T G Lawson


Affiliation: Bates College
Country: USA


  1. Carmody M, Zimmer J, Cushman C, Nguyen T, Lawson T. The ubiquitin-protein ligase E6AP/UBE3A supports early encephalomyocarditis virus replication. Virus Res. 2018;: pubmed publisher
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    Lawson T, Gronros D, Evans P, Bastien M, Michalewich K, Clark J, et al. Identification and characterization of a protein destruction signal in the encephalomyocarditis virus 3C protease. J Biol Chem. 1999;274:9871-80 pubmed
    ..The other is a Ubc5-dependent E3 that appears to recognize a different, unidentified feature of the 3C protease. ..
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    Lawson T, Sweep M, Schlax P, Bohnsack R, Haas A. Kinetic analysis of the conjugation of ubiquitin to picornavirus 3C proteases catalyzed by the mammalian ubiquitin-protein ligase E3alpha. J Biol Chem. 2001;276:39629-37 pubmed
  4. Carmody M, Notarianni T, Sambel L, Walsh S, Burke J, Armstrong J, et al. E6AP/UBE3A catalyzes encephalomyocarditis virus 3C protease polyubiquitylation and promotes its concentration reduction in virus-infected cells. Biochem Biophys Res Commun. 2017;494:63-69 pubmed publisher
    ..We also discovered that ARIH1 functions with UbcH7 to catalyze EMCV 3Cpro monoubiquitylation, but this activity does not influence the in vivo 3Cpro concentration. ..