John F Kerrigan

Summary

Affiliation: Barrow Neurological Institute
Country: USA

Publications

  1. ncbi request reprint The histopathology of hypothalamic hamartomas: study of 57 cases
    Stephen W Coons
    Division of Neuropathology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neuropathol Exp Neurol 66:131-41. 2007
  2. ncbi request reprint Gelastic seizures misdiagnosed as gastroesophageal reflux disease
    Laura L Sweetman
    Division of Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Clin Pediatr (Phila) 46:325-8. 2007
  3. ncbi request reprint Electrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsy
    John F Kerrigan
    Department of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Epilepsia 45:346-54. 2004
  4. ncbi request reprint Hypothalamic hamartoma and infantile spasms
    John F Kerrigan
    Epilepsy Center and Division of Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Epilepsia 48:89-95. 2007
  5. ncbi request reprint The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy
    John F Kerrigan
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 12:119-31. 2005
  6. ncbi request reprint Chromosomal abnormality at 6p25.1-25.3 identifies a susceptibility locus for hypothalamic hamartoma associated with epilepsy
    John F Kerrigan
    Epilepsy Center and Division of Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Res 75:70-3. 2007
  7. ncbi request reprint GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
    Do Young Kim
    Division of Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsia 49:861-71. 2008
  8. pmc Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas
    Guohui Li
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    Ann Neurol 69:664-72. 2011
  9. pmc GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, NRC 445, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Exp Neurol 213:397-404. 2008
  10. doi request reprint Seizure outcome and complications following hypothalamic hamartoma treatment in adults: endoscopic, open, and Gamma Knife procedures
    Cornelia Drees
    Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosurg 117:255-61. 2012

