S Peter Hong

Summary

Affiliation: Battelle Memorial Institute
Country: USA

Publications

  1. doi Toxicokinetics of methyleugenol in F344 rats and B6C3F₁ mice
    S Peter Hong
    Battelle Memorial Institute, Columbus, OH, USA
    Xenobiotica 43:293-302. 2013
  2. doi Pharmacokinetics of MMB4 DMS in rats, rabbits, and dogs following a single IV administration
    S Peter Hong
    Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:30S-7S. 2013
  3. doi Comparative toxicokinetics of MMB4 DMS in rats, rabbits, dogs, and monkeys following single and repeated intramuscular administration
    S Peter Hong
    Battelle, Columbus, OH 43201, USA
    Int J Toxicol 32:38S-48S. 2013
  4. doi Evaluations of in vitro metabolism, drug-drug interactions mediated by reversible and time-dependent inhibition of CYPs, and plasma protein binding of MMB4 DMS
    S Peter Hong
    Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:75S-87S. 2013
  5. doi In vivo acetylcholinesterase reactivation in male guinea pigs and rhesus macaques following cyclosarin exposure and treatment with 1,1'-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate
    Jill A Harvilchuck
    Medical Chemical Defense, Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:99S-107S. 2013
  6. ncbi Toxicokinetics of isoeugenol in F344 rats and B6C3F1 mice
    S Peter Hong
    Battelle Memorial Institute, Columbus, OH, USA
    Xenobiotica 43:1010-7. 2013
  7. doi Absorption, distribution, metabolism, and excretion of 14C-MMB4 DMS administered intramuscularly to Sprague-Dawley rats and New Zealand White rabbits
    Bozena D Lusiak
    Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:88S-98S. 2013
  8. doi Efficacy and pharmacokinetic/pharmacodynamic study of 1,1'-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate in guinea pigs and rhesus macaques exposed to cyclosarin
    Jill A Harvilchuck
    Medical Chemical Defense, Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:108S-17S. 2013

Detail Information

Publications8

  1. doi Toxicokinetics of methyleugenol in F344 rats and B6C3F₁ mice
    S Peter Hong
    Battelle Memorial Institute, Columbus, OH, USA
    Xenobiotica 43:293-302. 2013
    ..There was no sex difference in plasma toxicokinetics of MEG following gavage administration both in rats and mice...
  2. doi Pharmacokinetics of MMB4 DMS in rats, rabbits, and dogs following a single IV administration
    S Peter Hong
    Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:30S-7S. 2013
    ..The current study revealed a similarity in the volume of distribution to the central compartment for MMB4 among the 3 species tested while demonstrating species-related differences in the elimination half-life and clearance of MMB4...
  3. doi Comparative toxicokinetics of MMB4 DMS in rats, rabbits, dogs, and monkeys following single and repeated intramuscular administration
    S Peter Hong
    Battelle, Columbus, OH 43201, USA
    Int J Toxicol 32:38S-48S. 2013
    ..Based on the TK results obtained from the current study and published investigations, it was found that the apparent volume of distribution and clearance values were similar among various preclinical species, except for the rat. ..
  4. doi Evaluations of in vitro metabolism, drug-drug interactions mediated by reversible and time-dependent inhibition of CYPs, and plasma protein binding of MMB4 DMS
    S Peter Hong
    Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:75S-87S. 2013
    ..These results suggest that MMB4 was not extensively bound to plasma protein, and there were no overt species-related differences in the extent of MMB4 bound to plasma protein. ..
  5. doi In vivo acetylcholinesterase reactivation in male guinea pigs and rhesus macaques following cyclosarin exposure and treatment with 1,1'-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate
    Jill A Harvilchuck
    Medical Chemical Defense, Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:99S-107S. 2013
    ..In comparison, 6 of 6 animals treated with 1.2 mg/kg MMB4 DMS were observed as clinically normal 24 hours post-challenge...
  6. ncbi Toxicokinetics of isoeugenol in F344 rats and B6C3F1 mice
    S Peter Hong
    Battelle Memorial Institute, Columbus, OH, USA
    Xenobiotica 43:1010-7. 2013
    ..2437). The collective toxicokinetic data supported that low bioavailability following administration of IEG was the result of extensive first-pass metabolism...
  7. doi Absorption, distribution, metabolism, and excretion of 14C-MMB4 DMS administered intramuscularly to Sprague-Dawley rats and New Zealand White rabbits
    Bozena D Lusiak
    Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:88S-98S. 2013
    ..Two metabolites of MMB4 DMS were detected in rat and rabbit urine; their structure was confirmed by liquid chromatography with tandem mass spectrometry as 4-pyridine aldoxime and isonicotinic acid (pyridine-4-carboxylic acid). ..
  8. doi Efficacy and pharmacokinetic/pharmacodynamic study of 1,1'-methylenebis{4-[(hydroxyimino)methyl] pyridinium} dimethanesulfonate in guinea pigs and rhesus macaques exposed to cyclosarin
    Jill A Harvilchuck
    Medical Chemical Defense, Battelle, 505 King Avenue, Columbus, OH 43201, USA
    Int J Toxicol 32:108S-17S. 2013
    ..The QOL scores improved with increasing MMB4 DMS dose in both species. The estimated ED80s were 25.5 mg/kg MMB4 DMS (human equivalent dose [HED] of 5.5 mg/kg) and ≤ 0.1 mg/kg (HED of 0.03 mg/kg) in guinea pigs and NHPs, respectively...