Research Topics
Species | David E BlaskSummaryAffiliation: Bassett Healthcare Country: USA Publications
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Detail Information
Publications
Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude ratsDavid E Blask
Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, New York 13326, USA
Cancer Res 65:11174-84. 2005..These mechanistic studies are the first to provide a rational biological explanation for the increased breast cancer risk in female night shift workers...- Light during darkness, melatonin suppression and cancer progressionDavid E Blask
Laboratory of Experimental Neuroendocrinology Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
Neuro Endocrinol Lett 23:52-6. 2002.... - Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppressionDavid E Blask
Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
Breast Cancer Res Treat 79:313-20. 2003..This is the first biological evidence for a potential link between constant light exposure and increased human breast oncogenesis involving MLT suppression and stimulation of tumor LA metabolism... - Human cancer xenograft perfusion in situ in rats: a new perfusion system that minimizes delivery time and maintains normal tissue physiology and responsiveness to growth-inhibitory agentsErin M Dauchy
Laboratory of Chrononeuroendocrine Oncology, Bassett Research Institute, Cooperstown, NY, USA
J Am Assoc Lab Anim Sci 45:38-44. 2006..This new system provides rapid perfusate delivery for use with both normal and neoplastic tissues while maintaining normal physiologic tissue parameters... 
Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenograftsRobert T Dauchy
Laboratory of Chrono Neuroendocrine Oncology, Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, Louisiana Cancer Research Consortium, New Orleans, LA 70112 2699, USA
J Pineal Res 47:32-42. 2009....- Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acidsRobert T Dauchy
Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, NY, USA
Comp Med 57:377-82. 2007.... - Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo ratsLaura C Smith
Bassett Research Institute, Cooperstown, NY 13326, USA
Nutr Cancer 56:204-13. 2006..These results provide in vivo evidence that dietary fish oil suppressed a specific linoleic acid-dependent, inhibitory G protein-coupled, growth-promoting signaling pathway in rat hepatoma 7288CTC... - Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathwayLeonard A Sauer
Bassett Research Institute, Cooperstown, NY 13326, USA
J Nutr 135:2124-9. 2005..The results suggest that EPA regulates cell proliferation in MCF-7 xenografts via a novel inhibitory G protein-coupled, (n-3) FFA receptor-mediated signal transduction pathway... - Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acidRobert T Dauchy
Bassett Research Institute, The Mary Imogene Bassett Hospital, One Atwell Road, Cooperstown, NY 13326, USA
Cancer Lett 209:7-15. 2004.... - Light at night activates IGF-1R/PDK1 signaling and accelerates tumor growth in human breast cancer xenograftsJinghai Wu
Bassett Research Institute and Department of Internal Medicine, Bassett Healthcare Network, Cooperstown, New York, USA
Cancer Res 71:2622-31. 2011..Taken together, our findings demonstrate that LAN exposure can accelerate tumor growth in vivo, in part through continuous activation of IGF-1R/PDK1 signaling... - Conjugated linoleic acid isomers and trans fatty acids inhibit fatty acid transport in hepatoma 7288CTC and inguinal fat pads in Buffalo ratsLeonard A Sauer
Bassett Research Institute, Cooperstown, NY 13326, USA
J Nutr 134:1989-97. 2004..These results support the idea that an inhibitory GPC FFAR reduces cAMP and controls FA transport by CLA isomers and trans FAs. Ligand activity is conferred by the presence of a trans double bond proximal to the carboxyl group... - Dietary factors and growth and metabolism in experimental tumorsLeonard A Sauer
Bassett Research Institute, Cooperstown, NY 13326, USA
J Nutr Biochem 18:637-49. 2007.... 
Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at nightDavid E Blask
Laboratory of Chrono Neuroendocrine Oncology, Tulane University School of Medicine, New Orleans, LA, USA
J Pineal Res 51:259-69. 2011....- Melatonin, sleep disturbance and cancer riskDavid E Blask
Laboratory of Chrono Neuroendocrine Oncology, Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA
Sleep Med Rev 13:257-64. 2009.... - Melatonin uptake and growth prevention in rat hepatoma 7288CTC in response to dietary melatonin: melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxyoctadecadienoic acid and the potential rolDavid E Blask
Laboratory of Chrono-Neuroendocrine Oncology, Bassett Research Institute, One Atwell Road, Cooperstown, NY 13326, USA
Carcinogenesis 25:951-60. 2004.... - Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signalDavid E Blask
Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
Endocrine 27:179-88. 2005..Dietary melatonin supplementation working in concert with the endogenous melatonin signal has the potential to be a new preventive/therapeutic strategy to optimize the host/cancer balance in favor of host survival and quality of life... - Physiologic melatonin concentration, omega-3 fatty acids, and conjugated linoleic acid inhibit fatty acid transport in rodent hind limb skeletal muscle in vivoRobert T Dauchy
Laboratory of Experimental Neuroendocrinolgy/Oncology, Bassett Research Institute, Cooperstown, New York 13326-1394, USA
Comp Med 53:186-90. 2003..Glucose uptake and glycerol production in the hind limb were not affected.These investigations suggest a novel role for MLT, omega-3 FAs, and CLA in the regulation of FA transport and fat metabolism in skeletal muscle... - Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapyDavid E Blask
Laboratory of Experimental Neuroendocrinology Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
Curr Top Med Chem 2:113-32. 2002..It also provides the first biological explanation of melatonin-induced enhancement of the efficacy and reduced toxicity of chemo- and radiotherapy in cancer patients... - Light during darkness and cancer: relationships in circadian photoreception and tumor biologySamar A Jasser
Department of Neurology, Light Research Program, Thomas Jefferson University, 1025 Walnut Street, Suite 507, Philadelphia, PA 19107, USA
Cancer Causes Control 17:515-23. 2006..Continued rigorous empirical inquiry into the physiology and clinical implications of these habitual, integrated aspects of life is highly warranted at this time... - Re: Melatonin and breast cancer: a prospective studyWilliam J M Hrushesky
J Natl Cancer Inst 96:888-9. 2004 - Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseasesRichard G Stevens
Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 6325, USA
Environ Health Perspect 115:1357-62. 2007..Third are effects of light-induced physiologic disruption on disease occurrence and prognosis, and how prevention and treatment could be improved by application of this knowledge...