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..The other is a Ubc5-dependent E3 that appears to recognize a different, unidentified feature of the 3C protease. ..
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Carmody M, Notarianni T, Sambel L, Walsh S, Burke J, Armstrong J, et al. E6AP/UBE3A catalyzes encephalomyocarditis virus 3C protease polyubiquitylation and promotes its concentration reduction in virus-infected cells. Biochem Biophys Res Commun. 2017;494:63-69 pubmed publisher
..We also discovered that ARIH1 functions with UbcH7 to catalyze EMCV 3Cpro monoubiquitylation, but this activity does not influence the in vivo 3Cpro concentration. ..