Jie Wu

Summary

Affiliation: Barrow Neurological Institute
Country: USA

Publications

  1. ncbi request reprint Roles of nicotinic acetylcholine receptors in stem cell survival/apoptosis, proliferation and differentiation
    J X Shen
    Division of Neurology, Director, Neurophysiology Laboratory, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    Curr Mol Med 13:1455-64. 2013
  2. pmc α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation
    Yuan Liu
    Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Guang Zhou Road 300, Nanjing 210029, China
    J Neuroinflammation 9:98. 2012
  3. doi request reprint Double target concept for smoking cessation
    Jie Wu
    Shantou University Medical College, China
    Acta Pharmacol Sin 31:1015-8. 2010
  4. ncbi request reprint Electrophysiological properties and subunit composition of GABAA receptors in patients with gelastic seizures and hypothalamic hamartoma
    Jie Wu
    Neurophysiology Lab, Div of Neurology, Barrow Neurological Inst, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    J Neurophysiol 98:5-15. 2007
  5. pmc GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, NRC 445, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Exp Neurol 213:397-404. 2008
  6. pmc Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors
    Jie Wu
    Neurophysiology Laboratory, Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    J Physiol 576:103-18. 2006
  7. ncbi request reprint Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta
    Jie Wu
    Neurophysiology Laboratory, Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 319:155-64. 2006
  8. pmc Naturally-expressed nicotinic acetylcholine receptor subtypes
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, United States
    Biochem Pharmacol 82:800-7. 2011
  9. pmc Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons
    Kechun Yang
    Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013 4496, USA
    J Physiol 587:345-61. 2009
  10. doi request reprint alpha-Chloralose diminishes gamma oscillations in rat hippocampal slices
    Kui Wang
    Neurophysiology Laboratory, Division of Neurology, NRC 444, St Joseph s Hospital and Medical Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Neurosci Lett 441:66-71. 2008

Research Grants

Collaborators

Detail Information

Publications89

  1. ncbi request reprint Roles of nicotinic acetylcholine receptors in stem cell survival/apoptosis, proliferation and differentiation
    J X Shen
    Division of Neurology, Director, Neurophysiology Laboratory, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    Curr Mol Med 13:1455-64. 2013
    ..In this review, we summarize current development in cholinergic modulations of stem cell survival/apoptosis, proliferation and differentiation in order to evaluate the impact of nAChRs in stem cell biology and pathology. ..
  2. pmc α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation
    Yuan Liu
    Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Guang Zhou Road 300, Nanjing 210029, China
    J Neuroinflammation 9:98. 2012
    ..The objective of the present study was to determine whether nicotine-induced neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model occurs via α7-nAChR-mediated inhibition of astrocytes...
  3. doi request reprint Double target concept for smoking cessation
    Jie Wu
    Shantou University Medical College, China
    Acta Pharmacol Sin 31:1015-8. 2010
    ..I discuss how to use this double target concept to interpret recent therapies and to develop new candidate compounds for smoking cessation...
  4. ncbi request reprint Electrophysiological properties and subunit composition of GABAA receptors in patients with gelastic seizures and hypothalamic hamartoma
    Jie Wu
    Neurophysiology Lab, Div of Neurology, Barrow Neurological Inst, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    J Neurophysiol 98:5-15. 2007
    ..These findings bear relevance to a broader understanding of inhibitory neurotransmission in human HH tissue...
  5. pmc GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, NRC 445, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Exp Neurol 213:397-404. 2008
    ..Taken collectively, we provide novel evidence for and mechanistic insights into HH epileptogenicity: GABA(A)R-mediated excitation...
  6. pmc Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors
    Jie Wu
    Neurophysiology Laboratory, Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    J Physiol 576:103-18. 2006
    ..Diversity in alpha4*-nAChR is of potential relevance to nervous system function, disease, and nicotine dependence...
  7. ncbi request reprint Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta
    Jie Wu
    Neurophysiology Laboratory, Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 319:155-64. 2006
    ..These effects of iptakalim stimulate further pharmacological investigation and the development of possible therapeutic applications...
  8. pmc Naturally-expressed nicotinic acetylcholine receptor subtypes
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, United States
    Biochem Pharmacol 82:800-7. 2011
    ..Importantly, the nAChRs that exist as new isoforms or subtypes or have interesting distributions require alteration in thinking about their roles in health and disease...
