Donald J Messner
Affiliation: Bastyr University
- Iron overload causes oxidative stress and impaired insulin signaling in AML-12 hepatocytesDonald J Messner
Bastyr University, 14500 Juanita Drive NE, Kenmore, WA 98028 4966, USA
Dig Dis Sci 58:1899-908. 2013..Iron overload is associated with increased severity of nonalcoholic fatty liver disease (NAFLD) including progression to nonalcoholic steatohepatitis and hepatocellular carcinoma...
- Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound ironDonald J Messner
Bastyr University, 14500 Juanita Drive, Kenmore, WA 98028, USA
BMC Gastroenterol 8:2. 2008..The primary aim of this study was to investigate NTBI-related hepatic carcinogenesis using T51B rat liver epithelial cells, a non-neoplastic cell line previously developed for carcinogenicity and tumor promotion studies...
- Curcumin reduces the toxic effects of iron loading in rat liver epithelial cellsDonald J Messner
Bastyr University Research Center, Bastyr University, Kenmore, WA 98028, USA
Liver Int 29:63-72. 2009..The aim of this study was to quantify its effects on iron overload and the resulting downstream toxic effects in cultured T51B rat liver epithelial cells...
- Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cellsDonald J Messner
Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA
J Cell Biochem 99:241-55. 2006..In contrast, specific blockade of PP2A mimics p53-related responses to OA in T51B cells, suggesting that PP2A is the target for this response to OA...