Jie Wu

Summary

Affiliation: Barrow Neurological Institute
Country: USA

Publications

  1. ncbi Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons
    Kechun Yang
    Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013 4496, USA
    J Physiol 587:345-61. 2009
  2. ncbi Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels
    S Suga
    Department of Physiology, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
    BMC Pharmacol 1:3. 2001
  3. ncbi Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain dopamine neurons
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 311:80-91. 2004
  4. ncbi Iptakalim as a human nicotinic acetylcholine receptor antagonist
    Jun Hu
    Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 316:914-25. 2006
  5. ncbi beta-Amyloid directly inhibits human alpha4beta2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cells
    Jie Wu
    Division of Neurology, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Biol Chem 279:37842-51. 2004
  6. ncbi 2-aminoethoxydiphenyl borate inhibits agonist-induced Ca2+ signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cells
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Pflugers Arch 448:592-5. 2004
  7. ncbi Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy model
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    Brain Res 1013:230-40. 2004
  8. ncbi Electrophysiological properties of human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Ann Neurol 58:371-82. 2005
  9. ncbi Intracellular energy failure does not underlie hyperthermic spreading depressions in immature rat hippocampal slice
    Jie Wu
    Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    Brain Res 987:240-3. 2003
  10. ncbi Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices
    J Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    BMC Neurosci 2:18. 2001

Detail Information

Publications88

  1. ncbi Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons
    Kechun Yang
    Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013 4496, USA
    J Physiol 587:345-61. 2009
    ..Interestingly, each DAergic neuron predominantly expresses only one particularly functional nAChR subtype, which may have distinct but important roles in regulation of VTA DA neuronal function, DA transmission and nicotine dependence...
  2. ncbi Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels
    S Suga
    Department of Physiology, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
    BMC Pharmacol 1:3. 2001
    ..In this study, we investigated the non-PKC effects of PMA on electrical excitability of rat pancreatic beta-cells by using patch-clamp techniques...
  3. ncbi Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain dopamine neurons
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 311:80-91. 2004
    ....
  4. ncbi Iptakalim as a human nicotinic acetylcholine receptor antagonist
    Jun Hu
    Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 316:914-25. 2006
    ..Thus, alpha4beta2-nAChRs are among the molecular targets of Ipt, which has utility as a tool in functional characterization and pharmacological profiling of nAChRs...
  5. ncbi beta-Amyloid directly inhibits human alpha4beta2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cells
    Jie Wu
    Division of Neurology, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Biol Chem 279:37842-51. 2004
    ..These findings suggest that halpha4beta2-nAChRs are sensitive and perhaps pathophysiologically relevant targets for Abeta neurotoxicity in AD...
  6. ncbi 2-aminoethoxydiphenyl borate inhibits agonist-induced Ca2+ signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cells
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Pflugers Arch 448:592-5. 2004
    ....
  7. ncbi Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy model
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    Brain Res 1013:230-40. 2004
    ..The present results are also consistent with recent findings that mutation of the gamma2 subunit of the GABAA receptor changes benzodiazepine modulation in families with generalized epilepsy syndromes...
  8. ncbi Electrophysiological properties of human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Ann Neurol 58:371-82. 2005
    ..These findings suggest that human HH tissues, associated with gelastic seizures, contained predominantly small GABAergic inhibitory neurons that exhibited intrinsic "pacemaker-like" behavior...
  9. ncbi Intracellular energy failure does not underlie hyperthermic spreading depressions in immature rat hippocampal slice
    Jie Wu
    Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    Brain Res 987:240-3. 2003
    ..This study suggests that HSD is not be mediated by depletion of intracellular ATP during hyperthermia...
  10. ncbi Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices
    J Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    BMC Neurosci 2:18. 2001
    ..This may serve as an in vitro model of febrile seizures...
  11. ncbi 2-Aminoethoxydiphenyl borate modulates kinetics of intracellular Ca(2+) signals mediated by inositol 1,4,5-trisphosphate-sensitive Ca(2+) stores in single pancreatic acinar cells of mouse
    J Wu
    Department of Physiology, Hirosaki University School of Medicine, Hirosaki, Japan
    Mol Pharmacol 58:1368-74. 2000
    ..Moreover, this regulation seems to be mediated through InsP(3)-sensitive Ca(2+) pools. 2APB may act as a novel, useful pharmacological tool to study the genesis of intracellular Ca(2+) signals...