Collaborators

Detail Information

Publications42

  1. ncbi request reprint The histopathology of hypothalamic hamartomas: study of 57 cases
    Stephen W Coons
    Division of Neuropathology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neuropathol Exp Neurol 66:131-41. 2007
    ..Nodules of these small neurons were a universal feature of the microarchitecture of HH lesions associated with epilepsy. Characterization of these neurons may aid in understanding the mechanism of seizure development in HH...
  2. ncbi request reprint Gelastic seizures misdiagnosed as gastroesophageal reflux disease
    Laura L Sweetman
    Division of Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Clin Pediatr (Phila) 46:325-8. 2007
    ..Gelastic seizures should be considered among the conditions that can mimic reflux symptoms...
  3. ncbi request reprint Electrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsy
    John F Kerrigan
    Department of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Epilepsia 45:346-54. 2004
    ....
  4. ncbi request reprint Hypothalamic hamartoma and infantile spasms
    John F Kerrigan
    Epilepsy Center and Division of Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Epilepsia 48:89-95. 2007
    ..A small number of patients with hypothalamic hamartoma (HH) present with infantile spasms (IS) as an initial or early seizure type. We describe the clinical features of IS associated with HH...
  5. ncbi request reprint The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy
    John F Kerrigan
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 12:119-31. 2005
    ..Refractory epilepsy associated with HH is the premier human model for subcortical epilepsy and an excellent model for secondary epileptogenesis and epileptic encephalopathy...
  6. ncbi request reprint Chromosomal abnormality at 6p25.1-25.3 identifies a susceptibility locus for hypothalamic hamartoma associated with epilepsy
    John F Kerrigan
    Epilepsy Center and Division of Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Res 75:70-3. 2007
    ..8 Mb to 9.7 Mb. There are 38 RefSeq genes within the duplicated regions, and no known coding sequences within the deletion. This unique patient helps identify 6p25.1-25.3 as a possible susceptibility locus for sporadic HH...
  7. ncbi request reprint GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
    Do Young Kim
    Division of Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsia 49:861-71. 2008
    ..Here, we examined the role of GABAA receptors in surgically resected HH tissue...
  8. pmc Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas
    Guohui Li
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    Ann Neurol 69:664-72. 2011
    ..Recently, functional GABA(A) receptor (GABA(A) R) rundown has been described in surgically resected human temporal lobe epilepsy tissue. We asked whether functional GABA(A) R rundown also occurs in human HH neurons...
  9. pmc GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, NRC 445, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    Exp Neurol 213:397-404. 2008
    ..Taken collectively, we provide novel evidence for and mechanistic insights into HH epileptogenicity: GABA(A)R-mediated excitation...
  10. doi request reprint Seizure outcome and complications following hypothalamic hamartoma treatment in adults: endoscopic, open, and Gamma Knife procedures
    Cornelia Drees
    Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosurg 117:255-61. 2012
    ..This study aimed at identifying outcomes with respect to seizures, morbidity, and mortality in adult patients undergoing resective or Gamma Knife surgery (GKS) to treat intractable epilepsy associated with hypothalamic hamartoma (HH)...
  11. pmc Identification of somatic chromosomal abnormalities in hypothalamic hamartoma tissue at the GLI3 locus
    David W Craig
    The Translational Genomics Research Institute, Neurogenomics Division, Phoenix, AZ 85004, USA
    Am J Hum Genet 82:366-74. 2008
    ..Chromosomal abnormalities including the GLI3 locus were seen in 8 of 55 (15%) of the resected HH tissue samples. These somatic mutations appear to be highly variable...
  12. pmc Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas
    Do Young Kim
    Divisions of Pediatric Neurology and Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Res 83:89-93. 2009
    ..These results suggest that HCO(3)(-) efflux through GABA(A) receptors on a subpopulation of large HH neurons may contribute to membrane depolarization and subsequent activation of L-type calcium channels...
  13. ncbi request reprint Hypothalamic hamartomas: neuropathological features with and without prior gamma knife radiosurgery
    John F Kerrigan
    Hypothalamic Hamartoma Program, Phoenix Children s Hospital, Phoenix, AZ 85013, USA neuropub chw edu
    Stereotact Funct Neurosurg 91:45-55. 2013
    ..The neuropathological consequences of Gamma Knife radiosurgery (GK) on hypothalamic hamartoma (HH) are unknown...
  14. doi request reprint Orbitozygomatic resection for hypothalamic hamartoma and epilepsy: patient selection and outcome
    Adib A Abla
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    Childs Nerv Syst 27:265-77. 2011
    ..This study aims to examine the outcomes of ten patients after orbitozygomatic (OZ) pterional surgery in cases of refractory epilepsy caused by hypothalamic hamartomas (HH)...
  15. ncbi request reprint Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesis
    Kristina A Fenoglio
    Division of Neurology and Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 14:51-9. 2007
