ANDREJ ROMANOVSKY

Summary

Affiliation: Barrow Neurological Institute
Country: USA

Publications

  1. ncbi request reprint Heat defense control in an experimental heat disorder
    A A Romanovsky
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Int J Biometeorol 43:172-5. 2000
  2. ncbi request reprint Fever and hypothermia in systemic inflammation: recent discoveries and revisions
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Front Biosci 10:2193-216. 2005
  3. ncbi request reprint Do fever and anapyrexia exist? Analysis of set point-based definitions
    Andrej A Romanovsky
    Trauma Research, St Joseph s Hospital, 350 W Thomas Rd, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 287:R992-5. 2004
  4. ncbi request reprint Microsomal prostaglandin E synthase-1, ephrins, and ephrin kinases as suspected therapeutic targets in arthritis: exposed by "criminal profiling"
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, Arizona 85013 USA
    Ann N Y Acad Sci 1069:183-94. 2006
  5. ncbi request reprint Signaling the brain in the early sickness syndrome: are sensory nerves involved?
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Front Biosci 9:494-504. 2004
  6. ncbi request reprint Cells that trigger fever
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Cell Cycle 5:2195-7. 2006
  7. ncbi request reprint Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 292:R37-46. 2007
  8. ncbi request reprint The organum vasculosum laminae terminalis in immune-to-brain febrigenic signaling: a reappraisal of lesion experiments
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 285:R420-8. 2003
  9. pmc The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Pharmacol Rev 61:228-61. 2009
  10. ncbi request reprint Thermoregulatory manifestations of systemic inflammation: lessons from vagotomy
    A A Romanovsky
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Auton Neurosci 85:39-48. 2000