  12. ncbi Role of alpha7-nicotinic acetylcholine receptors in tetanic stimulation-induced gamma oscillations in rat hippocampal slices
    Chuanzhe Song
    Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013-4496, USA
    Neuropharmacology 48:869-80. 2005
    ..It is concluded that alpha7-nAChRs in hippocampal slices play important roles in regulation of gamma oscillations, thus potentially helping to explain roles of nAChRs in cognitive functions such as learning, memory and attention...
  13. ncbi alpha-Chloralose diminishes gamma oscillations in rat hippocampal slices
    Kui Wang
    Neurophysiology Laboratory, Division of Neurology, NRC 444, St Joseph s Hospital and Medical Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Neurosci Lett 441:66-71. 2008
    ..Enhancement of GABAergic leak current and prolongation of GABAergic sIPSCs by alpha-chloralose likely underlie its disruption of neuronal network synchronization in the hippocampus...
  14. ncbi Functional nicotinic acetylcholine receptors containing ?6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons
    Kechun Yang
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    J Neurosci 31:2537-48. 2011
    ..These presynaptic ?6?2*-nAChRs likely play important roles in nicotinic modulation of DA neuronal activity...
  15. ncbi A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides
    Qiang Liu
    Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    J Neurosci 29:918-29. 2009
    ....
  16. ncbi GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
    Do Young Kim
    Division of Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsia 49:861-71. 2008
    ..Here, we examined the role of GABAA receptors in surgically resected HH tissue...
  17. ncbi Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors
    Jie Wu
    Neurophysiology Laboratory, Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    J Physiol 576:103-18. 2006
    ..Diversity in alpha4*-nAChR is of potential relevance to nervous system function, disease, and nicotine dependence...
  18. ncbi GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, NRC 445, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Exp Neurol 213:397-404. 2008
    ..Taken collectively, we provide novel evidence for and mechanistic insights into HH epileptogenicity: GABA(A)R-mediated excitation...
  19. ncbi The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptors
    Chao Zheng
    Senior Staff Scientist, Director of Neural Physiology Laboratory, Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Rd, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 335:401-8. 2010
    ....
  20. ncbi Roles for nicotinic acetylcholine receptor subunit large cytoplasmic loop sequences in receptor expression and function
    Yen Ping Kuo
    Department of Neurobiology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA
    J Pharmacol Exp Ther 314:455-66. 2005
    ..These studies are consistent with unexpected roles of nested C2 sequences in nAChR function...
  21. ncbi Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas
    Guohui Li
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    Ann Neurol 69:664-72. 2011
    ..Recently, functional GABA(A) receptor (GABA(A) R) rundown has been described in surgically resected human temporal lobe epilepsy tissue. We asked whether functional GABA(A) R rundown also occurs in human HH neurons...
  22. ncbi Agonist-induced hump current production in heterologously-expressed human alpha4beta2-nicotinic acetylcholine receptors
    Qiang Liu
    Divisions of Neurology, Barrow Neurological Institute, St Josephos Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    Acta Pharmacol Sin 29:305-19. 2008
    ..To characterize the functional and pharmacological features of agonist-induced hump currents in human alpha4beta2-nicotinic acetylcholine receptors (nAChR)...
  23. ncbi Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release
    Naoko Misaki
    Department of Physiology, Hirosaki University School of Medicine, Zaifucho, Japan
    J Pharmacol Exp Ther 322:871-8. 2007
    ....
  24. ncbi Functional properties of homomeric, human alpha 7-nicotinic acetylcholine receptors heterologously expressed in the SH-EP1 human epithelial cell line
    Lingke Zhao
    Division of Neurology, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 305:1132-41. 2003
    ....
  25. ncbi U18666A, a cholesterol-inhibition agent, modulates human neuronal nicotinic acetylcholine receptors heterologously expressed in SH-EP1 cell line
    Chao Zheng
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    J Neurochem 108:1526-38. 2009
    ..These data indicate that U18666A is a potent antagonist of alpha4beta2-nAChRs and may be useful as a tool in the functional characterization and pharmacological profiling of nAChRs, as well as a potential candidate for smoking cessation...
