Research Topics
Genomes and GenesSpecies | Jie WuSummaryAffiliation: Barrow Neurological Institute Country: USA Publications
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Detail Information
Publications
Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neuronsKechun Yang
Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013 4496, USA
J Physiol 587:345-61. 2009..Interestingly, each DAergic neuron predominantly expresses only one particularly functional nAChR subtype, which may have distinct but important roles in regulation of VTA DA neuronal function, DA transmission and nicotine dependence...- Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channelsS Suga
Department of Physiology, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
BMC Pharmacol 1:3. 2001..In this study, we investigated the non-PKC effects of PMA on electrical excitability of rat pancreatic beta-cells by using patch-clamp techniques... 
Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain dopamine neuronsJie Wu
Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
J Pharmacol Exp Ther 311:80-91. 2004....- Iptakalim as a human nicotinic acetylcholine receptor antagonistJun Hu
Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013 4496, USA
J Pharmacol Exp Ther 316:914-25. 2006..Thus, alpha4beta2-nAChRs are among the molecular targets of Ipt, which has utility as a tool in functional characterization and pharmacological profiling of nAChRs... - beta-Amyloid directly inhibits human alpha4beta2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cellsJie Wu
Division of Neurology, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
J Biol Chem 279:37842-51. 2004..These findings suggest that halpha4beta2-nAChRs are sensitive and perhaps pathophysiologically relevant targets for Abeta neurotoxicity in AD... - 2-aminoethoxydiphenyl borate inhibits agonist-induced Ca2+ signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cellsJie Wu
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
Pflugers Arch 448:592-5. 2004.... - Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy modelJie Wu
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
Brain Res 1013:230-40. 2004..The present results are also consistent with recent findings that mutation of the gamma2 subunit of the GABAA receptor changes benzodiazepine modulation in families with generalized epilepsy syndromes... - Electrophysiological properties of human hypothalamic hamartomasJie Wu
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Ann Neurol 58:371-82. 2005..These findings suggest that human HH tissues, associated with gelastic seizures, contained predominantly small GABAergic inhibitory neurons that exhibited intrinsic "pacemaker-like" behavior... - Intracellular energy failure does not underlie hyperthermic spreading depressions in immature rat hippocampal sliceJie Wu
Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
Brain Res 987:240-3. 2003..This study suggests that HSD is not be mediated by depletion of intracellular ATP during hyperthermia... - 2-Aminoethoxydiphenyl borate modulates kinetics of intracellular Ca(2+) signals mediated by inositol 1,4,5-trisphosphate-sensitive Ca(2+) stores in single pancreatic acinar cells of mouseJ Wu
Department of Physiology, Hirosaki University School of Medicine, Hirosaki, Japan
Mol Pharmacol 58:1368-74. 2000..Moreover, this regulation seems to be mediated through InsP(3)-sensitive Ca(2+) pools. 2APB may act as a novel, useful pharmacological tool to study the genesis of intracellular Ca(2+) signals... - Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slicesJ Wu
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
BMC Neurosci 2:18. 2001..This may serve as an in vitro model of febrile seizures... - Role of alpha7-nicotinic acetylcholine receptors in tetanic stimulation-induced gamma oscillations in rat hippocampal slicesChuanzhe Song
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
Neuropharmacology 48:869-80. 2005..It is concluded that alpha7-nAChRs in hippocampal slices play important roles in regulation of gamma oscillations, thus potentially helping to explain roles of nAChRs in cognitive functions such as learning, memory and attention... - Functional nicotinic acetylcholine receptors containing α6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neuronsKechun Yang
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
J Neurosci 31:2537-48. 2011..These presynaptic α6β2*-nAChRs likely play important roles in nicotinic modulation of DA neuronal activity... 