  9. pmc Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons
    Kechun Yang
    Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013 4496, USA
    J Physiol 587:345-61. 2009
    ..Interestingly, each DAergic neuron predominantly expresses only one particularly functional nAChR subtype, which may have distinct but important roles in regulation of VTA DA neuronal function, DA transmission and nicotine dependence...
  10. doi request reprint alpha-Chloralose diminishes gamma oscillations in rat hippocampal slices
    Kui Wang
    Neurophysiology Laboratory, Division of Neurology, NRC 444, St Joseph s Hospital and Medical Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Neurosci Lett 441:66-71. 2008
    ..Enhancement of GABAergic leak current and prolongation of GABAergic sIPSCs by alpha-chloralose likely underlie its disruption of neuronal network synchronization in the hippocampus...
  11. pmc Functional nicotinic acetylcholine receptors containing α6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons
    Kechun Yang
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    J Neurosci 31:2537-48. 2011
    ..These presynaptic α6β2*-nAChRs likely play important roles in nicotinic modulation of DA neuronal activity...
  12. ncbi request reprint Role of alpha7-nicotinic acetylcholine receptors in tetanic stimulation-induced gamma oscillations in rat hippocampal slices
    Chuanzhe Song
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Neuropharmacology 48:869-80. 2005
    ..It is concluded that alpha7-nAChRs in hippocampal slices play important roles in regulation of gamma oscillations, thus potentially helping to explain roles of nAChRs in cognitive functions such as learning, memory and attention...
  13. ncbi request reprint GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
    Do Young Kim
    Division of Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsia 49:861-71. 2008
    ..Here, we examined the role of GABAA receptors in surgically resected HH tissue...
  14. pmc A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides
    Qiang Liu
    Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    J Neurosci 29:918-29. 2009
    ....
  15. doi request reprint The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptors
    Chao Zheng
    Senior Staff Scientist, Director of Neural Physiology Laboratory, Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Rd, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 335:401-8. 2010
    ....
  16. ncbi request reprint Iptakalim as a human nicotinic acetylcholine receptor antagonist
    Jun Hu
    Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 316:914-25. 2006
    ..Thus, alpha4beta2-nAChRs are among the molecular targets of Ipt, which has utility as a tool in functional characterization and pharmacological profiling of nAChRs...
  17. doi request reprint Agonist-induced hump current production in heterologously-expressed human alpha4beta2-nicotinic acetylcholine receptors
    Qiang Liu
    Divisions of Neurology, Barrow Neurological Institute, St Josephos Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    Acta Pharmacol Sin 29:305-19. 2008
    ..To characterize the functional and pharmacological features of agonist-induced hump currents in human alpha4beta2-nicotinic acetylcholine receptors (nAChR)...
  18. pmc Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area
    Ming Gao
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosci 30:13814-25. 2010
    ....
  19. doi request reprint U18666A, a cholesterol-inhibition agent, modulates human neuronal nicotinic acetylcholine receptors heterologously expressed in SH-EP1 cell line
    Chao Zheng
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    J Neurochem 108:1526-38. 2009
    ..These data indicate that U18666A is a potent antagonist of alpha4beta2-nAChRs and may be useful as a tool in the functional characterization and pharmacological profiling of nAChRs, as well as a potential candidate for smoking cessation...
  20. pmc Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas
    Guohui Li
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    Ann Neurol 69:664-72. 2011
    ..Recently, functional GABA(A) receptor (GABA(A) R) rundown has been described in surgically resected human temporal lobe epilepsy tissue. We asked whether functional GABA(A) R rundown also occurs in human HH neurons...
  21. ncbi request reprint Roles for nicotinic acetylcholine receptor subunit large cytoplasmic loop sequences in receptor expression and function
    Yen Ping Kuo
    Department of Neurobiology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA
    J Pharmacol Exp Ther 314:455-66. 2005
    ..These studies are consistent with unexpected roles of nested C2 sequences in nAChR function...
  22. ncbi request reprint Electrophysiological properties of human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Ann Neurol 58:371-82. 2005
    ..These findings suggest that human HH tissues, associated with gelastic seizures, contained predominantly small GABAergic inhibitory neurons that exhibited intrinsic "pacemaker-like" behavior...
  23. ncbi request reprint Functional properties of homomeric, human alpha 7-nicotinic acetylcholine receptors heterologously expressed in the SH-EP1 human epithelial cell line
    Lingke Zhao
    Division of Neurology, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 305:1132-41. 2003
    ....