  26. ncbi Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area
    Ming Gao
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosci 30:13814-25. 2010
    ....
  27. ncbi 1-Methyl-4-phenylpridinium (MPP+)-induced functional run-down of GABA(A) receptor-mediated currents in acutely dissociated dopaminergic neurons
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Neurochem 83:87-99. 2002
    ..It is concluded that extracellular perfusion of MPP+ induces a functional run-down of GABA(A) receptors, which may cause an imbalance of excitation and inhibition of DAergic neurons...
  28. ncbi Hydrogen peroxide mobilizes Ca2+ through two distinct mechanisms in rat hepatocytes
    Hirohiko Sato
    Department of Physiology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Acta Pharmacol Sin 30:78-89. 2009
    ..Hydrogen peroxide (H2O2) is produced during liver transplantation. Ischemia/reperfusion induces oxidation and causes intracellular Ca2+ overload, which harms liver cells. Our goal was to determine the precise mechanisms of these processes...
  29. ncbi Electrophysiological properties and subunit composition of GABAA receptors in patients with gelastic seizures and hypothalamic hamartoma
    Jie Wu
    Neurophysiology Lab, Div of Neurology, Barrow Neurological Inst, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    J Neurophysiol 98:5-15. 2007
    ..These findings bear relevance to a broader understanding of inhibitory neurotransmission in human HH tissue...
  30. ncbi Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta
    Jie Wu
    Neurophysiology Laboratory, Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    J Pharmacol Exp Ther 319:155-64. 2006
    ..These effects of iptakalim stimulate further pharmacological investigation and the development of possible therapeutic applications...
  31. ncbi Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesis
    Kristina A Fenoglio
    Division of Neurology and Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 14:51-9. 2007
    ..These observations constitute the basis for future investigations aimed at elucidating the mechanisms of subcortical epileptogenesis...
  32. ncbi ?7?2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their ?7-?7 interfaces
    Teresa A Murray
    Barrow Neurological Institute, Phoenix, Arizona, USA
    Mol Pharmacol 81:175-88. 2012
    ..On the basis of our findings, we have constructed a model predicting receptor function that is based on stoichiometry and position of ?2 subunits within the ?7?2 nAChRs...
  33. ncbi Nicotinic acetylcholine receptor alpha7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptors
    Teresa A Murray
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Acta Pharmacol Sin 30:828-41. 2009
    ..The aim of this work was to create a FP fusion in the nAChR alpha7 subunit without compromising formation of functional receptors...
  34. ncbi Cooling abolishes neuronal network synchronization in rat hippocampal slices
    Sam P Javedan
    Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Epilepsia 43:574-80. 2002
    ..Cooling also suppresses transition from gamma oscillation to ictal bursting at higher stimulus intensities. These findings suggest that cooling may disrupt network synchrony necessary for epileptiform activity...
  35. ncbi Kinetics of desensitization and recovery from desensitization for human alpha4beta2-nicotinic acetylcholine receptors stably expressed in SH-EP1 cells
    Kewei D Yu
    Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Acta Pharmacol Sin 30:805-17. 2009
    ..Studies were conducted to define the kinetics of the onset of and recovery from desensitization for human alpha4beta2-nicotinic acetylcholine receptors (nAChR) heterologously expressed in the SH-EP1 human epithelial cell line...
  36. ncbi Hypothalamic hamartomas associated with epilepsy: ultrastructural features
    John Beggs
    Division of Neuropathology, and The Comprehensive Epilepsy Center, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Neuropathol Exp Neurol 67:657-68. 2008
    ....
  37. ncbi Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta
    Chen Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Neuropharmacology 59:567-72. 2010
    ..Collectively, the blockade of neuronal K(ATP) channels by THB in SNc DA neurons is a novel pharmacological mechanism of THB, which may contribute to its neuroprotective effects in PD...
  38. ncbi Attenuation of CNS inflammatory responses by nicotine involves ?7 and non-?7 nicotinic receptors
    Junwei Hao
    Division of Neurology, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Exp Neurol 227:110-9. 2011
    ....
