JOHN GLENDINNING

Summary

Affiliation: Barnard College
Country: USA

Publications

  1. pmc Identification of chemosensory receptor genes in Manduca sexta and knockdown by RNA interference
    Natalie Howlett
    Department of Biological Sciences Barnard College, Columbia University, New York, NY 10027, USA
    BMC Genomics 13:211. 2012
  2. pmc Fetal ethanol exposure attenuates aversive oral effects of TrpV1, but not TrpA1 agonists in rats
    John I Glendinning
    Department of Biology, Barnard College, Columbia University, New York, NY 10027, USA
    Exp Biol Med (Maywood) 237:236-40. 2012
  3. ncbi request reprint Temporal coding mediates discrimination of "bitter" taste stimuli by an insect
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, New York, New York 10027, USA
    J Neurosci 26:8900-8. 2006
  4. ncbi request reprint The hungry caterpillar: an analysis of how carbohydrates stimulate feeding in Manduca sexta
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    J Exp Biol 210:3054-67. 2007
  5. ncbi request reprint How do predators cope with chemically defended foods?
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, New York 10027, USA
    Biol Bull 213:252-66. 2007
  6. pmc Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    Physiol Behav 93:757-65. 2008
  7. doi request reprint Contribution of orosensory stimulation to strain differences in oil intake by mice
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, United States
    Physiol Behav 95:476-83. 2008
  8. doi request reprint Induced preference for host plant chemicals in the tobacco hornworm: contribution of olfaction and taste
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, New York, NY 10027, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195:591-601. 2009
  9. pmc Differential effects of sucrose and fructose on dietary obesity in four mouse strains
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, New York, NY 10027, United States
    Physiol Behav 101:331-43. 2010
  10. ncbi request reprint Initial licking responses of mice to sweeteners: effects of tas1r3 polymorphisms
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    Chem Senses 30:601-14. 2005