alpha-Chloralose diminishes gamma oscillations in rat hippocampal slicesKui Wang
Neurophysiology Laboratory, Division of Neurology, NRC 444, St Joseph s Hospital and Medical Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Neurosci Lett 441:66-71. 2008..Enhancement of GABAergic leak current and prolongation of GABAergic sIPSCs by alpha-chloralose likely underlie its disruption of neuronal network synchronization in the hippocampus...- A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptidesQiang Liu
Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
J Neurosci 29:918-29. 2009.... - GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomasDo Young Kim
Division of Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Epilepsia 49:861-71. 2008..Here, we examined the role of GABAA receptors in surgically resected HH tissue... - Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptorsJie Wu
Neurophysiology Laboratory, Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
J Physiol 576:103-18. 2006..Diversity in alpha4*-nAChR is of potential relevance to nervous system function, disease, and nicotine dependence... - Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin releaseNaoko Misaki
Department of Physiology, Hirosaki University School of Medicine, Zaifucho, Japan
J Pharmacol Exp Ther 322:871-8. 2007.... - GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomasJie Wu
Division of Neurology, NRC 445, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
Exp Neurol 213:397-404. 2008..Taken collectively, we provide novel evidence for and mechanistic insights into HH epileptogenicity: GABA(A)R-mediated excitation... - The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptorsChao Zheng
Senior Staff Scientist, Director of Neural Physiology Laboratory, Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Rd, Phoenix, AZ 85013 4496, USA
J Pharmacol Exp Ther 335:401-8. 2010.... - Roles for nicotinic acetylcholine receptor subunit large cytoplasmic loop sequences in receptor expression and functionYen Ping Kuo
Department of Neurobiology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA
J Pharmacol Exp Ther 314:455-66. 2005..These studies are consistent with unexpected roles of nested C2 sequences in nAChR function... - Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental areaMing Gao
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
J Neurosci 30:13814-25. 2010.... - U18666A, a cholesterol-inhibition agent, modulates human neuronal nicotinic acetylcholine receptors heterologously expressed in SH-EP1 cell lineChao Zheng
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
J Neurochem 108:1526-38. 2009..These data indicate that U18666A is a potent antagonist of alpha4beta2-nAChRs and may be useful as a tool in the functional characterization and pharmacological profiling of nAChRs, as well as a potential candidate for smoking cessation... - Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomasGuohui Li
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
Ann Neurol 69:664-72. 2011..Recently, functional GABA(A) receptor (GABA(A) R) rundown has been described in surgically resected human temporal lobe epilepsy tissue. We asked whether functional GABA(A) R rundown also occurs in human HH neurons... - Agonist-induced hump current production in heterologously-expressed human alpha4beta2-nicotinic acetylcholine receptorsQiang Liu
Divisions of Neurology, Barrow Neurological Institute, St Josephos Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
Acta Pharmacol Sin 29:305-19. 2008..To characterize the functional and pharmacological features of agonist-induced hump currents in human alpha4beta2-nicotinic acetylcholine receptors (nAChR)... - Functional properties of homomeric, human alpha 7-nicotinic acetylcholine receptors heterologously expressed in the SH-EP1 human epithelial cell lineLingke Zhao
Division of Neurology, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ 85013 4496, USA
J Pharmacol Exp Ther 305:1132-41. 2003.... - Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compactaJie Wu
Neurophysiology Laboratory, Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
J Pharmacol Exp Ther 319:155-64. 2006..These effects of iptakalim stimulate further pharmacological investigation and the development of possible therapeutic applications... - 1-Methyl-4-phenylpridinium (MPP+)-induced functional run-down of GABA(A) receptor-mediated currents in acutely dissociated dopaminergic neuronsJie Wu
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
J Neurochem 83:87-99. 2002..It is concluded that extracellular perfusion of MPP+ induces a functional run-down of GABA(A) receptors, which may cause an imbalance of excitation and inhibition of DAergic neurons... - Hydrogen peroxide mobilizes Ca2+ through two distinct mechanisms in rat hepatocytesHirohiko Sato
Department of Physiology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
Acta Pharmacol Sin 30:78-89. 2009..Hydrogen peroxide (H2O2) is produced during liver transplantation. Ischemia/reperfusion induces oxidation and causes intracellular Ca2+ overload, which harms liver cells. Our goal was to determine the precise mechanisms of these processes... - Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesisKristina A Fenoglio