  24. ncbi request reprint Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy model
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    Brain Res 1013:230-40. 2004
    ..The present results are also consistent with recent findings that mutation of the gamma2 subunit of the GABAA receptor changes benzodiazepine modulation in families with generalized epilepsy syndromes...
  25. ncbi request reprint Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesis
    Kristina A Fenoglio
    Division of Neurology and Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 14:51-9. 2007
    ..These observations constitute the basis for future investigations aimed at elucidating the mechanisms of subcortical epileptogenesis...
  26. ncbi request reprint beta-Amyloid directly inhibits human alpha4beta2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cells
    Jie Wu
    Division of Neurology, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Biol Chem 279:37842-51. 2004
    ..These findings suggest that halpha4beta2-nAChRs are sensitive and perhaps pathophysiologically relevant targets for Abeta neurotoxicity in AD...
  27. doi request reprint Acute exposure to the mitochondrial complex I toxin rotenone impairs synaptic long-term potentiation in rat hippocampal slices
    Ryoichi Kimura
    Department of Physiology, Shantou University Medical College, Shantou, China
    CNS Neurosci Ther 18:641-6. 2012
    ..To evaluate the acute effects of the mitochondrial complex I inhibitor rotenone on rat hippocampal synaptic plasticity...
  28. pmc α7β2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their α7-α7 interfaces
    Teresa A Murray
    Barrow Neurological Institute, Phoenix, Arizona, USA
    Mol Pharmacol 81:175-88. 2012
    ..On the basis of our findings, we have constructed a model predicting receptor function that is based on stoichiometry and position of β2 subunits within the α7β2 nAChRs...
  29. doi request reprint Nicotinic acetylcholine receptor alpha7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptors
    Teresa A Murray
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Acta Pharmacol Sin 30:828-41. 2009
    ..The aim of this work was to create a FP fusion in the nAChR alpha7 subunit without compromising formation of functional receptors...
  30. ncbi request reprint 1-Methyl-4-phenylpridinium (MPP+)-induced functional run-down of GABA(A) receptor-mediated currents in acutely dissociated dopaminergic neurons
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Neurochem 83:87-99. 2002
    ..It is concluded that extracellular perfusion of MPP+ induces a functional run-down of GABA(A) receptors, which may cause an imbalance of excitation and inhibition of DAergic neurons...
  31. doi request reprint Kinetics of desensitization and recovery from desensitization for human alpha4beta2-nicotinic acetylcholine receptors stably expressed in SH-EP1 cells
    Kewei D Yu
    Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Acta Pharmacol Sin 30:805-17. 2009
    ..Studies were conducted to define the kinetics of the onset of and recovery from desensitization for human alpha4beta2-nicotinic acetylcholine receptors (nAChR) heterologously expressed in the SH-EP1 human epithelial cell line...
  32. ncbi request reprint Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain dopamine neurons
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 311:80-91. 2004
    ....
  33. pmc Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors
    Junwei Hao
    Division of Neurology, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Exp Neurol 227:110-9. 2011
    ....
  34. doi request reprint Cortical control of VTA function and influence on nicotine reward
    Jie Wu
    Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA Departments of Physiology, Shantou University Medical College, Shantou, Guangdong, China Electronic address
    Biochem Pharmacol 86:1173-80. 2013
    ..Moreover, addiction may develop due to nicotine perturbing the PFC-VTA coupling and thereby eliminating the PFC-dependent cognitive control over behavior. ..
  35. pmc A novel nicotinic mechanism underlies β-amyloid-induced neuronal hyperexcitation
    Qiang Liu
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosci 33:7253-63. 2013
    ..This novel mechanism involving α7-nAChRs in mediation of Aβ effects provides potentially new therapeutic targets for treatment of AD...
  36. doi request reprint Hypothalamic hamartomas associated with epilepsy: ultrastructural features
    John Beggs
    Division of Neuropathology, and The Comprehensive Epilepsy Center, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Neuropathol Exp Neurol 67:657-68. 2008
    ....
  37. doi request reprint Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiology
    Ke chun Yang
    Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Acta Pharmacol Sin 30:740-51. 2009
    ..In this review, we mainly focus on the recent advances in the understanding of alpha6*-nAChR function, pharmacology and pathophysiology...