  39. ncbi Regulation by cycloheximide and lowered temperature of cell-surface alpha7-nicotinic acetylcholine receptor expression on transfected SH-EP1 cells
    Katherine M Schroeder
    Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurochem 85:581-91. 2003
    ..Although these effects are not simply due to protein synthesis inhibition or reduced cell proliferation, they do involve an increase in intracellular receptor pool size...
  40. ncbi Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiology
    Ke chun Yang
    Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Acta Pharmacol Sin 30:740-51. 2009
    ..In this review, we mainly focus on the recent advances in the understanding of alpha6*-nAChR function, pharmacology and pathophysiology...
  41. ncbi Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat
    Huifang Li
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Room A343, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5235, USA
    Neuropharmacology 51:121-8. 2006
    ..Selective reductions in GABA(A) receptor subunits in thalamus may play a role in pathophysiology of absence epilepsy...
  42. ncbi Systematic administration of iptakalim, an ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in rats
    Yong Yang
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, PR China
    J Neurosci Res 80:442-9. 2005
    ..The selective activation of mitochondrial ATP-sensitive potassium channels may provide a new therapeutic strategy for prevention and treatment of neurodegenerative disorders such as Parkinson's disease...
  43. ncbi Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats
    Yong Yang
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, PR China
    Int J Neuropsychopharmacol 9:51-61. 2006
    ....
  44. ncbi Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats
    Sen Wang
    Department of Pharmacology and Neurobiology, Nanjing Medical University, Nanjing, Jiangsu Province, PR China
    Neuropsychopharmacology 31:933-40. 2006
    ..ii) KATP channels regulate extracellular neurotransmitter levels in the striatum of unilateral 6-OHDA-lesioned rats and may play neuroprotective roles due to their effects on glutamate transporters...
  45. ncbi Acute exposure to the mitochondrial complex I toxin rotenone impairs synaptic long-term potentiation in rat hippocampal slices
    Ryoichi Kimura
    Department of Physiology, Shantou University Medical College, Shantou, China
    CNS Neurosci Ther 18:641-6. 2012
    ..To evaluate the acute effects of the mitochondrial complex I inhibitor rotenone on rat hippocampal synaptic plasticity...
  46. ncbi Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells
    Takanori Kudo
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    J Pharmacol Exp Ther 318:1203-10. 2006
    ....
  47. ncbi Double target concept for smoking cessation
    Jie Wu
    Shantou University Medical College, China
    Acta Pharmacol Sin 31:1015-8. 2010
    ..I discuss how to use this double target concept to interpret recent therapies and to develop new candidate compounds for smoking cessation...
  48. ncbi Iptakalim inhibits nicotine-induced enhancement of extracellular dopamine and glutamate levels in the nucleus accumbens of rats
    Qiang Liu
    Laboratory of Neuropharmacology, Department of Anatomy, Histology and Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, PR China
    Brain Res 1085:138-43. 2006
    ..Therefore, Ipt may serve as a novel compound to block nicotine-induced dopamine and glutamate release in the brain reward center, in turn decreasing nicotine reinforcement and dependence...
  49. ncbi Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 280:12305-9. 2005
    ..Finally, knockdown of endogenous Gab1 by small interference RNA abrogated flow activation of Akt and eNOS. These data demonstrate a critical role of Gab1 in flow-stimulated PI3K/Akt/eNOS signal pathway in endothelial cells...
  50. ncbi Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase
    Ying Zi Gong
    Department of Physiology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Eur J Pharmacol 600:18-25. 2008
    ..5 channels by binding to the open state of the channels, independently of their effects on lipoxygenase activity. The putative binding site for CDC appears to be related to arginine 487 located in the outer pore region...
  51. ncbi Naturally-expressed nicotinic acetylcholine receptor subtypes
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, United States
    Biochem Pharmacol 82:800-7. 2011
    ..Importantly, the nAChRs that exist as new isoforms or subtypes or have interesting distributions require alteration in thinking about their roles in health and disease...
  52. ncbi Nicotine and inflammatory neurological disorders
    Wen Hua Piao
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Acta Pharmacol Sin 30:715-22. 2009
    ..This review provides a synopsis summarizing the effects of nicotine on the immune system and its (nicotine) influences on various neurological diseases...
