamal M Abdo
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, MD EC 35, PO Box 12233, Research Triangle Park, NC 27709 9998, USA
    Arch Toxicol 77:702-11. 2003

Collaborators

  • A Nyska
  • N J Walker
  • M J Hooth
  • S Peter Hong
  • Merrill R Osheroff
  • Brian L Burback
  • Dean J Kobs
  • Bozena D Lusiak
  • Seth T Gibbs
  • Claire R Croutch
  • Jill A Harvilchuck
  • Michael E Wyde
  • Kamal M Abdo
  • Michael A Hawk
  • Matthew Buccellato
  • Laura E Elcock
  • Jamie S Richey
  • Molly Vallant
  • Stephen D Cooper
  • Angelique P J M Braen
  • John D Toft
  • James C Blake
  • Joel Mahler
  • Milton Hejtmancik
  • John R Bucher

Detail Information

Publications11

  1. doi request reprint Comparative Toxicology Studies in Sprague-Dawley Rats, Rhesus Monkeys, and New Zealand White Rabbits to Determine a No Observed Adverse Effect Level for 1,1'-Methylenebis[4-[(hydroxyimino)methyl]-pyridinium] Dimethanesulfonate
    Merrill R Osheroff
    505 King Avenue, Battelle Columbus, OH 43201, USA Email
    Int J Toxicol 32:59S-74S. 2013
    ..The NZW rabbit was the most sensitive species, and the no observed adverse effect level (NOAEL) was determined as 50 mg/kg/d; the NOAEL in the rat was 100 mg/kg/d; and the NOAEL in rhesus monkeys was >600 mg/kg/d. ..
  2. ncbi request reprint Toxicokinetics of 2-methylimidazole in male and female F344 rats
    Jerry D Johnson
    Battelle Memorial Institute, Columbus, Ohio 43201, USA
    J Toxicol Environ Health A 65:869-79. 2002
    ....
  3. doi request reprint Comparative Toxicokinetics of MMB4 DMS in Rats, Rabbits, Dogs, and Monkeys Following Single and Repeated Intramuscular Administration
    S Peter Hong
    Battelle, Columbus, OH 43201, USA Email
    Int J Toxicol 32:38S-48S. 2013
    ..Based on the TK results obtained from the current study and published investigations, it was found that the apparent volume of distribution and clearance values were similar among various preclinical species, except for the rat. ..
  4. doi request reprint Absorption, Distribution, Metabolism, and Excretion of 14C-MMB4 DMS Administered Intramuscularly to Sprague-Dawley Rats and New Zealand White Rabbits
    Bozena D Lusiak
    Battelle, 505 King Avenue, Columbus, OH 43201, USA Email
    Int J Toxicol 32:88S-98S. 2013
    ..Two metabolites of MMB4 DMS were detected in rat and rabbit urine; their structure was confirmed by liquid chromatography with tandem mass spectrometry as 4-pyridine aldoxime and isonicotinic acid (pyridine-4-carboxylic acid). ..
  5. doi request reprint In Vivo Acetylcholinesterase Reactivation in Male Guinea Pigs and Rhesus Macaques Following Cyclosarin Exposure and Treatment With 1,1'-Methylenebis{4-[(hydroxyimino)methyl] pyridinium} Dimethanesulfonate
    Jill A Harvilchuck
    Medical Chemical Defense, Battelle, 505 King Avenue, Columbus, OH 43201, USA Email
    Int J Toxicol 32:99S-107S. 2013
    ..In comparison, 6 of 6 animals treated with 1.2 mg/kg MMB4 DMS were observed as clinically normal 24 hours post-challenge. ..
  6. doi request reprint Evaluations of In Vitro Metabolism, Drug-Drug Interactions Mediated by Reversible and Time-Dependent Inhibition of CYPs, and Plasma Protein Binding of MMB4 DMS
    S Peter Hong
    Battelle, 505 King Avenue, Columbus, OH 43201, USA Email
    Int J Toxicol 32:75S-87S. 2013
    ..These results suggest that MMB4 was not extensively bound to plasma protein, and there were no overt species-related differences in the extent of MMB4 bound to plasma protein. ..
  7. doi request reprint Pharmacokinetics of MMB4 DMS in Rats, Rabbits, and Dogs Following a Single IV Administration
    S Peter Hong
    Battelle, 505 King Avenue, Columbus, OH 43201, USA Email
    Int J Toxicol 32:30S-7S. 2013
    ..The current study revealed a similarity in the volume of distribution to the central compartment for MMB4 among the 3 species tested while demonstrating species-related differences in the elimination half-life and clearance of MMB4. ..
  8. ncbi request reprint Oral and dermal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces cutaneous papillomas and squamous cell carcinomas in female hemizygous Tg.AC transgenic mice
    Michael E Wyde
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 82:34-45. 2004
    ..Differences in response between the routes of exposure may reflect pharmacokinetic differences in the delivery of TCDD to the skin over the duration of the study...
  9. ncbi request reprint Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice
    Michelle J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicology 204:123-40. 2004
    ..Treatment-related nonneoplastic lesions did not occur in mice. Treatment-related neoplastic lesions did not occur in rats or mice...
  10. ncbi request reprint Toxicity and carcinogenicity of Elmiron in F344/N rats and B6C3F1 mice following 2 years of gavage administration
    Kamal M Abdo
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, MD EC 35, PO Box 12233, Research Triangle Park, NC 27709 9998, USA
    Arch Toxicol 77:702-11. 2003
    ..Under the conditions of these 2-year studies, Elmiron was carcinogenic to mice but not rats...
  11. ncbi request reprint Lysosomal-storage disorder induced by elmiron following 90-days gavage administration in rats and mice
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:178-87. 2002
    ..The cytoplasmic membrane-bound structures within macrophages were lysosomes containing membranous material of cellular origin and, perhaps, remnants of the deposited test material, Elmiron...