    ..These observations constitute the basis for future investigations aimed at elucidating the mechanisms of subcortical epileptogenesis...
  16. doi request reprint Cognitive functioning before and after surgical resection for hypothalamic hamartoma and epilepsy
    Jennifer V Wethe
    From the Divisions of Neurology and Neurosurgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ
    Neurology 81:1044-50. 2013
    ..To determine whether patients with hypothalamic hamartoma (HH) improve in their cognitive functioning after neurosurgical resection of their HH and explore what variables correlate with cognitive outcome...
  17. ncbi request reprint Transcallosal resection of hypothalamic hamartoma for intractable epilepsy
    Yu tze Ng
    Comprehensive Epilepsy Center, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Epilepsia 47:1192-202. 2006
    ..To present the results of transcallosal surgical resection of hypothalamic hamartoma (HH) in 26 patients with refractory epilepsy in a prospective outcome study...
  18. pmc L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue
    Kristina A Simeone
    Divisions of Neurology and Pediatric Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Epilepsia 52:531-40. 2011
    ..In this study, we examined whether blocking L-type calcium channels attenuates emergent activity of HH neuronal networks...
  19. doi request reprint EEG and video-EEG seizure monitoring has limited utility in patients with hypothalamic hamartoma and epilepsy
    Matthew Troester
    Division of Pediatric Neurology, Barrow Neurological Institute and Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Epilepsia 52:1137-43. 2011
    ..We sought to determine the spectrum of electroencephalography (EEG) abnormalities in a large cohort of HH patients...
  20. ncbi request reprint Hypothalamic hamartomas associated with epilepsy: ultrastructural features
    John Beggs
    Division of Neuropathology, and The Comprehensive Epilepsy Center, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Neuropathol Exp Neurol 67:657-68. 2008
    ....
  21. doi request reprint Rhythmical and periodic EEG patterns do not predict short-term outcome in critically ill patients with subarachnoid hemorrhage
    Amy Z Crepeau
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    J Clin Neurophysiol 30:247-54. 2013
    ..When continuous EEG is used in patients in the neuro-intensive care unit, rhythmical and periodic patterns of uncertain significance are frequently encountered. It is unknown how these findings impact patient outcome...
  22. ncbi request reprint Intellectual functioning in presurgical patients with hypothalamic hamartoma and refractory epilepsy
    George P Prigatano
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Behav 13:149-55. 2008
    ..It was predicted that the level of estimated intelligence and the pattern of intellectual test performance would significantly correlate with the size of the HH and neuroanatomical features...
  23. ncbi request reprint In situ single-unit recording of hypothalamic hamartomas under endoscopic direct visualization
    Gregory P Lekovic
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Neurosurgery 65:E1195-6; discussion E1196. 2009
    ....
  24. doi request reprint Surgical resection of hypothalamic hamartomas for severe behavioral symptoms
    Yu tze Ng
    Division of Pediatric Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Epilepsy Behav 20:75-8. 2011
    ..HH resection can result in significant improvement in behavioral functioning, even in patients with relatively infrequent seizures. Further investigation under approved human research protocols is warranted...
  25. ncbi request reprint Endoscopic surgery for hypothalamic hamartomas causing medically refractory gelastic epilepsy
    Harold L Rekate
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    Childs Nerv Syst 22:874-80. 2006
    ..The purpose of this study is to report our experiences with endoscopic removal of these hamartomas...
  26. doi request reprint Interobserver agreement in the interpretation of EEG patterns in critically ill adults
    Paula A Gerber
    Division of Neurology and Epilepsy Center, Barrow Neurological Institute, Phoenix, Arizona, USA
    J Clin Neurophysiol 25:241-9. 2008
    ..Even when standardized terminology is used, the description of rhythmic and periodic EEG patterns varies significantly. Further refinement of the proposed terminology is required to improve inter- and intraobserver agreement...
  27. doi request reprint Syndrome of alternating hypernatremia and hyponatremia after hypothalamic hamartoma surgery
    Adib A Abla
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Neurosurg Focus 30:E6. 2011
    ..The triphasic response after surgery in the pituitary region can also explain variations in sodium parameters in such cases...
  28. ncbi request reprint Electrophysiological properties and subunit composition of GABAA receptors in patients with gelastic seizures and hypothalamic hamartoma
    Jie Wu
    Neurophysiology Lab, Div of Neurology, Barrow Neurological Inst, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013 4496, USA
    J Neurophysiol 98:5-15. 2007
    ..These findings bear relevance to a broader understanding of inhibitory neurotransmission in human HH tissue...
  29. ncbi request reprint Anterior motor strip displacement in a boy with right frontal gray matter heterotopia undergoing epilepsy surgery
    Andrew S Little
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Behav 11:241-6. 2007
    ..In addition, he is one of the few reported cases of focal cortical dysplasia resection with resultant improved behavior. These observations of unusual cortical representations have implications in epilepsy surgery planning...