  38. doi request reprint Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta
    Chen Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Neuropharmacology 59:567-72. 2010
    ..Collectively, the blockade of neuronal K(ATP) channels by THB in SNc DA neurons is a novel pharmacological mechanism of THB, which may contribute to its neuroprotective effects in PD...
  39. pmc Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides
    Qiang Liu
    Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    BMC Neurosci 13:155. 2012
    ..To extend our previous work, we evaluated the expression and pharmacology of α7β2-nAChRs in hippocampal interneurons and their sensitivity to Aβ...
  40. pmc Impact of prefrontal cortex in nicotine-induced excitation of ventral tegmental area dopamine neurons in anesthetized rats
    Die Zhang
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    J Neurosci 32:12366-75. 2012
    ..Finally, systemic injection of bicuculline prevented nicotine-induced firing alterations in the neurons with type-I response. We propose that the mPFC plays a critical role in systemic nicotine-induced excitation of VTA DA neurons...
  41. ncbi request reprint Regulation by cycloheximide and lowered temperature of cell-surface alpha7-nicotinic acetylcholine receptor expression on transfected SH-EP1 cells
    Katherine M Schroeder
    Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurochem 85:581-91. 2003
    ..Although these effects are not simply due to protein synthesis inhibition or reduced cell proliferation, they do involve an increase in intracellular receptor pool size...
  42. ncbi request reprint 2-aminoethoxydiphenyl borate inhibits agonist-induced Ca2+ signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cells
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Pflugers Arch 448:592-5. 2004
    ....
  43. pmc Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synuclein
    Qiang Liu
    Division of Neurology, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    PLoS ONE 8:e55886. 2013
    ....
  44. ncbi request reprint Intracellular energy failure does not underlie hyperthermic spreading depressions in immature rat hippocampal slice
    Jie Wu
    Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    Brain Res 987:240-3. 2003
    ..This study suggests that HSD is not be mediated by depletion of intracellular ATP during hyperthermia...
  45. doi request reprint Nicotine and inflammatory neurological disorders
    Wen Hua Piao
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Acta Pharmacol Sin 30:715-22. 2009
    ..This review provides a synopsis summarizing the effects of nicotine on the immune system and its (nicotine) influences on various neurological diseases...
  46. ncbi request reprint Cooling abolishes neuronal network synchronization in rat hippocampal slices
    Sam P Javedan
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Epilepsia 43:574-80. 2002
    ..We sought to determine whether cooling brain tissue from 34 to 21 degrees C could abolish tetany-induced neuronal network synchronization (gamma oscillations) without blocking normal synaptic transmission...
  47. pmc The neuropharmacology of (-)-stepholidine and its potential applications
    Kechun Yang
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Curr Neuropharmacol 5:289-94. 2007
    ..Therefore, SPD is a novel, natural compound with potentially therapeutic roles in the treatment of schizophrenia and/or PD...
  48. ncbi request reprint Neuronal nicotinic acetylcholine receptors serve as sensitive targets that mediate beta-amyloid neurotoxicity
    Qiang Liu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Acta Pharmacol Sin 27:1277-86. 2006
    ..In this review, we summarize current studies performed in our laboratory and in others to address the question of how Abeta modulates neuronal nAChRs, especially nAChR subunit function...
  49. doi request reprint Neuronal nicotinic acetylcholine receptors are important targets for alcohol reward and dependence
    Jie Wu
    1 Ningbo University Medical School, Ningbo 315211, China 2 Division of Neurology and Neurobiology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4409, USA
    Acta Pharmacol Sin 35:311-5. 2014
    ..Here, we briefly summarize recent lines of evidence showing how EtOH modulates nAChRs in the mesolimbic pathway, which provides a perspective that nAChRs are important targets mediating alcohol abuse. ..
  50. ncbi request reprint The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells
    Mitsutoshi Nakada
    Neuro Oncology Research, Barrow Neurological Institute, Phoenix, Arizona, USA
    Cancer Res 64:3179-85. 2004
    ..Dysregulation of EphB2 expression or function may underlie glioma invasion...
  51. ncbi request reprint Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells
    Takanori Kudo
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    J Pharmacol Exp Ther 318:1203-10. 2006
    ....
  52. ncbi request reprint Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824
    Liwei Chen
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Mol Cancer Ther 4:1311-9. 2005
    ..LAQ824 effectively inhibited cell proliferation and induced apoptosis of these prostate cancer cells. These results reveal that LAQ824 is a potent agent for depletion of androgen receptor and a potential new drug for prostate cancer...