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Heat defense control in an experimental heat disorder
    A A Romanovsky
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Int J Biometeorol 43:172-5. 2000
    ..We speculate that postheating thermoregulatory disorders are associated with threshold dissociation, thus representing the poikilothermic (wide dead-band) type of T(b) control...
  2. ncbi request reprint Fever and hypothermia in systemic inflammation: recent discoveries and revisions
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Front Biosci 10:2193-216. 2005
    ..Several new targets for antipyretic therapy, including mPGES-1, have been identified...
  3. ncbi request reprint Do fever and anapyrexia exist? Analysis of set point-based definitions
    Andrej A Romanovsky
    Trauma Research, St Joseph s Hospital, 350 W Thomas Rd, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 287:R992-5. 2004
    ..A radical solution is to transform all definitions based on comparing T(b) with the SP into definitions based on balancing active and passive processes of T(b) control...
  4. ncbi request reprint Microsomal prostaglandin E synthase-1, ephrins, and ephrin kinases as suspected therapeutic targets in arthritis: exposed by "criminal profiling"
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, Arizona 85013 USA
    Ann N Y Acad Sci 1069:183-94. 2006
    ..Studies to test this new hypothesis seem warranted, and our prediction is that the "smoking gun" will be found...
  5. ncbi request reprint Signaling the brain in the early sickness syndrome: are sensory nerves involved?
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Front Biosci 9:494-504. 2004
    ..We speculate that these mechanisms are triggered by peripherally originated, blood-borne prostaglandin E2...
  6. ncbi request reprint Cells that trigger fever
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Cell Cycle 5:2195-7. 2006
    ..Hence, pulmonary and hepatic macrophages that recognize LPS via the TLR4 and rapidly produce PGE(2) are likely triggers of the fever response...
  7. ncbi request reprint Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 292:R37-46. 2007
    ..The term balance point is proposed to designate the regulated level of T(b) and to attract attention to the multiple feedback, feedforward, and open-loop components that contribute to thermal balance...
  8. ncbi request reprint The organum vasculosum laminae terminalis in immune-to-brain febrigenic signaling: a reappraisal of lesion experiments
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 285:R420-8. 2003
    ..Hence, the changed febrile responsiveness of OVLT-lesioned animals is given an alternative interpretation, unrelated to febrigenic signaling to the brain...
  9. pmc The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Pharmacol Rev 61:228-61. 2009
    ..Strategies for creating hyperthermia-free TRPV1 antagonists are outlined. The potential physiological and pathological significance of TRPV1-mediated thermoregulatory effects is discussed...
  10. ncbi request reprint Thermoregulatory manifestations of systemic inflammation: lessons from vagotomy
    A A Romanovsky
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Auton Neurosci 85:39-48. 2000
    ..6) A hepatoceliac vagal, presumably efferent, mechanism ('an anti-inflammatory pathway') counteracts the development of lipopolysaccharide-induced hypothermia and shock...
  11. ncbi request reprint Neural route of pyrogen signaling to the brain
    A A Romanovsky
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Clin Infect Dis 31:S162-7. 2000
    ..We speculate that this mechanism is triggered by blood-borne prostaglandins of the E series...
  12. ncbi request reprint Lipopolysaccharide transport from the peritoneal cavity to the blood: is it controlled by the vagus nerve?
    A A Romanovsky
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Auton Neurosci 85:133-40. 2000
    ..The design of the present study did not allow for evaluating the rapid, hematogenous transport. The results obtained suggest that the abdominal vagus does not control the slow. lymphogenous escape of LPS from the peritoneal cavity...
  13. ncbi request reprint Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality
    Andrej A Romanovsky
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Appl Physiol 92:2667-79. 2002
    ..0-29.0 degrees C). Skin thermometry or thermography is a definition-based, simple, and inexpensive technique to determine whether experimental or housing conditions are neutral, subneutral, or supraneutral for a given animal...
  14. ncbi request reprint Cold-seeking behavior as a thermoregulatory strategy in systemic inflammation
    Maria C Almeida
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Eur J Neurosci 23:3359-67. 2006
    ..This is the first well-controlled study to report SI-associated cold-seeking behavior in rats. Cold-seeking behavior is likely to be an important defense response in severe SI...
  15. pmc Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia?
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 297:R485-94. 2009
    ..The expression of splenic COX-1 was unaffected by LPS. We conclude that COX-1, but not COX-2, mediates LPS hypothermia, and that both COX isoforms are required for LPS hypotension...
  16. ncbi request reprint Fever responses of Zucker rats with and without fatty mutation of the leptin receptor
    Andrei I Ivanov
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Am J Physiol Regul Integr Comp Physiol 282:R311-6. 2002
    ..The normal febrile responses of fatty Zucker rats to pyrogenic stimuli at thermoneutrality indicate that fatty mutation does not interrupt febrigenic signaling from the periphery to the brain...
