Do Young Kim

Summary

Affiliation: Barrow Neurological Institute
Country: USA

Publications

  1. ncbi request reprint GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
    Do Young Kim
    Division of Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsia 49:861-71. 2008
  2. doi request reprint The ketogenic diet and epilepsy
    Do Young Kim
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Curr Opin Clin Nutr Metab Care 11:113-20. 2008
  3. pmc Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors
    Do Young Kim
    Barrow Neurological Institute and St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurochem 114:130-41. 2010
  4. pmc Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas
    Do Young Kim
    Divisions of Pediatric Neurology and Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Res 83:89-93. 2009
  5. pmc L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue
    Kristina A Simeone
    Divisions of Neurology and Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Epilepsia 52:531-40. 2011
  6. pmc GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, NRC 445, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Exp Neurol 213:397-404. 2008
  7. ncbi request reprint Ketone bodies are protective against oxidative stress in neocortical neurons
    Do Young Kim
    Barrow Neurological Institute and St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurochem 101:1316-26. 2007
  8. ncbi request reprint Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesis
    Kristina A Fenoglio
    Division of Neurology and Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 14:51-9. 2007
  9. ncbi request reprint Electrophysiological properties of human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Ann Neurol 58:371-82. 2005
  10. pmc Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis
    Do Young Kim
    Barrow Neurological Institute, Medical Center, St Joseph s Hospital, Phoenix, Arizona, United States of America
    PLoS ONE 7:e35476. 2012

Collaborators

Detail Information

Publications17

  1. ncbi request reprint GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
    Do Young Kim
    Division of Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsia 49:861-71. 2008
    ..Here, we examined the role of GABAA receptors in surgically resected HH tissue...
  2. doi request reprint The ketogenic diet and epilepsy
    Do Young Kim
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Curr Opin Clin Nutr Metab Care 11:113-20. 2008
    ....
  3. pmc Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors
    Do Young Kim
    Barrow Neurological Institute and St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurochem 114:130-41. 2010
    ..In summary, our data demonstrate that ketones can preserve synaptic function in CA1 hippocampus induced by MRC dysfunction, likely through an antioxidant action and enhanced ATP generation...
  4. pmc Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas
    Do Young Kim
    Divisions of Pediatric Neurology and Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Res 83:89-93. 2009
    ..These results suggest that HCO(3)(-) efflux through GABA(A) receptors on a subpopulation of large HH neurons may contribute to membrane depolarization and subsequent activation of L-type calcium channels...
  5. pmc L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue
    Kristina A Simeone
    Divisions of Neurology and Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Epilepsia 52:531-40. 2011
    ..In this study, we examined whether blocking L-type calcium channels attenuates emergent activity of HH neuronal networks...
  6. pmc GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, NRC 445, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Exp Neurol 213:397-404. 2008
    ..Taken collectively, we provide novel evidence for and mechanistic insights into HH epileptogenicity: GABA(A)R-mediated excitation...
  7. ncbi request reprint Ketone bodies are protective against oxidative stress in neocortical neurons
    Do Young Kim
    Barrow Neurological Institute and St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurochem 101:1316-26. 2007
    ..Taken together, our data suggest that KB may prevent mPT and oxidative injury in neocortical neurons, most likely by decreasing mitochondrial ROS production...
  8. ncbi request reprint Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesis
    Kristina A Fenoglio
    Division of Neurology and Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 14:51-9. 2007
    ..These observations constitute the basis for future investigations aimed at elucidating the mechanisms of subcortical epileptogenesis...
  9. ncbi request reprint Electrophysiological properties of human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Ann Neurol 58:371-82. 2005
    ..These findings suggest that human HH tissues, associated with gelastic seizures, contained predominantly small GABAergic inhibitory neurons that exhibited intrinsic "pacemaker-like" behavior...
  10. pmc Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis
    Do Young Kim
    Barrow Neurological Institute, Medical Center, St Joseph s Hospital, Phoenix, Arizona, United States of America
    PLoS ONE 7:e35476. 2012
    ....
  11. doi request reprint Ketogenic diet in the treatment of seizures associated with hypothalamic hamartomas
    Kevin E Chapman
    Barrow Neurological Institute and St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Res 94:218-21. 2011
    ..These preliminary results suggest that seizures associated with HH may respond favorably to the KD, and that ketone bodies might directly modulate the intrinsic epileptogenicity of HH tissue. ..
  12. pmc The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
    Phillip Stafford
    Neuro Oncology Research, Barrow Neurological Institute7 of St, Joseph s Hospital and Medical Center, Phoenix, AZ, 85013, USA
    Nutr Metab (Lond) 7:74. 2010
    ....
  13. pmc Excitatory actions of GABA in the suprachiasmatic nucleus
    Hee Joo Choi
    Department of Physiology and Neuroscience Research Institute, Korea University College of Medicine, Seoul 136 705, Republic of Korea
    J Neurosci 28:5450-9. 2008
    ..Together, this work indicates that GABA can play an excitatory role in communication between adult SCN neurons and that this excitation is critically dependent on NKCC1...
  14. ncbi request reprint Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock
    Do Young Kim
    Department of Physiology and Neuroscience Research Institute, Korea University College of Medicine, Seoul, Korea 136 705
    Eur J Neurosci 21:1215-22. 2005
    ..Moreover, the results point to the possibility that a nocturnal modulation of T-type Ca(2+) current in retinorecipient neurons is related to the differential involvement of T-type VGCC in phase delays and advances...
  15. ncbi request reprint Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluR-PLCbeta4 signaling
    Donghyun Park
    National CRI Center for Calcium and Learning, Korea Institute of Science and Technology, Box 131, Cheongryang, Seoul 136 791, Republic of Korea
    Nat Neurosci 6:337-8. 2003
  16. ncbi request reprint N-acetylcysteine prevents LPS-induced pro-inflammatory cytokines and MMP2 production in gingival fibroblasts
    Do Young Kim
    Department of Periodontology, Seoul National University, Seoul 110 749, Korea
    Arch Pharm Res 30:1283-92. 2007
    ..Furthermore, this work suggests that antioxidants may be useful in adjunctive therapies that complement conventional periodontal treatments...
  17. ncbi request reprint Electrically stimulated relaxation is not mediated by GABA in cat lower esophageal sphincter muscle
    Sun Young Park
    Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul 156 756, Korea
    Arch Pharm Res 29:400-4. 2006
    ..This suggests that GABA and the GABA receptor are not involved in the electrically stimulated NANC relaxation in the cat LES...