A D Craig

Summary

Affiliation: Barrow Neurological Institute
Country: USA

Publications

  1. ncbi request reprint Responses of spinothalamic lamina I neurons to repeated brief contact heat stimulation in the cat
    A D Craig
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurophysiol 87:1902-14. 2002
  2. ncbi request reprint Human feelings: why are some more aware than others?
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ 85013, USA
    Trends Cogn Sci 8:239-41. 2004
  3. ncbi request reprint Distribution of trigeminothalamic and spinothalamic lamina I terminations in the macaque monkey
    A D Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Comp Neurol 477:119-48. 2004
  4. ncbi request reprint Can the basis for central neuropathic pain be identified by using a thermal grill?
    A D Bud Craig
    Pain 135:215-6. 2008
  5. doi request reprint How do you feel--now? The anterior insula and human awareness
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Nat Rev Neurosci 10:59-70. 2009
  6. doi request reprint Cooling, pain, and other feelings from the body in relation to the autonomic nervous system
    A D Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, AZ, USA Electronic address
    Handb Clin Neurol 117:103-9. 2013
  7. ncbi request reprint Interoception: the sense of the physiological condition of the body
    A D Craig
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Curr Opin Neurobiol 13:500-5. 2003
  8. ncbi request reprint Distribution of trigeminothalamic and spinothalamic lamina I terminations in the cat
    A D Craig
    Atkinson Pain Research Laboratory, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Somatosens Mot Res 20:209-22. 2003
  9. ncbi request reprint Lamina I, but not lamina V, spinothalamic neurons exhibit responses that correspond with burning pain
    A D Craig
    Atkinson Research Lab, Barrow Neurological Inst, 350 West Thomas Rd, Phoenix, AZ 85013, USA
    J Neurophysiol 92:2604-9. 2004
  10. ncbi request reprint Forebrain emotional asymmetry: a neuroanatomical basis?
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Trends Cogn Sci 9:566-71. 2005

Research Grants

  1. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
  2. Fine Structure of Lamina I TSST Terminals in VP
    Arthur Craig; Fiscal Year: 2004
  3. FINE STRUCTURE OF TSTT TERMINALS ON VMPO
    Arthur Craig; Fiscal Year: 2001
  4. Lamina I and Homeostasis
    Arthur Craig; Fiscal Year: 2005