  17. pmc Cellular and molecular bases of the initiation of fever
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona, United States of America
    PLoS Biol 4:e284. 2006
    ..Whether PGE2 produced at the level of the blood-brain barrier also contributes to the development of the first phase remains to be clarified...
  18. ncbi request reprint Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital, Phoenix, Arizona 85013, USA
    J Neurosci 27:7459-68. 2007
    ..We conclude that tonic activation of TRPV1 channels in the abdominal viscera by yet unidentified nonthermal factors inhibits skin vasoconstriction and thermogenesis, thus having a suppressive effect on T(b)...
  19. ncbi request reprint Prostaglandin E(2)-synthesizing enzymes in fever: differential transcriptional regulation
    Andrei I Ivanov
    Trauma Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1104-17. 2002
    ..Neither sPLA(2)-V nor cPGES was induced by LPS. The high magnitude of upregulation of mPGES and sPLA(2)-IIA (1,257-fold and 133-fold, respectively) makes these enzymes attractive targets for anti-inflammatory therapy...
  20. ncbi request reprint A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    FASEB J 18:1949-51. 2004
    ....
  21. ncbi request reprint Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide fever
    Andrei I Ivanov
    Trauma Research and Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Am J Physiol Regul Integr Comp Physiol 284:R698-706. 2003
    ..By increasing the blood-brain gradient of PGE(2), this mechanism likely facilitates penetration of PGE(2) into the brain and prevents its elimination from the brain...
  22. ncbi request reprint Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature
    Alla Y Rudaya
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Rd, Phoenix, Arizona 85013, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1244-52. 2005
    ..The present investigation identifies experimental conditions to study LPS-induced mono-, bi-, and polyphasic fevers and late hypothermia in mice and provides detailed characteristics of these responses...
  23. ncbi request reprint Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responses
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Rd, Phoenix, Arizona 85013, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1253-7. 2005
    ..It also suggests that no product of the COX-1 gene, including the splice variant COX-1b (COX-3), is essential for these responses...
  24. ncbi request reprint Thermoregulatory responses of rats to conventional preparations of lipopolysaccharide are caused by lipopolysaccharide per se-- not by lipoprotein contaminants
    Alexandre A Steiner
    Trauma Research, St Joseph s Hospital, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 289:R348-R352. 2005
    ..All T(b) responses to dLPS were identical to those of cLPS. We conclude that all known T(b) responses to LPS preparations are triggered by LPS per se and not by non-TLR4-signaling contaminants of such preparations...
  25. pmc Platelet-activating factor: a previously unrecognized mediator of fever
    Andrei I Ivanov
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Physiol 553:221-8. 2003
    ..BN 52021 (but not its vehicle) was similarly effective in attenuating LPS (10 microg kg-1, i.v.) fever. It is concluded that PAF is a highly potent endogenous pyrogenic substance and a mediator of LPS fever...
  26. ncbi request reprint Bilateral splanchnicotomy does not affect lipopolysaccharide-induced fever in rats
    M Devrim Dogan
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Brain Res 993:227-9. 2003
    ..However, all phases of the febrile response of splanchnicotomized rats to intravenous LPS (10 microg/kg) were similar to those of sham-operated controls. Hence, the splanchnic nerve is likely uninvolved in LPS fever...
  27. pmc Febrigenic signaling to the brain does not involve nitric oxide
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Rd, Phoenix, AZ 85013, USA
    Br J Pharmacol 141:1204-13. 2004
    ..It is concluded that NO is uninvolved in febrigenic signaling to the brain...
  28. ncbi request reprint Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of alpha1-acid glycoprotein
    Andrei I Ivanov
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Rd, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 288:R872-8. 2005
    ..We conclude that, in the absence of albumin, AGP and possibly other carriers participate in immune-to-brain signaling by binding and transporting amphipathic inflammatory mediators...
  29. ncbi request reprint Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in rats
    Andrei I Ivanov
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital, Phoenix, Arizona 85013, USA
    Physiol Genomics 21:152-60. 2005
    ....
  30. pmc Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor
    M Devrim Dogan
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Br J Pharmacol 143:1023-32. 2004
    ..The action of CAP on this mechanism is likely TRPV-1-independent. It is speculated that this mechanism may be the production of prostaglandin E(2) by macrophages in LPS-processing organs...
  31. pmc Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Blood 107:4000-2. 2006
    ..The first phase is triggered via the TLR4 on hematopoietic cells. The second and third phases involve TLR4 signaling in both hematopoietic and nonhematopoietic cells...
  32. pmc Role for the cholecystokinin-A receptor in fever: a study of a mutant rat strain and a pharmacological analysis
    Andrei I Ivanov