  30. ncbi request reprint Neurosurgical treatment of status epilepticus
    Yu tze Ng
    Department of Pediatric Neurology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurosurg 105:378-81. 2006
    ..The purpose of this study was to report the cases of five patients with status epilepticus who were treated successfully with neurosurgery...
  31. ncbi request reprint Nonconvulsive status epilepticus in patients suffering spontaneous subarachnoid hemorrhage
    Andrew S Little
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosurg 106:805-11. 2007
    ..The authors evaluated the risk factors, electroencephalographic (EEG) characteristics, hospital course, and clinical outcomes associated with NCSE in a population with SAH treated at a single institution...
  32. doi request reprint Decreased quality of life in children with hypothalamic hamartoma and treatment-resistant epilepsy
    Cleo Park
    Division of Pediatric Neurology and Hypothalamic Hamartoma Program, Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix Children s Hospital, Phoenix, AZ, USA
    J Child Neurol 28:50-5. 2013
    ..Research examining the efficacy of recently developed surgical treatments for hypothalamic hamartoma should include health-related quality of life as an outcome measure...
  33. ncbi request reprint Gamma Knife surgery for hypothalamic hamartomas and epilepsy: patient selection and outcomes
    Adib A Abla
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosurg 113:207-14. 2010
    ..The authors present outcomes obtained in patients who underwent Gamma Knife surgery (GKS) at 1 institution as part of a multimodal treatment of refractory epilepsy caused by hypothalamic hamartomas (HHs)...
  34. ncbi request reprint Surgical strategies for approaching hypothalamic hamartomas causing gelastic seizures in the pediatric population: transventricular compared with skull base approaches
    Iman Feiz-Erfan
    Division of Neurological Surgery and Child Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosurg 103:325-32. 2005
    ..The authors provide evidence that direct resection of hypothalamic hamartomas (HHs) can improve associated gelastic and nongelastic seizures...
  35. pmc Ketogenic diet in the treatment of seizures associated with hypothalamic hamartomas
    Kevin E Chapman
    Barrow Neurological Institute and St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Res 94:218-21. 2011
    ..These preliminary results suggest that seizures associated with HH may respond favorably to the KD, and that ketone bodies might directly modulate the intrinsic epileptogenicity of HH tissue. ..
  36. doi request reprint Utility and safety of prolonged video-EEG monitoring in a tertiary pediatric epilepsy monitoring unit
    Daniel K Arrington
    Department of Pediatric Neurology, St Joseph s Hospital and Medical Center, Phoenix, AZ 80045, USA
    Epilepsy Behav 27:346-50. 2013
    ..Video-EEG monitoring had a high yield in capturing events and differentiating epileptic from nonepileptic events. Our pediatric patients experienced greater risk of status epilepticus but lesser risk of injury...
  37. ncbi request reprint Successful resection of a hypothalamic hamartoma and a Rathke cleft cyst. Case report
    Yu tze Ng
    Department of Pediatrics, Barrow Neurological Institute, St Joseph s Hospital, Phoenix, Arizona 85013, USA
    J Neurosurg 102:78-80. 2005
    ..Neuropathological studies confirmed the neuroimaging diagnoses for the two lesions. The patient has been seizure free for 6 months postoperatively...
  38. ncbi request reprint Treatment of refractory status epilepticus with hemispherectomy
    Dawn C Duane
    Division of Child Neurology, Children s Health Center, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Epilepsia 45:1001-4. 2004
    ..This case illustrates a potentially life-saving procedure for refractory status epilepticus and several techniques including a spike-suppression test to aid in prediction of cessation of seizures after hemispherectomy...
  39. ncbi request reprint Leukoencephalopathy with bilateral anterior temporal lobe cysts
    John B Bodensteiner
    Children s Health Center of St Joseph s Hospital and The Barrow Neurological Institute, Phoenix, AZ, USA
    J Child Neurol 21:419-22. 2006
    ..This is a distinctive, probably genetic, condition with characteristic neuroimaging and clinical features. In the appropriate clinical situation, the neuroimaging features are diagnostic...
  40. ncbi request reprint Electrophysiological properties of human hypothalamic hamartomas
    Jie Wu
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Ann Neurol 58:371-82. 2005
    ..These findings suggest that human HH tissues, associated with gelastic seizures, contained predominantly small GABAergic inhibitory neurons that exhibited intrinsic "pacemaker-like" behavior...
  41. ncbi request reprint Clinical application of functional MRI for memory using emotional enhancement: deficit and recovery with limbic encephalitis
    Leslie Baxter
    Department of Neuropsychology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Behav 11:454-9. 2007
    ..This case study demonstrates that using emotional stimuli to enhance memory responsivity may be an effective way to visualize clinical changes in individual patients...
  42. ncbi request reprint Respiratory syncytial virus infection and neurologic abnormalities: retrospective cohort study
    Nathaniel Kho
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    J Child Neurol 19:859-64. 2004
    ....