Detail Information

Publications38

  1. ncbi request reprint Responses of spinothalamic lamina I neurons to repeated brief contact heat stimulation in the cat
    A D Craig
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurophysiol 87:1902-14. 2002
    ..These findings support the concept that the lamina I STT projection comprises several discrete sensory channels that are integrated in the forebrain to generate distinct sensations...
  2. ncbi request reprint Human feelings: why are some more aware than others?
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ 85013, USA
    Trends Cogn Sci 8:239-41. 2004
    ....
  3. ncbi request reprint Distribution of trigeminothalamic and spinothalamic lamina I terminations in the macaque monkey
    A D Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Comp Neurol 477:119-48. 2004
    ..These findings demonstrate phylogenetically novel primate lamina I TSTT projections important for sensory and motivational aspects of pain, temperature, itch, muscle ache, sensual touch, and other interoceptive feelings from the body...
  4. ncbi request reprint Can the basis for central neuropathic pain be identified by using a thermal grill?
    A D Bud Craig
    Pain 135:215-6. 2008
  5. doi request reprint How do you feel--now? The anterior insula and human awareness
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Nat Rev Neurosci 10:59-70. 2009
    ..New findings suggest a fundamental role for the AIC (and the von Economo neurons it contains) in awareness, and thus it needs to be considered as a potential neural correlate of consciousness...
  6. doi request reprint Cooling, pain, and other feelings from the body in relation to the autonomic nervous system
    A D Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, AZ, USA Electronic address
    Handb Clin Neurol 117:103-9. 2013
    ..These findings suggest that bodily feelings provide important measures of the body's condition, support emotional well-being and awareness, and can be a significant therapeutic avenue. ..
  7. ncbi request reprint Interoception: the sense of the physiological condition of the body
    A D Craig
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Curr Opin Neurobiol 13:500-5. 2003
    ....
  8. ncbi request reprint Distribution of trigeminothalamic and spinothalamic lamina I terminations in the cat
    A D Craig
    Atkinson Pain Research Laboratory, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Somatosens Mot Res 20:209-22. 2003
    ..The novel identification of spinal lamina I input to the lateral habenula could be significant for homeostatic behaviors...
  9. ncbi request reprint Lamina I, but not lamina V, spinothalamic neurons exhibit responses that correspond with burning pain
    A D Craig
    Atkinson Research Lab, Barrow Neurological Inst, 350 West Thomas Rd, Phoenix, AZ 85013, USA
    J Neurophysiol 92:2604-9. 2004
    ..In contrast, lamina V wide-dynamic-range (WDR) neurons show a significantly different response pattern. This finding indicates that burning pain is signaled by modality-selective lamina I neurons and not convergent lamina V WDR neurons...
  10. ncbi request reprint Forebrain emotional asymmetry: a neuroanatomical basis?
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Trends Cogn Sci 9:566-71. 2005
    ..It can subsume differing views of emotion and the forebrain because it suggests that emotions are organized according to the fundamental principle of autonomic opponency for the management of physical and mental energy...
  11. ncbi request reprint Retrograde analyses of spinothalamic projections in the macaque monkey: input to posterolateral thalamus
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Comp Neurol 499:953-64. 2006
    ....
  12. ncbi request reprint Retrograde analyses of spinothalamic projections in the macaque monkey: input to ventral posterior nuclei
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Comp Neurol 499:965-78. 2006
    ..Together with the preceding observation that STT input to VMpo originates almost entirely from lamina I, these findings provide strong evidence that the primate STT consists of anatomically and functionally differentiable components...
  13. doi request reprint Retrograde analyses of spinothalamic projections in the macaque monkey: input to the ventral lateral nucleus
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Comp Neurol 508:315-28. 2008
    ..Together with the preceding observations of selective STT projections to other thalamic regions, these results provide compelling evidence that the primate STT consists of anatomically and functionally differentiable components...
  14. pmc Emotional moments across time: a possible neural basis for time perception in the anterior insula
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, AZ 85041, USA
    Philos Trans R Soc Lond B Biol Sci 364:1933-42. 2009
    ..This model does not describe the mechanism of the time base, but it suggests a possible relationship with interoceptive afferent activity, such as heartbeat-related inputs...
  15. doi request reprint The sentient self
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ 85013, USA
    Brain Struct Funct 214:563-77. 2010
    ..Issues that need to be addressed are highlighted. A possible basis for subjectivity in a cinemascopic model of awareness is presented...
  16. doi request reprint Significance of the insula for the evolution of human awareness of feelings from the body
    A D Bud Craig
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona, USA
    Ann N Y Acad Sci 1225:72-82. 2011
    ..This review presents the author's views regarding the principles of organization of this system and discusses a possible sequence for its evolution, as well as particular issues of historical interest...
  17. ncbi request reprint A new view of pain as a homeostatic emotion
    A D Craig
    Atkinson Pain Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Trends Neurosci 26:303-7. 2003
    ..These findings indicate that the human feeling of pain is both a distinct sensation and a motivation - that is, a specific emotion that reflects homeostatic behavioral drive, similar to temperature, itch, hunger and thirst...
  18. ncbi request reprint Association of spinothalamic lamina I neurons and their ascending axons with calbindin-immunoreactivity in monkey and human
    A D Craig
    Division of Neurosurgery, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Pain 97:105-15. 2002
    ..These findings support the view that lamina I STT neurons are involved in spinal cordotomies that reduce pain, temperature and itch sensations...
  19. ncbi request reprint Pain mechanisms: labeled lines versus convergence in central processing
    A D Bud Craig
    Atkinson Pain Research Laboratory, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Annu Rev Neurosci 26:1-30. 2003
    ..Recent functional and anatomical findings provide compelling support for a new perspective that views pain in humans as a homeostatic emotion that integrates both specific labeled lines and convergent somatic activity...