Division of Neurology and Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Semin Pediatr Neurol 14:51-9. 2007..These observations constitute the basis for future investigations aimed at elucidating the mechanisms of subcortical epileptogenesis... - Electrophysiological properties and subunit composition of GABAA receptors in patients with gelastic seizures and hypothalamic hamartomaJie Wu
Neurophysiology Lab, Div of Neurology, Barrow Neurological Inst, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
J Neurophysiol 98:5-15. 2007..These findings bear relevance to a broader understanding of inhibitory neurotransmission in human HH tissue... - α7β2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their α7-α7 interfacesTeresa A Murray
Barrow Neurological Institute, Phoenix, Arizona, USA
Mol Pharmacol 81:175-88. 2012..On the basis of our findings, we have constructed a model predicting receptor function that is based on stoichiometry and position of β2 subunits within the α7β2 nAChRs... - Nicotinic acetylcholine receptor alpha7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptorsTeresa A Murray
Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
Acta Pharmacol Sin 30:828-41. 2009..The aim of this work was to create a FP fusion in the nAChR alpha7 subunit without compromising formation of functional receptors... - Kinetics of desensitization and recovery from desensitization for human alpha4beta2-nicotinic acetylcholine receptors stably expressed in SH-EP1 cellsKewei D Yu
Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Acta Pharmacol Sin 30:805-17. 2009..Studies were conducted to define the kinetics of the onset of and recovery from desensitization for human alpha4beta2-nicotinic acetylcholine receptors (nAChR) heterologously expressed in the SH-EP1 human epithelial cell line... - Cooling abolishes neuronal network synchronization in rat hippocampal slicesSam P Javedan
Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
Epilepsia 43:574-80. 2002..We sought to determine whether cooling brain tissue from 34 to 21 degrees C could abolish tetany-induced neuronal network synchronization (gamma oscillations) without blocking normal synaptic transmission... - A novel nicotinic mechanism underlies β-amyloid-induced neuronal hyperexcitationQiang Liu
Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
J Neurosci 33:7253-63. 2013..This novel mechanism involving α7-nAChRs in mediation of Aβ effects provides potentially new therapeutic targets for treatment of AD... - Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compactaChen Wu
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
Neuropharmacology 59:567-72. 2010..Collectively, the blockade of neuronal K(ATP) channels by THB in SNc DA neurons is a novel pharmacological mechanism of THB, which may contribute to its neuroprotective effects in PD... - Hypothalamic hamartomas associated with epilepsy: ultrastructural featuresJohn Beggs
Division of Neuropathology, and The Comprehensive Epilepsy Center, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
J Neuropathol Exp Neurol 67:657-68. 2008.... - Regulation by cycloheximide and lowered temperature of cell-surface alpha7-nicotinic acetylcholine receptor expression on transfected SH-EP1 cellsKatherine M Schroeder
Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
J Neurochem 85:581-91. 2003..Although these effects are not simply due to protein synthesis inhibition or reduced cell proliferation, they do involve an increase in intracellular receptor pool size... - Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptorsJunwei Hao
Division of Neurology, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Exp Neurol 227:110-9. 2011.... - Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiologyKe chun Yang
Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Acta Pharmacol Sin 30:740-51. 2009..In this review, we mainly focus on the recent advances in the understanding of alpha6*-nAChR function, pharmacology and pathophysiology... - Systematic administration of iptakalim, an ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in ratsYong Yang
Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, PR China
J Neurosci Res 80:442-9. 2005..The selective activation of mitochondrial ATP-sensitive potassium channels may provide a new therapeutic strategy for prevention and treatment of neurodegenerative disorders such as Parkinson's disease... - Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the ratHuifang Li
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Room A343, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5235, USA
Neuropharmacology 51:121-8. 2006..Selective reductions in GABA(A) receptor subunits in thalamus may play a role in pathophysiology of absence epilepsy... - Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptidesQiang Liu
Divisions of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
BMC Neurosci 13:155. 2012..To extend our previous work, we evaluated the expression and pharmacology of α7β2-nAChRs in hippocampal interneurons and their sensitivity to Aβ... - Impact of prefrontal cortex in nicotine-induced excitation of ventral tegmental area dopamine neurons in anesthetized ratsDie Zhang
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
J Neurosci 32:12366-75. 2012..Finally, systemic injection of bicuculline prevented nicotine-induced firing alterations in the neurons with type-I response. We propose that the mPFC plays a critical role in systemic nicotine-induced excitation of VTA DA neurons... - Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in ratsYong Yang
Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, PR China
Int J Neuropsychopharmacol 9:51-61. 2006.... - Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned ratsSen Wang
Department of Pharmacology and Neurobiology, Nanjing Medical University, Nanjing, Jiangsu Province, PR China
Neuropsychopharmacology 31:933-40. 2006..ii) KATP channels regulate extracellular neurotransmitter levels in the striatum of unilateral 6-OHDA-lesioned rats and may play neuroprotective roles due to their effects on glutamate transporters... - Acute exposure to the mitochondrial complex I toxin rotenone impairs synaptic long-term potentiation in rat hippocampal slicesRyoichi Kimura
Department of Physiology, Shantou University Medical College, Shantou, China
CNS Neurosci Ther 18:641-6. 2012..To evaluate the acute effects of the mitochondrial complex I inhibitor rotenone on rat hippocampal synaptic plasticity... - Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cellsTakanori Kudo
Third Department of Internal Medicine, Hirosaki University School of Medicine, Japan
J Pharmacol Exp Ther 318:1203-10. 2006.... - Double target concept for smoking cessationJie Wu
Shantou University Medical College, China
Acta Pharmacol Sin 31:1015-8. 2010..I discuss how to use this double target concept to interpret recent therapies and to develop new candidate compounds for smoking cessation... - Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cellsZheng Gen Jin
Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 280:12305-9. 2005..Finally, knockdown of endogenous Gab1 by small interference RNA abrogated flow activation of Akt and eNOS. These data demonstrate a critical role of Gab1 in flow-stimulated PI3K/Akt/eNOS signal pathway in endothelial cells... - Iptakalim inhibits nicotine-induced enhancement of extracellular dopamine and glutamate levels in the nucleus accumbens of ratsQiang Liu
Laboratory of Neuropharmacology, Department of Anatomy, Histology and Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, PR China
Brain Res 1085:138-43. 2006..Therefore, Ipt may serve as a novel compound to block nicotine-induced dopamine and glutamate release in the brain reward center, in turn decreasing nicotine reinforcement and dependence... - Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synucleinQiang Liu
Division of Neurology, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
PLoS ONE 8:e55886. 2013.... - Naturally-expressed nicotinic acetylcholine receptor subtypesJie Wu
Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, United States
Biochem Pharmacol 82:800-7. 2011..Importantly, the nAChRs that exist as new isoforms or subtypes or have interesting distributions require alteration in thinking about their roles in health and disease... - Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenaseYing Zi Gong
Department of Physiology, Shiga University of Medical Science, Otsu, Shiga, Japan
Eur J Pharmacol 600:18-25. 2008..5 channels by binding to the open state of the channels, independently of their effects on lipoxygenase activity. The putative binding site for CDC appears to be related to arginine 487 located in the outer pore region... - Nicotine and inflammatory neurological disordersWen Hua Piao
Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Acta Pharmacol Sin 30:715-22. 2009..This review provides a synopsis summarizing the effects of nicotine on the immune system and its (nicotine) influences on various neurological diseases... - Iptakalim hydrochloride protects cells against neurotoxin-induced glutamate transporter dysfunction in in vitro and in vivo modelsYan Ling Yang
Department of Pharmacology and Neurobiology, Nanjing Medical University, 140 Hanzhong Road, Nanjing City, Jiangsu Province 210029, PR China
Brain Res 1049:80-8. 2005..The cellular mechanisms of this protective effect may involve the opening of K(ATP) channels. Collectively, Ipt may serve as a novel and effective drug for PD therapy... - Neuronal nicotinic acetylcholine receptors serve as sensitive targets that mediate beta-amyloid neurotoxicityQiang Liu
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
Acta Pharmacol Sin 27:1277-86. 2006..In this review, we summarize current studies performed in our laboratory and in others to address the question of how Abeta modulates neuronal nAChRs, especially nAChR subunit function... - The neuropharmacology of (-)-stepholidine and its potential applicationsKechun Yang
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Curr Neuropharmacol 5:289-94. 2007..Therefore, SPD is a novel, natural compound with potentially therapeutic roles in the treatment of schizophrenia and/or PD... - Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824Liwei Chen
Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Mol Cancer Ther 4:1311-9. 2005..LAQ824 effectively inhibited cell proliferation and induced apoptosis of these prostate cancer cells. These results reveal that LAQ824 is a potent agent for depletion of androgen receptor and a potential new drug for prostate cancer... - The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cellsMitsutoshi Nakada
Neuro Oncology Research, Barrow Neurological Institute, Phoenix, Arizona, USA