  53. ncbi Iptakalim hydrochloride protects cells against neurotoxin-induced glutamate transporter dysfunction in in vitro and in vivo models
    Yan-Ling Yang
    Department of Pharmacology and Neurobiology, Nanjing Medical University, 140 Hanzhong Road, Nanjing City, Jiangsu Province 210029, PR China
    Brain Res 1049:80-8. 2005
    ..The cellular mechanisms of this protective effect may involve the opening of K(ATP) channels. Collectively, Ipt may serve as a novel and effective drug for PD therapy...
  54. ncbi The neuropharmacology of (-)-stepholidine and its potential applications
    Kechun Yang
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Curr Neuropharmacol 5:289-94. 2007
    ..Therefore, SPD is a novel, natural compound with potentially therapeutic roles in the treatment of schizophrenia and/or PD...
  55. ncbi Neuronal nicotinic acetylcholine receptors serve as sensitive targets that mediate beta-amyloid neurotoxicity
    Qiang Liu
    Division of Neurology, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Acta Pharmacol Sin 27:1277-86. 2006
    ..In this review, we summarize current studies performed in our laboratory and in others to address the question of how Abeta modulates neuronal nAChRs, especially nAChR subunit function...
  56. ncbi Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824
    Liwei Chen
    Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Mol Cancer Ther 4:1311-9. 2005
    ..LAQ824 effectively inhibited cell proliferation and induced apoptosis of these prostate cancer cells. These results reveal that LAQ824 is a potent agent for depletion of androgen receptor and a potential new drug for prostate cancer...
  57. ncbi The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells
    Mitsutoshi Nakada
    Neuro Oncology Research, Barrow Neurological Institute, Phoenix, Arizona, USA
    Cancer Res 64:3179-85. 2004
    ..Dysregulation of EphB2 expression or function may underlie glioma invasion...
  58. ncbi Thimerosal modulates the agonist-specific cytosolic Ca2+ oscillatory patterns in single pancreatic acinar cells of mouse
    J Wu
    Department of Physiology 1, Hirosaki University School of Medicine, Japan
    FEBS Lett 390:149-52. 1996
    ..We conclude that thimerosal modulates the agonist-specific cytosolic Ca2+ oscillatory patterns mediated by sensitizing the InsP3-induced Ca2+ release...
  59. ncbi Mutational analysis of roles for extracellular cysteine residues in the assembly and function of human alpha 7-nicotinic acetylcholine receptors
    T Dunckley
    Division of Neurobiology and Division of Neurology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Biochemistry 42:870-6. 2003
    ..These results suggest that disulfide bond formation between C138 and either C150 or C164, if it occurs, has no significant effect on alpha7-nAChR assembly or function...
  60. ncbi Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor
    Yuan Ren
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 279:8497-505. 2004
    ....
  61. ncbi [Effects of intrauterine acute ischemia on epidermal growth factor and its receptor of the fetal kidney in rats]
    Jie Wu
    Zhonghua Er Ke Za Zhi 41:614-5. 2003
  62. ncbi Effect of atorvastatin on tumor necrosis factor alpha serum concentration and mRNA expression of adipose in hypercholesterolemic rabbits
    Shui-Ping Zhao
    Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, PR China
    J Cardiovasc Pharmacol 46:185-9. 2005
    ..Atorvastatin reduced TNFalpha serum concentration in hypercholesterolemic rabbits, which might be because of its cholesterol-lowering effect and direct inhibition of TNFalpha expression in adipose...
  63. ncbi [Development of toxin targeting to VEGF-KDR]
    Jie Wu
    Medical Research Department, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China
    Zhonghua Zhong Liu Za Zhi 26:78-81. 2004
    ..CONCLUSION: These studies demonstrate the small peptide, P5, maybe be used as carrier of toxin targeting to KDR...
  64. ncbi [Construction of recombinant vector pEGFP-ANG and expression of angiogenin gene in HUVECs]
    Hong Bin Zhang
    Department of Medical Research, General Hospital of Guangzhou Military Command, Guangzhou 510010, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:15-8. 2004
    ..To express the recombinant angiogenin protein in mammalian cells...