  53. ncbi request reprint Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat
    Huifang Li
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Room A343, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5235, USA
    Neuropharmacology 51:121-8. 2006
    ..Selective reductions in GABA(A) receptor subunits in thalamus may play a role in pathophysiology of absence epilepsy...
  54. ncbi request reprint Iptakalim inhibits nicotine-induced enhancement of extracellular dopamine and glutamate levels in the nucleus accumbens of rats
    Qiang Liu
    Laboratory of Neuropharmacology, Department of Anatomy, Histology and Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, PR China
    Brain Res 1085:138-43. 2006
    ..Therefore, Ipt may serve as a novel compound to block nicotine-induced dopamine and glutamate release in the brain reward center, in turn decreasing nicotine reinforcement and dependence...
  55. ncbi request reprint Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats
    Sen Wang
    Department of Pharmacology and Neurobiology, Nanjing Medical University, Nanjing, Jiangsu Province, PR China
    Neuropsychopharmacology 31:933-40. 2006
    ..ii) KATP channels regulate extracellular neurotransmitter levels in the striatum of unilateral 6-OHDA-lesioned rats and may play neuroprotective roles due to their effects on glutamate transporters...
  56. ncbi request reprint Iptakalim hydrochloride protects cells against neurotoxin-induced glutamate transporter dysfunction in in vitro and in vivo models
    Yan Ling Yang
    Department of Pharmacology and Neurobiology, Nanjing Medical University, 140 Hanzhong Road, Nanjing City, Jiangsu Province 210029, PR China
    Brain Res 1049:80-8. 2005
    ..The cellular mechanisms of this protective effect may involve the opening of K(ATP) channels. Collectively, Ipt may serve as a novel and effective drug for PD therapy...
  57. ncbi request reprint Systematic administration of iptakalim, an ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in rats
    Yong Yang
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, PR China
    J Neurosci Res 80:442-9. 2005
    ..The selective activation of mitochondrial ATP-sensitive potassium channels may provide a new therapeutic strategy for prevention and treatment of neurodegenerative disorders such as Parkinson's disease...
  58. ncbi request reprint Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release
    Naoko Misaki
    Department of Physiology, Hirosaki University School of Medicine, Zaifucho, Japan
    J Pharmacol Exp Ther 322:871-8. 2007
    ....
  59. ncbi request reprint Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 280:12305-9. 2005
    ..Finally, knockdown of endogenous Gab1 by small interference RNA abrogated flow activation of Akt and eNOS. These data demonstrate a critical role of Gab1 in flow-stimulated PI3K/Akt/eNOS signal pathway in endothelial cells...
  60. ncbi request reprint Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats
    Yong Yang
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, PR China
    Int J Neuropsychopharmacol 9:51-61. 2006
    ....
  61. ncbi request reprint [Effects of intrauterine acute ischemia on epidermal growth factor and its receptor of the fetal kidney in rats]
    Jie Wu
    Zhonghua Er Ke Za Zhi 41:614-5. 2003
  62. ncbi request reprint [Development of toxin targeting to VEGF-KDR]
    Jie Wu
    Medical Research Department, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China
    Zhonghua Zhong Liu Za Zhi 26:78-81. 2004
    ..To develop toxin targeting vascular endothelial growth factor receptor II (VEGF-II/KDR) fused with a KDR-binling peptide screened from peptide library...
  63. ncbi request reprint Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells
    Ramadevi Nimmanapalli
    Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute University of South Florida, Tampa, Florida 33614, USA
    Cancer Res 63:5126-35. 2003
    ..Therefore, LAQ824 may be a promising therapeutic agent in the treatment of imatinib-sensitive or -refractory human leukemia...
  64. ncbi request reprint Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2
    Jay F Dorsey
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Blood 99:1388-97. 2002
    ..All of these changes are characteristics of megakaryocytic differentiation. Together, these results reveal Gab2 as a limiting signaling component for Erk MAP kinase activation and terminal differentiation of K562 CML cells...
  65. ncbi request reprint Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking
    Jianbo Yang
    Department of Laboratory Medicine and Pathology and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:30219-26. 2002
    ..Our data suggest that Etk may be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1...