Research Grants

Collaborators

Detail Information

Publications24

  1. pmc Identification of chemosensory receptor genes in Manduca sexta and knockdown by RNA interference
    Natalie Howlett
    Department of Biological Sciences Barnard College, Columbia University, New York, NY 10027, USA
    BMC Genomics 13:211. 2012
    ..The ability to connect molecular genetic mechanisms, including potential lineage-specific changes in chemosensory genes, to ecologically relevant behaviors and specializations in M. sexta would be greatly beneficial...
  2. pmc Fetal ethanol exposure attenuates aversive oral effects of TrpV1, but not TrpA1 agonists in rats
    John I Glendinning
    Department of Biology, Barnard College, Columbia University, New York, NY 10027, USA
    Exp Biol Med (Maywood) 237:236-40. 2012
    ..We propose that fetal ethanol exposure increases ethanol avidity not only by making ethanol smell and taste better, but also by attenuating ethanol's capsaicin-like burning sensations...
  3. ncbi request reprint Temporal coding mediates discrimination of "bitter" taste stimuli by an insect
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, New York, New York 10027, USA
    J Neurosci 26:8900-8. 2006
    ..We found that the pattern of stimulus generalization in both intact and lat-ablated caterpillars could only be predicted by temporal coding. We conclude that temporal codes from the periphery can mediate discriminative taste processing...
  4. ncbi request reprint The hungry caterpillar: an analysis of how carbohydrates stimulate feeding in Manduca sexta
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    J Exp Biol 210:3054-67. 2007
    ..We propose that the brain of M. sexta monitors input from the different classes of carbohydrate-sensitive taste cell, and generates protracted feeding responses only when all three classes are activated...
  5. ncbi request reprint How do predators cope with chemically defended foods?
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, New York 10027, USA
    Biol Bull 213:252-66. 2007
    ..The available evidence indicates that predators have mixed success overcoming these defenses. This conclusion is based on reports of free-ranging predators rejecting unpalatable but harmless prey, or voluntarily ingesting toxic prey...
  6. pmc Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    Physiol Behav 93:757-65. 2008
    ..This study provides the first evidence that rodents respond to the presence of "bitter" substances in their gastrointestinal tract by generating both behavioral and physiological responses...
  7. doi request reprint Contribution of orosensory stimulation to strain differences in oil intake by mice
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, United States
    Physiol Behav 95:476-83. 2008
    ....
  8. doi request reprint Induced preference for host plant chemicals in the tobacco hornworm: contribution of olfaction and taste
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, New York, NY 10027, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195:591-601. 2009
    ..We conclude that even though olfaction helps caterpillars locate potato foliage, it is the "tuned" gustatory response that ultimately mediates the induced preference...
  9. pmc Differential effects of sucrose and fructose on dietary obesity in four mouse strains
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, New York, NY 10027, United States
    Physiol Behav 101:331-43. 2010
    ....
  10. ncbi request reprint Initial licking responses of mice to sweeteners: effects of tas1r3 polymorphisms
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    Chem Senses 30:601-14. 2005
    ..There was also considerable variation among strains with the same Tas1r3 allele. We conclude that Tas1r3 polymorphisms contribute to strain differences in initial lick responsiveness to low but not high concentrations of sweeteners...
  11. ncbi request reprint Diet-induced plasticity in the taste system of an insect: localization to a single transduction pathway in an identified taste cell
    J I Glendinning
    Department of Biological Science, Barnard College, Columbia University, New York, NY 10027, USA
    J Exp Biol 202:2091-102. 1999
    ..We conclude that caffeine causes desensitization through a direct effect on a single transduction pathway within the bitter-sensitive taste cell...
  12. ncbi request reprint Contribution of different bitter-sensitive taste cells to feeding inhibition in a caterpillar (Manduca sexta)
    J I Glendinning
    Department of Biological Science, Barnard College, Columbia University, New York, New York 10027, USA
    Behav Neurosci 113:840-54. 1999
    ..Thus, the different pairs of bitter-sensitive taste cells appear to make partially redundant contributions to feeding inhibition...
  13. ncbi request reprint How do inositol and glucose modulate feeding in Manduca sexta caterpillars?
    J I Glendinning
    Department of Biological Science, Barnard College, Columbia University, New York, NY 10027, USA
    J Exp Biol 203:1299-315. 2000
    ..We conclude that sensory input from the inositol-sensitive taste cells, but not the sugar-sensitive taste cells, plays an important role in regulating feeding in M. sexta...
  14. ncbi request reprint A peripheral mechanism for behavioral adaptation to specific "bitter" taste stimuli in an insect
    J I Glendinning
    Department of Biological Science, Barnard College, Columbia University, New York, New York 10027, USA
    J Neurosci 21:3688-96. 2001
    ....
  15. ncbi request reprint Selective adaptation to noxious foods by a herbivorous insect
    J I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, NY 10027, USA
    J Exp Biol 204:3355-67. 2001
    ..We propose that toxicity is a more significant barrier to dietary adaptation than 'bitterness' in this insect...
  16. ncbi request reprint A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function
    John I Glendinning
    Department of Biological Science, Barnard College, Columbia University, New York, NY 10027, USA
    Chem Senses 27:461-74. 2002
    ..This screen represents a significant improvement over the common two-bottle preference test because it assesses taste function more specifically and in a fraction of the time...
  17. ncbi request reprint Contribution of different taste cells and signaling pathways to the discrimination of "bitter" taste stimuli by an insect
    John I Glendinning
    Department of Biological Science, Barnard College, Columbia University, New York, New York 10027, USA
    J Neurosci 22:7281-7. 2002
    ..We propose that the heterogeneous population of bitter-sensitive taste cells and signaling pathways within this insect facilitates the discrimination of bitter taste stimuli...
  18. ncbi request reprint Contribution of alpha-gustducin to taste-guided licking responses of mice
    John I Glendinning
    Department of Biological Science, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    Chem Senses 30:299-316. 2005
    ..There was no significant effect of deleting alpha-gustducin on licking responses to NH4Cl or HCl...
  19. pmc Taste does not determine daily intake of dilute sugar solutions in mice
    J I Glendinning
    Dept of Biological Sciences, Barnard College, Columbia Univ, 3009 Broadway, New York, NY 10027, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1333-41. 2010
    ....
  20. pmc Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice
    Masashi Inoue
    Laboratory of Cellular Neurobiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Physiol Genomics 32:82-94. 2007
    ....
  21. ncbi request reprint Flavor preferences conditioned in C57BL/6 mice by intragastric carbohydrate self-infusion
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210 2889, USA
    Physiol Behav 79:783-8. 2003
    ..Our understanding of flavor-nutrient learning can be advanced by studying this process in selected mouse strains and genetically modified animals...
  22. pmc Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins
    Anthony Sclafani
    Dept of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1504-13. 2007
    ..The experience-induced rescue of fat and Polycose preferences in the KO mice likely reflects the action of a postoral-conditioning mechanism, which functions in the absence of alpha-gustducin and Trpm5...
  23. ncbi request reprint Trpm5 null mice respond to bitter, sweet, and umami compounds
    Sami Damak
    Department of Neuroscience, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Chem Senses 31:253-64. 2006
    ..Thus, while Trpm5 is an important factor in many taste responses, its absence does not eliminate all taste responses. We conclude that Trpm5-dependent and Trpm5-independent pathways underlie bitter, sweet, and umami tastes...
  24. ncbi request reprint Sugar and fat conditioned flavor preferences in C57BL/6J and 129 mice: oral and postoral interactions
    Anthony Sclafani
    Dept of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 289:R712-20. 2005
    ....

Research Grants3

  1. HIGH-THROUGHPUT SCEENS FOR ASSESSING TASTE SENSITIVITY
    JOHN GLENDINNING; Fiscal Year: 2001
    ..A normative data-base for both screens will be established and made available to the scientific community. The assay procedures developed will be applicable by a single laboratory technician with limited experience. ..