  65. ncbi Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component system
    Jie Wu
    School of Dentistry, Meharry Medical College, Nashville, TN, USA
    FEMS Microbiol Lett 271:214-21. 2007
    ..Unlike the regulatory mechanism of FimA by FimR, this regulation of the mfa1 gene is accomplished by FimR directly binding to the promoter region of mfa1...
  66. ncbi Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvants
    Liang Jin
    Minigene Pharmacy Laboratory, Biopharmaceutical College, China Pharmaceutical University, Tongjia Xiang 24, Nanjing 210009, PR China
    Vaccine 25:2043-50. 2007
    ..Specific antibodies were successfully induced and lasted for more than 20 weeks in animals immunized with the fusion protein via intranasal route even in the absence of adjuvants...
  67. ncbi Time-course of changes to nitric oxide signaling pathways in form-deprivation myopia in guinea pigs
    Jie Wu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, Guangdong, China
    Brain Res 1186:155-63. 2007
    ..Our main observations were a change in NOS activity and an up-regulation in cGMP concentrations in posterior ocular tissues during the development of myopia. The function of elevated NOS activity may be mediated by cGMP...
  68. ncbi Constructing networks with correlation maximization methods
    Joseph C Mellor
    Program in Bioinformatics, Boston University
    Genome Inform 15:149-59. 2004
    ..We show how statistical strength and information are equivalent criteria in limiting cases, and demonstrate the application of these measures to simple systems of gene regulation...
  69. ncbi Changes in muscarinic acetylcholine receptor expression in form deprivation myopia in guinea pigs
    Qiong Liu
    State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center, SunYat sen University, Guangzhou, China
    Mol Vis 13:1234-44. 2007
    ....
  70. ncbi Stability of plasmid and expression of a recombinant gonadotropin-releasing hormone (GnRH) vaccine in Escherichia coli
    Jinshu Xu
    School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, Nanjing, People s Republic of China
    Appl Microbiol Biotechnol 73:780-8. 2006
    ..The amount of the fusion protein was also up to 40% of the total cell protein after the 50th generation. These data would be useful for the industrial production of the recombinant GnRH vaccine...
  71. ncbi Prenatal restraint stress impairs learning and memory and hippocampal PKCbeta1 expression and translocation in offspring rats
    Jie Wu
    Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi an Jiaotong University School of Medicine, Xi an Shaanxi, 710061, PR China
    Brain Res 1141:205-13. 2007
    ..Our results suggest that deficient signal transduction of PKCbeta1 in the hippocampus resulting from prenatal restraint stress may play an important role in the impairment of learning and memory abilities of offspring...
  72. ncbi A role for Grb2-associated binder-1 in growth hormone signaling
    Sung-Oh Kim
    Department of Medicine, Division of Endocrinology and Metabolism, University of Alabama, Birmingham, Alabama 35294, USA
    Endocrinology 143:4856-67. 2002
    ..Our results suggest selective involvement of Gab1 in GH-induced ERK activation and implicate the Gab1 PH domain as critical in this involvement...
  73. ncbi [Comparison of serum biochemistry between specific pathogen-free and conventional aged Wistar rats]
    Yu-hua Xiao
    Department of Medical Research, General Hospital of Guangzhou Command, Guangzhou 510010, China
    Di Yi Jun Yi Da Xue Xue Bao 24:733-5. 2004
    ..01), and Mg was significantly different (P<0.05). CONCLUSION: Different microbiological profiles affect serum biochemistry of aged Wistar rats...
  74. ncbi A heterozygote phenotype is present in the jvs +/- mutant mouse livers
    Karim Lahjouji
    Division of Medical Genetics, Hĵpital Sainte Justine, Montreal, Que, Canada
    Mol Genet Metab 76:76-80. 2002
    ..We speculate that in situations of lipolytic stress, some SCD heterozygotes might develop clinical symptoms of carnitine deficiency...
  75. ncbi Relationship between the U wave on electrocardiogram and the midmyocardium of the left ventricular wall
    Cuntai Zhang
    Department of Cardiology, Tongji Hospital Tongji Medical University, Wuhan 430030, China
    Chin Med J (Engl) 115:509-12. 2002
    ..CONCLUSION: The U wave may originate from the delayed repolarization of the midmyocardium...