  66. ncbi request reprint Relationship between the U wave on electrocardiogram and the midmyocardium of the left ventricular wall
    Cuntai Zhang
    Department of Cardiology, Tongji Hospital Tongji Medical University, Wuhan 430030, China
    Chin Med J (Engl) 115:509-12. 2002
    ..To investigate the relationship between the U wave on electrocardiogram and the midmyocardium in rabbit left ventricle free wall in vivo...
  67. ncbi request reprint A heterozygote phenotype is present in the jvs +/- mutant mouse livers
    Karim Lahjouji
    Division of Medical Genetics, Hĵpital Sainte Justine, Montreal, Que, Canada
    Mol Genet Metab 76:76-80. 2002
    ..We speculate that in situations of lipolytic stress, some SCD heterozygotes might develop clinical symptoms of carnitine deficiency...
  68. ncbi request reprint A role for Grb2-associated binder-1 in growth hormone signaling
    Sung Oh Kim
    Department of Medicine, Division of Endocrinology and Metabolism, University of Alabama, Birmingham, Alabama 35294, USA
    Endocrinology 143:4856-67. 2002
    ..Our results suggest selective involvement of Gab1 in GH-induced ERK activation and implicate the Gab1 PH domain as critical in this involvement...
  69. ncbi request reprint Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells
    Mei Huang
    Molecular Oncology, H Lee Moffitt Cancer Center, Research Institute, Tampa, Florida, FL 33612, USA
    Oncogene 21:8804-16. 2002
    ....
  70. ncbi request reprint Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene
    Jie Wu
    Department of Pharmacology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
    Int J Dev Neurosci 21:333-46. 2003
    ....
  71. ncbi request reprint Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor
    Yuan Ren
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 279:8497-505. 2004
    ....
  72. ncbi request reprint [Construction of recombinant vector pEGFP-ANG and expression of angiogenin gene in HUVECs]
    Hong Bin Zhang
    Department of Medical Research, General Hospital of Guangzhou Military Command, Guangzhou 510010, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:15-8. 2004
    ..To express the recombinant angiogenin protein in mammalian cells...
  73. ncbi request reprint [Comparison of serum biochemistry between specific pathogen-free and conventional aged Wistar rats]
    Yu Hua Xiao
    Department of Medical Research, General Hospital of Guangzhou Command, Guangzhou 510010, China
    Di Yi Jun Yi Da Xue Xue Bao 24:733-5. 2004
    ..To investigate the differences in serum biochemistry between specific pathogen-free (SPF) and conventional aged Wistar rats...
  74. ncbi request reprint Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells
    Fei Guo
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Blood 105:1246-55. 2005
    ....
  75. ncbi request reprint Prenatal restraint stress impairs learning and memory and hippocampal PKCbeta1 expression and translocation in offspring rats
    Jie Wu
    Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi an Jiaotong University School of Medicine, Xi an Shaanxi, 710061, PR China
    Brain Res 1141:205-13. 2007
    ..Our results suggest that deficient signal transduction of PKCbeta1 in the hippocampus resulting from prenatal restraint stress may play an important role in the impairment of learning and memory abilities of offspring...
  76. pmc Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component system
    Jie Wu
    School of Dentistry, Meharry Medical College, Nashville, TN, USA
    FEMS Microbiol Lett 271:214-21. 2007
    ..Unlike the regulatory mechanism of FimA by FimR, this regulation of the mfa1 gene is accomplished by FimR directly binding to the promoter region of mfa1...
  77. ncbi request reprint Stability of plasmid and expression of a recombinant gonadotropin-releasing hormone (GnRH) vaccine in Escherichia coli
    Jinshu Xu
    School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, Nanjing, People s Republic of China
    Appl Microbiol Biotechnol 73:780-8. 2006
    ..The amount of the fusion protein was also up to 40% of the total cell protein after the 50th generation. These data would be useful for the industrial production of the recombinant GnRH vaccine...
  78. ncbi request reprint Two approaches to construct mammalian expression vector of shRNA to reduce expression and replication of HBV in vitro
    Hong Bin Zhang
    Department of Medical Research, Guangzhou Liuhuaqiao Hospital, Liuhua road 111, Guangzhou, Guangdong Province, P R China
    Mol Biol Rep 35:465-72. 2008
    ..The pU6 derived plasmids might be a useful shRNA delivery system in mammalian cells. In addition, we found siRNA based on stealth 2311 was a potent RNAi target of HBV genome...
  79. ncbi request reprint Changes in muscarinic acetylcholine receptor expression in form deprivation myopia in guinea pigs
    Qiong Liu
    State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center, SunYat sen University, Guangzhou, China
    Mol Vis 13:1234-44. 2007
    ....
