Michael W Greene

Summary

Affiliation: Bassett Healthcare
Country: USA

Publications

  1. ncbi Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation
    Michael W Greene
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305, USA
    J Biol Chem 278:8199-211. 2003
  2. ncbi Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta
    Michael W Greene
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biochem J 378:105-16. 2004
  3. ncbi Circadian rhythms and tumor growth
    Michael W Greene
    Bassett Research Institute, Bassett Healthcare Network, Cooperstown, NY 13326 1301, USA
    Cancer Lett 318:115-23. 2012
  4. ncbi PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function
    Michael W Greene
    Bassett Research Institute, Mary Imogene Bassett Hospital, Cooperstown, NY 13326, USA
    Biochem Biophys Res Commun 349:976-86. 2006
  5. ncbi TNFalpha activation of PKCdelta, mediated by NFkappaB and ER stress, cross-talks with the insulin signaling cascade
    Michael W Greene
    Bassett Research Institute, Mary Imogene Bassett Hospital, Cooperstown, NY 13326, United States
    Cell Signal 22:274-84. 2010
  6. ncbi PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death
    Michael W Greene
    Bassett Research Institute, Bassett Medical Center, Bassett Healthcare Network, Cooperstown, New York 13326, USA
    J Biol Chem 285:42115-29. 2010
  7. ncbi Light at night activates IGF-1R/PDK1 signaling and accelerates tumor growth in human breast cancer xenografts
    Jinghai Wu
    Bassett Research Institute and Department of Internal Medicine, Bassett Healthcare Network, Cooperstown, New York, USA
    Cancer Res 71:2622-31. 2011
  8. ncbi Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation
    Michael W Greene
    Global Research and Development, Pfizer, Inc, Groton, Connecticut 06340, USA
    Biochemistry 41:7082-91. 2002

Collaborators

Detail Information

Publications8

  1. ncbi Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation
    Michael W Greene
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305, USA
    J Biol Chem 278:8199-211. 2003
    ..In summary, our results indicate that the insulin-stimulated degradation of IRS-1 via the phosphatidylinositol 3-kinase pathway is in part dependent upon the Ser(312) phosphorylation of IRS-1...
  2. ncbi Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta
    Michael W Greene
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biochem J 378:105-16. 2004
    ..These results indicate that PKCdelta modulates the ability of the insulin receptor to tyrosine-phosphorylate IRS-1 by direct phosphorylation of the IRS-1 molecule...
  3. ncbi Circadian rhythms and tumor growth
    Michael W Greene
    Bassett Research Institute, Bassett Healthcare Network, Cooperstown, NY 13326 1301, USA
    Cancer Lett 318:115-23. 2012
    ..Recent attention has focused on the signaling pathways activated by the circadian controlled factors because these pathways hold the potential for the development of novel strategies for cancer prevention and treatment...
  4. ncbi PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function
    Michael W Greene
    Bassett Research Institute, Mary Imogene Bassett Hospital, Cooperstown, NY 13326, USA
    Biochem Biophys Res Commun 349:976-86. 2006
    ..In summary, our data are consistent with the hypothesis that Ser24 is a negative regulatory phosphorylation site in IRS-1...
  5. ncbi TNFalpha activation of PKCdelta, mediated by NFkappaB and ER stress, cross-talks with the insulin signaling cascade
    Michael W Greene
    Bassett Research Institute, Mary Imogene Bassett Hospital, Cooperstown, NY 13326, United States
    Cell Signal 22:274-84. 2010
    ....
  6. ncbi PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death
    Michael W Greene
    Bassett Research Institute, Bassett Medical Center, Bassett Healthcare Network, Cooperstown, New York 13326, USA
    J Biol Chem 285:42115-29. 2010
    ....
  7. ncbi Light at night activates IGF-1R/PDK1 signaling and accelerates tumor growth in human breast cancer xenografts
    Jinghai Wu
    Bassett Research Institute and Department of Internal Medicine, Bassett Healthcare Network, Cooperstown, New York, USA
    Cancer Res 71:2622-31. 2011
    ..Taken together, our findings demonstrate that LAN exposure can accelerate tumor growth in vivo, in part through continuous activation of IGF-1R/PDK1 signaling...
  8. ncbi Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation
    Michael W Greene
    Global Research and Development, Pfizer, Inc, Groton, Connecticut 06340, USA
    Biochemistry 41:7082-91. 2002
    ..These data suggest that Ser/Thr phosphorylation can have both a positive and a negative regulatory role on tyrosine phosphorylation of IRS-1 and IRS-2 by insulin and IGF-1 receptors...