  76. ncbi Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking
    Jianbo Yang
    Department of Laboratory Medicine and Pathology and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:30219-26. 2002
    ..Our data suggest that Etk may be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1...
  77. ncbi Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2
    Jay F Dorsey
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Blood 99:1388-97. 2002
    ..All of these changes are characteristics of megakaryocytic differentiation. Together, these results reveal Gab2 as a limiting signaling component for Erk MAP kinase activation and terminal differentiation of K562 CML cells...
  78. ncbi Role of differential expression of streptococcal arginine deiminase in inhibition of fimA expression in Porphyromonas gingivalis
    Xinghua Lin
    School of Dentistry, Meharry Medical College, Nashville, TN 37208, USA
    J Bacteriol 190:4367-71. 2008
    ..In this study, we demonstrate the differential expression of arcA in two streptococcal species. The expression level of arcA in streptococci appears to be controlled by both cis and trans elements...
  79. ncbi Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells
    Fei Guo
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Blood 105:1246-55. 2005
    ....
  80. ncbi Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells
    Mei Huang
    Molecular Oncology, H Lee Moffitt Cancer Center, Research Institute, Tampa, Florida, FL 33612, USA
    Oncogene 21:8804-16. 2002
    ....
  81. ncbi Facile synthesis of chromeno[4,3-b]quinolin-6-ones from unexpected reactions of aryl isocyanides with 4-chloro-2-oxo-2H-chromene-3-carbaldehyde
    Jie Wu
    Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China
    Org Biomol Chem 4:1348-51. 2006
    ..An unexpected reaction of aryl isocyanides with 4-chloro-2-oxo-2H-chromene-3-carbaldehyde leads to chromeno[4,3-b]quinolin-6-ones in good yields...
  82. ncbi Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model
    Jinshu Xu
    School of Pharmacy, Nanjing Medical University, Nanjing, PR China
    Cancer Lett 259:240-50. 2008
    ..001). The conjugation of the recombinant GnRH peptide to Hsp65 could be considered a promising approach for the development of an efficacious vaccine against the prostate cancer...
  83. ncbi Synthesis of functionalized 1,2-dihydroisoquinolines via multicomponent one-pot reaction of 2-alkynylbenzaldehyde, amine, zinc, and allylic bromide or benzyl bromide
    Ke Gao
    Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
    J Org Chem 72:8611-3. 2007
    ....
  84. ncbi Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90
    Warren Fiskus
    Medical College of Georgia Cancer Center, Augusta, Georgia 30912, USA
    Clin Cancer Res 13:4882-90. 2007
    ..Here, we determined the effect of HA-HDIs on the levels and activity of ERalpha, as well as on the survival of ERalpha-expressing, estrogen-responsive human breast cancer MCF-7 and BT-474 cells...
  85. ncbi Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells
    Ramadevi Nimmanapalli
    Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute University of South Florida, Tampa, Florida 33614, USA
    Cancer Res 63:5126-35. 2003
    ..Therefore, LAQ824 may be a promising therapeutic agent in the treatment of imatinib-sensitive or -refractory human leukemia...
  86. ncbi Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene
    Jie Wu
    Department of Pharmacology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
    Int J Dev Neurosci 21:333-46. 2003
    ....
  87. ncbi Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib)
    Zhengming Chen
    Molecular Oncology Program, SRB-3, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, and the Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Mol Pharmacol 69:1527-33. 2006
    ..These results suggest that BMS-354825 is a potent inhibitor of PDGF-stimulated VSMC activities and a potential agent for the development of a new therapy for vascular obstructive diseases such as restenosis...
  88. ncbi Two approaches to construct mammalian expression vector of shRNA to reduce expression and replication of HBV in vitro
    Hong Bin Zhang
    Department of Medical Research, Guangzhou Liuhuaqiao Hospital, Liuhua road 111, Guangzhou, Guangdong Province, P R China
    Mol Biol Rep 35:465-72. 2008
    ..The pU6 derived plasmids might be a useful shRNA delivery system in mammalian cells. In addition, we found siRNA based on stealth 2311 was a potent RNAi target of HBV genome...