  80. ncbi request reprint Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90
    Warren Fiskus
    Medical College of Georgia Cancer Center, Augusta, Georgia 30912, USA
    Clin Cancer Res 13:4882-90. 2007
    ..Here, we determined the effect of HA-HDIs on the levels and activity of ERalpha, as well as on the survival of ERalpha-expressing, estrogen-responsive human breast cancer MCF-7 and BT-474 cells...
  81. ncbi request reprint Synthesis of functionalized 1,2-dihydroisoquinolines via multicomponent one-pot reaction of 2-alkynylbenzaldehyde, amine, zinc, and allylic bromide or benzyl bromide
    Ke Gao
    Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
    J Org Chem 72:8611-3. 2007
    ....
  82. ncbi request reprint Time-course of changes to nitric oxide signaling pathways in form-deprivation myopia in guinea pigs
    Jie Wu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, Guangdong, China
    Brain Res 1186:155-63. 2007
    ..Our main observations were a change in NOS activity and an up-regulation in cGMP concentrations in posterior ocular tissues during the development of myopia. The function of elevated NOS activity may be mediated by cGMP...
  83. ncbi request reprint Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model
    Jinshu Xu
    School of Pharmacy, Nanjing Medical University, Nanjing, PR China
    Cancer Lett 259:240-50. 2008
    ..001). The conjugation of the recombinant GnRH peptide to Hsp65 could be considered a promising approach for the development of an efficacious vaccine against the prostate cancer...
  84. pmc Role of differential expression of streptococcal arginine deiminase in inhibition of fimA expression in Porphyromonas gingivalis
    Xinghua Lin
    School of Dentistry, Meharry Medical College, Nashville, TN 37208, USA
    J Bacteriol 190:4367-71. 2008
    ..In this study, we demonstrate the differential expression of arcA in two streptococcal species. The expression level of arcA in streptococci appears to be controlled by both cis and trans elements...
  85. ncbi request reprint Facile synthesis of chromeno[4,3-b]quinolin-6-ones from unexpected reactions of aryl isocyanides with 4-chloro-2-oxo-2H-chromene-3-carbaldehyde
    Jie Wu
    Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China
    Org Biomol Chem 4:1348-51. 2006
    ..An unexpected reaction of aryl isocyanides with 4-chloro-2-oxo-2H-chromene-3-carbaldehyde leads to chromeno[4,3-b]quinolin-6-ones in good yields...
  86. ncbi request reprint Effect of atorvastatin on tumor necrosis factor alpha serum concentration and mRNA expression of adipose in hypercholesterolemic rabbits
    Shui Ping Zhao
    Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, PR China
    J Cardiovasc Pharmacol 46:185-9. 2005
    ..Atorvastatin reduced TNFalpha serum concentration in hypercholesterolemic rabbits, which might be because of its cholesterol-lowering effect and direct inhibition of TNFalpha expression in adipose...
  87. ncbi request reprint Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib)
    Zhengming Chen
    Molecular Oncology Program, SRB 3, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, and the Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Mol Pharmacol 69:1527-33. 2006
    ..These results suggest that BMS-354825 is a potent inhibitor of PDGF-stimulated VSMC activities and a potential agent for the development of a new therapy for vascular obstructive diseases such as restenosis...
  88. ncbi request reprint Constructing networks with correlation maximization methods
    Joseph C Mellor
    Program in Bioinformatics, Boston University
    Genome Inform 15:149-59. 2004
    ..We show how statistical strength and information are equivalent criteria in limiting cases, and demonstrate the application of these measures to simple systems of gene regulation...
  89. ncbi request reprint Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvants
    Liang Jin
    Minigene Pharmacy Laboratory, Biopharmaceutical College, China Pharmaceutical University, Tongjia Xiang 24, Nanjing 210009, PR China
    Vaccine 25:2043-50. 2007
    ..Specific antibodies were successfully induced and lasted for more than 20 weeks in animals immunized with the fusion protein via intranasal route even in the absence of adjuvants...

Research Grants1

  1. GABAergic excitation in human hypothalamic hamartoma
    Jie Wu; Fiscal Year: 2007
    ..Knowledge about excitatory GABAA receptor function of HH neurons will also aid selection of superior strategies for pharmaceutical development to prevent and control human gelastic seizures. ..