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Physiol 547:941-9. 2003
    ..None of the three known phases of the febrile response of rats to LPS requires the CCK-A receptor...
  33. pmc Leptin: at the crossroads of energy balance and systemic inflammation
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Prog Lipid Res 46:89-107. 2007
    ..g., fasting) can exaggerate both hypothermia and behavioral depression. Since these manifestations aid energy conservation, exaggeration of these manifestations under conditions of negative energy balance is likely to be beneficial...
  34. pmc The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors
    Alexandre A Steiner
    St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Physiol 589:2415-31. 2011
    ..In conclusion, the present study reveals a novel, critical role of brain CB1 receptors in LPS hypothermia. Brain CB1 receptors may constitute a new therapeutic target in systemic inflammation and sepsis...
  35. pmc Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia
    Andras Garami
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosci 30:1435-40. 2010
    ....
  36. pmc Nicotine administration and withdrawal affect survival in systemic inflammation models
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Rd, Phoenix, AZ 85013, USA
    J Appl Physiol 105:1028-34. 2008
    ..We conclude that acute nicotine administration and nicotine withdrawal affect survival in systemic inflammation and that these effects strongly depend on whether inflammation is aseptic or septic...
  37. doi request reprint Fever response to intravenous prostaglandin E2 is mediated by the brain but does not require afferent vagal signaling
    Youichirou Ootsuka
    Department of Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R1294-303. 2008
    ..We conclude that the febrile response to circulating PGE2 is mediated by the brain, but that it does not require vagal afferent signaling...
  38. ncbi request reprint Prostaglandin E2 as a mediator of fever: synthesis and catabolism
    Andrei I Ivanov
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Front Biosci 9:1977-93. 2004
    ..The high magnitude of up-regulation of mPGES and sPLA2-IIA (1,260 and 130 fold, respectively) and that of down-regulation of 15-PGES (30 fold) during LPS fever makes these enzymes attractive targets for anti-inflammatory therapy...
  39. ncbi request reprint Near-term suppression of fever: inhibited synthesis or accelerated catabolism of prostaglandin E2?
    Andrei I Ivanov
    Am J Physiol Regul Integr Comp Physiol 284:R860-1; author reply R861-5. 2003
  40. ncbi request reprint Eicosanoids in non-febrile thermoregulation
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, The University of Michigan Health Systems, Ann Arbor, MI 48109 0642, USA
    Prog Brain Res 162:15-25. 2007
    ..Newly discovered signaling pathways for eicosanoids, such as the endovanilloid system, may participate in thermoregulation, but further studies are required before definitive conclusions can be made...
  41. ncbi request reprint The spleen: another mystery about its function
    Andrej A Romanovsky
    Am J Physiol Regul Integr Comp Physiol 284:R1378-9. 2003
  42. ncbi request reprint Vioxx, Celebrex, Bextra....do we have a new target for anti-inflammatory and antipyretic therapy?
    Andrej A Romanovsky
    Am J Physiol Regul Integr Comp Physiol 288:R1098-9. 2005
  43. ncbi request reprint Cholecystokinin: possible mediator of fever and hypothermia
    Zoltan Szelenyi
    Department of Pathophysiology, Faculty of Medicine, University of Pecs, H 7602 Pecs, P O B 99, Hungary
    Front Biosci 9:301-8. 2004
    ..The relationship between the putative CCK-ergic febrile mechanism and the established central PGE mediation needs further study...
  44. ncbi request reprint Putative dual role of ephrin-Eph receptor interactions in inflammation
    Andrei I Ivanov
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    IUBMB Life 58:389-94. 2006
    ..Taking into consideration the abundance of ephrins and Eph receptors in tissues and the robustness of their signaling effects, the proposed involvement is likely to be substantial and may constitute a novel therapeutic target...
  45. ncbi request reprint Anorexia: the toll for lipopolysaccharide recognition
    Andrej A Romanovsky
    Am J Physiol Regul Integr Comp Physiol 287:R274-5. 2004
  46. doi request reprint Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
    Narender R Gavva
    Department of Neuroscience, MS 29 2 B, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Pain 136:202-10. 2008
    ....

Research Grants6

  1. BLOOD-BRAIN SIGNALING IN INFLAMMATION--ROLE OF ALBUMIN
    ANDREJ ROMANOVSKY; Fiscal Year: 2002
    ..This mechanism, if confirmed, will constitute a new target for therapeutic interventions in systemic inflammation. ..
  2. Blood-Brain Signaling in Inflammation: Lipid Mediators of Fever and Hypothermia
    ANDREJ ROMANOVSKY; Fiscal Year: 2007
    ..We will identify some of the mechanisms involved. We may also gain insight into the therapeutic use of selective COX inhibitors in systemic inflammation. ..
  3. Blood-Brain Signaling in Inflammation: Lipid Mediators of Fever and Hypothermia
    ANDREJ ROMANOVSKY; Fiscal Year: 2009
    ..We will identify some of the mechanisms involved. We may also gain insight into the therapeutic use of selective COX inhibitors in systemic inflammation. ..
  4. Blood-Brain Signaling in Inflammation: Lipid Mediators of Fever and Hypothermia
    Andrej A Romanovsky; Fiscal Year: 2010
    ..We will identify some of the mechanisms involved. We may also gain insight into the therapeutic use of selective COX inhibitors in systemic inflammation. ..