Cancer Res 64:3179-85. 2004..Dysregulation of EphB2 expression or function may underlie glioma invasion... - Thimerosal modulates the agonist-specific cytosolic Ca2+ oscillatory patterns in single pancreatic acinar cells of mouseJ Wu
Department of Physiology 1, Hirosaki University School of Medicine, Japan
FEBS Lett 390:149-52. 1996..We conclude that thimerosal modulates the agonist-specific cytosolic Ca2+ oscillatory patterns mediated by sensitizing the InsP3-induced Ca2+ release... - Mutational analysis of roles for extracellular cysteine residues in the assembly and function of human alpha 7-nicotinic acetylcholine receptorsT Dunckley
Division of Neurobiology and Division of Neurology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
Biochemistry 42:870-6. 2003..These results suggest that disulfide bond formation between C138 and either C150 or C164, if it occurs, has no significant effect on alpha7-nAChR assembly or function... - [Effects of intrauterine acute ischemia on epidermal growth factor and its receptor of the fetal kidney in rats]Jie Wu
Zhonghua Er Ke Za Zhi 41:614-5. 2003 - [Development of toxin targeting to VEGF-KDR]Jie Wu
Medical Research Department, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China
Zhonghua Zhong Liu Za Zhi 26:78-81. 2004..To develop toxin targeting vascular endothelial growth factor receptor II (VEGF-II/KDR) fused with a KDR-binling peptide screened from peptide library... - Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factorYuan Ren
Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Biol Chem 279:8497-505. 2004.... - [Construction of recombinant vector pEGFP-ANG and expression of angiogenin gene in HUVECs]Hong Bin Zhang
Department of Medical Research, General Hospital of Guangzhou Military Command, Guangzhou 510010, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:15-8. 2004..To express the recombinant angiogenin protein in mammalian cells... - Effect of atorvastatin on tumor necrosis factor alpha serum concentration and mRNA expression of adipose in hypercholesterolemic rabbitsShui Ping Zhao
Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, PR China
J Cardiovasc Pharmacol 46:185-9. 2005..Atorvastatin reduced TNFalpha serum concentration in hypercholesterolemic rabbits, which might be because of its cholesterol-lowering effect and direct inhibition of TNFalpha expression in adipose... - Constructing networks with correlation maximization methodsJoseph C Mellor
Program in Bioinformatics, Boston University
Genome Inform 15:149-59. 2004..We show how statistical strength and information are equivalent criteria in limiting cases, and demonstrate the application of these measures to simple systems of gene regulation... - Changes in muscarinic acetylcholine receptor expression in form deprivation myopia in guinea pigsQiong Liu
State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center, SunYat sen University, Guangzhou, China
Mol Vis 13:1234-44. 2007.... - Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvantsLiang Jin
Minigene Pharmacy Laboratory, Biopharmaceutical College, China Pharmaceutical University, Tongjia Xiang 24, Nanjing 210009, PR China
Vaccine 25:2043-50. 2007..Specific antibodies were successfully induced and lasted for more than 20 weeks in animals immunized with the fusion protein via intranasal route even in the absence of adjuvants... - Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component systemJie Wu
School of Dentistry, Meharry Medical College, Nashville, TN, USA
FEMS Microbiol Lett 271:214-21. 2007..Unlike the regulatory mechanism of FimA by FimR, this regulation of the mfa1 gene is accomplished by FimR directly binding to the promoter region of mfa1... - Time-course of changes to nitric oxide signaling pathways in form-deprivation myopia in guinea pigsJie Wu
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, Guangdong, China
Brain Res 1186:155-63. 2007..Our main observations were a change in NOS activity and an up-regulation in cGMP concentrations in posterior ocular tissues during the development of myopia. The function of elevated NOS activity may be mediated by cGMP... - Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle traffickingJianbo Yang
Department of Laboratory Medicine and Pathology and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 277:30219-26. 2002..Our data suggest that Etk may be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1... - Relationship between the U wave on electrocardiogram and the midmyocardium of the left ventricular wallCuntai Zhang
Department of Cardiology, Tongji Hospital Tongji Medical University, Wuhan 430030, China
Chin Med J (Engl) 115:509-12. 2002..To investigate the relationship between the U wave on electrocardiogram and the midmyocardium in rabbit left ventricle free wall in vivo... - A heterozygote phenotype is present in the jvs +/- mutant mouse liversKarim Lahjouji
Division of Medical Genetics, Hĵpital Sainte Justine, Montreal, Que, Canada
Mol Genet Metab 76:76-80. 2002..We speculate that in situations of lipolytic stress, some SCD heterozygotes might develop clinical symptoms of carnitine deficiency... - A role for Grb2-associated binder-1 in growth hormone signalingSung Oh Kim
Department of Medicine, Division of Endocrinology and Metabolism, University of Alabama, Birmingham, Alabama 35294, USA
Endocrinology 143:4856-67. 2002..Our results suggest selective involvement of Gab1 in GH-induced ERK activation and implicate the Gab1 PH domain as critical in this involvement... - Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cellsRamadevi Nimmanapalli
Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute University of South Florida, Tampa, Florida 33614, USA
Cancer Res 63:5126-35. 2003..Therefore, LAQ824 may be a promising therapeutic agent in the treatment of imatinib-sensitive or -refractory human leukemia... - Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyreneJie Wu
Department of Pharmacology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
Int J Dev Neurosci 21:333-46. 2003.... - Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cellsMei Huang
Molecular Oncology, H Lee Moffitt Cancer Center, Research Institute, Tampa, Florida, FL 33612, USA
Oncogene 21:8804-16. 2002.... - Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90Warren Fiskus
Medical College of Georgia Cancer Center, Augusta, Georgia 30912, USA
Clin Cancer Res 13:4882-90. 2007..Here, we determined the effect of HA-HDIs on the levels and activity of ERalpha, as well as on the survival of ERalpha-expressing, estrogen-responsive human breast cancer MCF-7 and BT-474 cells... - Synthesis of functionalized 1,2-dihydroisoquinolines via multicomponent one-pot reaction of 2-alkynylbenzaldehyde, amine, zinc, and allylic bromide or benzyl bromideKe Gao
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
J Org Chem 72:8611-3. 2007.... - Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse modelJinshu Xu
School of Pharmacy, Nanjing Medical University, Nanjing, PR China
Cancer Lett 259:240-50. 2008..001). The conjugation of the recombinant GnRH peptide to Hsp65 could be considered a promising approach for the development of an efficacious vaccine against the prostate cancer... - Prenatal restraint stress impairs learning and memory and hippocampal PKCbeta1 expression and translocation in offspring ratsJie Wu
Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi an Jiaotong University School of Medicine, Xi an Shaanxi, 710061, PR China
Brain Res 1141:205-13. 2007..Our results suggest that deficient signal transduction of PKCbeta1 in the hippocampus resulting from prenatal restraint stress may play an important role in the impairment of learning and memory abilities of offspring... - Role of differential expression of streptococcal arginine deiminase in inhibition of fimA expression in Porphyromonas gingivalisXinghua Lin
School of Dentistry, Meharry Medical College, Nashville, TN 37208, USA
J Bacteriol 190:4367-71. 2008..In this study, we demonstrate the differential expression of arcA in two streptococcal species. The expression level of arcA in streptococci appears to be controlled by both cis and trans elements... - Stability of plasmid and expression of a recombinant gonadotropin-releasing hormone (GnRH) vaccine in Escherichia coliJinshu Xu
School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, Nanjing, People s Republic of China
Appl Microbiol Biotechnol 73:780-8. 2006..The amount of the fusion protein was also up to 40% of the total cell protein after the 50th generation. These data would be useful for the industrial production of the recombinant GnRH vaccine... - Facile synthesis of chromeno[4,3-b]quinolin-6-ones from unexpected reactions of aryl isocyanides with 4-chloro-2-oxo-2H-chromene-3-carbaldehydeJie Wu
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China
Org Biomol Chem 4:1348-51. 2006..An unexpected reaction of aryl isocyanides with 4-chloro-2-oxo-2H-chromene-3-carbaldehyde leads to chromeno[4,3-b]quinolin-6-ones in good yields... - Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib)Zhengming Chen
Molecular Oncology Program, SRB 3, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, and the Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, FL 33612, USA
Mol Pharmacol 69:1527-33. 2006..These results suggest that BMS-354825 is a potent inhibitor of PDGF-stimulated VSMC activities and a potential agent for the development of a new therapy for vascular obstructive diseases such as restenosis... - Two approaches to construct mammalian expression vector of shRNA to reduce expression and replication of HBV in vitroHong Bin Zhang
Department of Medical Research, Guangzhou Liuhuaqiao Hospital, Liuhua road 111, Guangzhou, Guangdong Province, P R China
Mol Biol Rep 35:465-72. 2008..The pU6 derived plasmids might be a useful shRNA delivery system in mammalian cells. In addition, we found siRNA based on stealth 2311 was a potent RNAi target of HBV genome... - Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cellsFei Guo
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
Blood 105:1246-55. 2005.... - [Comparison of serum biochemistry between specific pathogen-free and conventional aged Wistar rats]Yu Hua Xiao
Department of Medical Research, General Hospital of Guangzhou Command, Guangzhou 510010, China
Di Yi Jun Yi Da Xue Xue Bao 24:733-5. 2004..To investigate the differences in serum biochemistry between specific pathogen-free (SPF) and conventional aged Wistar rats... - Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2Jay F Dorsey
Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Blood 99:1388-97. 2002..All of these changes are characteristics of megakaryocytic differentiation. Together, these results reveal Gab2 as a limiting signaling component for Erk MAP kinase activation and terminal differentiation of K562 CML cells...