  20. ncbi request reprint Differential projections of thermoreceptive and nociceptive lamina I trigeminothalamic and spinothalamic neurons in the cat
    A D Craig
    Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurophysiol 86:856-70. 2001
    ....
  21. ncbi request reprint Quantitative response characteristics of thermoreceptive and nociceptive lamina I spinothalamic neurons in the cat
    A D Craig
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, 350 W Thomas Rd, Phoenix, AZ 85013, USA
    J Neurophysiol 86:1459-80. 2001
    ..Together these results support the concept that these classes of lamina I STT cells provide discrete sensory channels for the sensations of temperature and pain...
  22. ncbi request reprint Striatal projections of the vagal-responsive region of the thalamic parafascicular nucleus in macaque monkeys
    S Ito
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Comp Neurol 506:301-27. 2008
    ..These findings suggest the broad involvement of homeostatic afferent activity in striatal function and perhaps a role for the striatum in autonomic function...
  23. ncbi request reprint Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch
    D Andrew
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, Arizona 85013, USA
    Nat Neurosci 4:72-7. 2001
    ..These findings can explain why a lesion of the lateral STT disrupts itch along with pain and temperature sensations. Our findings provide strong evidence that itch is subserved by specific neural elements both peripherally and centrally...
  24. pmc Spinothalamic lamina I neurones selectively responsive to cutaneous warming in cats
    D Andrew
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    J Physiol 537:489-95. 2001
    ..Additionally, a role in thermoregulation, a defining feature of mammalian homeostasis, is suggested...
  25. ncbi request reprint Synaptology of trigemino- and spinothalamic lamina I terminations in the posterior ventral medial nucleus of the macaque
    J Beggs
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Comp Neurol 459:334-54. 2003
    ....
  26. ncbi request reprint A distinct thermoreceptive subregion of lamina I in nucleus caudalis of the owl monkey
    A D Craig
    Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Comp Neurol 404:221-34. 1999
    ..In addition, these observations corroborate other findings that have indicated that lamina I COLD cells are pyramidal neurons and are not physiologically modulated by substance P or serotonin, in contrast to nociceptive neurons...
  27. ncbi request reprint Responses of spinothalamic lamina I neurons to maintained noxious mechanical stimulation in the cat
    D Andrew
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurophysiol 87:1889-901. 2002
    ..quot; Nonetheless, none of the units studied showed increasing responses during the stimuli, suggesting a role for other ascending neurons or forebrain integration in the augmenting pain produced by maintained mechanical stimulation...
  28. ncbi request reprint Thermosensory activation of insular cortex
    A D Craig
    Division of Neurosurgery, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, Arizona 85013, USA
    Nat Neurosci 3:184-90. 2000
    ..Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal cortices...
  29. ncbi request reprint Functional imaging of an illusion of pain
    A D Craig
    Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Nature 384:258-60. 1996
    ..Disruption of thermosensory and pain integration may account for the central pain syndrome that can occur after stroke damage...
  30. ncbi request reprint Vagal-evoked activity in the parafascicular nucleus of the primate thalamus
    Shin ichi Ito
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    J Neurophysiol 94:2976-82. 2005
    ..This finding indicates that a role for this vagal activation site in the anti-epileptic effects of VNS needs to be considered...
  31. ncbi request reprint Laser-evoked potentials are graded and somatotopically organized anteroposteriorly in the operculoinsular cortex of anesthetized monkeys
    Ulf Baumgartner
    Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ 85013, USA
    J Neurophysiol 96:2802-8. 2006
    ....
  32. pmc Quantitative responses of spinothalamic lamina I neurones to graded mechanical stimulation in the cat
    David Andrew
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    J Physiol 545:913-31. 2002
    ....
  33. ncbi request reprint Differentiation of lamina I spinomedullary and spinothalamic neurons in the cat
    David Andrew
    Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Comp Neurol 458:257-71. 2003
    ..These findings are consistent with the concept that lamina I projections constitute an ascending homeostatic afferent pathway relating the physiological condition of the body...
  34. ncbi request reprint Vagal input to lateral area 3a in cat cortex
    Shin ichi Ito
    Atkinson Pain Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurophysiol 90:143-54. 2003
    ..The possibilities are considered that this vagal input is involved in motor control and in the sensory experience of visceral afferent activity...
  35. ncbi request reprint Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex
    Le H Hua
    Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 289:R319-R325. 2005
    ..Finally, another focus of strongly graded activation, which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex...
  36. ncbi request reprint Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging
    J C W Brooks
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Neuroimage 27:201-9. 2005
    ..037). Based on single subject analyses, the average standard space (MNI) coordinates for face, hand and foot activity were (-40,-16,11), (-40,-19,14) and (-35,-21,11) respectively...
  37. ncbi request reprint Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
    Gastroenterology 131:1925-42. 2006
  38. ncbi request reprint Disruption of thermal perception in a multiple sclerosis patient with central pain
    Chantal Morin
    Department of Anesthesiology, McGill University, Montreal, Quebec, Canada
    Clin J Pain 18:191-5. 2002
    ..To investigate integrative thermal perception in a patient with multiple sclerosis...

Research Grants16

  1. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
    ..This research will provide new insights into the synergy between lamina I and V STT neurons and into the integration underlying pain, temperature and itch sensations that is altered in clinical disorders. ..
  2. Fine Structure of Lamina I TSST Terminals in VP
    Arthur Craig; Fiscal Year: 2004
    ..These studies will advance our understanding of the anatomical substrates for pain sensation in the primate thalamus. ..
  3. FINE STRUCTURE OF TSTT TERMINALS ON VMPO
    Arthur Craig; Fiscal Year: 2001
    ....
  4. Lamina I and Homeostasis
    Arthur Craig; Fiscal Year: 2005
    ..The fundamental knowledge will provide new opportunities for explaining maladaptive homeostatic responses to somatic physiological changes, including such human pathological conditions as fibromyalgia. ..